CA2790559A1 - Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds - Google Patents
Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds Download PDFInfo
- Publication number
- CA2790559A1 CA2790559A1 CA2790559A CA2790559A CA2790559A1 CA 2790559 A1 CA2790559 A1 CA 2790559A1 CA 2790559 A CA2790559 A CA 2790559A CA 2790559 A CA2790559 A CA 2790559A CA 2790559 A1 CA2790559 A1 CA 2790559A1
- Authority
- CA
- Canada
- Prior art keywords
- biologically active
- active composition
- wound dressing
- lipoic acid
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US12/757,562 US8632512B2 (en) | 2010-04-09 | 2010-04-09 | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
| US12/757,562 | 2010-04-09 | ||
| PCT/US2011/031441 WO2011127188A2 (en) | 2010-04-09 | 2011-04-06 | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
Publications (1)
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| CA2790559A1 true CA2790559A1 (en) | 2011-10-13 |
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| CA2790559A Abandoned CA2790559A1 (en) | 2010-04-09 | 2011-04-06 | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
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| Country | Link |
|---|---|
| US (1) | US8632512B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2555805B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5988309B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN105126156A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2011237638B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2790559A1 (cg-RX-API-DMAC10.html) |
| TW (1) | TW201141548A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2011127188A2 (cg-RX-API-DMAC10.html) |
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| US11298453B2 (en) | 2003-10-28 | 2022-04-12 | Smith & Nephew Plc | Apparatus and method for wound cleansing with actives |
| GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
| GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
| WO2011103462A1 (en) | 2010-02-18 | 2011-08-25 | Osiris Therapeutics, Inc. | Methods of manufacture of immunocompatible amniotic membrane products |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| EP4162968A1 (en) | 2010-12-08 | 2023-04-12 | ConvaTec Technologies Inc. | System for removing exudates from a wound site |
| CN103347561B (zh) | 2010-12-08 | 2016-09-07 | 康沃特克科技公司 | 用于评估伤口分泌液的集成系统 |
| EP2648794B1 (en) | 2010-12-08 | 2019-08-28 | ConvaTec Technologies Inc. | Wound exudate system accessory |
| US8597264B2 (en) | 2011-03-24 | 2013-12-03 | Kci Licensing, Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
| EP3851131A1 (en) | 2011-05-31 | 2021-07-21 | LifeCell Corporation | Adipose tissue matrices |
| GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
| GB201117296D0 (en) | 2011-10-07 | 2011-11-16 | Neotherix Ltd | Sampling device |
| CN102492109A (zh) * | 2011-11-28 | 2012-06-13 | 西安科技大学 | 一种可生物降解高回弹软质聚氨酯泡沫塑料及其制备方法 |
| GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
| GB201120693D0 (en) | 2011-12-01 | 2012-01-11 | Convatec Technologies Inc | Wound dressing for use in vacuum therapy |
| USD733896S1 (en) | 2012-05-04 | 2015-07-07 | Genadyne Biotechnologies, Inc. | Abdominal dressing |
| ES2753156T3 (es) | 2012-07-13 | 2020-04-07 | Lifecell Corp | Procedimientos de tratamiento mejorado de tejido adiposo |
| EP3332816B1 (en) | 2012-09-26 | 2020-11-04 | LifeCell Corporation | Processed adipose tissue |
