CA2803962A1 - Miniature hplc device - Google Patents
Miniature hplc device Download PDFInfo
- Publication number
- CA2803962A1 CA2803962A1 CA2803962A CA2803962A CA2803962A1 CA 2803962 A1 CA2803962 A1 CA 2803962A1 CA 2803962 A CA2803962 A CA 2803962A CA 2803962 A CA2803962 A CA 2803962A CA 2803962 A1 CA2803962 A1 CA 2803962A1
- Authority
- CA
- Canada
- Prior art keywords
- liquid
- reservoir
- liquid chromatography
- column
- chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 25
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 239000012530 fluid Substances 0.000 claims abstract description 23
- 238000004811 liquid chromatography Methods 0.000 claims abstract description 18
- 238000004891 communication Methods 0.000 claims abstract description 8
- 230000003287 optical effect Effects 0.000 claims description 17
- 238000012545 processing Methods 0.000 claims description 15
- 238000004128 high performance liquid chromatography Methods 0.000 description 34
- 239000007789 gas Substances 0.000 description 31
- 238000001514 detection method Methods 0.000 description 21
- 239000012071 phase Substances 0.000 description 17
- 238000004458 analytical method Methods 0.000 description 8
- 238000000180 cavity ring-down spectroscopy Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000000926 separation method Methods 0.000 description 7
- 230000005526 G1 to G0 transition Effects 0.000 description 6
- 239000006096 absorbing agent Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000003480 eluent Substances 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 238000009428 plumbing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000004224 UV/Vis absorption spectrophotometry Methods 0.000 description 1
- 238000004847 absorption spectroscopy Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000004226 microchip electrophoresis Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012764 semi-quantitative analysis Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/22—Injection in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Fluid Mechanics (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1010737.3A GB201010737D0 (en) | 2010-06-25 | 2010-06-25 | Minature HPLC device |
| GB1010737.3 | 2010-06-25 | ||
| PCT/GB2011/051217 WO2011161481A1 (en) | 2010-06-25 | 2011-06-27 | Miniature hplc device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2803962A1 true CA2803962A1 (en) | 2011-12-29 |
Family
ID=42583011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2803962A Abandoned CA2803962A1 (en) | 2010-06-25 | 2011-06-27 | Miniature hplc device |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9354209B2 (enExample) |
| EP (1) | EP2585820A1 (enExample) |
| JP (1) | JP6043715B2 (enExample) |
| CN (2) | CN103180726B (enExample) |
| AU (1) | AU2011268682B2 (enExample) |
| BR (1) | BR112012032726A2 (enExample) |
| CA (1) | CA2803962A1 (enExample) |
| GB (1) | GB201010737D0 (enExample) |
| WO (1) | WO2011161481A1 (enExample) |
| ZA (1) | ZA201300607B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201213537D0 (en) * | 2012-07-30 | 2012-09-12 | Imp Innovations Ltd | Self-limiting injection assembly for sample introduction in HPLC |
| WO2014055331A1 (en) * | 2012-10-03 | 2014-04-10 | Waters Technologies Corporation | A chromatography column |
| CN103439309A (zh) * | 2013-08-19 | 2013-12-11 | 南通大学 | 高灵敏度的co气体光谱传感器的制备方法 |
| TWI579553B (zh) | 2013-11-24 | 2017-04-21 | 中央研究院 | 以紫外光－可見光檢測之高效能液相層析設備及方法 |
| WO2015110860A1 (en) * | 2014-01-24 | 2015-07-30 | Dh Technologies Development Pte. Ltd. | Systems and methods for delivering liquid to an ion source |
| GB2534936B (en) * | 2015-02-06 | 2021-09-08 | Agilent Technologies Inc | Liquid chromatography analysis unit |
| JP6704920B2 (ja) * | 2015-10-14 | 2020-06-03 | アルプスアルパイン株式会社 | 流路構造体および測定対象液体の測定装置 |
| US9513220B1 (en) | 2015-12-29 | 2016-12-06 | International Business Machines Corporation | On-chip molecule fluorescence detection |
| FR3055703B1 (fr) * | 2016-09-05 | 2020-12-18 | Elichens | Procede d’analyse d’un gaz |
| JP6696578B2 (ja) * | 2016-09-26 | 2020-05-20 | 株式会社島津製作所 | 切替バルブ、バイナリポンプ及びそのバイナリポンプを備えた液体クロマトグラフ |
| CN116183705A (zh) * | 2017-03-30 | 2023-05-30 | 九零八图案公司 | 生物样品的微射流分析 |
| EP3756002B1 (en) * | 2018-02-23 | 2023-11-29 | Silcotek Corp. | Liquid chromatography technique |
| CN108593813B (zh) * | 2018-07-17 | 2020-04-10 | 厦门大学 | 手持式一体化液相色谱仪 |
