CA2845994C - Method for detecting nucleosomes containing histone variants - Google Patents

Method for detecting nucleosomes containing histone variants Download PDF

Info

Publication number
CA2845994C
CA2845994C CA2845994A CA2845994A CA2845994C CA 2845994 C CA2845994 C CA 2845994C CA 2845994 A CA2845994 A CA 2845994A CA 2845994 A CA2845994 A CA 2845994A CA 2845994 C CA2845994 C CA 2845994C
Authority
CA
Canada
Prior art keywords
histone
nucleosomes
nucleosome
cancer
variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2845994A
Other languages
English (en)
French (fr)
Other versions
CA2845994A1 (en
Inventor
Jacob Vincent Micallef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Belgian Volition SPRL
Original Assignee
Belgian Volition SPRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Belgian Volition SPRL filed Critical Belgian Volition SPRL
Publication of CA2845994A1 publication Critical patent/CA2845994A1/en
Application granted granted Critical
Publication of CA2845994C publication Critical patent/CA2845994C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104Lupus erythematosus [SLE]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/12Pulmonary diseases
    • G01N2800/122Chronic or obstructive airway disorders, e.g. asthma COPD
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/325Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA2845994A 2011-09-01 2012-08-31 Method for detecting nucleosomes containing histone variants Active CA2845994C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161530304P 2011-09-01 2011-09-01
US61/530,304 2011-09-01
GBGB1115098.4A GB201115098D0 (en) 2011-09-01 2011-09-01 Method for detecting nucleosomes containing histone variants
GB1115098.4 2011-09-01
PCT/GB2012/052131 WO2013030579A1 (en) 2011-09-01 2012-08-31 Method for detecting nucleosomes containing histone variants

Publications (2)

Publication Number Publication Date
CA2845994A1 CA2845994A1 (en) 2013-03-07
CA2845994C true CA2845994C (en) 2020-10-13

Family

ID=44882049

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2845994A Active CA2845994C (en) 2011-09-01 2012-08-31 Method for detecting nucleosomes containing histone variants

Country Status (20)

