CA2802278A1 - An assay for measurement of antibodies binding to a therapeutic monoclonal antibody - Google Patents

An assay for measurement of antibodies binding to a therapeutic monoclonal antibody Download PDF

Info

Publication number
CA2802278A1
CA2802278A1 CA2802278A CA2802278A CA2802278A1 CA 2802278 A1 CA2802278 A1 CA 2802278A1 CA 2802278 A CA2802278 A CA 2802278A CA 2802278 A CA2802278 A CA 2802278A CA 2802278 A1 CA2802278 A1 CA 2802278A1
Authority
CA
Canada
Prior art keywords
tmab
antibody
monoclonal antibody
sample
solid phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2802278A
Other languages
English (en)
French (fr)
Inventor
Veit Peter Grunert
Ursula Klause
Pavel Kubalec
Matthias Rothfuss
Barbara Upmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2802278A1 publication Critical patent/CA2802278A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2802278A 2010-08-19 2011-08-17 An assay for measurement of antibodies binding to a therapeutic monoclonal antibody Abandoned CA2802278A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10173408.5 2010-08-19
EP10173408 2010-08-19
PCT/EP2011/064178 WO2012022774A1 (en) 2010-08-19 2011-08-17 An assay for measurement of antibodies binding to a therapeutic monoclonal antibody

Publications (1)

Publication Number Publication Date
CA2802278A1 true CA2802278A1 (en) 2012-02-23

Family

ID=42727619

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2802278A Abandoned CA2802278A1 (en) 2010-08-19 2011-08-17 An assay for measurement of antibodies binding to a therapeutic monoclonal antibody

Country Status (7)

Country Link
US (1) US9081016B2 (cg-RX-API-DMAC7.html)
EP (1) EP2606362B1 (cg-RX-API-DMAC7.html)
JP (1) JP5805190B2 (cg-RX-API-DMAC7.html)
CN (1) CN103109190B (cg-RX-API-DMAC7.html)
CA (1) CA2802278A1 (cg-RX-API-DMAC7.html)
ES (1) ES2555864T3 (cg-RX-API-DMAC7.html)
WO (1) WO2012022774A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104614535B (zh) * 2015-02-10 2017-11-28 深圳市新产业生物医学工程股份有限公司 甲状腺微粒体抗体检测试剂盒及其制备方法和应用
US11119096B2 (en) * 2016-07-08 2021-09-14 W. Health L.P. Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples
CN106093413A (zh) * 2016-07-18 2016-11-09 本·沙朗 一种抗英夫利西抗体elisa检测试剂盒和检测方法
CA3075900A1 (en) * 2017-09-15 2019-03-21 Beckman Coulter, Inc. Flow based assays for therapeutics
US20190302124A1 (en) * 2018-03-27 2019-10-03 Laboratory Corporation Of America Holdings Compositions and Methods for Identifying Subjects Who May Benefit From Treatment With Therapeutic Agents
JP7570421B2 (ja) * 2020-01-02 2024-10-21 エフ． ホフマン－ラ ロシュ アーゲー Ａｄａ応答特定アッセイ
CN115552244A (zh) * 2020-05-08 2022-12-30 豪夫迈·罗氏有限公司 用于高药物耐受性测试的高离子强度解离测定
CN117590002B (zh) * 2023-11-23 2024-10-22 上海领检科技有限公司 一种TNFα抗药抗体的检测方法及检测试剂盒

