CA2804857C - Pancreatic cancer biomarkers and uses thereof - Google Patents

Pancreatic cancer biomarkers and uses thereof Download PDF

Info

Publication number
CA2804857C
CA2804857C CA2804857A CA2804857A CA2804857C CA 2804857 C CA2804857 C CA 2804857C CA 2804857 A CA2804857 A CA 2804857A CA 2804857 A CA2804857 A CA 2804857A CA 2804857 C CA2804857 C CA 2804857C
Authority
CA
Canada
Prior art keywords
individual
pancreatic cancer
biomarkers
biomarker
aptamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2804857A
Other languages
English (en)
French (fr)
Other versions
CA2804857A1 (en
Inventor
Stephen Alaric Williams
Michael Riel-Mehan
Rachel M. Ostroff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Somalogic Operating Co Inc
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somalogic Inc filed Critical Somalogic Inc
Publication of CA2804857A1 publication Critical patent/CA2804857A1/en
Application granted granted Critical
Publication of CA2804857C publication Critical patent/CA2804857C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2804857A 2010-08-13 2011-08-12 Pancreatic cancer biomarkers and uses thereof Active CA2804857C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US37368710P 2010-08-13 2010-08-13
US61/373,687 2010-08-13
US41868910P 2010-12-01 2010-12-01
US61/418,689 2010-12-01
US201161482347P 2011-05-04 2011-05-04
US201161482480P 2011-05-04 2011-05-04
US61/482,480 2011-05-04
US61/482,347 2011-05-04
PCT/US2011/047570 WO2012021795A2 (en) 2010-08-13 2011-08-12 Pancreatic cancer biomarkers and uses thereof

Publications (2)

Publication Number Publication Date
CA2804857A1 CA2804857A1 (en) 2012-02-16
CA2804857C true CA2804857C (en) 2021-07-06

Family

ID=45565264

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2804857A Active CA2804857C (en) 2010-08-13 2011-08-12 Pancreatic cancer biomarkers and uses thereof

Country Status (12)