Country Link
US (5) US9400276B2 (cg-RX-API-DMAC7.html)
EP (2) EP3301449B1 (cg-RX-API-DMAC7.html)
JP (2) JP2014529405A (cg-RX-API-DMAC7.html)
KR (1) KR102130855B1 (cg-RX-API-DMAC7.html)
CN (2) CN104053993A (cg-RX-API-DMAC7.html)
AU (1) AU2012300643B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014004584B1 (cg-RX-API-DMAC7.html)
CA (1) CA2845994C (cg-RX-API-DMAC7.html)
DK (1) DK2751569T3 (cg-RX-API-DMAC7.html)
ES (2) ES2662380T3 (cg-RX-API-DMAC7.html)
GB (1) GB201115098D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20180362T1 (cg-RX-API-DMAC7.html)
HU (1) HUE038517T2 (cg-RX-API-DMAC7.html)
MX (1) MX349561B (cg-RX-API-DMAC7.html)
PL (1) PL2751569T3 (cg-RX-API-DMAC7.html)
PT (1) PT2751569T (cg-RX-API-DMAC7.html)
RU (2) RU2014112348A (cg-RX-API-DMAC7.html)
SG (2) SG10201601168QA (cg-RX-API-DMAC7.html)
WO (1) WO2013030579A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201401296B (cg-RX-API-DMAC7.html)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201115098D0 (en) 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10087485B2 (en) 2012-06-06 2018-10-02 The Trustees Of Princeton University DNA barcoding of designer mononucleosome and chromatin array libraries for the profiling of chromatin readers, writers, erasers, and modulators thereof
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3213084B2 (en) 2014-10-29 2023-12-13 Belgian Volition SPRL Method for the enrichment of circulating tumor dna
EP3256858B1 (en) * 2015-02-10 2020-03-25 B.R.A.H.M.S GmbH Histone h4 peptide as a biomarker
GB201511512D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell-free nucleosomes as biomarkers
GB201511542D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell free nucleosomes as biomarkers
GB201518665D0 (en) 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for enrichment of cell free nucleosomes
GB201518674D0 (en) 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for detecting nuleosomes containing histone modifications and variants
GB201604806D0 (en) * 2016-03-22 2016-05-04 Singapore Volition Pte Ltd Method of identifying a cancer of unknown origin
GB201612815D0 (en) * 2016-07-25 2016-09-07 Belgian Volition Sa Novel combination test
TWI726009B (zh) * 2016-11-28 2021-05-01 比利時商比利時意志有限公司 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途
KR20190104030A (ko) 2016-12-09 2019-09-05 더 브로드 인스티튜트, 인코퍼레이티드 Crispr 이펙터 시스템 기반 진단
AU2018234832A1 (en) 2017-03-15 2019-10-10 Massachusetts Institute Of Technology CRISPR effector system based diagnostics for virus detection
GB201721569D0 (en) 2017-12-21 2018-02-07 Belgian Volition Sprl Method for the detection and treatment of colorectal adenomas
CA3087362A1 (en) 2018-01-29 2019-08-01 The Broad Institute, Inc. Crispr effector system based diagnostics
FI4215621T3 (fi) 2018-03-01 2025-07-28 Epicypher Inc Nukleosomimodifikaatioiden kvantifiointi kemiallisesti määriteltyjä rekombinanttinukleosomeja käyttämällä
CN112236520B (zh) 2018-04-02 2025-01-24 格里尔公司 甲基化标记和标靶甲基化探针板
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
GB201912251D0 (en) 2019-08-27 2019-10-09 Belgian Volition Sprl Method of isolating circulating nucleosomes
KR20220111246A (ko) 2019-08-27 2022-08-09 벨지언 볼리션 에스알엘 순환 뉴클레오솜을 단리하는 방법
PL4070111T3 (pl) 2019-12-02 2025-02-03 Belgian Volition Srl Zastosowanie wolnych pozakomórkowych nukleosomsów jako biomarkerów
BR112022018792A2 (pt) 2020-03-20 2022-11-01 Belgian Volition Srl Método de triagem usando níveis de nucleossomos livres de células
JP2023544112A (ja) 2020-09-21 2023-10-20 ベルジアン ボリション エスアールエル 血液中の遊離ヌクレオソームのインラインモニタリングのための装置
TW202238131A (zh) 2020-11-25 2022-10-01 比利時商比利時意志有限公司 測量無細胞核蛋白染色質片段之方法
TW202238132A (zh) 2020-12-08 2022-10-01 比利時商比利時意志有限公司 多發性硬化症之診斷方法
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
TW202242146A (zh) 2021-01-13 2022-11-01 比利時商比利時意志有限公司 肺癌的檢測方法
GB202108185D0 (en) 2021-06-08 2021-07-21 Belgian Volition Sprl Standardisation of nucleosome assays using biologically derived calibrants
GB202108452D0 (en) 2021-06-14 2021-07-28 Belgian Volition Sprl Triaging method using cell free nucleosome levels
WO2023073179A1 (en) 2021-10-29 2023-05-04 Belgian Volition Srl Homogeneous immunoassay method
GB202117799D0 (en) 2021-12-09 2022-01-26 Belgian Volition Srl Method for the detection of blood cancer
WO2023170298A1 (en) 2022-03-11 2023-09-14 Belgian Volition Srl Differential diagnosis method
GB202205212D0 (en) 2022-04-08 2022-05-25 Belgian Volition Sprl Method for transplant organ health assessment
CA3265699A1 (en) 2022-08-25 2024-02-29 Belgian Volition Srl METHOD FOR DETECTING DEMENTIA
EP4577833A1 (en) 2022-08-25 2025-07-02 Belgian Volition SRL Method for measuring cell free chromatin
EP4639165A1 (en) 2022-12-19 2025-10-29 Belgian Volition SRL Assessment of biological samples for nucleic acid analysis
EP4639173A1 (en) 2022-12-19 2025-10-29 Belgian Volition SRL Calibration
GB202300607D0 (en) 2023-01-16 2023-03-01 Belgian Volition Srl Proteins and methods for isolating circulating nucleosomes
GB202303562D0 (en) 2023-03-10 2023-04-26 Belgian Volition Sprl Sample collection for liquid biopsy
WO2024213795A1 (en) 2023-04-14 2024-10-17 Belgian Volition Srl Diagnosis method using cell free nucleosome levels
WO2024223947A1 (en) 2023-04-28 2024-10-31 Belgian Volition Srl Use of cell free nucleosomes as biomarkers of carcinomas
GB202307768D0 (en) 2023-05-24 2023-07-05 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
GB202310137D0 (en) 2023-07-03 2023-08-16 Belgian Volition Srl Method for the detection of cancer
WO2025012440A1 (en) 2023-07-13 2025-01-16 Belgian Volition Srl Method for detection of the potential of a body fluid sample to produce extracellular traps
WO2025061853A1 (en) 2023-09-19 2025-03-27 Belgian Volition Srl Lateral flow test device
WO2025093747A1 (en) 2023-11-02 2025-05-08 Belgian Volition Srl Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules
WO2025181348A1 (en) 2024-03-01 2025-09-04 Belgian Volition Srl Method for determining the origin of circulating dna
WO2025253002A1 (en) 2024-06-07 2025-12-11 Belgian Volition Srl Sample collection for liquid biopsy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4276843B2 (ja) * 2001-03-23 2009-06-10 芳之 金井 モノヌクレオソーム及びその製造方法、ヌクレオソームに特異的な抗体の測定方法、自己免疫病診断方法、ヌクレオソームdna製造方法、dnaプレート、dnaプレート製造方法、並びに抗dna抗体測定法
US20040186274A1 (en) 2001-07-03 2004-09-23 Allis C. David Methylation of histone h4 at arginine 3
DE10207735A1 (de) * 2002-02-15 2003-08-28 Euroimmun Gmbh Verfahren zur Herstellung einer Nukleosomen-Präparation und deren Verwendung zur in vitro-Diagnose von Lupus erythematodes disseminatus (LED)
EP1483415A4 (en) * 2002-02-20 2006-02-01 Univ Virginia NON-INVASIVE DIAGNOSTIC TEST USING HISTONE MODIFICATION MARKERS
GB0319376D0 (en) * 2003-08-18 2003-09-17 Chroma Therapeutics Ltd Histone modification detection
WO2005040814A1 (en) * 2003-10-14 2005-05-06 Cancer Research Technology Limited Methods and means of cancer detection by histone modification
EP1907856A2 (en) * 2005-07-27 2008-04-09 Oncomethylome Sciences SA Angiogenesis inhibition based upon icam 1 or junb expression levels
CA2621953A1 (en) * 2005-09-09 2007-03-22 University Of Iowa Research Foundation Biomarkers associated with age-related macular degeneration
US20110312897A1 (en) * 2008-09-17 2011-12-22 The Rockefeller University Cathepsin l proteolytically processes histone h3 during mouse embryonic stem cell differentiation
EP2270510A1 (en) * 2009-07-02 2011-01-05 EMBL (European Molecular Biology Laboratory) Diagnostic method for predicting the risk of cancer recurrence based on Histone macroH2A isoforms
GB201115098D0 (en) 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants

