CA2837153C - Procede de detection et de quantification d'une molecule cible dans un tissu - Google Patents

Procede de detection et de quantification d'une molecule cible dans un tissu Download PDF

Info

Publication number
CA2837153C
CA2837153C CA2837153A CA2837153A CA2837153C CA 2837153 C CA2837153 C CA 2837153C CA 2837153 A CA2837153 A CA 2837153A CA 2837153 A CA2837153 A CA 2837153A CA 2837153 C CA2837153 C CA 2837153C
Authority
CA
Canada
Prior art keywords
tissue
molecule
fabric
sample
standard
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2837153A
Other languages
English (en)
French (fr)
Other versions
CA2837153A1 (fr
Inventor
Jonathan STAUBER
David BONNEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imabiotech
Original Assignee
Imabiotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imabiotech filed Critical Imabiotech
Publication of CA2837153A1 publication Critical patent/CA2837153A1/fr
Application granted granted Critical
Publication of CA2837153C publication Critical patent/CA2837153C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N2001/2893—Preparing calibration standards

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
CA2837153A 2011-05-31 2012-05-29 Procede de detection et de quantification d'une molecule cible dans un tissu Active CA2837153C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1154731 2011-05-31
FR1154731A FR2976076B1 (fr) 2011-05-31 2011-05-31 Procede de detection et de quantification d'une molecule cible dans un tissu
PCT/FR2012/051205 WO2012164221A1 (fr) 2011-05-31 2012-05-29 Procede de detection et de quantification d'une molecule cible dans un tissu

Publications (2)

Publication Number Publication Date
CA2837153A1 CA2837153A1 (fr) 2012-12-06
CA2837153C true CA2837153C (fr) 2019-06-25

Family

ID=46420402

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2837153A Active CA2837153C (fr) 2011-05-31 2012-05-29 Procede de detection et de quantification d'une molecule cible dans un tissu

Country Status (12)

Country Link
US (1) US10132796B2 (OSRAM)
EP (1) EP2715310B1 (OSRAM)
JP (1) JP6170911B2 (OSRAM)
KR (1) KR102004350B1 (OSRAM)
CN (1) CN103688151B (OSRAM)
AU (1) AU2012264458B2 (OSRAM)
CA (1) CA2837153C (OSRAM)
DK (1) DK2715310T3 (OSRAM)
ES (1) ES2922478T3 (OSRAM)
FR (1) FR2976076B1 (OSRAM)
IN (1) IN2013MN02451A (OSRAM)
WO (1) WO2012164221A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014128309A1 (en) 2013-02-25 2014-08-28 Imabiotech Method to evaluate the tissue targeting of a molecule of interest
CN103336128A (zh) * 2013-06-08 2013-10-02 天津药物研究院 一种检测小分子多肽类药物组织分布的方法
KR102696044B1 (ko) * 2015-11-06 2024-08-16 벤타나 메디컬 시스템즈, 인코포레이티드 대표 진단법
KR101996666B1 (ko) * 2016-05-02 2019-07-04 주식회사 엘지화학 정량 분석 방법
US11289316B2 (en) 2018-05-30 2022-03-29 Shimadzu Corporation Spectrum data processing device and analyzer
EP4111174A4 (en) * 2020-02-27 2024-03-27 Nicoya Lifesciences, Inc. SYSTEMS AND METHODS FOR CHARACTERIZING AN ASSAY FROM REGIONS OF INTEREST USING OPTICAL REACTIONS
WO2021175842A1 (en) 2020-03-02 2021-09-10 Universiteit Maastricht Quality control standards for mass spectrometry imaging
CN115326915A (zh) * 2022-08-01 2022-11-11 中央民族大学 一种植物组织微阵列maldi-msi高通量分析方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL149171A0 (en) * 1999-11-16 2002-11-10 Genentech Inc Elisa for vegf
KR20050070034A (ko) * 2002-10-04 2005-07-05 미쯔비시 웰 파마 가부시키가이샤 질량 분석용 플레이트, 그 제조 방법 및 그 용도
US20040096907A1 (en) * 2002-11-06 2004-05-20 Bernd Bohrmann Quantification of beta amyloid
JP2005181011A (ja) * 2003-12-17 2005-07-07 Yoshio Yamauchi タンパク質解析方法
JP4547173B2 (ja) 2004-03-17 2010-09-22 シスメックス株式会社 糖尿病診療支援システム
CA2611266C (en) 2005-06-07 2015-11-24 Centre National De La Recherche Scientifique (Cnrs) Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections
EP2163900A1 (en) 2008-09-04 2010-03-17 Commissariat A L'energie Atomique New method of imaging by mass spectrometry and new mass tag associated trityl derivatives
WO2010041459A1 (ja) * 2008-10-08 2010-04-15 積水メディカル株式会社 薬物代謝物の定量分析方法及び分析装置
WO2011073740A1 (en) 2009-12-15 2011-06-23 Centre National De La Recherche Scientifique (Cnrs) Matrices for mass spectrometry imaging
FR2973112B1 (fr) 2011-03-21 2018-05-25 Imabiotech Procede de detection et de quantification d'une molecule cible dans un echantillon
EP2767832A1 (en) 2013-02-18 2014-08-20 Imabiotech Photo or chemolabile conjugates for molecules detection
WO2014128309A1 (en) 2013-02-25 2014-08-28 Imabiotech Method to evaluate the tissue targeting of a molecule of interest

