CA2805622C - Method for hydrophilizing surfaces of fluidic components and parts containing such components - Google Patents
Method for hydrophilizing surfaces of fluidic components and parts containing such components Download PDFInfo
- Publication number
- CA2805622C CA2805622C CA2805622A CA2805622A CA2805622C CA 2805622 C CA2805622 C CA 2805622C CA 2805622 A CA2805622 A CA 2805622A CA 2805622 A CA2805622 A CA 2805622A CA 2805622 C CA2805622 C CA 2805622C
- Authority
- CA
- Canada
- Prior art keywords
- chitosan
- aqueous solution
- measurement channel
- analyzer
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 37
- 229920001661 Chitosan Polymers 0.000 claims abstract description 151
- 238000005259 measurement Methods 0.000 claims abstract description 62
- 239000007864 aqueous solution Substances 0.000 claims abstract description 19
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 50
- 230000006196 deacetylation Effects 0.000 claims description 19
- 238000003381 deacetylation reaction Methods 0.000 claims description 19
- 238000003908 quality control method Methods 0.000 claims description 13
- 239000000243 solution Substances 0.000 abstract description 55
- 238000009736 wetting Methods 0.000 description 27
- 238000000576 coating method Methods 0.000 description 16
- 239000011248 coating agent Substances 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 10
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 239000007789 gas Substances 0.000 description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
- 239000003570 air Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000010410 layer Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 125000003277 amino group Chemical group 0.000 description 7
- 239000012482 calibration solution Substances 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- -1 n-ProPyl Chemical group 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 238000005429 filling process Methods 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000003032 molecular docking Methods 0.000 description 2
- 238000009832 plasma treatment Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 241001211987 Barea Species 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 238000010222 PCR analysis Methods 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003679 aging effect Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001228 polyisocyanate Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- RDZTWEVXRGYCFV-UHFFFAOYSA-M sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate Chemical compound [Na+].OCCN1CCN(CCS([O-])(=O)=O)CC1 RDZTWEVXRGYCFV-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10170613.3 | 2010-07-23 | ||
| EP10170613A EP2409766A1 (de) | 2010-07-23 | 2010-07-23 | Verfahren zur Hydrophilisierung von Oberflächen fluidischer Komponenten und derartige Komponenten enthaltende Bauteile |
| PCT/EP2011/062506 WO2012010653A1 (de) | 2010-07-23 | 2011-07-21 | Verfahren zur hydrophilisierung von oberflächen fluidischer komponenten und derartige komponenten enthaltende bauteile |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2805622A1 CA2805622A1 (en) | 2012-01-26 |
| CA2805622C true CA2805622C (en) | 2015-04-28 |
Family
ID=42799763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2805622A Expired - Fee Related CA2805622C (en) | 2010-07-23 | 2011-07-21 | Method for hydrophilizing surfaces of fluidic components and parts containing such components |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9623440B2 (enExample) |
| EP (2) | EP2409766A1 (enExample) |
| JP (1) | JP5848763B2 (enExample) |
| CN (1) | CN102958612B (enExample) |
| CA (1) | CA2805622C (enExample) |
| WO (1) | WO2012010653A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100161267A1 (en) * | 2008-12-19 | 2010-06-24 | Roche Diagnostics Operations, Inc. | Device and Method for Automatic Calibration Verification of an Analyzer |
| JP2015521293A (ja) | 2012-05-31 | 2015-07-27 | ザ・ユニバーシテイ・オブ・ノース・カロライナ・アト・チャペル・ヒル | 溶解に誘導される構造化表面の湿潤 |
| JP5768174B1 (ja) * | 2014-06-24 | 2015-08-26 | 日本写真印刷株式会社 | 培養容器 |
| DK3559664T3 (da) * | 2016-12-23 | 2021-03-08 | Radiometer Medical Aps | Sensorsamling til flergangsbrug til legemsvæsker |
