CA2819251A1 - Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol - Google Patents
Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol Download PDFInfo
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- CA2819251A1 CA2819251A1 CA2819251A CA2819251A CA2819251A1 CA 2819251 A1 CA2819251 A1 CA 2819251A1 CA 2819251 A CA2819251 A CA 2819251A CA 2819251 A CA2819251 A CA 2819251A CA 2819251 A1 CA2819251 A1 CA 2819251A1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US61/500,662 | 2011-06-24 | ||
| PCT/US2011/062413 WO2012075020A1 (en) | 2010-11-29 | 2011-11-29 | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
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| AU2010303270A1 (en) | 2009-10-09 | 2012-05-03 | Zafgen Corporation | Sulphone compounds for use in the treatment of obesity |
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| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
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| WO2012103333A1 (en) | 2011-01-26 | 2012-08-02 | Zafgen Corporation | Tetrazole compounds and methods of making and using same |
| JP5876513B2 (ja) | 2011-03-08 | 2016-03-02 | ザフゲン，インコーポレイテッド | オキサスピロ［２．５］オクタン誘導体および類似体 |
| BR112013028665A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| CN103764652B (zh) | 2011-05-06 | 2016-03-23 | 扎夫根股份有限公司 | 三环吡唑磺酰胺化合物及其制备和使用方法 |
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| CA2861390A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| MX2014013599A (es) | 2012-05-08 | 2015-05-11 | Zafgen Inc | Tratamiento de la obesidad hipotalamica con inhibidores de metap2. |
| US9573918B2 (en) | 2012-05-09 | 2017-02-21 | Zafgen, Inc. | Fumigillol compounds and methods of making and using same |
| KR20150080614A (ko) | 2012-11-05 | 2015-07-09 | 자프겐 인크. | 비만의 치료 및/또는 제어에서 사용하기 위한 트리시클릭 화합물 |
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| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
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| US20190329042A1 (en) * | 2018-02-26 | 2019-10-31 | Daniel John DiLorenzo | Method, apparatus, surgical technique, and optimal stimulation parameters for noninvasive & minimally invasive autonomic vector neuromodulation for physiologic optimization and for the treatment of obesity, cardiac disease, pulmonary disorders, hypertension, and other conditions |
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| PH26256A (en) | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
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| US6017954A (en) | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
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-
2011
- 2011-11-29 CA CA2819251A patent/CA2819251A1/en not_active Abandoned
- 2011-11-29 CN CN2011800646973A patent/CN103379905A/zh active Pending
- 2011-11-29 JP JP2013541073A patent/JP2013543899A/ja active Pending
- 2011-11-29 MX MX2013005989A patent/MX2013005989A/es active IP Right Grant
- 2011-11-29 WO PCT/US2011/062413 patent/WO2012075020A1/en not_active Ceased
- 2011-11-29 US US13/990,271 patent/US9173865B2/en not_active Expired - Fee Related
- 2011-11-29 EP EP11794331.6A patent/EP2646016B1/en active Active
- 2011-11-29 BR BR112013013411A patent/BR112013013411A2/pt not_active IP Right Cessation
- 2011-11-29 KR KR1020137016894A patent/KR20140009273A/ko not_active Withdrawn
- 2011-11-29 AU AU2011336785A patent/AU2011336785A1/en not_active Abandoned
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2013
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- 2013-10-17 US US14/056,816 patent/US8980946B2/en not_active Expired - Fee Related
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2015
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- 2015-09-17 US US14/856,929 patent/US20160243073A1/en not_active Abandoned
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2017
- 2017-09-13 US US15/703,398 patent/US20180221328A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140009273A (ko) | 2014-01-22 |
| US20140051752A1 (en) | 2014-02-20 |
| EP2646016A1 (en) | 2013-10-09 |
| US20140045934A1 (en) | 2014-02-13 |
| CN103379905A (zh) | 2013-10-30 |
| US20140045935A1 (en) | 2014-02-13 |
| US20160243073A1 (en) | 2016-08-25 |
| JP2013543899A (ja) | 2013-12-09 |
| MX2013005989A (es) | 2013-08-21 |
| WO2012075020A1 (en) | 2012-06-07 |
| AU2011336785A1 (en) | 2013-06-20 |
| US9173865B2 (en) | 2015-11-03 |
| BR112013013411A2 (pt) | 2016-09-13 |
| US9000035B2 (en) | 2015-04-07 |
| EP2646016B1 (en) | 2017-05-17 |
| US20180221328A1 (en) | 2018-08-09 |
| US8980946B2 (en) | 2015-03-17 |
| US20150209321A1 (en) | 2015-07-30 |
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