Also Published As

Publication number Publication date
US10132796B2 (en) 2018-11-20
KR20140051187A (ko) 2014-04-30
JP6170911B2 (ja) 2017-07-26
ES2922478T3 (es) 2022-09-15
CN103688151B (zh) 2016-05-18
WO2012164221A1 (fr) 2012-12-06
AU2012264458A1 (en) 2014-01-09
US20140106391A1 (en) 2014-04-17
AU2012264458B2 (en) 2015-09-24
JP2014520259A (ja) 2014-08-21
EP2715310A1 (fr) 2014-04-09
IN2013MN02451A (OSRAM) 2015-04-17
FR2976076B1 (fr) 2015-02-27
FR2976076A1 (fr) 2012-12-07
KR102004350B1 (ko) 2019-07-26
CA2837153A1 (fr) 2012-12-06
EP2715310B1 (fr) 2022-04-27
CN103688151A (zh) 2014-03-26
DK2715310T3 (da) 2022-07-25

Similar Documents

Publication Publication Date Title
CA2837153C (fr) Procede de detection et de quantification d'une molecule cible dans un tissu
FR2973112A1 (fr) Procede de detection et de quantification d'une molecule cible dans un echantillon
Schuhmann et al. Intensity-independent noise filtering in FT MS and FT MS/MS spectra for shotgun lipidomics
Massonnet et al. A concise tutorial review of TOF-SIMS based molecular and cellular imaging
Chughtai et al. Mass spectrometric imaging for biomedical tissue analysis
Fung et al. Emerging role of clinical mass spectrometry in pathology
EP2124192A1 (en) Method for the analysis of tissue sections
Patti et al. Detection of carbohydrates and steroids by cation-enhanced nanostructure-initiator mass spectrometry (NIMS) for biofluid analysis and tissue imaging
Franck et al. Improving tissue preparation for matrix-assisted laser desorption ionization mass spectrometry imaging. Part 1: using microspotting
Nimesh et al. Current status and future perspectives of mass spectrometry imaging
Holbrook et al. Quantitative mass spectrometry imaging: therapeutics & biomolecules
Saigusa et al. Conductive adhesive film expands the utility of matrix-assisted laser desorption/ionization mass spectrometry imaging
CA2959111A1 (fr) Methode de caracterisation d'un echantillon par imagerie par spectrometrie de masse
Liu et al. Mass spectrometry imaging for biomedical applications
Minerva et al. Direct profiling and identification of peptide expression differences in the pancreas of control and ob/ob mice by imaging mass spectrometry
CA2799229C (fr) Procede d'evaluation toxicologique, procede de criblage toxicologique et systeme associe
Bao et al. 2-Hydroxy-5-nitro-3-(trifluoromethyl) pyridine as a Novel Matrix for Enhanced MALDI Imaging of Tissue Metabolites
Hou et al. Applications of spatially resolved omics in the field of endocrine tumors
Ngai et al. Mini review: Highlight of recent advances and applications of MALDI mass spectrometry imaging in 2024
Lukowski et al. An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue
Amer et al. Universal photosensitizer for isomer-selective lipid imaging with high molecular coverage
González-Rodríguez et al. Mass fingerprinting for high-throughput analyses of food: authentication and quality control
Okyem et al. Spatially mapping neuropeptide isomers via MALDI trapped ion mobility MS imaging
Zhang Applications of spatially
Hanrieder MALDI Mass Spectrometry Imaging of Neuropeptides

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170517