Country Link
US (3) US20120040861A1 (https=)
EP (1) EP2603622A4 (https=)
JP (1) JP5931874B2 (https=)
KR (1) KR101857462B1 (https=)
CN (2) CN103415624B (https=)
AU (3) AU2011289284B2 (https=)
BR (1) BR112013003391B8 (https=)
CA (1) CA2804857C (https=)
IL (1) IL224014A (https=)
MX (2) MX350533B (https=)
SG (3) SG187045A1 (https=)
WO (1) WO2012021795A2 (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10359425B2 (en) * 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
WO2012006632A2 (en) 2010-07-09 2012-01-12 Somalogic, Inc. Lung cancer biomarkers and uses thereof
SG187045A1 (en) 2010-08-13 2013-02-28 Somalogic Inc Pancreatic cancer biomarkers and uses thereof
NL2009015C2 (en) * 2012-04-10 2013-10-15 Biosparq B V Method for classification of a sample on the basis of spectral data, method for creating a database and method for using this database, and corresponding computer program, data storage medium and system.
HK1214652A1 (zh) * 2013-03-13 2016-07-29 克里蒂科斯有限责任公司 用於检测胰腺癌的方法和组合物
US20140272963A1 (en) * 2013-03-14 2014-09-18 Abbott Molecular Inc. Cell preparations and cell supports and their use in theranosis
CN103324846A (zh) * 2013-06-13 2013-09-25 浙江加州国际纳米技术研究院绍兴分院 结直肠癌症治疗预后生物标记物的筛选方法
CN103310105A (zh) * 2013-06-13 2013-09-18 浙江加州国际纳米技术研究院绍兴分院 筛选非小细胞肺癌治疗疗效生物标记物的方法
JP6652916B2 (ja) * 2013-06-20 2020-02-26 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 膵臓がんを診断するための方法
KR101594980B1 (ko) * 2013-10-31 2016-02-17 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법
KR101594981B1 (ko) * 2013-10-31 2016-02-17 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법
CN105408751A (zh) 2013-10-31 2016-03-16 Sk电信有限公社 用于诊断胰腺癌的组合物以及使用该组合物诊断胰腺癌的方法
KR20150129932A (ko) * 2014-05-12 2015-11-23 연세대학교 산학협력단 보체인자 b 단백질에 특이적으로 결합하는 항체를 포함하는 췌장암 진단용 키트
US9506925B2 (en) 2014-07-02 2016-11-29 Dragon Victory Development Ltd. Specific biomarker set for non-invasive diagnosis of liver cancer
US9885718B2 (en) 2014-07-02 2018-02-06 Dragon Victory Development Ltd. Specific biomarker set for non-invasive diagnosis of liver cancer
WO2016060382A1 (ko) * 2014-10-17 2016-04-21 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법
KR20160045547A (ko) 2014-10-17 2016-04-27 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법
WO2016094330A2 (en) * 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
JP2016214239A (ja) * 2015-05-15 2016-12-22 国立大学法人高知大学 膵がんマーカー
US20180216194A1 (en) * 2015-07-28 2018-08-02 The Johns Hopkins University Compositions and methods for detecting pancreatic cancer
WO2017044715A1 (en) * 2015-09-09 2017-03-16 Somalogic, Inc. Methods for developing personalized drug treatment plans and targeted drug development based on proteomic profiles
US11051790B2 (en) * 2015-11-10 2021-07-06 Exact Imaging, Inc. System comprising indicator features in high-resolution micro-ultrasound images
JP6498107B2 (ja) * 2015-11-30 2019-04-10 日本電信電話株式会社 分類装置、方法、及びプログラム
CN116008563B (zh) * 2016-02-08 2025-12-19 私募蛋白质体操作有限公司 非酒精性脂肪肝疾病(nafld)和非酒精性脂肪性肝炎(nash)生物标记及其用途
GB201608192D0 (en) * 2016-05-10 2016-06-22 Immunovia Ab Method, array and use thereof
EP3458992B1 (en) * 2016-05-19 2022-03-02 Quartz Bio SA Biomarkers signature discovery and selection
JP7057913B2 (ja) * 2016-06-09 2022-04-21 株式会社島津製作所 ビッグデータ解析方法及び該解析方法を利用した質量分析システム
CN110023950B (zh) * 2016-10-28 2023-08-08 拜克门寇尔特公司 物质准备评估系统
WO2018156973A1 (en) 2017-02-24 2018-08-30 Board Of Regents, The University Of Texas System Assay for detection of early stage pancreatic cancer
CN108931650A (zh) * 2017-05-24 2018-12-04 宜昌市中心人民医院 一种激肽释放酶7在血液中的活性检测方法及其作为诊断胰腺癌的血清标志物上的应用
CN108931651A (zh) * 2017-05-24 2018-12-04 宜昌市中心人民医院 一种激肽释放酶7在血液中的含量检测方法及其作为诊断胰腺癌的血清标志物上的应用
