PT2948455T - N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3 - Google Patents
N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3Info
- Publication number
- PT2948455T PT2948455T PT147138440T PT14713844T PT2948455T PT 2948455 T PT2948455 T PT 2948455T PT 147138440 T PT147138440 T PT 147138440T PT 14713844 T PT14713844 T PT 14713844T PT 2948455 T PT2948455 T PT 2948455T
- Authority
- PT
- Portugal
- Prior art keywords
- substituted
- receptor
- pyrazines
- triazolo
- dihydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13161863 | 2013-03-29 | ||
EP13193025 | 2013-11-15 | ||
EP14154303 | 2014-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2948455T true PT2948455T (pt) | 2017-11-15 |
Family
ID=50391185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT147138440T PT2948455T (pt) | 2013-03-29 | 2014-03-28 | N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3 |
Country Status (29)
Country | Link |
---|---|
US (3) | US9422299B2 (pt) |
EP (2) | EP3219715A1 (pt) |
JP (2) | JP6316932B2 (pt) |
KR (2) | KR102364835B1 (pt) |
CN (1) | CN105229008B (pt) |
AU (1) | AU2014242906B2 (pt) |
BR (1) | BR112015024907B1 (pt) |
CA (1) | CA2907809C (pt) |
CY (1) | CY1119576T1 (pt) |
DK (1) | DK2948455T5 (pt) |
EA (1) | EA027570B1 (pt) |
ES (1) | ES2646488T3 (pt) |
FI (1) | FIC20240019I1 (pt) |
HK (2) | HK1244273A1 (pt) |
HR (1) | HRP20171688T1 (pt) |
HU (1) | HUE035870T2 (pt) |
IL (1) | IL241473B (pt) |
LT (1) | LT2948455T (pt) |
MX (1) | MX370000B (pt) |
NL (1) | NL301272I2 (pt) |
NO (1) | NO2948455T3 (pt) |
NZ (1) | NZ712802A (pt) |
PL (1) | PL2948455T3 (pt) |
PT (1) | PT2948455T (pt) |
RS (1) | RS56501B1 (pt) |
SG (1) | SG11201508005XA (pt) |
SI (1) | SI2948455T1 (pt) |
WO (1) | WO2014154895A1 (pt) |
ZA (1) | ZA201506234B (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011234398B8 (en) | 2010-04-02 | 2015-03-05 | Ogeda Sa | Novel NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
MX367774B (es) | 2011-10-03 | 2019-09-04 | Ogeda S A | N-ACIL-5,6,7, (8-SUSTITUIDO)-TETRAHIDRO- [1,2,4] TRIAZOLO [4,3-a] PIRAZINAS QUIRALES, NOVEDOSAS, COMO ANTAGONISTAS SELECTIVOS DE RECEPTOR DE NK-3; COMPOSICIÓN FARMACÉUTICA, MÉTODOS PARA USO EN TRASTORNOS MEDIADOS POR RECEPTOR DE NK-3 Y SU SÍNTESIS QUIRAL. |
AU2014242908B2 (en) | 2013-03-29 | 2018-07-19 | Ogeda Sa | Novel N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
LT2948455T (lt) * | 2013-03-29 | 2017-11-27 | Ogeda S.A. | N-acil-(3-pakeisto)-(8-pakeisto)-5,6-dihidro- [1,2,4]triazol[4,3-a]pirazinai, kaip selektyvūs nk-3 receptorių antagonistai, farmacinė kompozicija, būdai, skirti naudoti nk-3 receptoriaus sąlygotų sutrikimų gydymui |
US10183948B2 (en) | 2013-03-29 | 2019-01-22 | Ogeda Sa | N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists |
CA2907813C (en) | 2013-03-29 | 2021-09-07 | Euroscreen Sa | Novel n-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders |
TR201902080T4 (tr) | 2014-09-25 | 2019-03-21 | Ogeda Sa | N-asil-(3-sübstitüe)-(8-sübstitüe)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinlerinin yeni kiral sentezleri. |
