CA2793313C - Composes antagonistes selectifs du recepteur nk-3, composition pharmaceutique et methodes pour une utilisation dans des troubles a mediation par des recepteurs nk-3 - Google Patents
Composes antagonistes selectifs du recepteur nk-3, composition pharmaceutique et methodes pour une utilisation dans des troubles a mediation par des recepteurs nk-3 Download PDFInfo
- Publication number
- CA2793313C CA2793313C CA2793313A CA2793313A CA2793313C CA 2793313 C CA2793313 C CA 2793313C CA 2793313 A CA2793313 A CA 2793313A CA 2793313 A CA2793313 A CA 2793313A CA 2793313 C CA2793313 C CA 2793313C
- Authority
- CA
- Canada
- Prior art keywords
- pyrazin
- triazolo
- dihydro
- methanone
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *C(*)(*1C(N)=**=C1C1(*)*=I)C(*)(*)*1IN Chemical compound *C(*)(*1C(N)=**=C1C1(*)*=I)C(*)(*)*1IN 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Theoretical Computer Science (AREA)
- Databases & Information Systems (AREA)
Abstract
La présente invention concerne de nouveaux composés de formule I et leur utilisation comme composés thérapeutiques.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10305343 | 2010-04-02 | ||
EP10305343.5 | 2010-04-02 | ||
US37902810P | 2010-09-01 | 2010-09-01 | |
US61/379028 | 2010-09-01 | ||
PCT/EP2011/055218 WO2011121137A1 (fr) | 2010-04-02 | 2011-04-04 | Nouveaux composés antagonistes sélectifs du récepteur nk-3, composition pharmaceutique et méthodes pour une utilisation dans des troubles à médiation par des récepteurs nk-3 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2793313A1 CA2793313A1 (fr) | 2011-10-06 |
CA2793313C true CA2793313C (fr) | 2018-01-23 |
Family
ID=42314283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2793313A Active CA2793313C (fr) | 2010-04-02 | 2011-04-04 | Composes antagonistes selectifs du recepteur nk-3, composition pharmaceutique et methodes pour une utilisation dans des troubles a mediation par des recepteurs nk-3 |
Country Status (20)
Country | Link |
---|---|
US (4) | US8871761B2 (fr) |
EP (2) | EP2552920B1 (fr) |
JP (1) | JP5822911B2 (fr) |
KR (1) | KR101878888B1 (fr) |
CN (1) | CN102906093B (fr) |
AU (1) | AU2011234398B8 (fr) |
BR (1) | BR112012025101B1 (fr) |
CA (1) | CA2793313C (fr) |
DK (1) | DK2552920T3 (fr) |
EA (1) | EA023161B1 (fr) |
ES (1) | ES2627688T3 (fr) |
HR (1) | HRP20170712T1 (fr) |
HU (1) | HUE032770T2 (fr) |
LT (1) | LT2552920T (fr) |
MX (1) | MX342161B (fr) |
PL (1) | PL2552920T3 (fr) |
PT (1) | PT2552920T (fr) |
RS (1) | RS55997B1 (fr) |
SI (1) | SI2552920T1 (fr) |
WO (1) | WO2011121137A1 (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2424869B1 (fr) * | 2009-04-29 | 2016-06-22 | Glaxo Group Limited | DÉRIVÉS DE 5,6,7,8-TÉTRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE COMME MODULATEURS DE P2X7 |
US8592590B2 (en) * | 2009-12-29 | 2013-11-26 | Eli Lilly And Company | Tetrahydrotriazolopyridine compounds as selective MGLU5 receptor potentiators useful for the treatment of schizophrenia |
US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
EP2552920B1 (fr) | 2010-04-02 | 2017-03-15 | Ogeda Sa | Nouveaux composés antagonistes sélectifs du récepteur nk-3, composition pharmaceutique et procédé pour une utilisation dans des troubles médiés par les récepteurs nk-3 |
SI2763992T1 (sl) | 2011-10-03 | 2016-08-31 | Euroscreen S.A. | Novi kiralni n-acil-5,6,7,(8-substituirani)-tetrahidro-(1,2,4)triazolo (4,3-a)pirazini kot selektivni nk-3 receptor antagonisti, farmacevtski sestavek, in postopki za uporabo v nk-3 posredovanih motnjah |
US9096596B2 (en) | 2013-03-14 | 2015-08-04 | Janssen Pharmaceutica Nv | P2X7 modulators |
TWI644671B (zh) | 2013-03-14 | 2018-12-21 | 比利時商健生藥品公司 | P2x7調節劑 |
JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