| BR112015014816A2 (pt) | 2012-12-20 | 2017-07-11 | Convatec Technologies Inc | processamento de fibras celulósicas modificadas quimicamente |
| CN103156730A (zh) * | 2013-03-13 | 2013-06-19 | 潘银根 | 异种脱细胞真皮基质护创系统 |
| CN103622782B (zh) * | 2013-03-13 | 2015-01-28 | 潘银根 | 生物膜护创系统 |
| EP2976095B1 (en) * | 2013-03-15 | 2020-12-23 | 3M Innovative Properties Company | Wound healing compositions |
| WO2015021319A1 (en) * | 2013-08-07 | 2015-02-12 | Plurogen Therapeutics, Inc. | Delivery of medicants under continuous negative pressure dressing |
| JP2015105249A (ja) * | 2013-11-29 | 2015-06-08 | 富士フイルム株式会社 | 化粧料 |
| US10226566B2 (en) | 2014-04-23 | 2019-03-12 | Genadyne Biotechnologies, Inc. | System and process for removing bodily fluids from a body opening |
| SG11201609253PA (en) * | 2014-05-07 | 2016-12-29 | Osiris Therapeutics Inc | Immunocompatible chorionic membrane products |
| AU2014393404A1 (en) * | 2014-05-07 | 2016-11-24 | Osiris Therapeutics, Inc. | Immunocompatible amniotic membrane products |
| KR20160147058A (ko) * | 2014-05-07 | 2016-12-21 | 오시리스 쎄라퓨틱스, 인크. | 치료적 태반 조성물, 이의 제조방법 및 사용방법 |
| EP2944565B1 (en) | 2014-05-13 | 2017-09-27 | Entrotech, Inc. | Erosion protective sleeve |
| JP6670827B2 (ja) | 2014-05-16 | 2020-03-25 | スリーエム イノベイティブ プロパティズ カンパニー | 一体化させたエラストマー材料を備える多孔性エラストマー材料を含む物品、並びにその製造方法 |
| AU2015302021B2 (en) * | 2014-08-11 | 2019-05-30 | 3M Innovative Properties Company | Protease modulating wound interface layer for use with negative pressure wound therapy |
| WO2016118644A1 (en) | 2015-01-20 | 2016-07-28 | Plurogen Therapeutics, Llc | Compositions and methods of treating microbes |
| WO2017027461A1 (en) * | 2015-08-13 | 2017-02-16 | C.R. Bard, Inc. | Prosthetic repair system and method of use |
| GB2543544A (en) | 2015-10-21 | 2017-04-26 | Brightwake Ltd | Wound dressing |
| JP6055069B1 (ja) * | 2015-12-10 | 2016-12-27 | サンアロー株式会社 | 臓器、組織又は器官モデル |
| EP3436820A2 (en) | 2016-03-30 | 2019-02-06 | Qualizyme Diagnostics GmbH&Co KG | Detecting microbial infection in wounds |
| ES2904480T3 (es) | 2016-03-30 | 2022-04-05 | Convatec Technologies Inc | Detección de infecciones microbianas en heridas |
| GB201608099D0 (en) | 2016-05-09 | 2016-06-22 | Convatec Technologies Inc | Negative pressure wound dressing |
| ES2841427T3 (es) | 2016-07-05 | 2021-07-08 | Lifecell Corp | Matrices de tejido que incorporan múltiples tipos de tejido |
| JP2019525799A (ja) | 2016-07-08 | 2019-09-12 | コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ | 流体収集装置 |
| AU2017292881B2 (en) | 2016-07-08 | 2022-03-17 | Convatec Technologies Inc. | Flexible negative pressure system |
| BR112019000316A2 (pt) | 2016-07-08 | 2019-04-16 | Convatec Technologies Inc. | detecção de fluxo de fluido |
| CN107789660A (zh) * | 2016-08-31 | 2018-03-13 | 杜建 | 一种用于皮肤及软组织损伤的医用敷料 |
| US20200038248A1 (en) * | 2016-10-05 | 2020-02-06 | Temple University- Of The Commonwealth System Of Higher Education | Negative Pressure Enhanced Cellular Infiltration |
| WO2018226627A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Composite dressings for improved granulation and reduced maceration with negative-pressure treatment |
| WO2018226691A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Methods for manufacturing and assembling dual material tissue interface for negative-pressure therapy |