PL3271015T3 (pl) * | 2015-03-16 | 2024-03-11 | Ogeda N.V. | Antagoniści receptora nk-3 do traktowania leczniczego lub kosmetycznego nadmiaru tłuszczu w ciele |
KR102122470B1 (ko) * | 2016-12-08 | 2020-06-12 | 주식회사 엘지화학 | 변성제 및 이로부터 유래된 작용기를 포함하는 변성 공액디엔계 중합체 |
EP3428168A1 (en) * | 2017-07-12 | 2019-01-16 | Ogeda Sa | Deuterated fezolinetant |
JP2021014404A (ja) * | 2017-10-13 | 2021-02-12 | アステラス製薬株式会社 | トリアゾロピラジン誘導体の塩及び結晶 |
JP2020050814A (ja) * | 2018-09-28 | 2020-04-02 | 住友ベークライト株式会社 | フェノール変性リグニン樹脂を含む樹脂材料、それを用いたフェノール変性リグニン樹脂組成物および構造体 |
MX2021007505A (es) | 2018-12-21 | 2021-10-13 | Ogeda Sa | Síntesis de 3-metil-1,2,4-tiadiazol-5-carbohidrazida o de su forma deuterada con metil-d3. |
WO2020211798A1 (zh) * | 2019-04-16 | 2020-10-22 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
CN113527307A (zh) * | 2020-04-20 | 2021-10-22 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
CN113549074A (zh) * | 2020-04-26 | 2021-10-26 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
WO2022022680A1 (zh) | 2020-07-30 | 2022-02-03 | 上海翰森生物医药科技有限公司 | 含氮并环类衍生物抑制剂、其制备方法和应用 |
US20230271967A1 (en) | 2020-08-04 | 2023-08-31 | Teva Pharmaceuticals International Gmbh | Solid state forms of fezolinetant and salts thereof |
CN115260180B (zh) * | 2021-04-30 | 2024-05-28 | 长春金赛药业有限责任公司 | 含三氮唑稠环类衍生物、药物组合物及其制备方法和应用 |
CN115990164A (zh) * | 2021-10-18 | 2023-04-21 | 武汉大学 | 速激肽受体3抑制剂的用途 |
WO2023138681A1 (zh) * | 2022-01-24 | 2023-07-27 | 上海翰森生物医药科技有限公司 | 含氮并环类衍生物抑制剂的酸式盐或晶型及其制备方法和应用 |
WO2024083150A1 (zh) * | 2022-10-19 | 2024-04-25 | 长春金赛药业有限责任公司 | 一种nk3r拮抗剂的晶型及其制备方法和应用 |
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GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
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EP2085398A1 (en) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
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GB0907515D0 (en) | 2009-04-30 | 2009-06-10 | Glaxo Group Ltd | Compounds |
US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
AU2011234398B8 (en) | 2010-04-02 | 2015-03-05 | Ogeda Sa | Novel NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
MX367774B (es) | 2011-10-03 | 2019-09-04 | Ogeda S A | N-ACIL-5,6,7, (8-SUSTITUIDO)-TETRAHIDRO- [1,2,4] TRIAZOLO [4,3-a] PIRAZINAS QUIRALES, NOVEDOSAS, COMO ANTAGONISTAS SELECTIVOS DE RECEPTOR DE NK-3; COMPOSICIÓN FARMACÉUTICA, MÉTODOS PARA USO EN TRASTORNOS MEDIADOS POR RECEPTOR DE NK-3 Y SU SÍNTESIS QUIRAL. |
AU2014242908B2 (en) | 2013-03-29 | 2018-07-19 | Ogeda Sa | Novel N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
LT2948455T (lt) * | 2013-03-29 | 2017-11-27 | Ogeda S.A. | N-acil-(3-pakeisto)-(8-pakeisto)-5,6-dihidro- [1,2,4]triazol[4,3-a]pirazinai, kaip selektyvūs nk-3 receptorių antagonistai, farmacinė kompozicija, būdai, skirti naudoti nk-3 receptoriaus sąlygotų sutrikimų gydymui |
TR201902080T4 (tr) | 2014-09-25 | 2019-03-21 | Ogeda Sa | N-asil-(3-sübstitüe)-(8-sübstitüe)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinlerinin yeni kiral sentezleri. |
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