US10053463B2 (en) | 2013-03-14 | 2018-08-21 | Janssen Pharmaceutica Nv | Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators |
AU2014242907B2 (en) * | 2013-03-29 | 2018-06-28 | Ogeda Sa | Novel N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
PT2948455T (pt) * | 2013-03-29 | 2017-11-15 | Ogeda S A | N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3 |
US10183948B2 (en) | 2013-03-29 | 2019-01-22 | Ogeda Sa | N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists |
JP6275242B2 (ja) * | 2013-03-29 | 2018-02-07 | オゲダ エス.エー. | 選択的NK−3受容体拮抗薬としての新規なN−アシル−(3位置換)−(8−メチル)−5,6−ジヒドロ−[1,2,4]トリアゾロ[4,3−a]ピラジン、その医薬組成物、NK−3受容体媒介性障害で使用する方法 |
WO2014170648A1 (fr) * | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | Composé antagoniste du récepteur nk3 (nk3ra) utilisé dans une méthode pour traiter le syndrome des ovaires polykystiques (sopk) |
GB201315846D0 (en) | 2013-09-05 | 2013-10-23 | Imp Innovations Ltd | Method for treating or preventing hot flushes |
EP3105226B1 (fr) | 2014-02-13 | 2019-09-04 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
US9493442B2 (en) | 2014-02-13 | 2016-11-15 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
CR20200199A (es) | 2014-02-13 | 2020-06-19 | Incyte Corp | CICLOPROPILAMINA COMO INHIBIDOR DE LA LSD1 (Divisional 2016-0396) |
WO2016007731A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines et imidazopyrazines à utiliser en tant qu'inhibiteurs de lsd1 |
WO2016007736A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines en tant qu'inhibiteurs de lsd1 |
WO2016007722A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1 |
WO2016007727A1 (fr) * | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1 |
CA2960972C (fr) * | 2014-09-12 | 2023-10-03 | Janssen Pharmaceutica Nv | N-acyl-triazolopyrazines modulant le p2x7 |
EP3191492B1 (fr) | 2014-09-12 | 2019-01-09 | Janssen Pharmaceutica NV | Modulateurs de p2x7 |
TR201902080T4 (tr) | 2014-09-25 | 2019-03-21 | Ogeda Sa | N-asil-(3-sübstitüe)-(8-sübstitüe)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinlerinin yeni kiral sentezleri. |
NZ773981A (en) * | 2015-03-16 | 2024-03-22 | Ogeda Sa | Nk-3 receptor antagonists for therapeutic or cosmetic treatment of excess body fat |
AU2016243939B2 (en) | 2015-04-03 | 2020-09-03 | Incyte Holdings Corporation | Heterocyclic compounds as LSD1 inhibitors |
TWI765860B (zh) | 2015-08-12 | 2022-06-01 | 美商英塞特公司 | Lsd1抑制劑之鹽 |
JP6999574B2 (ja) | 2016-04-22 | 2022-01-18 | インサイト・コーポレイション | Lsd1阻害剤の製剤 |
US10925876B2 (en) | 2016-05-18 | 2021-02-23 | Merck Sharp & Dohme Corp. | Methods for using triazolo-pyrazinyl soluble guanylate cyclase activators in fibrotic disorders |
JP2021014404A (ja) * | 2017-10-13 | 2021-02-12 | アステラス製薬株式会社 | トリアゾロピラジン誘導体の塩及び結晶 |
JP7447020B2 (ja) * | 2018-01-26 | 2024-03-11 | レコルダーティ インドゥストリア キミカ エ ファルマチェウチカ ソシエタ・ペル・アチオニ | トリアゾール、イミダゾールおよびピロール縮合ピペラジン誘導体、およびmGlu5受容体のモジュレータとしてのそれらの使用 |
US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
WO2020065613A1 (fr) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Modulateurs de la monoacylglycérol lipase |
MX2021003661A (es) | 2018-09-28 | 2021-08-19 | Janssen Pharmaceutica Nv | Moduladores de la monoacilglicerol lipasa. |
WO2020211798A1 (fr) * | 2019-04-16 | 2020-10-22 | 上海翰森生物医药科技有限公司 | Inhibiteur contenant un dérivé d'anneau bicyclique, et son procédé de préparation et ses utilisations |
US11839663B2 (en) | 2019-09-30 | 2023-12-12 | Janssen Pharmaceutica Nv | Radiolabelled MGL pet ligands |
WO2021191359A1 (fr) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Modulateurs de la monoacylglycérol lipase |
CN113527307A (zh) * | 2020-04-20 | 2021-10-22 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
CN113549074A (zh) * | 2020-04-26 | 2021-10-26 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
AU2021317809A1 (en) | 2020-07-30 | 2023-02-16 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Nitrogen-containing fused ring derivative inhibitor, preparation method therefor and use thereof |