| DE102018205903A1 (de) | 2018-04-18 | 2019-10-24 | Robert Bosch Gmbh | Schallsensor und Fluidtank mit Schallsensor |
| DK3647781T3 (da) * | 2018-10-29 | 2024-08-05 | EXIAS Medical GmbH | Målepatron til måling af en flydende prøve |
| CN114778628B (zh) * | 2022-04-25 | 2024-05-24 | 北京怡成生物电子技术股份有限公司 | 柔性工作电极及酶传感器 |
| CN116060148B (zh) * | 2023-02-17 | 2024-06-07 | 西南石油大学 | 一种纳米通道原位可控疏水改性方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH625065A5 (enExample) | 1977-11-16 | 1981-08-31 | Avl Ag | |
| US4752426A (en) | 1985-06-27 | 1988-06-21 | Yoshito Ikada | Process for manufacture of plastic resinous tubes |
| US5091205A (en) | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
| JPH05288717A (ja) * | 1992-04-13 | 1993-11-02 | Kurita Water Ind Ltd | キャピラリーコーティング剤 |
| US5578073A (en) | 1994-09-16 | 1996-11-26 | Ramot Of Tel Aviv University | Thromboresistant surface treatment for biomaterials |
| EP1190252B1 (en) * | 1999-04-28 | 2008-12-31 | Eidgenössische Technische Hochschule Zürich | Polyionic coatings in analytic and sensor devices |
| SE9904802D0 (sv) * | 1999-12-23 | 1999-12-23 | Amersham Pharm Biotech Ab | Microfluidic surfaces |
| IL164947A (en) * | 2002-05-09 | 2009-06-15 | Hemoteq Ag | Medical products comprising a haemocompatible coating and methods for their production |
| US7375404B2 (en) * | 2003-12-05 | 2008-05-20 | University Of Maryland Biotechnology Institute | Fabrication and integration of polymeric bioMEMS |
| JP2005288717A (ja) | 2004-03-31 | 2005-10-20 | Fuji Shoko Kk | ラミネート装置およびラミネート方法 |
| US8394338B2 (en) * | 2004-04-26 | 2013-03-12 | Roche Diagnostics Operations, Inc. | Process for hydrophilizing surfaces of fluidic components and systems |
| JP4683538B2 (ja) * | 2004-05-06 | 2011-05-18 | セイコーインスツル株式会社 | 分析用マイクロチップを含む分析システムと分析方法 |
| JP2006292472A (ja) * | 2005-04-07 | 2006-10-26 | Konica Minolta Medical & Graphic Inc | マイクロ総合分析システム |
| US8481125B2 (en) * | 2005-05-21 | 2013-07-09 | Advanced Liquid Logic Inc. | Mitigation of biomolecular adsorption with hydrophilic polymer additives |
| JP2006337249A (ja) * | 2005-06-03 | 2006-12-14 | Canon Inc | カンチレバーセンサを利用するターゲット物質の検出方法及び検出装置 |
| JP2009520209A (ja) * | 2005-12-19 | 2009-05-21 | バイオスケール， インコーポレイテッド | バイオプロセス液を分析するための方法および装置 |
| JP5001015B2 (ja) * | 2006-09-28 | 2012-08-15 | 富士フイルム株式会社 | 非特異吸着を抑制した表面を有する生化学用器具 |
| WO2008078781A1 (ja) | 2006-12-26 | 2008-07-03 | Sekisui Chemical Co., Ltd. | ヘモグロビン類の測定方法及び電気泳動装置 |
| JP4854525B2 (ja) * | 2007-01-12 | 2012-01-18 | 積水化学工業株式会社 | ヘモグロビン類の測定方法 |
| JP4996959B2 (ja) * | 2007-03-30 | 2012-08-08 | 株式会社日立ハイテクノロジーズ | 分注プローブを備えた自動分析装置およびその制御方法 |
| JP2008249449A (ja) | 2007-03-30 | 2008-10-16 | Kanai Hiroaki | プローブ針とその製造方法 |
| US20090130746A1 (en) * | 2007-10-25 | 2009-05-21 | Canon U.S. Life Sciences, Inc. | Microchannel surface coating |
| CN101970112B (zh) | 2007-11-13 | 2014-05-07 | 霍夫曼-拉罗奇有限公司 | 模块化的传感器盒 |
| DE502008001880D1 (de) * | 2008-01-07 | 2011-01-05 | Roche Diagnostics Gmbh | Reagenzienkassette |
| WO2010040047A2 (en) * | 2008-10-02 | 2010-04-08 | University Of Maryland Biotechnology Institute Off. Of Research Admin./Tech.Dev. | Chitosan-coated wires for biosensing |
-
2010
- 2010-07-23 EP EP10170613A patent/EP2409766A1/de not_active Withdrawn
-
2011
- 2011-07-21 JP JP2013520153A patent/JP5848763B2/ja active Active
- 2011-07-21 CN CN201180031673.8A patent/CN102958612B/zh active Active
- 2011-07-21 EP EP11734112.3A patent/EP2595752B1/de active Active
- 2011-07-21 CA CA2805622A patent/CA2805622C/en not_active Expired - Fee Related
- 2011-07-21 WO PCT/EP2011/062506 patent/WO2012010653A1/de not_active Ceased
-
2013
- 2013-01-23 US US13/747,667 patent/US9623440B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2595752B1 (de) | 2018-08-22 |
| JP5848763B2 (ja) | 2016-01-27 |
| US20130136657A1 (en) | 2013-05-30 |
| HK1177606A1 (en) | 2013-08-23 |
| WO2012010653A1 (de) | 2012-01-26 |
| EP2409766A1 (de) | 2012-01-25 |
| US9623440B2 (en) | 2017-04-18 |
| JP2013532818A (ja) | 2013-08-19 |
| EP2595752A1 (de) | 2013-05-29 |
| CN102958612A (zh) | 2013-03-06 |
| CA2805622A1 (en) | 2012-01-26 |
| CN102958612B (zh) | 2015-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130116 |
|
| MKLA | Lapsed |
Effective date: 20190722 |