| WO2022153571A1 (ja) * | 2021-01-15 | 2022-07-21 | エースバイオアナリシス株式会社 | 走査ユニット、システムおよび方法、ならびにマイクロカラム |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2389891B1 (enExample) * | 1977-05-02 | 1981-07-03 | Prolabo Sa | |
| EP0583003A1 (en) | 1992-08-13 | 1994-02-16 | Perseptive Biosystems, Inc. | Fluid metering, mixing and composition control system |
| US5408326A (en) * | 1993-04-28 | 1995-04-18 | Shell Oil Company | Dual-wavelength absorption detector adapted for continuous-flow detection |
| US6277257B1 (en) | 1997-06-25 | 2001-08-21 | Sandia Corporation | Electrokinetic high pressure hydraulic system |
| JPH11287791A (ja) * | 1998-04-01 | 1999-10-19 | Naohiro Soga | キャピラリーカラム |
| JP2003502655A (ja) * | 1999-06-22 | 2003-01-21 | アジレント・テクノロジーズ・インコーポレーテッド | 微小流体デバイスの操作用装置 |
| US20030223913A1 (en) * | 2002-06-03 | 2003-12-04 | Nanostream, Inc. | Microfluidic separation devices and methods |
| US20040124085A1 (en) * | 2002-06-26 | 2004-07-01 | California Institute Of Technology | Microfluidic devices and methods with electrochemically actuated sample processing |
| US7530257B2 (en) * | 2002-09-27 | 2009-05-12 | Honeywell International Inc. | Phased micro analyzer VIII |
| US7700745B2 (en) * | 2003-02-28 | 2010-04-20 | Japan Science And Technology Agency | Method for separating carbohydrate in glycoside-linkage-having compound, carbohydrate separating system, carbohydrate separating reagent kit, standard sample for carbohydrate separation, and evaluation system |
| JP4307221B2 (ja) * | 2003-11-11 | 2009-08-05 | 株式会社日立ハイテクノロジーズ | 進捗管理方法及び装置 |
| CN1749750A (zh) * | 2004-09-13 | 2006-03-22 | 聂智明 | 高效液相色谱仪 |
| CN1755351A (zh) * | 2004-09-30 | 2006-04-05 | 中国科学院大连化学物理研究所 | 发光二极管诱导荧光微型检测器 |
| CN100406886C (zh) * | 2005-06-22 | 2008-07-30 | 夏之宁 | 一种微型化的液相色谱分离方法 |
| JP2009508729A (ja) | 2005-09-21 | 2009-03-05 | ウオーターズ・インベストメンツ・リミテツド | 高圧チュービング |
| JP2009516162A (ja) * | 2005-11-11 | 2009-04-16 | モレキュラー・ビジョン・リミテッド | マイクロ流体装置 |
| JP2007163252A (ja) * | 2005-12-13 | 2007-06-28 | Sekisui Chem Co Ltd | 液体クロマトグラフ用測定カートリッジ及び液体クロマトグラフ装置 |
| WO2007112224A2 (en) | 2006-03-24 | 2007-10-04 | Waters Investments Limited | Ceramic-based chromatography apparatus and methods for making same |
| US8268625B2 (en) | 2006-03-24 | 2012-09-18 | Arkray, Inc. | Method of measuring glycated hemoglobin concentration and concentration measuring apparatus |
| US8696597B2 (en) | 2006-04-03 | 2014-04-15 | Nipro Diagnostics, Inc. | Diagnostic meter |
| JP4253667B2 (ja) * | 2006-06-02 | 2009-04-15 | 株式会社日立ハイテクノロジーズ | 分離分析装置 |
| CN1963497A (zh) * | 2006-11-08 | 2007-05-16 | 浙江大学 | 微分析芯片上的微液相色谱分离方法及其装置 |
| CN101206205B (zh) * | 2006-12-22 | 2011-08-10 | 中国科学院大连化学物理研究所 | 微流量液相色谱在线大体积进样的方法和专用装置 |
| JP4946647B2 (ja) * | 2007-06-14 | 2012-06-06 | 株式会社島津製作所 | 試料前処理装置及び液体クロマトグラフ装置 |
| KR100966590B1 (ko) | 2007-12-11 | 2010-06-29 | 한국전자통신연구원 | 생체신호 측정 장치들의 상호 협업 방법 및 시스템 |
| JP5181650B2 (ja) * | 2007-12-13 | 2013-04-10 | 株式会社島津製作所 | 分析システム |
-
2010
- 2010-06-25 GB GBGB1010737.3A patent/GB201010737D0/en not_active Ceased
-
2011
- 2011-06-27 AU AU2011268682A patent/AU2011268682B2/en not_active Ceased
- 2011-06-27 WO PCT/GB2011/051217 patent/WO2011161481A1/en not_active Ceased
- 2011-06-27 JP JP2013515975A patent/JP6043715B2/ja not_active Expired - Fee Related
- 2011-06-27 US US13/806,233 patent/US9354209B2/en not_active Expired - Fee Related
- 2011-06-27 CN CN201180031388.6A patent/CN103180726B/zh not_active Expired - Fee Related
- 2011-06-27 EP EP11730056.6A patent/EP2585820A1/en not_active Withdrawn
- 2011-06-27 BR BR112012032726A patent/BR112012032726A2/pt not_active IP Right Cessation
- 2011-06-27 CN CN201510312059.9A patent/CN105004821A/zh active Pending
- 2011-06-27 CA CA2803962A patent/CA2803962A1/en not_active Abandoned
-
2013
- 2013-01-23 ZA ZA2013/00607A patent/ZA201300607B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013529780A (ja) | 2013-07-22 |
| GB201010737D0 (en) | 2010-08-11 |
| EP2585820A1 (en) | 2013-05-01 |
| US20130219999A1 (en) | 2013-08-29 |
| CN103180726A (zh) | 2013-06-26 |
| ZA201300607B (en) | 2014-05-26 |
| AU2011268682A1 (en) | 2013-01-10 |
| AU2011268682B2 (en) | 2015-01-29 |
| CN105004821A (zh) | 2015-10-28 |
| CN103180726B (zh) | 2015-07-01 |
| JP6043715B2 (ja) | 2016-12-14 |
| US9354209B2 (en) | 2016-05-31 |
| BR112012032726A2 (pt) | 2018-02-27 |
| WO2011161481A1 (en) | 2011-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160614 |
|
| FZDE | Discontinued |
Effective date: 20210312 |
|
| FZDE | Discontinued |
Effective date: 20210312 |