JP2013529780A - 小型hplc装置 - Google Patents
小型hplc装置 Download PDFInfo
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- JP2013529780A JP2013529780A JP2013515975A JP2013515975A JP2013529780A JP 2013529780 A JP2013529780 A JP 2013529780A JP 2013515975 A JP2013515975 A JP 2013515975A JP 2013515975 A JP2013515975 A JP 2013515975A JP 2013529780 A JP2013529780 A JP 2013529780A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/22—Injection in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
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- Analytical Chemistry (AREA)
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- Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Fluid Mechanics (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
【解決手段】
液体クロマトグラフィー装置は、液体媒体のための1つ以上の液体容器(3)と、分析される試料のための試料容器(5)と、液体容器(5)および試料容器に流体連結するクロマトグラフィーカラム(4)とを含む。当該装置は、使用中、クロマトグラフィーカラム(4)を通して液体容器(3)から液体を押すために、圧力下のガスを含むガス容器(1)をさらに含む。
【選択図】図1
Description
組み込み微小HPLCの採用は、「面倒であることが証明されており、その大きな理由は圧力に関する。すなわち、オンチップで組み込まれたポンプにより高圧を生成すること、および高圧に位置付けられるマイクロチップを作成することの難しさである。したがって、その他のチップに基づく分析技術に比較してだけではなく、分析技術としてのHPLCの重要性の観点において、オンチップ液体クロマトグラフィーは未開発である。」(Khirevich et al.Anal.Chem.,2009,81(12),pp4937−4945)。
Claims (12)
- 液体媒体のための1つ以上の液体容器と、
分析される試料のための試料容器と、
前記液体容器および前記試料容器に流体連結するクロマトグラフィーカラムと、を含み、
使用中、前記クロマトグラフィーカラムを通して前記液体容器から液体を押すために、圧力下のガスを含むガス容器をさらに含む液体クロマトグラフィー装置。 - 前記クロマトグラフィーカラムは、1〜5,000マイクロメートル、好ましくは20〜200マイクロメートルの範囲の幅を有するチャネルに備えられる、請求項1に記載の液体クロマトグラフィー装置。
- 前記クロマトグラフィーカラムは、1〜100センチメートル、好ましくは2〜20センチメートルの範囲の幅を有するチャネルに備えられる、請求項1または2に記載の液体クロマトグラフィー装置。
- 前記クロマトグラフィーカラムの下流であり、当該クロマトグラフィーカラムと流体連結する流体チャネル近傍に配置される1つ以上の光検出器をさらに含む、いずれかの前出請求項に記載の液体クロマトグラフィー装置。
- 前記光検出器は、少なくとも1つのLEDを光源として含む、請求項4に記載の液体クロマトグラフィー装置。
- 前記光検出器は、前記流体チャネルの両側に、対向する反射面を含み、
前記対向する反射面は光キャビティを定義する、請求項4に記載の液体クロマトグラフィー装置。 - 前記反射面は前記流体チャネルの壁上の層として提供される、請求項6に記載の液体クロマトグラフィー装置。
- 前記光検出器は複数の光源を含む、請求項4〜7のいずれか一項に記載の液体クロマトグラフィー装置。
- 後続の廃棄用に前記クロマトグラフィーカラムを通過した流体を保持するために、前記クロマトグラフィーカラムと流体連結する流体廃棄容器をさらに含む、いずれかの前出請求項に記載の液体クロマトグラフィー装置。
- 電池駆動される、いずれかの前出請求項に記載の液体クロマトグラフィー装置。
- 使い捨て可能である、いずれかの前出請求項に記載の液体クロマトグラフィー装置。
- 前記クロマトグラフィーの結果を処理するために、スマートフォン等の携帯用データ処理装置に接続可能である、いずれかの前出請求項に記載の液体クロマトグラフィー装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1010737.3A GB201010737D0 (en) | 2010-06-25 | 2010-06-25 | Minature HPLC device |
GB1010737.3 | 2010-06-25 | ||
PCT/GB2011/051217 WO2011161481A1 (en) | 2010-06-25 | 2011-06-27 | Miniature hplc device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013529780A true JP2013529780A (ja) | 2013-07-22 |
JP2013529780A5 JP2013529780A5 (ja) | 2014-08-14 |
JP6043715B2 JP6043715B2 (ja) | 2016-12-14 |
Family
ID=42583011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013515975A Expired - Fee Related JP6043715B2 (ja) | 2010-06-25 | 2011-06-27 | 小型hplc装置 |
Country Status (10)
Country | Link |
---|---|
US (1) | US9354209B2 (ja) |
EP (1) | EP2585820A1 (ja) |
JP (1) | JP6043715B2 (ja) |
CN (2) | CN103180726B (ja) |
AU (1) | AU2011268682B2 (ja) |
BR (1) | BR112012032726A2 (ja) |
CA (1) | CA2803962A1 (ja) |
GB (1) | GB201010737D0 (ja) |
WO (1) | WO2011161481A1 (ja) |
ZA (1) | ZA201300607B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017504024A (ja) * | 2014-01-24 | 2017-02-02 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 液体をイオン源に送達するためのシステムおよび方法 |
WO2017065163A1 (ja) * | 2015-10-14 | 2017-04-20 | アルプス電気株式会社 | 流路構造体および測定対象液体の測定装置 |
