CA2803697A1 - Beta carboline derivatives useful in the treatment of proliferative disorders - Google Patents

Beta carboline derivatives useful in the treatment of proliferative disorders Download PDF

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Publication number
CA2803697A1
CA2803697A1 CA2803697A CA2803697A CA2803697A1 CA 2803697 A1 CA2803697 A1 CA 2803697A1 CA 2803697 A CA2803697 A CA 2803697A CA 2803697 A CA2803697 A CA 2803697A CA 2803697 A1 CA2803697 A1 CA 2803697A1
Authority
CA
Canada
Prior art keywords
halo
hydrogen
hydroxy
optionally substituted
6alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2803697A
Other languages
English (en)
French (fr)
Inventor
Raphael Frederick
Bernard Masereel
Jeremy Reniers
Johan Wouters
Celine Bruyere
Robert Kiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Facultes Universitaires Notre Dame de la Paix
Universite Libre de Bruxelles ULB
Original Assignee
Facultes Universitaires Notre Dame de la Paix
Universite Libre de Bruxelles ULB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Facultes Universitaires Notre Dame de la Paix, Universite Libre de Bruxelles ULB filed Critical Facultes Universitaires Notre Dame de la Paix
Publication of CA2803697A1 publication Critical patent/CA2803697A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2803697A 2010-06-25 2011-06-24 Beta carboline derivatives useful in the treatment of proliferative disorders Abandoned CA2803697A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35860910P 2010-06-25 2010-06-25
EPPCT/EP2010/059083 2010-06-25
US61/358,609 2010-06-25
EP2010059083 2010-06-25
PCT/EP2011/060658 WO2011161256A1 (en) 2010-06-25 2011-06-24 Beta carboline derivatives useful in the treatment of proliferative disorders

Publications (1)

Publication Number Publication Date
CA2803697A1 true CA2803697A1 (en) 2011-12-29

Family

ID=44453837

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2803697A Abandoned CA2803697A1 (en) 2010-06-25 2011-06-24 Beta carboline derivatives useful in the treatment of proliferative disorders

Country Status (5)

Country Link
US (1) US9168247B2 (enExample)
EP (1) EP2585463A1 (enExample)
JP (1) JP2013533239A (enExample)
CA (1) CA2803697A1 (enExample)
WO (1) WO2011161256A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105120863B (zh) 2013-03-14 2021-06-04 奥斯特克有限公司 促进骨生长的烷基胺骆驼蓬碱衍生物
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US20160106722A1 (en) 2014-10-21 2016-04-21 Life Plus, LLC Human therapeutic agents
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
CN104530043B (zh) * 2014-12-03 2017-06-06 西北农林科技大学 9‑取代β‑咔啉类化合物及其用于制备预防或治疗肿瘤药物的应用
CN105753860B (zh) * 2014-12-16 2018-03-06 兰州大学 β‑咔啉类生物碱及其在制备抗肿瘤药物中的应用
EP3558971B1 (en) 2016-12-22 2022-02-23 Global Blood Therapeutics, Inc. Histone methyltransferase inhibitors
CN110997671A (zh) * 2017-06-09 2020-04-10 全球血液疗法股份有限公司 作为组蛋白甲基转移酶抑制剂的氮杂吲哚化合物
US11547712B2 (en) 2017-11-20 2023-01-10 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
CN111819193A (zh) 2018-01-05 2020-10-23 西奈山伊坎医学院 增加胰腺β细胞增殖的方法、治疗方法以及组合物
AU2019240065A1 (en) 2018-03-20 2020-09-24 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
CN113166058A (zh) 2018-08-14 2021-07-23 奥斯特克有限公司 氟β-咔啉化合物
ES3004565T3 (en) 2018-08-14 2025-03-12 Ossifi Therapeutics Llc Pyrrolo - dipyridine compounds for the treatment of bone loss
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
CN114644626A (zh) * 2020-12-18 2022-06-21 南京施江医药科技有限公司 一种苯环类化合物及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357122A3 (en) 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
DE19807993A1 (de) * 1998-02-26 1999-09-02 Bayer Ag Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
EP1268477B1 (en) * 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
KR100826817B1 (ko) * 2000-03-15 2008-05-02 사노피-아벤티스 도이칠란트 게엠베하 치환된 베타-카볼린
CN100503607C (zh) 2003-06-02 2009-06-24 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物类化合物及其应用
GB0705566D0 (en) * 2007-03-23 2007-05-02 Univ Dundee Method of treating learning impairment in down's syndrome subjects
WO2008157358A1 (en) 2007-06-15 2008-12-24 University Of Medicine And Dentistry Of New Jersey Methods for treating neoplasia and for identifying compositions useful in such therapy
EP2050747A1 (en) * 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
CN101139347B (zh) 2007-10-15 2010-11-24 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物类化合物及其应用
CN101429198B (zh) * 2007-11-09 2013-10-23 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物及其应用
EP2151441A1 (en) 2008-08-06 2010-02-10 Julius-Maximilians-Universität Würzburg Beta-carbolin-derivates as substrates for an enzyme
JP2012051804A (ja) 2008-12-26 2012-03-15 Kyoto Univ Ｅｇ５阻害剤

Also Published As

Publication number Publication date
US9168247B2 (en) 2015-10-27
WO2011161256A1 (en) 2011-12-29
US20130116273A1 (en) 2013-05-09
EP2585463A1 (en) 2013-05-01
JP2013533239A (ja) 2013-08-22
US20140005220A9 (en) 2014-01-02

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20170627