CA2798634C - Pyridone and aza-pyridone compounds and methods of use - Google Patents

Pyridone and aza-pyridone compounds and methods of use Download PDF

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Publication number
CA2798634C
CA2798634C CA2798634A CA2798634A CA2798634C CA 2798634 C CA2798634 C CA 2798634C CA 2798634 A CA2798634 A CA 2798634A CA 2798634 A CA2798634 A CA 2798634A CA 2798634 C CA2798634 C CA 2798634C
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CA
Canada
Prior art keywords
compound
oxo
hydroxymethyl
methyl
dihydropyridin
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Expired - Fee Related
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CA2798634A
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English (en)
French (fr)
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CA2798634A1 (en
Inventor
Antonio J. M. Barbosa
Peter A. Blomgren
Kevin S. Currie
Ravi Krishnamoorthy
Jeffrey E. Kropf
Seung H. Lee
Scott A. Mitchell
Daniel Ortwine
Aaron C. Schmitt
Xiaojing Wang
Jianjun Xu
Wendy Young
Honglu Zhang
Zhongdong Zhao
Pavel E. Zhichkin
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Genentech Inc
Gilead Connecticut Inc
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Genentech Inc
Gilead Connecticut Inc
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Priority to CA3034600A priority Critical patent/CA3034600C/en
Publication of CA2798634A1 publication Critical patent/CA2798634A1/en
Application granted granted Critical
Publication of CA2798634C publication Critical patent/CA2798634C/en
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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CA2798634A 2010-05-07 2011-05-06 Pyridone and aza-pyridone compounds and methods of use Expired - Fee Related CA2798634C (en)

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