ES2922478T3 - Método para detectar y cuantificar una molécula deseada en un tejido - Google Patents

Método para detectar y cuantificar una molécula deseada en un tejido Download PDF

Info

Publication number
ES2922478T3
ES2922478T3 ES12731087T ES12731087T ES2922478T3 ES 2922478 T3 ES2922478 T3 ES 2922478T3 ES 12731087 T ES12731087 T ES 12731087T ES 12731087 T ES12731087 T ES 12731087T ES 2922478 T3 ES2922478 T3 ES 2922478T3
Authority
ES
Spain
Prior art keywords
tissue
molecule
calibration
homogenized
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12731087T
Other languages
English (en)
Spanish (es)
Inventor
Jonathan Stauber
David Bonnel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imabiotech
Original Assignee
Imabiotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imabiotech filed Critical Imabiotech
Application granted granted Critical
Publication of ES2922478T3 publication Critical patent/ES2922478T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38Diluting, dispersing or mixing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866Grinding or homogeneising
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N2001/2893Preparing calibration standards

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
ES12731087T 2011-05-31 2012-05-29 Método para detectar y cuantificar una molécula deseada en un tejido Active ES2922478T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1154731A FR2976076B1 (fr) 2011-05-31 2011-05-31 Procede de detection et de quantification d'une molecule cible dans un tissu
PCT/FR2012/051205 WO2012164221A1 (fr) 2011-05-31 2012-05-29 Procede de detection et de quantification d'une molecule cible dans un tissu

Publications (1)

Publication Number Publication Date
ES2922478T3 true ES2922478T3 (es) 2022-09-15

Family

ID=46420402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12731087T Active ES2922478T3 (es) 2011-05-31 2012-05-29 Método para detectar y cuantificar una molécula deseada en un tejido

Country Status (12)

Country Link
US (1) US10132796B2 (OSRAM)
EP (1) EP2715310B1 (OSRAM)
JP (1) JP6170911B2 (OSRAM)
KR (1) KR102004350B1 (OSRAM)
CN (1) CN103688151B (OSRAM)
AU (1) AU2012264458B2 (OSRAM)
CA (1) CA2837153C (OSRAM)
DK (1) DK2715310T3 (OSRAM)
ES (1) ES2922478T3 (OSRAM)
FR (1) FR2976076B1 (OSRAM)
IN (1) IN2013MN02451A (OSRAM)
WO (1) WO2012164221A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014128309A1 (en) 2013-02-25 2014-08-28 Imabiotech Method to evaluate the tissue targeting of a molecule of interest
CN103336128A (zh) * 2013-06-08 2013-10-02 天津药物研究院 一种检测小分子多肽类药物组织分布的方法
KR102696044B1 (ko) * 2015-11-06 2024-08-16 벤타나 메디컬 시스템즈, 인코포레이티드 대표 진단법
KR101996666B1 (ko) * 2016-05-02 2019-07-04 주식회사 엘지화학 정량 분석 방법
US11289316B2 (en) 2018-05-30 2022-03-29 Shimadzu Corporation Spectrum data processing device and analyzer
EP4111174A4 (en) * 2020-02-27 2024-03-27 Nicoya Lifesciences, Inc. SYSTEMS AND METHODS FOR CHARACTERIZING AN ASSAY FROM REGIONS OF INTEREST USING OPTICAL REACTIONS
WO2021175842A1 (en) 2020-03-02 2021-09-10 Universiteit Maastricht Quality control standards for mass spectrometry imaging
CN115326915A (zh) * 2022-08-01 2022-11-11 中央民族大学 一种植物组织微阵列maldi-msi高通量分析方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL149171A0 (en) * 1999-11-16 2002-11-10 Genentech Inc Elisa for vegf
KR20050070034A (ko) * 2002-10-04 2005-07-05 미쯔비시 웰 파마 가부시키가이샤 질량 분석용 플레이트, 그 제조 방법 및 그 용도
US20040096907A1 (en) * 2002-11-06 2004-05-20 Bernd Bohrmann Quantification of beta amyloid
JP2005181011A (ja) * 2003-12-17 2005-07-07 Yoshio Yamauchi タンパク質解析方法
JP4547173B2 (ja) 2004-03-17 2010-09-22 シスメックス株式会社 糖尿病診療支援システム
CA2611266C (en) 2005-06-07 2015-11-24 Centre National De La Recherche Scientifique (Cnrs) Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections
EP2163900A1 (en) 2008-09-04 2010-03-17 Commissariat A L'energie Atomique New method of imaging by mass spectrometry and new mass tag associated trityl derivatives
WO2010041459A1 (ja) * 2008-10-08 2010-04-15 積水メディカル株式会社 薬物代謝物の定量分析方法及び分析装置
WO2011073740A1 (en) 2009-12-15 2011-06-23 Centre National De La Recherche Scientifique (Cnrs) Matrices for mass spectrometry imaging
FR2973112B1 (fr) 2011-03-21 2018-05-25 Imabiotech Procede de detection et de quantification d'une molecule cible dans un echantillon
EP2767832A1 (en) 2013-02-18 2014-08-20 Imabiotech Photo or chemolabile conjugates for molecules detection
WO2014128309A1 (en) 2013-02-25 2014-08-28 Imabiotech Method to evaluate the tissue targeting of a molecule of interest