JP2020515849A (ja) * | 2017-03-30 | 2020-05-28 | 908 デバイセズ インク.908 Devices Inc. | 生物学的試料のマイクロ流体分析 |
Families Citing this family (10)
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GB201213537D0 (en) * | 2012-07-30 | 2012-09-12 | Imp Innovations Ltd | Self-limiting injection assembly for sample introduction in HPLC |
WO2014055331A1 (en) * | 2012-10-03 | 2014-04-10 | Waters Technologies Corporation | A chromatography column |
CN103439309A (zh) * | 2013-08-19 | 2013-12-11 | 南通大学 | 高灵敏度的co气体光谱传感器的制备方法 |
TWI579553B (zh) | 2013-11-24 | 2017-04-21 | 中央研究院 | 以紫外光-可見光檢測之高效能液相層析設備及方法 |
GB2534936B (en) * | 2015-02-06 | 2021-09-08 | Agilent Technologies Inc | Liquid chromatography analysis unit |
US9513220B1 (en) | 2015-12-29 | 2016-12-06 | International Business Machines Corporation | On-chip molecule fluorescence detection |
FR3055703B1 (fr) * | 2016-09-05 | 2020-12-18 | Elichens | Procede d’analyse d’un gaz |
EP3517782B1 (en) * | 2016-09-26 | 2024-06-12 | Shimadzu Corporation | Switching valve, binary pump, and liquid chromatograph with binary pump |
CN111771123A (zh) * | 2018-02-23 | 2020-10-13 | 西尔科特克公司 | 液相色谱技术 |
CN108593813B (zh) * | 2018-07-17 | 2020-04-10 | 厦门大学 | 手持式一体化液相色谱仪 |
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JPH11287791A (ja) * | 1998-04-01 | 1999-10-19 | Naohiro Soga | キャピラリーカラム |
JP2003502655A (ja) * | 1999-06-22 | 2003-01-21 | アジレント・テクノロジーズ・インコーポレーテッド | 微小流体デバイスの操作用装置 |
WO2004077048A1 (ja) * | 2003-02-28 | 2004-09-10 | Japan Science And Technology Agency | グリコシド結合含有化合物中の糖の分離方法、糖分離システム、糖分離用試薬キット、糖分離用標準化試料、および、評価システム |
JP2006515059A (ja) * | 2002-06-26 | 2006-05-18 | カリフォルニア インスティチュート オブ テクノロジー | 試料処理が電気化学的に作動するマイクロ流体装置および方法 |
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JP2007163252A (ja) * | 2005-12-13 | 2007-06-28 | Sekisui Chem Co Ltd | 液体クロマトグラフ用測定カートリッジ及び液体クロマトグラフ装置 |
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2010
- 2010-06-25 GB GBGB1010737.3A patent/GB201010737D0/en not_active Ceased
-
2011
- 2011-06-27 CN CN201180031388.6A patent/CN103180726B/zh not_active Expired - Fee Related
- 2011-06-27 AU AU2011268682A patent/AU2011268682B2/en not_active Ceased
- 2011-06-27 CN CN201510312059.9A patent/CN105004821A/zh active Pending
- 2011-06-27 US US13/806,233 patent/US9354209B2/en not_active Expired - Fee Related
- 2011-06-27 BR BR112012032726A patent/BR112012032726A2/pt not_active IP Right Cessation
- 2011-06-27 EP EP11730056.6A patent/EP2585820A1/en not_active Withdrawn
- 2011-06-27 WO PCT/GB2011/051217 patent/WO2011161481A1/en active Application Filing
- 2011-06-27 JP JP2013515975A patent/JP6043715B2/ja not_active Expired - Fee Related
- 2011-06-27 CA CA2803962A patent/CA2803962A1/en not_active Abandoned
-
2013
- 2013-01-23 ZA ZA2013/00607A patent/ZA201300607B/en unknown
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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EP2585820A1 (en) | 2013-05-01 |
CN105004821A (zh) | 2015-10-28 |
US9354209B2 (en) | 2016-05-31 |
CA2803962A1 (en) | 2011-12-29 |
AU2011268682A1 (en) | 2013-01-10 |
WO2011161481A1 (en) | 2011-12-29 |
GB201010737D0 (en) | 2010-08-11 |
JP6043715B2 (ja) | 2016-12-14 |
BR112012032726A2 (pt) | 2018-02-27 |
AU2011268682B2 (en) | 2015-01-29 |
US20130219999A1 (en) | 2013-08-29 |
CN103180726B (zh) | 2015-07-01 |
CN103180726A (zh) | 2013-06-26 |
ZA201300607B (en) | 2014-05-26 |
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