CA2851690C - Treatment protocol of diabetes type 2 - Google Patents
Treatment protocol of diabetes type 2 Download PDFInfo
- Publication number
- CA2851690C CA2851690C CA2851690A CA2851690A CA2851690C CA 2851690 C CA2851690 C CA 2851690C CA 2851690 A CA2851690 A CA 2851690A CA 2851690 A CA2851690 A CA 2851690A CA 2851690 C CA2851690 C CA 2851690C
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- patient
- treatment
- lixisenatide
- patients
- pharmaceutically acceptable
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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- 231100000857 poor renal function Toxicity 0.000 description 1
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- 201000001474 proteinuria Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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- 238000004448 titration Methods 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11187169.5 | 2011-10-28 | ||
| EP11187169 | 2011-10-28 | ||
| PCT/EP2012/071271 WO2013060850A1 (en) | 2011-10-28 | 2012-10-26 | Treatment protocol of diabetes type 2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2851690A1 CA2851690A1 (en) | 2013-05-02 |
| CA2851690C true CA2851690C (en) | 2022-07-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2851690A Active CA2851690C (en) | 2011-10-28 | 2012-10-26 | Treatment protocol of diabetes type 2 |
Country Status (15)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736082A (zh) | 2008-10-17 | 2014-04-23 | 赛诺菲-安万特德国有限公司 | 胰岛素和glp-1激动剂的组合 |
| CN102711804B (zh) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | 包含glp-1激动剂和甲硫氨酸的药物组合物 |
| US20110118178A1 (en) * | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| AU2010317995B2 (en) | 2009-11-13 | 2014-04-17 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine |
| PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| ES2550357T3 (es) | 2011-08-29 | 2015-11-06 | Sanofi-Aventis Deutschland Gmbh | Combinación farmacéutica para su uso en el control glucémico en pacientes de diabetes de tipo 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| MX2015008114A (es) | 2012-12-21 | 2015-11-06 | Sanofi Sa | Derivados de exendina-4. |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| US20160038077A1 (en) * | 2013-06-27 | 2016-02-11 | Inspark Technologies, Inc. | Systems, Devices, and/or Methods for Identifying Time Periods of Insufficient Blood Glucose Testing |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／升糖素受體促效劑 |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| RU2016132342A (ru) | 2014-01-09 | 2018-02-14 | Санофи | Стабилизированные фармацевтические составы на основе инсулиновых аналогов и/или инсулиновых производных |
| KR20160104726A (ko) | 2014-01-09 | 2016-09-05 | 사노피 | 인슐린 유사체 및/또는 인슐린 유도체의 안정화된 무글리세롤 약제학적 제형 |
| JP6735674B2 (ja) | 2014-01-09 | 2020-08-05 | サノフイＳａｎｏｆｉ | インスリンアスパルトの安定化された医薬製剤 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| KR102578030B1 (ko) * | 2014-12-12 | 2023-09-14 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린 글라진／릭시세나티드 고정비 제형 |
| TWI706779B (zh) * | 2015-01-16 | 2020-10-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 小兒第２型糖尿病病患之治療 |
| TWI748945B (zh) * | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| WO2025124473A1 (zh) * | 2023-12-12 | 2025-06-19 | 江苏恒瑞医药股份有限公司 | Glp-1类似物治疗代谢疾病的方法及医药用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| KR20060119927A (ko) * | 2003-09-02 | 2006-11-24 | 프로시디온 리미티드 | 혈당 조절을 위한 조합 요법 |
| JP2008509145A (ja) * | 2004-08-03 | 2008-03-27 | エミスフィアー テクノロジーズ インコーポレイテッド | 抗糖尿病性経口インスリン−ビグアニドの組み合わせ |
| DK2393412T3 (en) * | 2009-02-04 | 2017-12-11 | Sanofi Aventis Deutschland | MEDICAL DEVICE AND PROCEDURE FOR PROVIDING Glycemic Control Information |
| JP5980466B2 (ja) * | 2009-11-13 | 2016-08-31 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン及びメトホルミンへの付加療法を含む２型糖尿病の治療方法 |
| KR20110052990A (ko) * | 2009-11-13 | 2011-05-19 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린 글라르긴 및 메트포르민에 대한 부가적 요법을 포함하는 2형 당뇨병의 치료 방법 |
| EP2329848B2 (en) * | 2009-11-13 | 2019-06-19 | Sanofi-Aventis Deutschland GmbH | Lixisenatide as add-on therapy to insulin glargine and metformin for treating type 2 diabetes |
| US20110118178A1 (en) * | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| US9821032B2 (en) * | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
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2012
- 2012-10-26 BR BR112014010200-7A patent/BR112014010200A2/pt not_active Application Discontinuation
- 2012-10-26 WO PCT/EP2012/071271 patent/WO2013060850A1/en not_active Ceased
- 2012-10-26 JP JP2014537630A patent/JP6329487B2/ja active Active
- 2012-10-26 CN CN201711071123.4A patent/CN107693783A/zh active Pending
- 2012-10-26 KR KR1020147011152A patent/KR101967941B1/ko active Active
- 2012-10-26 RU RU2014121386/15A patent/RU2014121386A/ru unknown
- 2012-10-26 AU AU2012328388A patent/AU2012328388B2/en active Active
- 2012-10-26 CA CA2851690A patent/CA2851690C/en active Active
- 2012-10-26 MY MYPI2014000971A patent/MY170713A/en unknown
- 2012-10-26 SG SG11201401175SA patent/SG11201401175SA/en unknown
- 2012-10-26 US US13/661,476 patent/US20130296236A1/en not_active Abandoned
- 2012-10-26 IN IN2616CHN2014 patent/IN2014CN02616A/en unknown
- 2012-10-26 EP EP12775720.1A patent/EP2771024B1/en active Active
- 2012-10-26 CN CN201280065132.1A patent/CN104066441A/zh active Pending
- 2012-10-26 MX MX2014005139A patent/MX359329B/es active IP Right Grant
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2014
- 2014-04-24 IL IL23225114A patent/IL232251B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014010200A2 (pt) | 2020-10-27 |
| JP6329487B2 (ja) | 2018-05-23 |
| KR20140093935A (ko) | 2014-07-29 |
| MX2014005139A (es) | 2014-08-27 |
| JP2015501314A (ja) | 2015-01-15 |
| HK1198577A1 (en) | 2015-04-30 |
| EP2771024B1 (en) | 2018-11-28 |
| MY170713A (en) | 2019-08-27 |
| CN107693783A (zh) | 2018-02-16 |
| RU2014121386A (ru) | 2015-12-10 |
| WO2013060850A1 (en) | 2013-05-02 |
| AU2012328388A1 (en) | 2014-05-15 |
| IN2014CN02616A (cg-RX-API-DMAC10.html) | 2015-06-26 |
| EP2771024A1 (en) | 2014-09-03 |
| US20130296236A1 (en) | 2013-11-07 |
| CA2851690A1 (en) | 2013-05-02 |
| AU2012328388B2 (en) | 2017-06-15 |
| MX359329B (es) | 2018-09-25 |
| SG11201401175SA (en) | 2014-09-26 |
| CN104066441A (zh) | 2014-09-24 |
| IL232251A0 (en) | 2014-06-30 |
| KR101967941B1 (ko) | 2019-04-10 |
| IL232251B (en) | 2019-10-31 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20170928 |
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| EEER | Examination request |
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