CA2815029A1 - Derives d'imidazo[1,2-b]pyridazine et d'imidazo[4,5-b]pyridine en tant qu'inhibiteurs des jak - Google Patents

Derives d'imidazo[1,2-b]pyridazine et d'imidazo[4,5-b]pyridine en tant qu'inhibiteurs des jak Download PDF

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Publication number
CA2815029A1
CA2815029A1 CA2815029A CA2815029A CA2815029A1 CA 2815029 A1 CA2815029 A1 CA 2815029A1 CA 2815029 A CA2815029 A CA 2815029A CA 2815029 A CA2815029 A CA 2815029A CA 2815029 A1 CA2815029 A1 CA 2815029A1
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Prior art keywords
group
branched
linear
hydrogen atom
cycloalkyl
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Pending
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CA2815029A
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Inventor
Jacob Gonzalez Rodriguez
Bernat Vidal Juan
Laura Vidal Gispert
Jordi Bach Tana
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Almirall SA
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Almirall SA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43585650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2815029(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall SA filed Critical Almirall SA
Publication of CA2815029A1 publication Critical patent/CA2815029A1/fr
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2815029A 2010-11-26 2011-11-24 Derives d'imidazo[1,2-b]pyridazine et d'imidazo[4,5-b]pyridine en tant qu'inhibiteurs des jak Pending CA2815029A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10382318.3 2010-11-26
EP20100382318 EP2463289A1 (fr) 2010-11-26 2010-11-26 Dérivés imidazo[1,2-b]pyridazine en tant qu'inhibiteur JAK
US201161436212P 2011-01-26 2011-01-26
US61/436,212 2011-01-26
PCT/EP2011/005929 WO2012069202A1 (fr) 2010-11-26 2011-11-24 Dérivés d'imidazo[1,2-b]pyridazine et d'imidazo[4,5-b]pyridine en tant qu'inhibiteurs des jak

Publications (1)

Publication Number Publication Date
CA2815029A1 true CA2815029A1 (fr) 2012-05-31

Family

ID=43585650

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2815029A Pending CA2815029A1 (fr) 2010-11-26 2011-11-24 Derives d'imidazo[1,2-b]pyridazine et d'imidazo[4,5-b]pyridine en tant qu'inhibiteurs des jak

Country Status (22)

Country Link
US (1) US9133200B2 (fr)
EP (2) EP2463289A1 (fr)
JP (1) JP5809704B2 (fr)
KR (1) KR20140004637A (fr)
CN (1) CN103228654A (fr)
AR (1) AR087328A1 (fr)
AU (1) AU2011334146A1 (fr)
BR (1) BR112013012965A2 (fr)
CA (1) CA2815029A1 (fr)
CL (1) CL2013001464A1 (fr)
CO (1) CO6781467A2 (fr)
CR (1) CR20130210A (fr)
EA (1) EA201300620A1 (fr)
GT (1) GT201300137A (fr)
IL (1) IL225232A0 (fr)
MX (1) MX2013005257A (fr)
NZ (1) NZ608718A (fr)
PE (1) PE20140390A1 (fr)
SG (1) SG190042A1 (fr)
TW (1) TW201236683A (fr)
UY (1) UY33752A (fr)
WO (1) WO2012069202A1 (fr)

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EP2463289A1 (fr) 2010-11-26 2012-06-13 Almirall, S.A. Dérivés imidazo[1,2-b]pyridazine en tant qu'inhibiteur JAK
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CA3157394A1 (fr) 2019-12-19 2021-06-24 Helena ERIKSSON Composes pour le traitement de maladies oculaires associees a une vascularisation excessive
JP2023530088A (ja) 2020-06-12 2023-07-13 インサイト・コーポレイション Ａｌｋ２阻害剤としての活性を有するイミダゾピリダジン化合物
JP2024510246A (ja) * 2021-03-15 2024-03-06 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ ヤヌスキナーゼ阻害剤としてのヘテロ環誘導体
WO2022194781A1 (fr) * 2021-03-15 2022-09-22 Chiesi Farmaceutici S.P.A. Dérivés hétérocycliques comme inhibiteurs de janus kinase
KR20220129495A (ko) * 2021-03-16 2022-09-23 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물의 결정형
BR112023018672A2 (pt) * 2021-03-16 2023-10-03 Hk Inno N Corp Sal de ácido orgânico, composição e uso
WO2023133201A1 (fr) * 2022-01-05 2023-07-13 K36 Therapeutics, Inc. Pipéridinyl-méthyl-purine amines enrichies en deutérium et composés associés et leur utilisation dans le traitement de maladies et d'états
WO2024052512A1 (fr) * 2022-09-09 2024-03-14 Chiesi Farmaceutici S.P.A. Dérivés hétérocycliques comme inhibiteurs de janus kinase
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CL2013001464A1 (es) 2013-09-06
CO6781467A2 (es) 2013-10-31
US20130309200A1 (en) 2013-11-21
NZ608718A (en) 2015-04-24
AU2011334146A1 (en) 2013-04-04
BR112013012965A2 (pt) 2016-08-23
SG190042A1 (en) 2013-06-28
IL225232A0 (en) 2013-06-27
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JP5809704B2 (ja) 2015-11-11
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TW201236683A (en) 2012-09-16
US9133200B2 (en) 2015-09-15
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CN103228654A (zh) 2013-07-31
AR087328A1 (es) 2014-03-19
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