CA2834696C - Csf-1r inhibitors for treatment of brain tumors - Google Patents

Csf-1r inhibitors for treatment of brain tumors Download PDF

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Publication number
CA2834696C
CA2834696C CA2834696A CA2834696A CA2834696C CA 2834696 C CA2834696 C CA 2834696C CA 2834696 A CA2834696 A CA 2834696A CA 2834696 A CA2834696 A CA 2834696A CA 2834696 C CA2834696 C CA 2834696C
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CA
Canada
Prior art keywords
tumor
compound
csf
blz945
brain
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Application number
CA2834696A
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English (en)
French (fr)
Other versions
CA2834696A1 (en
Inventor
Dylan DANIEL
Johanna JOYCE
James Sutton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Memorial Sloan Kettering Cancer Center
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Novartis AG
Memorial Sloan Kettering Cancer Center
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Publication of CA2834696A1 publication Critical patent/CA2834696A1/en
Application granted granted Critical
Publication of CA2834696C publication Critical patent/CA2834696C/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2834696A 2011-05-05 2012-05-04 Csf-1r inhibitors for treatment of brain tumors Active CA2834696C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161482723P 2011-05-05 2011-05-05
US61/482,723 2011-05-05
US201261624861P 2012-04-16 2012-04-16
US61/624,861 2012-04-16
PCT/US2012/036589 WO2012151523A1 (en) 2011-05-05 2012-05-04 Csf-1r inhibitors for treatment of brain tumors

Publications (2)

Publication Number Publication Date
CA2834696A1 CA2834696A1 (en) 2012-11-08
CA2834696C true CA2834696C (en) 2019-07-23

Family

ID=46062775

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2834696A Active CA2834696C (en) 2011-05-05 2012-05-04 Csf-1r inhibitors for treatment of brain tumors

Country Status (19)