WO2019010429A1 (en) * 2017-07-07 2019-01-10 The Trustees Of The University Of Pennsylvania METHODS OF DIAGNOSING PANCREATIC CANCER
US11062792B2 (en) * 2017-07-18 2021-07-13 Analytics For Life Inc. Discovering genomes to use in machine learning techniques
US11139048B2 (en) 2017-07-18 2021-10-05 Analytics For Life Inc. Discovering novel features to use in machine learning techniques, such as machine learning techniques for diagnosing medical conditions
CN107389776B (zh) * 2017-07-18 2020-06-02 宁波瑞瑧生物科技有限公司 一种用于检测药物分布的分析方法及其应用
KR101830314B1 (ko) 2017-07-26 2018-02-20 재단법인 구미전자정보기술원 인공지능 기반 베이지안 네트워크를 이용한 췌장암 진단에 필요한 정보제공 방법, 컴퓨터 프로그램 및 컴퓨터 판독 가능한 기록 매체
CN109425739B (zh) * 2017-08-31 2022-03-18 复旦大学 一组蛋白作为肿瘤标志物在制备恶性肿瘤诊断试剂和试剂盒中的用途
AU2019217331B2 (en) * 2018-01-30 2024-11-07 Sri International Computational generation of chemical synthesis routes and methods
JP7455757B2 (ja) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装
WO2019232361A1 (en) * 2018-05-31 2019-12-05 University Of Florida Research Foundation Personalized treatment of pancreatic cancer
WO2020041748A1 (en) * 2018-08-24 2020-02-27 The Regents Of The University Of California Mhc-ii genotype restricts the oncogenic mutational landscape
EP3853383A1 (en) * 2018-09-19 2021-07-28 Bluestar Genomics, Inc. Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions
CN109919688B (zh) * 2019-03-29 2021-03-05 杭州电子科技大学 一种考虑市场因素的电子烟产品线规划方法
CN114026253B (zh) * 2019-04-22 2025-08-12 奥比特基因组学公司 用于微卫星分析的方法和系统
EP3959719A4 (en) * 2019-04-26 2022-06-01 Sean Kelly DEVICE FOR PERSONAL PREDICTIVE ENRICHMENT OF A BIOMARKER AND METHODS OF USE THEREOF
EP4041888A4 (en) 2019-10-11 2023-11-01 Guardant Health, Inc. USE OF CELLULAR BACTERIAL NUCLEIC ACIDS FOR CANCER DETECTION
EP4045912A1 (en) * 2019-10-18 2022-08-24 Reccan Diagnostics AB Apparatuses and methods for detection of pancreatic cancer
CN111584010B (zh) * 2020-04-01 2022-05-27 昆明理工大学 一种基于胶囊神经网络和集成学习的关键蛋白质识别方法
EP4407042A3 (en) 2020-07-10 2024-09-18 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
CA3192386A1 (en) * 2020-09-10 2022-03-17 Jim ABRAHAM Metastasis predictor
CN114250298B (zh) * 2020-09-23 2024-09-24 中国医学科学院北京协和医院 胰腺导管腺癌的dna甲基化标志物及其应用
WO2022139465A1 (ko) * 2020-12-22 2022-06-30 두에이아이(주) 인공지능 라만 분석 기법을 이용한 췌장암 조기진단 방법
US20240369559A1 (en) * 2021-04-21 2024-11-07 Reccan Diagnostics Ab Pancreatic cancer detection
EP4326297A4 (en) * 2021-04-21 2025-06-04 Rutgers, the State University of New Jersey Methods for analyzing single-cell host-microbiome interactions and associated gene signatures in cancer
CN113096125B (zh) * 2021-05-11 2024-05-31 上海宝藤生物医药科技股份有限公司 低密度脂蛋白试剂浓度的确定方法、装置及存储介质
WO2023102443A2 (en) * 2021-11-30 2023-06-08 Venn Biosciences Corporation Diagnosis of pancreatic cancer using targeted quantification of site-specific protein glycosylation
EP4457358A1 (en) * 2021-12-30 2024-11-06 SomaLogic Operating Co., Inc. Next-generation sequencing for protein measurement
WO2023196571A1 (en) * 2022-04-08 2023-10-12 The Johns Hopkins University Machine learning detection of hypermetabolic cancer based on nuclear magnetic resonance spectra
JP2025524379A (ja) * 2022-06-10 2025-07-30 シティ・オブ・ホープ 膵臓がんにおけるバイオマーカー
KR102651556B1 (ko) * 2022-09-28 2024-03-27 주식회사 휴벳바이오 Ca19-9 수준이 낮은 환자의 췌장암 진단용 조성물
WO2024192491A1 (pt) * 2023-03-23 2024-09-26 Huna Ltda. Treinamento e aplicação de modelos de inteligência artificial para a previsão de ocorrência de câncer em um indivíduo
AU2024257583A1 (en) * 2023-04-19 2025-11-20 Molecular You Corporation Method of diagnosis and treatment of pancreatic cancer
KR20250169643A (ko) * 2024-05-22 2025-12-04 주식회사 베르티스 췌장암의 진단용 신규 바이오마커