| EP3634330A1 (en) | 2017-06-07 | 2020-04-15 | KCI Licensing, Inc. | Composite dressings for improved granulation reduced maceration with negative-pressure treatment |
| BR112019025760A2 (pt) | 2017-06-07 | 2020-06-23 | Kci Licensing, Inc. | Curativo para tratar um local de tecido com pressão negativa, aparelho para tratar um local de tecido com pressão negativa,sistema para tratar um local de tecido, uso de qualquer um dos curativos,aparelhos ou sistemas, método para tratar um ferimento superficial com pressão negativa, método para promover granulação em um ferimento superficial e sistemas, aparelhos e métodos |
| JP7204685B2 (ja) | 2017-06-07 | 2023-01-16 | スリーエム イノベイティブ プロパティズ カンパニー | 陰圧治療での肉芽形成を促進し浸軟を低減させる複合ドレッシング |
| AU2018281102A1 (en) | 2017-06-07 | 2019-12-19 | 3M Innovative Properties Company | Systems, apparatuses, and methods for negative-pressure treatment with reduced tissue in-growth |
| JP2020523073A (ja) | 2017-06-07 | 2020-08-06 | ケーシーアイ ライセンシング インコーポレイテッド | 陰圧治療のための剥がして貼るドレッシング |
| JP7297739B2 (ja) | 2017-10-18 | 2023-06-26 | ライフセル コーポレーション | 脂肪組織製品および製造方法 |
| US11123375B2 (en) | 2017-10-18 | 2021-09-21 | Lifecell Corporation | Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products |
| JP7463273B2 (ja) | 2017-10-19 | 2024-04-08 | ライフセル コーポレーション | 流動性無細胞組織マトリックス製品および製造方法 |
| US11246994B2 (en) | 2017-10-19 | 2022-02-15 | Lifecell Corporation | Methods for introduction of flowable acellular tissue matrix products into a hand |
| EP3703633B2 (en) | 2017-11-03 | 2024-06-26 | 3M Innovative Properties Company | Extended wear-time dressing |
| EP3710074B1 (en) | 2017-11-16 | 2024-03-20 | ConvaTec Limited | Fluid collection apparatus |
| EP3843678B1 (en) | 2018-08-28 | 2023-07-26 | KCI Licensing, Inc. | Dressings for reduced tissue ingrowth |
| AU2020267589B2 (en) * | 2019-05-08 | 2024-01-04 | Musculoskeletal Transplant Foundation | Tissue derived porous matrices and methods for making and using same |
| EP3976127B1 (en) | 2019-05-30 | 2025-09-24 | LifeCell Corporation | Biologic breast implant |
| SG11202112292QA (en) | 2019-06-03 | 2021-12-30 | Convatec Ltd | Methods and devices to disrupt and contain pathogens |
| WO2020263457A1 (en) * | 2019-06-26 | 2020-12-30 | Kci Licensing, Inc. | Dressing employing features for protection against maceration |
| US12178598B2 (en) * | 2019-08-09 | 2024-12-31 | Solventum Intellectual Properties Company | Negative-pressure system incorporating wound diagnostic capabilities |
| US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
| US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
| WO2024216269A1 (en) * | 2023-04-13 | 2024-10-17 | The Regents Of The University Of California | Adjustably stable adhesive compositions for medical and non-medical uses, and recycling |
| US12269925B1 (en) | 2024-08-13 | 2025-04-08 | The Regents Of The University Of California | Fast curing, biocompatible and biodegradable adhesives and sealants |
| CN119587755B (zh) * | 2024-12-10 | 2026-01-30 | 重庆大学 | 一种含有载药acc纳米颗粒的双网络水凝胶及其制备方法和应用 |
Family Cites Families (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1355846A (en) | 1920-02-06 | 1920-10-19 | David A Rannells | Medical appliance |
| US2547758A (en) | 1949-01-05 | 1951-04-03 | Wilmer B Keeling | Instrument for treating the male urethra |
| US2632443A (en) | 1949-04-18 | 1953-03-24 | Eleanor P Lesher | Surgical dressing |
