CA2824612C - Compounds, formulations, and methods for treating or preventing inflammatory skin disorders - Google Patents
Compounds, formulations, and methods for treating or preventing inflammatory skin disorders Download PDFInfo
- Publication number
- CA2824612C CA2824612C CA2824612A CA2824612A CA2824612C CA 2824612 C CA2824612 C CA 2824612C CA 2824612 A CA2824612 A CA 2824612A CA 2824612 A CA2824612 A CA 2824612A CA 2824612 C CA2824612 C CA 2824612C
- Authority
- CA
- Canada
- Prior art keywords
- skin
- pharmaceutically acceptable
- topical
- compounds
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000000034 method Methods 0.000 title abstract description 17
- 238000009472 formulation Methods 0.000 title description 29
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- A61K31/13—Amines
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US57414204P | 2004-05-25 | 2004-05-25 | |
| US10/853,585 US7439241B2 (en) | 2003-05-27 | 2004-05-25 | Compounds, formulations, and methods for treating or preventing rosacea |
| US60/574,142 | 2004-05-25 | ||
| US10/853,585 | 2004-05-25 | ||
| CA2567401A CA2567401C (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
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| CA2567401A Division CA2567401C (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
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| CA2824612C true CA2824612C (en) | 2016-08-16 |
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| CA2567401A Expired - Fee Related CA2567401C (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
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| CA2567401A Expired - Fee Related CA2567401C (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
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| JP (2) | JP4955543B2 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
| GB0611241D0 (en) * | 2006-06-07 | 2006-07-19 | Daniolabs Ltd | The treatment of increased sebum production |
| MX2012004890A (es) * | 2009-10-26 | 2012-09-28 | Galderma Pharma Sa | Metodos para tratar o prevenir eritema agudo. |
| EP2329849B1 (en) * | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| CA2792649A1 (en) | 2010-03-26 | 2011-09-29 | Michael Graeber | Improved methods and compositions for safe and effective treatment of telangiectasia |
| KR20170018974A (ko) | 2010-03-26 | 2017-02-20 | 갈데르마 리써어치 앤드 디벨로프먼트 | 홍반의 유효하고 안전한 치료를 위한 개선된 방법 및 조성물 |
| US8492557B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol |
| US20120082625A1 (en) * | 2010-09-28 | 2012-04-05 | Michael Graeber | Combination treatment for rosacea |
| US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
| JP2013540142A (ja) * | 2010-10-21 | 2013-10-31 | ガルデルマ・ソシエテ・アノニム | 局所ゲル組成物 |
| SG189896A1 (en) * | 2010-10-21 | 2013-06-28 | Galderma Sa | Brimonidine gel compositions and methods of use |
| CN101972272B (zh) * | 2010-10-31 | 2012-07-04 | 无锡龙腾画材有限公司 | 一种二氧化氯皮肤凝胶及其制备方法 |
| CA2818144C (en) * | 2010-11-16 | 2020-09-22 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| AU2012217858A1 (en) | 2011-02-15 | 2013-09-05 | Allergan, Inc. | Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea |
| FR2977493B1 (fr) * | 2011-07-05 | 2014-02-14 | Galderma Res & Dev | Nouvelle composition anesthesique stable pour la reduction des reactions cutanees |
| KR20140091543A (ko) * | 2011-10-19 | 2014-07-21 | 갈데르마 소시에떼아노님 | 전신용인 포스포디에스터레이즈타입-5-억제제에 의한 안면홍조를 경감시키는 방법 |
| US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
| UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
| WO2013078151A1 (en) | 2011-11-21 | 2013-05-30 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| ES2765264T3 (es) * | 2013-05-06 | 2020-06-08 | Allergan Inc | Agonistas alfa-adrenérgicos para el tratamiento de traumatismo tisular |
| WO2015013709A2 (en) * | 2013-07-26 | 2015-01-29 | Galderma Research & Development | Method for treating skin thickening |
| CN110585173A (zh) | 2013-10-07 | 2019-12-20 | 帝国制药美国公司 | 右旋美托咪啶经皮递送装置及其使用方法 |
| CN105764496B (zh) | 2013-10-07 | 2020-09-25 | 帝国制药美国公司 | 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物 |
| WO2015054059A2 (en) | 2013-10-07 | 2015-04-16 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions |
| US9937117B2 (en) | 2015-07-09 | 2018-04-10 | Galderma S.A. | Method of reducing hair loss associated with chemotherapy |