Country Link
US (3) US20140065141A1 (cg-RX-API-DMAC7.html)
EP (1) EP2704713B1 (cg-RX-API-DMAC7.html)
JP (1) JP6046702B2 (cg-RX-API-DMAC7.html)
KR (1) KR101938431B1 (cg-RX-API-DMAC7.html)
CN (1) CN103501785B (cg-RX-API-DMAC7.html)
BR (1) BR112013028095B1 (cg-RX-API-DMAC7.html)
CA (1) CA2834696C (cg-RX-API-DMAC7.html)
CY (1) CY1119642T1 (cg-RX-API-DMAC7.html)
DK (1) DK2704713T3 (cg-RX-API-DMAC7.html)
EA (1) EA023999B1 (cg-RX-API-DMAC7.html)
ES (1) ES2622527T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20170593T1 (cg-RX-API-DMAC7.html)
HU (1) HUE032754T2 (cg-RX-API-DMAC7.html)
LT (1) LT2704713T (cg-RX-API-DMAC7.html)
MX (1) MX347616B (cg-RX-API-DMAC7.html)
PL (1) PL2704713T3 (cg-RX-API-DMAC7.html)
PT (1) PT2704713T (cg-RX-API-DMAC7.html)
SI (1) SI2704713T1 (cg-RX-API-DMAC7.html)
WO (1) WO2012151523A1 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014147631A1 (en) * 2013-03-22 2014-09-25 Natco Pharma Limited Formulation comprising gefitinib as oral suspension
EP3294417B1 (en) 2015-05-08 2021-10-13 Memorial Sloan Kettering Cancer Center Compositions and methods for treatment of glioma
MY195000A (en) * 2015-05-27 2022-12-30 Ucb Biopharma Sprl Method for the treatment of neurological disease
EP3973988A1 (en) 2015-11-04 2022-03-30 Duke University Combination therapy of immunotoxin and checkpoint inhibitor
RU2019114208A (ru) * 2016-10-14 2020-11-16 Новартис Аг Кристаллические формы 4-(2-((1r,2r)-2-гидроксициклогексиламино)бензотиазол-6-илокси)-n-метилпиколинамида
JP2019534269A (ja) * 2016-10-14 2019-11-28 ノバルティス アーゲー Csf−1rの阻害剤を使用して眼疾患を治療するための方法
MA46716A (fr) 2016-11-03 2019-09-11 Juno Therapeutics Inc Polythérapie de thérapie cellulaire et d'inhibiteur de la microglie
EP3631468A1 (en) 2017-06-02 2020-04-08 Juno Therapeutics, Inc. Articles of manufacture and methods related to toxicity associated with cell therapy
US11413310B2 (en) 2017-06-02 2022-08-16 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
WO2019006427A1 (en) 2017-06-29 2019-01-03 Juno Therapeutics, Inc. WALL MODEL FOR ASSESSING TOXICITIES ASSOCIATED WITH IMMUNOTHERAPIES
MA50057A (fr) 2017-09-01 2020-07-08 Juno Therapeutics Inc Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire
US11564946B2 (en) 2017-11-01 2023-01-31 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
EP3836951A1 (en) 2018-08-13 2021-06-23 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
EP3886875B1 (en) 2018-11-30 2024-05-08 Juno Therapeutics, Inc. Methods for treatment using adoptive cell therapy
MX2021006244A (es) 2018-11-30 2021-09-10 Juno Therapeutics Inc Metodos de dosificacion y tratamiento de canceres de celulas b en terapia celular adoptiva.
CN110468210A (zh) * 2019-09-12 2019-11-19 暨南大学 Cdc45作为胶质母细胞瘤标志物及其作为治疗靶点的应用
CN115398231A (zh) 2019-12-06 2022-11-25 朱诺治疗学股份有限公司 与治疗b细胞恶性肿瘤的细胞疗法相关的毒性和反应的相关方法
BR112023004719A2 (pt) * 2020-09-21 2023-04-18 Hutchison Medipharma Ltd Compostos heteroaromáticos e usos dos mesmos
CN115969979B (zh) * 2022-12-30 2025-08-29 中国人民解放军陆军军医大学第一附属医院 C620-0580在制备抗胶质瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100721656B1 (ko) 2005-11-01 2007-05-23 주식회사 엘지화학 유기 전기 소자
KR20080112380A (ko) * 2006-04-14 2008-12-24 아스트라제네카 아베 Csf-1r 키나제 억제제로서의 4-아닐리노퀴놀린-3-카르복스아미드
CN101432281B (zh) * 2006-04-19 2013-08-28 诺瓦提斯公司 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法
ES2654847T3 (es) * 2006-04-19 2018-02-15 Novartis Ag Compuestos de benzoxazol y benzotiazol sustituidos en 6-O y métodos para inhibir la señalización CSF-1R
CA2649924C (en) 2006-04-20 2014-08-19 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
AU2008254425A1 (en) * 2007-05-21 2008-11-27 Novartis Ag CSF-1R inhibitors, compositions, and methods of use

Also Published As

Publication number Publication date
JP6046702B2 (ja) 2016-12-21
BR112013028095A2 (pt) 2016-12-27
LT2704713T (lt) 2017-04-25
CN103501785A (zh) 2014-01-08
US10537561B2 (en) 2020-01-21
HRP20170593T1 (hr) 2017-07-14
US20140065141A1 (en) 2014-03-06
EP2704713A1 (en) 2014-03-12
WO2012151523A1 (en) 2012-11-08
PL2704713T3 (pl) 2017-08-31
AU2012250574A8 (en) 2016-07-28
KR20140029475A (ko) 2014-03-10
PT2704713T (pt) 2017-04-24
CN103501785B (zh) 2016-10-26
EP2704713B1 (en) 2017-01-18
BR112013028095B1 (pt) 2020-03-03
JP2014513136A (ja) 2014-05-29
DK2704713T3 (en) 2017-04-24
HUE032754T2 (en) 2017-10-30
MX347616B (es) 2017-05-04
MX2013012939A (es) 2014-02-27
US20190030013A1 (en) 2019-01-31
KR101938431B1 (ko) 2019-01-14
EA201391629A1 (ru) 2016-01-29
AU2012250574A1 (en) 2013-11-28
SI2704713T1 (sl) 2017-05-31
US20150306085A1 (en) 2015-10-29
ES2622527T3 (es) 2017-07-06
AU2012250574B2 (en) 2016-07-07
CY1119642T1 (el) 2018-04-04
EA023999B1 (ru) 2016-08-31
CA2834696A1 (en) 2012-11-08

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Effective date: 20170412