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US20040254101A1 (en) * 1995-06-06 2004-12-16 Human Genome Sciences, Inc. Colon specific gene and protein and cancer
US6004267A (en) 1997-03-07 1999-12-21 University Of Florida Method for diagnosing and staging prostate cancer
US6335170B1 (en) 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
ATE400813T1 (de) 1999-09-10 2008-07-15 Takashi Muramatsu Tumormarker für frühes krebsstadium
US20030144476A1 (en) 2000-03-06 2003-07-31 Pankaj Agarwal Novel compounds
US6596503B1 (en) 2000-08-18 2003-07-22 East Carolina University Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof
US6631330B1 (en) 2000-08-21 2003-10-07 Assistance Publique-Hopitaux De Paris (Ap-Hp) Diagnosis method of inflammatory, fibrotic or cancerous disease using biochemical markers
US6576423B2 (en) * 2000-12-08 2003-06-10 The Board Of Regents Of The University Of Nebraska Specific mucin expression as a marker for pancreatic cancer
NZ528205A (en) 2001-03-12 2006-09-29 Monogen Inc Cell-based detection and differentiation of disease status in a cytological sample using a panel comprising a plurality of probes
CA2444691A1 (en) 2001-04-18 2002-10-31 Protein Design Labs, Inc. Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
US7189507B2 (en) 2001-06-18 2007-03-13 Pdl Biopharma, Inc. Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
US7622260B2 (en) 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
US20040009489A1 (en) 2001-09-28 2004-01-15 Golub Todd R. Classification of lung carcinomas using gene expression analysis
WO2003058201A2 (en) 2001-12-31 2003-07-17 Quark Biotech, Inc. Methods for identifying marker genes for cancer
CA2992643C (en) 2002-03-13 2019-06-18 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US20050260639A1 (en) * 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
ES2320443T3 (es) * 2002-09-30 2009-05-22 Oncotherapy Science, Inc. Genes y polipeptidos relacionados con canceres pancreaticos humanos.
AU2003295598B2 (en) 2002-11-15 2009-12-24 Genomic Health, Inc. Gene expression profiling of EGFR positive cancer
AU2003294828A1 (en) * 2002-12-17 2004-07-09 Sinogenomax Co. Ltd. Chinese National Human Genomecenter Specific markers for pancreatic cancer
CN1726395A (zh) * 2002-12-17 2006-01-25 北京诺赛基因组研究中心有限公司 胰腺癌的特异标记
US8014952B2 (en) 2002-12-18 2011-09-06 Queen Elizabeth Hospital Serum biomarkers in lung cancer
WO2004063355A2 (en) 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
AU2003900747A0 (en) 2003-02-18 2003-03-06 Garvan Institute Of Medical Research Diagnosis and treatment of pancreatic cancer
CA2516553C (en) 2003-02-20 2013-04-16 Genomic Health, Inc. Use of intronic rna to measure gene expression
CA2516591A1 (en) 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
US20050095611A1 (en) * 2003-05-02 2005-05-05 Chan Daniel W. Identification of biomarkers for detecting pancreatic cancer
CN1852974A (zh) * 2003-06-09 2006-10-25 密歇根大学董事会 用于治疗和诊断癌症的组合物和方法
EP1639090A4 (en) 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
ES2609234T3 (es) 2003-06-24 2017-04-19 Genomic Health, Inc. Predicción de la probabilidad de recidiva de cáncer
US7526387B2 (en) 2003-07-10 2009-04-28 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
AU2004264948A1 (en) 2003-08-15 2005-02-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Multifactorial assay for cancer detection
US7807392B1 (en) 2003-09-15 2010-10-05 Celera Corporation Lung disease targets and uses thereof
EP1682904A2 (en) 2003-11-04 2006-07-26 Roche Diagnostics GmbH Method for distinguishing who classified aml subtypes
US20050181451A1 (en) 2004-02-12 2005-08-18 Bates Harold M. Detection of asymptomatic coronary artery disease using atherogenic proteins and acute phase reactants
US7666583B2 (en) 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
US8019552B2 (en) 2004-03-05 2011-09-13 The Netherlands Cancer Institute Classification of breast cancer patients using a combination of clinical criteria and informative genesets
CA2563074C (en) 2004-04-09 2014-05-20 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
CA2578680C (en) 2004-04-15 2011-06-14 University Of Florida Research Foundation, Inc. Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
AU2005236075A1 (en) 2004-04-26 2005-11-03 Children's Medical Center Corporation Platelet biomarkers for the detection of disease
