CA2817960C - Modulation of alpha synuclein expression - Google Patents
Modulation of alpha synuclein expression Download PDFInfo
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- CA2817960C CA2817960C CA2817960A CA2817960A CA2817960C CA 2817960 C CA2817960 C CA 2817960C CA 2817960 A CA2817960 A CA 2817960A CA 2817960 A CA2817960 A CA 2817960A CA 2817960 C CA2817960 C CA 2817960C
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| US11359197B2 (en) | 2018-01-12 | 2022-06-14 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| US12241065B2 (en) | 2018-01-12 | 2025-03-04 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
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| AU2011329777B2 (en) | 2010-11-17 | 2016-06-09 | Ionis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| DK2864479T3 (en) | 2012-06-25 | 2018-10-22 | Ionis Pharmaceuticals Inc | MODULATION OF UBE3A-ATS EXPRESSION |
| AU2013336581A1 (en) * | 2012-10-26 | 2015-06-11 | Nlife Therapeutics, S.L. | Compositions and methods for the treatment of Parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types |
| US10762374B2 (en) * | 2014-12-30 | 2020-09-01 | Blinkfire Analytics, Inc. | High accuracy image identification system |
| JP6606557B2 (ja) * | 2015-04-16 | 2019-11-13 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | Ｃ９ｏｒｆ７２発現を調節するための組成物 |
| UA125963C2 (uk) | 2015-11-12 | 2022-07-20 | Ф. Хоффманн-Ля Рош Аг | Олігонуклеотид для індукції батьківської експресії ube3a |
| WO2017087282A1 (en) | 2015-11-18 | 2017-05-26 | Rosalind Franklin University Of Medicine And Science | Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease |
| US10370667B2 (en) | 2015-11-18 | 2019-08-06 | Rosalind Franklin University Of Medicine And Science | Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease |
| US11234995B2 (en) * | 2016-01-07 | 2022-02-01 | Osaka University | α-synuclein expression inhibitor |
| US10815271B2 (en) * | 2016-06-29 | 2020-10-27 | The Regents Of The University Of California | Structure-based peptide inhibitors of alpha-synuclein aggregation |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| EP3628737A4 (en) * | 2017-07-05 | 2021-01-20 | Osaka University | ENA-ANTISENSE-OLIGONUCLEOTIDE TO INHIBIT ALPHA-SYNUCLEIN EXPRESSION |
| TWI809004B (zh) * | 2017-11-09 | 2023-07-21 | 美商Ionis製藥公司 | 用於降低snca表現之化合物及方法 |
| JP2021511027A (ja) * | 2018-01-12 | 2021-05-06 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ | アルファ−シヌクレインアンチセンスオリゴヌクレオチド及びその使用 |
| PH12021550254A1 (en) * | 2018-08-03 | 2023-02-06 | Genzyme Corp | Variant rnai against alpha-synuclein |
| CN115777021A (zh) * | 2020-03-18 | 2023-03-10 | 马萨诸塞大学 | 用于snca调节的寡核苷酸 |
| WO2022072447A1 (en) * | 2020-10-01 | 2022-04-07 | Alnylam Pharmaceuticals, Inc. | Snca irna compositions and methods of use thereof for treating or preventing snca-associated neurodegenerative diseases |
| AU2022234522A1 (en) | 2021-03-08 | 2023-10-26 | Les Laboratoires Servier | Antisense oligonucleotides for inhibiting alpha-synuclein expression |
| EP4359525A1 (en) * | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| WO2023215863A2 (en) * | 2022-05-06 | 2023-11-09 | Ionis Pharmaceuticals, Inc. | Rnai agents for modulating snca |
| AU2024220937A1 (en) * | 2023-02-17 | 2025-10-02 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating alpha-synuclein expression |
| WO2025063239A1 (ja) * | 2023-09-20 | 2025-03-27 | 第一三共株式会社 | α－シヌクレインの発現を抑制するｓｉＲＮＡ |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11359197B2 (en) | 2018-01-12 | 2022-06-14 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| US11447775B2 (en) | 2018-01-12 | 2022-09-20 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| US12180478B2 (en) | 2018-01-12 | 2024-12-31 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| US12241065B2 (en) | 2018-01-12 | 2025-03-04 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
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| EP2640853B1 (en) | 2018-12-26 |
| US20250136982A1 (en) | 2025-05-01 |
| AU2011329777A1 (en) | 2013-05-02 |
| US9663783B2 (en) | 2017-05-30 |
| US20180073022A1 (en) | 2018-03-15 |
| AU2016225852A1 (en) | 2016-09-29 |
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| JP2017079786A (ja) | 2017-05-18 |
| EP2640853A4 (en) | 2015-01-07 |
| WO2012068405A3 (en) | 2012-07-12 |
| EP2640853A2 (en) | 2013-09-25 |
| AU2011329777B2 (en) | 2016-06-09 |
| JP2014501507A (ja) | 2014-01-23 |
| WO2012068405A2 (en) | 2012-05-24 |
| US10815480B2 (en) | 2020-10-27 |
| US12043831B2 (en) | 2024-07-23 |
| EP3521451A1 (en) | 2019-08-07 |
| US20140005252A1 (en) | 2014-01-02 |
| CA3077910A1 (en) | 2012-05-24 |
| US20210087562A1 (en) | 2021-03-25 |
| AU2016225852B2 (en) | 2018-09-27 |
| CA2817960A1 (en) | 2012-05-24 |
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