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508132A (en) 1974-05-20 1978-04-19 Technicon Instr Analysis of biological fluids
US5219730A (en) 1982-09-28 1993-06-15 New York University Idiotype-anti-idiotype immunoassay
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4628037A (en) 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4695393A (en) 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4554088A (en) 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4698302A (en) 1983-05-12 1987-10-06 Advanced Magnetics, Inc. Enzymatic reactions using magnetic particles
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
EP0170302A1 (fr) 1984-06-27 1986-02-05 l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
JPH0823558B2 (ja) 1984-11-27 1996-03-06 オ−ジエニクス リミテツド 検定装置
EP0222146B1 (de) 1985-10-16 1994-02-16 Fresenius AG Selektives Adsorbens zur Bindung von Immunkomplexen
WO1987002778A1 (en) 1985-10-22 1987-05-07 Cooper-Lipotech Solid-phase liposome immunoassay system
US6316607B1 (en) 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US4965392A (en) 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5935779A (en) 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5750373A (en) 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
ZA898290B (en) 1988-11-03 1991-06-26 Igen Inc Electrochemiluminescent assays
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
EP0448632A1 (en) 1988-12-09 1991-10-02 Centocor, Inc. Anti-idiotopic immunometric assay
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5364930A (en) 1990-10-16 1994-11-15 Northwestern University Synthetic C1q peptide fragments
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5516635A (en) 1991-10-15 1996-05-14 Ekins; Roger P. Binding assay employing labelled reagent
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
US5466416A (en) 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
US6241963B1 (en) 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
DE19806989A1 (de) 1998-02-19 1999-08-26 Roche Diagnostics Gmbh Erzeugung räumlich scharf begrenzter Festphasen für Bindungsassays
IT1315254B1 (it) 1999-11-05 2003-02-03 Diesse Diagnostica Senese Spa Metodo per la determinazione qualitativa e quantitativa di anticorpiumani di classe igc.
EP1230552B1 (en) 1999-11-16 2006-01-11 Genentech, Inc. Elisa for vegf
CA2543830A1 (en) 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
DE102004052729A1 (de) * 2004-10-30 2006-05-04 Roche Diagnostics Gmbh Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten
SI3264094T1 (sl) * 2005-04-04 2021-04-30 Biogen Ma Inc. Metode za ocenjevanje imunskega odziva na terapevtsko učinkovino
EP2389947A1 (en) * 2006-03-23 2011-11-30 Novartis AG Anti-tumor cell antigen antibody therapeutics
AU2007307652A1 (en) * 2006-10-10 2008-04-17 Squicor Compositions and methods for treating and diagnosing cancers
US8501417B2 (en) * 2007-06-26 2013-08-06 Vanderbilt University Immunological compositions as cancer biomarkers and/or therapeutics

Also Published As

Publication number Publication date
JP2013536419A (ja) 2013-09-19
CN103109190A (zh) 2013-05-15
JP5805190B2 (ja) 2015-11-04
CN103109190B (zh) 2015-07-22
EP2606362B1 (en) 2015-09-30
ES2555864T3 (es) 2016-01-11
US20130157892A1 (en) 2013-06-20
US9081016B2 (en) 2015-07-14
WO2012022774A1 (en) 2012-02-23
EP2606362A1 (en) 2013-06-26
HK1180767A1 (en) 2013-10-25

Similar Documents

Publication Publication Date Title
US9081016B2 (en) Assay for measurement of antibodies binding to a therapeutic monoclonal antibody
CN102625915B (zh) 糖蛋白的测定方法、试剂及糖链标记物
EP3136103B1 (en) Highly multiplexed assays
JP2021531448A (ja) 抗薬物抗体（ａｄａ）免疫アッセイにおける薬物標的干渉を軽減するための方法
CN113474657B (zh) 使用微粒去除非特异性结合信号的方法
US9575073B2 (en) Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
KR102433648B1 (ko) 항인간 헤모글로빈 모노클로날 항체 또는 항체 키트, 항인간 헤모글로빈 모노클로날 항체 고정화 불용성 담체 입자, 및 이들을 이용한 측정 시약 또는 측정 방법
EP1653233B1 (en) Method for determining antibodies of a particular class using an immune complex-specific antibody
US20120190563A1 (en) Methods for predicting sensitivity to treatment with a targeted tyrosine kinase inhibitor
JP7431226B2 (ja) レンバチニブ及びエベロリムスを含む併用療法のためのバイオマーカー
MX2012012986A (es) Metodos para predecir la sensibilidad al tratamiento con un inhibidor de cinasa de tirosina dirigido.
US20120115745A1 (en) Methods for predicting sensitivity to treatment with a targeted tyrosine kinase inhibitor
KR20180013878A (ko) 렌바티닙 및 에베로리무스를 포함하는 병용 요법을 위한 생체표지
JP7315965B2 (ja) ウィルス性肝癌の検出方法
HK1180767B (en) An assay for measurement of antibodies binding to a therapeutic monoclonal antibody
KR102802482B1 (ko) 치주질환 진단 방법, 이를 위한 조성물 및 키트
EP2223122B1 (en) Endogenous morphine or a naturally occuring metabolite thereof as a marker for sepsis
JP2015184125A (ja) 非特異的反応を抑制した免疫学的測定方法
CA3225576A1 (en) Methods, compositions, and kits for assay signal amplification

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160316

FZDE Discontinued

Effective date: 20180817