WO2006022643A1 (en) 2004-07-26 2006-03-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting pancreatic disease
MX2007001357A (es) 2004-08-02 2009-08-07 Childrens Medical Center Biomarcadores de plaquetas para cancer.
JP2006053113A (ja) 2004-08-16 2006-02-23 Medical Proteoscope Co Ltd 肺腺癌リンパ節転移診断方法及び診断キット
JP5020088B2 (ja) 2004-11-05 2012-09-05 ジェノミック ヘルス， インコーポレイテッド 遺伝子発現マーカーを使用する、化学療法に対する反応の予測
EP1815014B1 (en) 2004-11-05 2012-03-21 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
US8632983B2 (en) 2005-04-15 2014-01-21 Van Andel Research Institute Biomarkers for pancreatic cancer and diagnostic methods
WO2006135886A2 (en) 2005-06-13 2006-12-21 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1904649A2 (en) 2005-07-18 2008-04-02 Epigenomics AG Compositions and methods for cancer diagnostics comprising pan-cancer markers
US7521195B1 (en) 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
CN101283106A (zh) 2005-07-27 2008-10-08 肿瘤疗法科学股份有限公司 小细胞肺癌的诊断方法
EP1937837A2 (en) 2005-07-29 2008-07-02 Siemens Healthcare Diagnostics Inc. Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies
US7582441B1 (en) 2005-10-17 2009-09-01 Celera Corporation Methods and compositions for treating and diagnosing disease
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
US8329408B2 (en) 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
CN103245784A (zh) 2005-11-10 2013-08-14 肯塔基大学研究基金会 肺癌的诊断分析法
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
EP1969363B1 (en) 2005-12-22 2016-11-30 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
NZ593226A (en) 2006-01-11 2012-10-26 Genomic Health Inc Gene expression markers (efnb2) for colorectal cancer prognosis
EP2363711A1 (en) 2006-01-27 2011-09-07 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
EP1986655A4 (en) * 2006-02-06 2009-12-23 Tethys Bioscience Inc MARKERS ASSOCIATED WITH OSTEOPOROSIS AND METHODS OF USE
EP1991872A1 (en) * 2006-03-02 2008-11-19 Oncotherapy Science, Inc. Methods for diagnosing pancreatic cancer using reg4 protein
US7908091B2 (en) 2006-03-17 2011-03-15 Prometheus Laboratories Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
WO2007123772A2 (en) 2006-03-31 2007-11-01 Genomic Health, Inc. Genes involved in estrogen metabolism
CA2648385C (en) 2006-04-04 2020-09-01 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2302395B1 (en) 2006-06-07 2015-04-15 Health Diagnostic Laboratory, Inc. Markers associated with arteriovascular events and methods of use thereof
WO2008003024A2 (en) 2006-06-28 2008-01-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method and composition for diagnosing endometrial cancer
WO2008046911A2 (en) 2006-10-20 2008-04-24 Exiqon A/S Novel human micrornas associated with cancer
WO2008063413A2 (en) 2006-11-13 2008-05-29 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of lung cancer
WO2008086182A2 (en) 2007-01-04 2008-07-17 University Of Rochester Use of gene signatures to design novel cancer treatment regimens
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
KR100846354B1 (ko) 2007-03-21 2008-07-15 (주) 프로탄바이오 혈청 당단백질부터 분리한 폐암 진단용 마커
CA2681899C (en) * 2007-03-27 2018-06-19 Immunovia Ab Methods for diagnosis of pancreatic adenocarcinoma, and biomarkers and arrays for use in the same
US20080274481A1 (en) 2007-03-28 2008-11-06 Vermillion, Inc. Methods for diagnosing ovarian cancer
CA2681667A1 (en) 2007-05-18 2008-11-27 Duke University Serum biomarkers for the early detection of lung cancer
US20100183514A1 (en) * 2007-05-29 2010-07-22 President And Fellows Of Harvard College Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof
GB0717637D0 (en) 2007-09-10 2007-10-17 Univ Leiden Future cardiac event biomarkers
US8541183B2 (en) 2007-09-11 2013-09-24 Cancer Prevention And Cure, Ltd. Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof
US7888051B2 (en) 2007-09-11 2011-02-15 Cancer Prevention And Cure, Ltd. Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues
US20100267041A1 (en) * 2007-09-14 2010-10-21 Predictive Biosciences, Inc. Serial analysis of biomarkers for disease diagnosis
CA2700125A1 (en) 2007-09-18 2009-03-26 Board Of Regents Of The University Of Texas System Detection of saliva proteins modulated secondary to ductal carcinoma in situ of the breast