Also Published As

Publication number Publication date
SG10201601168QA (en) 2016-03-30
US10184945B2 (en) 2019-01-22
RU2018101257A (ru) 2019-02-21
CA2845994A1 (en) 2013-03-07
RU2014112348A (ru) 2015-10-10
ZA201401296B (en) 2014-12-23
US20190120853A1 (en) 2019-04-25
SG11201400202SA (en) 2014-03-28
JP2017215338A (ja) 2017-12-07
US20140206014A1 (en) 2014-07-24
PL2751569T3 (pl) 2018-06-29
US20160299152A1 (en) 2016-10-13
EP3301449C0 (en) 2023-08-09
HK1199758A1 (en) 2015-07-17
RU2716494C2 (ru) 2020-03-12
US20230116530A1 (en) 2023-04-13
KR20140078638A (ko) 2014-06-25
PT2751569T (pt) 2018-03-28
BR112014004584B1 (pt) 2021-07-06
JP6494703B2 (ja) 2019-04-03
US9400276B2 (en) 2016-07-26
MX349561B (es) 2017-08-02
KR102130855B1 (ko) 2020-07-09
HUE038517T2 (hu) 2018-10-29
GB201115098D0 (en) 2011-10-19
BR112014004584A2 (pt) 2017-05-16
JP2014529405A (ja) 2014-11-13
RU2018101257A3 (cg-RX-API-DMAC7.html) 2019-02-21
ES2662380T3 (es) 2018-04-06
EP3301449A1 (en) 2018-04-04
EP2751569B1 (en) 2017-12-27
AU2012300643B2 (en) 2017-06-15
HRP20180362T1 (hr) 2018-06-01
CN108107215A (zh) 2018-06-01
CN104053993A (zh) 2014-09-17
WO2013030579A1 (en) 2013-03-07
MX2014002444A (es) 2014-10-23
EP2751569A1 (en) 2014-07-09
ES2955475T3 (es) 2023-12-01
US20200341006A1 (en) 2020-10-29
HK1253354A1 (en) 2019-06-14
DK2751569T3 (en) 2018-03-12
AU2012300643A1 (en) 2014-03-06
EP3301449B1 (en) 2023-08-09

Similar Documents

Publication Publication Date Title
US20230116530A1 (en) Method for detecting nucleosomes containing histone variants
US20200347435A1 (en) Method for detecting nucleosomes containing nucleotides
US9222937B2 (en) Method for detecting nucleosomes
US20170003296A1 (en) Method for detecting histone modifications in nucleosomes
HK40008468A (en) Method for detecting nucleosomes containing nucleotides
HK1253354B (en) Method for detecting nucleosomes containing histone variants
HK1199758B (en) Method for detecting nucleosomes containing histone variants
HK1199760B (en) Method for detecting nucleosomes containing nucleotides
HK1199761B (en) Method for detecting nucleosomes

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170804