JP2024514007A (ja) * | 2021-04-21 | 2024-03-27 | 長春金賽薬業有限責任公司 | イミダゾール含有縮合環系誘導体、その調製方法及びその医薬上の応用 |
WO2024083150A1 (fr) * | 2022-10-19 | 2024-04-25 | 长春金赛药业有限责任公司 | Forme cristalline d'un antagoniste de nk3r, son procédé de préparation et son utilisation |
WO2024083160A1 (fr) * | 2022-10-21 | 2024-04-25 | 长春金赛药业有限责任公司 | Forme cristalline et substance amorphe de composé indoline spiro, son procédé de préparation et son utilisation |
WO2024083164A1 (fr) * | 2022-10-21 | 2024-04-25 | 长春金赛药业有限责任公司 | Solvate de composé spiro indoline, sa forme cristalline, son procédé de préparation et son utilisation |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1004609A (en) | 1911-02-07 | 1911-10-03 | Farbenfab Vorm Bayer F & Co | Triphenylmethane dye. |
JP3252483B2 (ja) | 1992-10-20 | 2002-02-04 | 東レ株式会社 | 3環性トリアゾロ誘導体の製造方法 |
EP1146873B1 (fr) | 1999-01-25 | 2005-03-16 | Smithkline Beecham Corporation | Anti-androgenes et procedes de traitement |
UA71951C2 (en) | 1999-04-01 | 2005-01-17 | Pfizer Prod Inc | Pyrimidines as sorbitol dehydrogenase inhibitors, a pharmaceutical composition containing them, intermediate compounds and a method for the preparation of intermediate compound |
EP1490335B1 (fr) | 2002-03-25 | 2007-09-19 | Merck & Co., Inc. | Inhibiteurs de la dipeptidyl peptidase beta-amino heterocycliques pour le traitement ou la prevention du diabete |
DE60307483T2 (de) | 2002-08-07 | 2007-07-05 | Novartis Ag | Organische verbindungen als mittel zur behandlung von aldosteronbedingten zuständen |
MY139563A (en) | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
AR043443A1 (es) | 2003-03-07 | 2005-07-27 | Merck & Co Inc | Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios |
JP2007507504A (ja) | 2003-09-30 | 2007-03-29 | メルク エンド カムパニー インコーポレーテッド | フェニルピロリジンエーテル系タキキニン受容体拮抗薬 |
PL1716152T3 (pl) | 2004-02-18 | 2009-01-30 | Astrazeneca Ab | Skondensowane związki heterocykliczne i ich zastosowanie jako antagonistów receptora metabotropowego do leczenia zaburzeń żołądkowo-jelitowych |
GB0509405D0 (en) | 2005-05-10 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
US7943617B2 (en) * | 2006-11-27 | 2011-05-17 | Bristol-Myers Squibb Company | Heterobicyclic compounds useful as kinase inhibitors |
CN101686989B (zh) * | 2007-06-21 | 2016-10-19 | 卡拉治疗学股份有限公司 | 取代的咪唑并杂环 |
JP5563466B2 (ja) | 2007-10-19 | 2014-07-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピペラジノ−ジヒドロチエノピリミジン誘導体 |
US8470816B2 (en) | 2007-12-03 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use thereof |
JP5635910B2 (ja) | 2008-01-09 | 2014-12-03 | アレイ バイオファーマ、インコーポレイテッド | AKTタンパク質キナーゼ阻害剤としての5H−シクロペンタ[d]ピリミジン |
EP2229394A1 (fr) | 2008-01-17 | 2010-09-22 | Grünenthal GmbH | Dérivés de sulfonamides substitués |
EP2090576A1 (fr) * | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, leur procédé de préparation et leur utilisation en tant que modulateurs des récepteurs metabotropiques du glutamate (mGluR) |
EP2085398A1 (fr) * | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, leur procédé de préparation et leur utilisation en tant que médicament |
EP2424869B1 (fr) * | 2009-04-29 | 2016-06-22 | Glaxo Group Limited | DÉRIVÉS DE 5,6,7,8-TÉTRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE COMME MODULATEURS DE P2X7 |
GB0907515D0 (en) | 2009-04-30 | 2009-06-10 | Glaxo Group Ltd | Compounds |
JPWO2011007756A1 (ja) | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
EP2552920B1 (fr) | 2010-04-02 | 2017-03-15 | Ogeda Sa | Nouveaux composés antagonistes sélectifs du récepteur nk-3, composition pharmaceutique et procédé pour une utilisation dans des troubles médiés par les récepteurs nk-3 |