US7892760B2 (en) 2007-11-19 2011-02-22 Celera Corporation Lung cancer markers, and uses thereof
US20090186370A1 (en) 2008-01-18 2009-07-23 Ogle Matthew F Diagnostic biomarkers for vascular aneurysm
GB0803192D0 (en) 2008-02-22 2008-04-02 Mubio Products Bv SCLC biomarker panel
WO2009114836A1 (en) 2008-03-14 2009-09-17 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
RU2011103915A (ru) * 2008-07-04 2012-08-10 Кабусики Кайся Тосиба (Jp) Способ и устройство кодирования/декодирования движущегося изображения
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
WO2012006632A2 (en) 2010-07-09 2012-01-12 Somalogic, Inc. Lung cancer biomarkers and uses thereof
CA3152591C (en) 2008-09-09 2023-08-29 Somalogic Operating Co., Inc. Lung cancer biomarkers and uses thereof
US20120143805A1 (en) 2008-09-09 2012-06-07 Somalogic, Inc. Cancer Biomarkers and Uses Thereof
NZ592241A (en) * 2008-09-15 2012-11-30 Herlev Hospital Ykl-40 as a marker for gastrointestinal cancers
US20100221752A2 (en) 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
CA2737004A1 (en) 2008-10-06 2010-04-15 Somalogic, Inc. Ovarian cancer biomarkers and uses thereof
US20120165217A1 (en) 2008-10-06 2012-06-28 Somalogic, Inc. Cancer Biomarkers and Uses Thereof
CA2741117A1 (en) 2008-10-30 2010-05-06 Centre De Recherche Public De La Sante Biomarkers for heart failure
WO2011109440A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
WO2010056374A2 (en) 2008-11-17 2010-05-20 Veracyte, Inc. Methods and compositions of molecular profiling for disease diagnostics
WO2010059742A1 (en) 2008-11-18 2010-05-27 Collabrx, Inc. Individualized cancer treatment
CA2745961A1 (en) 2008-12-04 2010-06-10 The Regents Of The University Of California Materials and methods for determining diagnosis and prognosis of prostate cancer
JP5678045B2 (ja) 2009-06-08 2015-02-25 シンギュレックス・インコーポレイテッド 高感度バイオマーカーパネル
ES2623633T3 (es) 2009-06-09 2017-07-11 Gendiag.Exe, S.L. Marcadores de riesgo para enfermedad cardiovascular
JP2012529914A (ja) 2009-06-15 2012-11-29 カーディオ ディーエクス インコーポレイティッド 冠動脈疾患リスクの判定法
WO2011022552A2 (en) 2009-08-19 2011-02-24 The Cleveland Clinic Foundation Marker Detection for Characterizing the Risk of Cardiovascular Disease or Complications Thereof
US20120178111A1 (en) 2009-09-23 2012-07-12 Diamandis Eleftherios P Methods and compositions for the detection of lung cancers
SG10201405975VA (en) * 2009-10-01 2014-11-27 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis
US9683996B2 (en) 2009-10-22 2017-06-20 The Regents Of The University Of California Assessment of solid tumor burden
US9217747B2 (en) 2009-10-29 2015-12-22 Health Diagnostic Laboratory, Inc. Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
US20120245235A1 (en) * 2009-12-01 2012-09-27 Compenda Bioscience, Inc Classification of cancers
CN102762743A (zh) 2009-12-09 2012-10-31 阿维埃尔公司 用于心血管疾病的诊断和分类的生物标记物检验
EP3178944B1 (en) 2010-01-11 2019-05-15 Genomic Health, Inc. Method to use gene expression to determine likelihood of clinical outcome of renal cancer
WO2011094483A2 (en) 2010-01-29 2011-08-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Immune gene signatures in cancer
CA2789494C (en) 2010-02-10 2021-08-17 The Regents Of The University Of California Salivary biomarkers for lung cancer detection
US9624547B2 (en) 2010-02-10 2017-04-18 The Regents Of The University Of California Salivary transcriptomic and proteomic biomarkers for breast cancer detection
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
SG187045A1 (en) 2010-08-13 2013-02-28 Somalogic Inc Pancreatic cancer biomarkers and uses thereof
CN103429753A (zh) 2010-09-27 2013-12-04 私募蛋白质体公司 间皮瘤生物标记及其用途
EP3825693A1 (en) 2011-04-29 2021-05-26 Cancer Prevention And Cure, Ltd. Methods of identification and diagnosis of lung diseases using classification systems and kits thereof
EP2748356A2 (en) 2011-08-22 2014-07-02 Somalogic, Inc. Renal cell carcinoma biomarkers and uses thereof
MX373248B (es) 2011-09-30 2020-05-11 Somalogic Operating Co Inc Prediccion de riesgo de evento cardiovascular y usos del mismo.
WO2013142114A1 (en) 2012-03-19 2013-09-26 The Brigham And Women's Hosptial, Inc. Growth differentiation factor (gdf) for treatment of diastolic heart failure
BR112016010165A2 (pt) 2013-11-21 2017-12-05 Somalogic Inc composições de nucleotídeos modificados de citidina-5-carboxamida e métodos relacionados às mesmas