Also Published As

Publication number Publication date
US10132796B2 (en) 2018-11-20
KR20140051187A (ko) 2014-04-30
JP6170911B2 (ja) 2017-07-26
CN103688151B (zh) 2016-05-18
WO2012164221A1 (fr) 2012-12-06
AU2012264458A1 (en) 2014-01-09
US20140106391A1 (en) 2014-04-17
AU2012264458B2 (en) 2015-09-24
JP2014520259A (ja) 2014-08-21
EP2715310A1 (fr) 2014-04-09
IN2013MN02451A (OSRAM) 2015-04-17
FR2976076B1 (fr) 2015-02-27
FR2976076A1 (fr) 2012-12-07
KR102004350B1 (ko) 2019-07-26
CA2837153A1 (fr) 2012-12-06
EP2715310B1 (fr) 2022-04-27
CN103688151A (zh) 2014-03-26
DK2715310T3 (da) 2022-07-25
CA2837153C (fr) 2019-06-25

Similar Documents

Publication Publication Date Title
ES2922478T3 (es) Método para detectar y cuantificar una molécula deseada en un tejido
Darie-Ion et al. Applications of MALDI-MS/MS-based proteomics in biomedical research
Neumann et al. Spatial metabolomics of the human kidney using MALDI trapped ion mobility imaging mass spectrometry
Hermann et al. Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging
Norris et al. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research
Cornett et al. MALDI imaging mass spectrometry: molecular snapshots of biochemical systems
Seeley et al. Molecular imaging of proteins in tissues by mass spectrometry
Bodzon‐Kulakowska et al. Imaging mass spectrometry: instrumentation, applications, and combination with other visualization techniques
ES2745648T3 (es) Método para detectar y cuantificar una molécula diana en una muestra
EP2124192B1 (en) Method for the analysis of tissue sections
Fung et al. Emerging role of clinical mass spectrometry in pathology
Bonta et al. A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS
Ryan et al. Protein identification in imaging mass spectrometry through spatially targeted liquid micro‐extractions
Crecelius et al. MALDI mass spectrometric imaging meets “omics”: recent advances in the fruitful marriage
Wisztorski et al. MALDI direct analysis and imaging of frozen versus FFPE tissues: what strategy for which sample?
Byliński et al. Direct analysis of samples of various origin and composition using specific types of mass spectrometry
Zubair et al. Trypsin and MALDI matrix pre‐coated targets simplify sample preparation for mapping proteomic distributions within biological tissues by imaging mass spectrometry
Verhaert et al. Imaging of similar mass neuropeptides in neuronal tissue by enhanced resolution MALDI MS with an ion trap–OrbitrapTM hybrid instrument
Végvári et al. Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry
Quanico et al. Combined MALDI mass spectrometry imaging and parafilm-assisted microdissection-based LC-MS/MS workflows in the study of the brain
Lukowski et al. An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue
Zhao et al. Mass spectrometry imaging: applications in drug distribution studies
Veerasammy et al. Sample preparation for metabolic profiling using MALDI mass spectrometry imaging
Steuer et al. MALDI-MS drug analysis in biological samples: opportunities and challenges
WO2023076662A1 (en) System and method for quantitative pathology using mass spectrometry imaging