CA2837084C - 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use - Google Patents

4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use Download PDF

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Publication number
CA2837084C
CA2837084C CA2837084A CA2837084A CA2837084C CA 2837084 C CA2837084 C CA 2837084C CA 2837084 A CA2837084 A CA 2837084A CA 2837084 A CA2837084 A CA 2837084A CA 2837084 C CA2837084 C CA 2837084C
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CA
Canada
Prior art keywords
thieno
carboxylic acid
thiophene
dihydronaphtho
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2837084A
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English (en)
French (fr)
Other versions
CA2837084A1 (en
Inventor
Joseph Barbosa
Kenneth Gordon Carson
Michael Walter Gardyan
Jason Patrick Healy
Qiang Han
Ross Mabon
Praveen Pabba
James Tarver, Jr.
Kristen M. TERRANOVA
Ashok Tunoori
Xiaolian Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lexicon Pharmaceuticals Inc
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Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of CA2837084A1 publication Critical patent/CA2837084A1/en
Application granted granted Critical
Publication of CA2837084C publication Critical patent/CA2837084C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2837084A 2011-05-27 2012-05-23 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use Active CA2837084C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161490839P 2011-05-27 2011-05-27
US61/490,839 2011-05-27
PCT/US2012/039087 WO2012166458A1 (en) 2011-05-27 2012-05-23 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use

Publications (2)

Publication Number Publication Date
CA2837084A1 CA2837084A1 (en) 2012-12-06
CA2837084C true CA2837084C (en) 2019-09-17

Family

ID=46201840

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2837084A Active CA2837084C (en) 2011-05-27 2012-05-23 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use

Country Status (12)

Country Link
US (2) US20120302562A1 (https=)
EP (1) EP2714675B1 (https=)
JP (1) JP6166718B2 (https=)
CN (1) CN103649072A (https=)
AU (1) AU2012262748B2 (https=)
CA (1) CA2837084C (https=)
DK (1) DK2714675T3 (https=)
ES (1) ES2715832T3 (https=)
HU (1) HUE043221T2 (https=)
PL (1) PL2714675T3 (https=)
PT (1) PT2714675T (https=)
WO (1) WO2012166458A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE043221T2 (hu) * 2011-05-27 2019-08-28 Lexicon Pharmaceuticals Inc Notum pektinacetilészteráz 4H-tieno[3,2-C]kromén-alapú inhibitorai és alkalmazási eljárásaik
EP4610656A3 (en) 2016-04-15 2025-11-19 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
BR112020003466B1 (pt) * 2017-08-31 2023-12-12 Daiichi Sankyo Company, Limited Métodos de produção de composto, e, composto
CN108948011A (zh) * 2018-08-14 2018-12-07 华南农业大学 一种普拉多沙星的制备方法
GB201814151D0 (en) * 2018-08-31 2018-10-17 Ucl Business Plc Compounds
CN109134493A (zh) * 2018-09-19 2019-01-04 浙江师范大学 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN112094182B (zh) * 2020-09-22 2021-11-12 中国海洋大学 一种医药中间体苯并环己酮化合物的绿色合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1917601C3 (de) * 1969-04-05 1980-09-25 Bayer Ag, 5090 Leverkusen Benzoxazolyl-(2)-dihydronaphtho [4,5-b] thiophene und deren Verwendung als optische Aufheller
DE2628878A1 (de) * 1976-06-26 1978-01-05 Bayer Ag Beschichtungszusammensetzung
US4487778A (en) * 1983-01-27 1984-12-11 Fmc Corporation Insecticidal esters derived from benzocycloalkane-thiophenemethyl compounds
GB8504702D0 (en) * 1985-02-23 1985-03-27 Zyma Sa Tricyclic compounds
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
FR2790959B1 (fr) 1999-03-15 2003-06-27 Pf Medicament Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant
UY26026A1 (es) * 1999-03-16 2000-10-31 Smithkline Beecham Corportion Inhibidores de proteasas
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
EP1530565A1 (en) 2002-07-19 2005-05-18 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
JPWO2005012284A1 (ja) * 2003-07-31 2007-09-27 大正製薬株式会社 ４，５−ジヒドロナフト［１，２−ｂ］チオフェン誘導体
WO2006080406A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
WO2006080439A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
ES2480994T3 (es) * 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
HUE043221T2 (hu) * 2011-05-27 2019-08-28 Lexicon Pharmaceuticals Inc Notum pektinacetilészteráz 4H-tieno[3,2-C]kromén-alapú inhibitorai és alkalmazási eljárásaik

Also Published As

Publication number Publication date
AU2012262748A1 (en) 2013-11-28
WO2012166458A1 (en) 2012-12-06
US20140256784A1 (en) 2014-09-11
AU2012262748B2 (en) 2017-03-02
JP2014517848A (ja) 2014-07-24
PL2714675T3 (pl) 2019-07-31
CA2837084A1 (en) 2012-12-06
US9624238B2 (en) 2017-04-18
EP2714675A1 (en) 2014-04-09
US20120302562A1 (en) 2012-11-29
CN103649072A (zh) 2014-03-19
EP2714675B1 (en) 2019-01-02
JP6166718B2 (ja) 2017-07-19
ES2715832T3 (es) 2019-06-06
DK2714675T3 (en) 2019-04-15
PT2714675T (pt) 2019-04-12
HUE043221T2 (hu) 2019-08-28

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