Also Published As

Publication number Publication date
BR112013003391A2 (pt) 2016-07-26
JP2013541697A (ja) 2013-11-14
SG10201710447QA (en) 2018-02-27
MX2013001042A (es) 2013-04-03
WO2012021795A3 (en) 2013-09-06
KR101857462B1 (ko) 2018-05-14
KR20130100096A (ko) 2013-09-09
AU2011289284B2 (en) 2015-04-09
IL224014A (en) 2017-09-28
BR112013003391B8 (pt) 2022-10-25
AU2015202907A1 (en) 2015-06-18
WO2012021795A2 (en) 2012-02-16
BR112013003391B1 (pt) 2020-03-31
EP2603622A2 (en) 2013-06-19
US11041866B2 (en) 2021-06-22
MX350533B (es) 2017-09-08
CN106198980A (zh) 2016-12-07
MX341517B (es) 2016-08-24
SG2014007454A (en) 2014-07-30
CA2804857A1 (en) 2012-02-16
CN106198980B (zh) 2018-09-07
US20180045739A1 (en) 2018-02-15
AU2015202907B2 (en) 2016-09-29
US20140073522A1 (en) 2014-03-13
AU2016269430A1 (en) 2016-12-22
AU2011289284A1 (en) 2013-02-21
CN103415624A (zh) 2013-11-27
CN103415624B (zh) 2017-03-01
EP2603622A4 (en) 2015-04-22
JP5931874B2 (ja) 2016-06-08
US20120040861A1 (en) 2012-02-16
AU2016269430B2 (en) 2018-05-10
SG187045A1 (en) 2013-02-28

Similar Documents

Publication Publication Date Title
CA2804857C (en) Pancreatic cancer biomarkers and uses thereof
CA2809282C (en) Mesothelioma biomarkers and uses thereof
AU2009291811B2 (en) Lung cancer biomarkers and uses thereof
EP2771692B1 (en) Lung cancer biomarkers and uses thereof
US20120101002A1 (en) Lung Cancer Biomarkers and Uses Thereof
WO2011031344A1 (en) Cancer biomarkers and uses thereof
WO2011043840A1 (en) Cancer biomarkers and uses thereof
US20220065872A1 (en) Lung Cancer Biomarkers and Uses Thereof
HK1229003B (zh) 胰腺癌生物标记及其用途
HK1196429A (en) Lung cancer biomarkers and uses thereof
HK1196429B (en) Lung cancer biomarkers and uses thereof

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160531

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251212

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20260323

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-6-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20260326