SI2763992T1 (sl) | 2011-10-03 | 2016-08-31 | Euroscreen S.A. | Novi kiralni n-acil-5,6,7,(8-substituirani)-tetrahidro-(1,2,4)triazolo (4,3-a)pirazini kot selektivni nk-3 receptor antagonisti, farmacevtski sestavek, in postopki za uporabo v nk-3 posredovanih motnjah |
AU2014242907B2 (en) | 2013-03-29 | 2018-06-28 | Ogeda Sa | Novel N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
JP6275242B2 (ja) | 2013-03-29 | 2018-02-07 | オゲダ エス.エー. | 選択的NK−3受容体拮抗薬としての新規なN−アシル−(3位置換)−(8−メチル)−5,6−ジヒドロ−[1,2,4]トリアゾロ[4,3−a]ピラジン、その医薬組成物、NK−3受容体媒介性障害で使用する方法 |
PT2948455T (pt) | 2013-03-29 | 2017-11-15 | Ogeda S A | N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3 |
-
2011
- 2011-04-04 EP EP11711922.2A patent/EP2552920B1/fr active Active
- 2011-04-04 LT LTEP11711922.2T patent/LT2552920T/lt unknown
- 2011-04-04 RS RS20170465A patent/RS55997B1/sr unknown
- 2011-04-04 WO PCT/EP2011/055218 patent/WO2011121137A1/fr active Application Filing
- 2011-04-04 PL PL11711922T patent/PL2552920T3/pl unknown
- 2011-04-04 CA CA2793313A patent/CA2793313C/fr active Active
- 2011-04-04 PT PT117119222T patent/PT2552920T/pt unknown
- 2011-04-04 MX MX2012011132A patent/MX342161B/es active IP Right Grant
- 2011-04-04 SI SI201131183A patent/SI2552920T1/sl unknown
- 2011-04-04 ES ES11711922.2T patent/ES2627688T3/es active Active
- 2011-04-04 KR KR1020127028933A patent/KR101878888B1/ko active IP Right Grant
- 2011-04-04 BR BR112012025101-5A patent/BR112012025101B1/pt active IP Right Grant
- 2011-04-04 HU HUE11711922A patent/HUE032770T2/en unknown
- 2011-04-04 EA EA201290940A patent/EA023161B1/ru unknown
- 2011-04-04 CN CN201180017571.0A patent/CN102906093B/zh active Active
- 2011-04-04 AU AU2011234398A patent/AU2011234398B8/en active Active
- 2011-04-04 EP EP16205883.8A patent/EP3176171A1/fr not_active Withdrawn
- 2011-04-04 JP JP2013501872A patent/JP5822911B2/ja active Active
- 2011-04-04 DK DK11711922.2T patent/DK2552920T3/en active
-
2012
- 2012-09-26 US US13/627,091 patent/US8871761B2/en active Active
-
2014
- 2014-08-29 US US14/473,147 patent/US9926325B2/en active Active
-
2017
- 2017-05-12 HR HRP20170712TT patent/HRP20170712T1/hr unknown
-
2018
- 2018-02-27 US US15/906,268 patent/US10544150B2/en active Active
-
2019
- 2019-12-20 US US16/722,353 patent/US20200125564A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2793313C (fr) | Composes antagonistes selectifs du recepteur nk-3, composition pharmaceutique et methodes pour une utilisation dans des troubles a mediation par des recepteurs nk-3 | |
US10065960B2 (en) | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders | |
DK2945632T3 (en) | HETEROBICYCLO SUBSTITUTED - [1,2,4] TRIAZOL [1,5-C] QUINAZOLIN-5-AMINE COMPOUNDS SUITABLE FOR TREATMENT OR PREVENTION OF DISORDERS IN CENTRAL NERVOUS SYSTEM | |
EP3500569B1 (fr) | 2-oxo-imidazopyridines en tant qu'inhibiteurs réversibles de btk et leurs utilisations | |
EP3356345A1 (fr) | Dérivés d'hétéroaryle à utiliser en tant qu'inhibiteurs de sépiaptérine réductase | |
CZ20021949A3 (cs) | Heterocyklické dihydropyrimidiny jako inhibitory draslíkových kanálků | |
NZ589926A (en) | Novel phenylimidazole derivatives as pde10a enzyme inhibitors | |
AU2011224316A1 (en) | Heterocyclic inhibitors of histamine receptors for the treatment of disease | |
WO2014001973A1 (fr) | Nouvelles 7h-pyrrolo[2,3-d]pyrimidines substituées par un groupe amino en position 4, utilisées comme inhibiteurs de lrrk2 | |
AU2020206477B2 (en) | Haloallylamine compounds and application thereof | |
EP3157920A1 (fr) | Dérivés d'indolizine servant d'inhibiteurs des phoshoinositide 3-kinases | |
CA3189912A1 (fr) | Composes bicycliques, compositions et utilisation de ceux-ci | |
WO2021257614A1 (fr) | Inhibiteurs hétérocycliques d'enpp1 | |
AU2019280356B2 (en) | ERK inhibitor and use thereof | |
EP4288431A1 (fr) | Inhibiteurs de shp2 azabicycliques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20151113 |