AU2011329777B2 - Modulation of alpha synuclein expression - Google Patents

Modulation of alpha synuclein expression Download PDF

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Publication number
AU2011329777B2
AU2011329777B2 AU2011329777A AU2011329777A AU2011329777B2 AU 2011329777 B2 AU2011329777 B2 AU 2011329777B2 AU 2011329777 A AU2011329777 A AU 2011329777A AU 2011329777 A AU2011329777 A AU 2011329777A AU 2011329777 B2 AU2011329777 B2 AU 2011329777B2
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compound
modified
certain embodiments
seq
alpha
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AU2011329777A1 (en
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C. Frank Bennett
Susan M. Freier
Jyothi Mallajosyula
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Ionis Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2011329777A 2010-11-17 2011-11-17 Modulation of alpha synuclein expression Active AU2011329777B2 (en)

Priority Applications (1)

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Application Number Priority Date Filing Date Title
US41484810P 2010-11-17 2010-11-17
US61/414,848 2010-11-17
PCT/US2011/061245 WO2012068405A2 (en) 2010-11-17 2011-11-17 Modulation of alpha synuclein expression

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AU2011329777A1 AU2011329777A1 (en) 2013-05-02
AU2011329777B2 true AU2011329777B2 (en) 2016-06-09

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US (4) US9663783B2 (enExample)
EP (2) EP3521451A1 (enExample)
JP (2) JP6126009B2 (enExample)
AU (2) AU2011329777B2 (enExample)
CA (2) CA2817960C (enExample)
WO (1) WO2012068405A2 (enExample)

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AU2011329777B2 (en) 2010-11-17 2016-06-09 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
DK2864479T3 (en) 2012-06-25 2018-10-22 Ionis Pharmaceuticals Inc MODULATION OF UBE3A-ATS EXPRESSION
AU2013336581A1 (en) * 2012-10-26 2015-06-11 Nlife Therapeutics, S.L. Compositions and methods for the treatment of Parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types
US10762374B2 (en) * 2014-12-30 2020-09-01 Blinkfire Analytics, Inc. High accuracy image identification system
JP6606557B2 (ja) * 2015-04-16 2019-11-13 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｃ９ｏｒｆ７２発現を調節するための組成物
UA125963C2 (uk) 2015-11-12 2022-07-20 Ф. Хоффманн-Ля Рош Аг Олігонуклеотид для індукції батьківської експресії ube3a
WO2017087282A1 (en) 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
US11234995B2 (en) * 2016-01-07 2022-02-01 Osaka University α-synuclein expression inhibitor
US10815271B2 (en) * 2016-06-29 2020-10-27 The Regents Of The University Of California Structure-based peptide inhibitors of alpha-synuclein aggregation
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WO2019009298A1 (ja) * 2017-07-05 2019-01-10 国立大学法人大阪大学 α－シヌクレイン発現抑制剤
EP3628737A4 (en) * 2017-07-05 2021-01-20 Osaka University ENA-ANTISENSE-OLIGONUCLEOTIDE TO INHIBIT ALPHA-SYNUCLEIN EXPRESSION
TWI809004B (zh) * 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
KR102839166B1 (ko) 2018-01-12 2025-07-28 브리스톨-마이어스 스큅 컴퍼니 알파-시누클레인을 표적화하는 안티센스 올리고뉴클레오티드 및 그의 용도
JP2021511027A (ja) * 2018-01-12 2021-05-06 ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ アルファ−シヌクレインアンチセンスオリゴヌクレオチド及びその使用
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CN115777021A (zh) * 2020-03-18 2023-03-10 马萨诸塞大学 用于snca调节的寡核苷酸
WO2022072447A1 (en) * 2020-10-01 2022-04-07 Alnylam Pharmaceuticals, Inc. Snca irna compositions and methods of use thereof for treating or preventing snca-associated neurodegenerative diseases
AU2022234522A1 (en) 2021-03-08 2023-10-26 Les Laboratoires Servier Antisense oligonucleotides for inhibiting alpha-synuclein expression
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WO2023215863A2 (en) * 2022-05-06 2023-11-09 Ionis Pharmaceuticals, Inc. Rnai agents for modulating snca
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