| JP2017052723A (ja) * | 2015-09-10 | 2017-03-16 | 株式会社Ｌｔｔバイオファーマ | ドライアイ改善剤 |
| CN106727462B (zh) * | 2016-11-14 | 2019-04-09 | 四川省人民医院 | 一种治疗面部皮炎的药物及其应用 |
| SG11202106716RA (en) * | 2019-01-12 | 2021-07-29 | Cellix Bio Private Ltd | Combination of selective alpha-adrenergic receptor agonist or an anticholinergic agent and lipoic acid and uses thereof |
| US20220218590A1 (en) * | 2019-05-14 | 2022-07-14 | Abend Fritz Ventures Llc | Compositions and methods for removal of skin adhesive patches, products, and residual adhesives |
| CN116600785A (zh) * | 2020-08-26 | 2023-08-15 | 奥蒂卡拉股份有限公司 | 用于治疗鼻、耳和其它组织感染和/或炎症的组合物、装置和方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| US4029792A (en) | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4164570A (en) * | 1973-09-24 | 1979-08-14 | David Clough | Stabilized aqueous catecholamine solutions |
| US4285967A (en) * | 1978-06-30 | 1981-08-25 | Estee Lauder Inc. | Cosmetic preparation for reducing redness of blemishes |
| US4256763A (en) * | 1978-09-19 | 1981-03-17 | Mchugh John E | Treatment of herpes simplex infections and acne |
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US4908387A (en) * | 1988-06-06 | 1990-03-13 | The Regents Of The University Of California | Use of beta2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis |
| CA2003198C (en) | 1988-11-29 | 1995-03-21 | Anthony J. Dziabo, Jr. | Aqueous ophthalmic solutions and method for preserving same |
| IT1252692B (it) * | 1991-11-27 | 1995-06-23 | Zambon Spa | Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi |
| US5736165A (en) | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
| US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5720962A (en) * | 1995-10-04 | 1998-02-24 | Au Pharmaceuticals, Inc. | Analgesic lotion for hemorrhoids and method of making such lotion |
| US6441047B2 (en) * | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
| US5916574A (en) * | 1996-10-09 | 1999-06-29 | Ideal Ideas, Inc. | Method of treating natural poison skin conditions |
| US5910312A (en) * | 1996-10-09 | 1999-06-08 | Ideal Ideas, Inc. | Acne treatment composition with vasoconstrictor |
| JPH1129482A (ja) * | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| CA2311344C (en) * | 1997-11-24 | 2006-02-07 | The Procter & Gamble Company | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability |
| US6159944A (en) * | 1998-02-27 | 2000-12-12 | Synchroneuron, Llc | Method for treating painful conditions of the anal region and compositions therefor |
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| US20020197300A1 (en) * | 1999-02-22 | 2002-12-26 | Schultz Clyde L. | Drug delivery system for anti-glaucomatous medication |
| US6284765B1 (en) * | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
| US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| AU7326901A (en) * | 2000-07-14 | 2002-01-30 | Allergan Sales Inc | Compositions containing alpha-2-adrenergic agonist components |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| JP3520076B2 (ja) * | 2001-10-02 | 2004-04-19 | 憲司 中村 | 皮膚外用剤 |
| US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
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Also Published As
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| EP2481412B1 (en) | 2017-09-27 |
| CN104490884A (zh) | 2015-04-08 |
| SI1761266T1 (sl) | 2013-08-30 |
| BRPI0511519A (pt) | 2007-12-26 |
| WO2005115395A2 (en) | 2005-12-08 |
| EP2481412A1 (en) | 2012-08-01 |
| CA2824612A1 (en) | 2005-12-08 |
| ES2424644T3 (es) | 2013-10-07 |
| EP1761266A4 (en) | 2009-11-11 |
| WO2005115395A3 (en) | 2009-04-09 |
| EP1761266A2 (en) | 2007-03-14 |
| JP2012072176A (ja) | 2012-04-12 |
| PT1761266E (pt) | 2013-06-04 |
| NZ552325A (en) | 2010-11-26 |
| CA2567401A1 (en) | 2005-12-08 |
| AU2005247467B2 (en) | 2010-12-02 |
| AU2005247467A1 (en) | 2005-12-08 |
| JP4955543B2 (ja) | 2012-06-20 |
| KR101257046B1 (ko) | 2013-04-22 |
| DK1761266T3 (da) | 2013-08-05 |
| EP1761266B1 (en) | 2013-05-08 |
| CA2567401C (en) | 2013-11-12 |
| KR20070032716A (ko) | 2007-03-22 |
| CN101426502A (zh) | 2009-05-06 |
| ES2647618T3 (es) | 2017-12-22 |
| JP2008500356A (ja) | 2008-01-10 |
| PL1761266T3 (pl) | 2013-09-30 |
| MXPA06013649A (es) | 2007-07-09 |
| JP5547705B2 (ja) | 2014-07-16 |
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