| GB692578A (en) | 1949-09-13 | 1953-06-10 | Minnesota Mining & Mfg | Improvements in or relating to drape sheets for surgical use |
| US2682873A (en) | 1952-07-30 | 1954-07-06 | Johnson & Johnson | General purpose protective dressing |
| NL189176B (nl) | 1956-07-13 | 1900-01-01 | Hisamitsu Pharmaceutical Co | Pleister op basis van een synthetische rubber. |
| GB801170A (en) | 1954-11-12 | 1958-09-10 | Pritchett & Gold & E P S Co | Improvements in surgical dressings |
| US2969057A (en) | 1957-11-04 | 1961-01-24 | Brady Co W H | Nematodic swab |
| US3066672A (en) | 1960-09-27 | 1962-12-04 | Jr William H Crosby | Method and apparatus for serial sampling of intestinal juice |
| US3367332A (en) | 1965-08-27 | 1968-02-06 | Gen Electric | Product and process for establishing a sterile area of skin |
| US3520300A (en) | 1967-03-15 | 1970-07-14 | Amp Inc | Surgical sponge and suction device |
| US3568675A (en) | 1968-08-30 | 1971-03-09 | Clyde B Harvey | Fistula and penetrating wound dressing |
| US3682180A (en) | 1970-06-08 | 1972-08-08 | Coilform Co Inc | Drain clip for surgical drain |
| BE789293Q (fr) | 1970-12-07 | 1973-01-15 | Parke Davis & Co | Pansement medico-chirugical pour brulures et lesions analogues |
| US3826254A (en) | 1973-02-26 | 1974-07-30 | Verco Ind | Needle or catheter retaining appliance |
| DE2527706A1 (de) | 1975-06-21 | 1976-12-30 | Hanfried Dr Med Weigand | Einrichtung zum einleiten von kontrastmittel in einen kuenstlichen darmausgang |
| DE2640413C3 (de) | 1976-09-08 | 1980-03-27 | Richard Wolf Gmbh, 7134 Knittlingen | Katheter-Überwachungsgerät |
| NL7710909A (nl) | 1976-10-08 | 1978-04-11 | Smith & Nephew | Samengestelde hechtstrook. |
| GB1562244A (en) | 1976-11-11 | 1980-03-05 | Lock P M | Wound dressing materials |
| US4080970A (en) | 1976-11-17 | 1978-03-28 | Miller Thomas J | Post-operative combination dressing and internal drain tube with external shield and tube connector |
| US4139004A (en) | 1977-02-17 | 1979-02-13 | Gonzalez Jr Harry | Bandage apparatus for treating burns |
| US4184510A (en) | 1977-03-15 | 1980-01-22 | Fibra-Sonics, Inc. | Valued device for controlling vacuum in surgery |
| US4165748A (en) | 1977-11-07 | 1979-08-28 | Johnson Melissa C | Catheter tube holder |
| US4245637A (en) | 1978-07-10 | 1981-01-20 | Nichols Robert L | Shutoff valve sleeve |
| SE414994B (sv) | 1978-11-28 | 1980-09-01 | Landstingens Inkopscentral | Venkateterforband |
| GB2047543B (en) | 1978-12-06 | 1983-04-20 | Svedman Paul | Device for treating tissues for example skin |
| US4284079A (en) | 1979-06-28 | 1981-08-18 | Adair Edwin Lloyd | Method for applying a male incontinence device |
| US4261363A (en) | 1979-11-09 | 1981-04-14 | C. R. Bard, Inc. | Retention clips for body fluid drains |
| US4569348A (en) | 1980-02-22 | 1986-02-11 | Velcro Usa Inc. | Catheter tube holder strap |
| US4480638A (en) | 1980-03-11 | 1984-11-06 | Eduard Schmid | Cushion for holding an element of grafted skin |
| US4297995A (en) | 1980-06-03 | 1981-11-03 | Key Pharmaceuticals, Inc. | Bandage containing attachment post |
| US4333468A (en) | 1980-08-18 | 1982-06-08 | Geist Robert W | Mesentery tube holder apparatus |
| US4465485A (en) | 1981-03-06 | 1984-08-14 | Becton, Dickinson And Company | Suction canister with unitary shut-off valve and filter features |
| US4392853A (en) | 1981-03-16 | 1983-07-12 | Rudolph Muto | Sterile assembly for protecting and fastening an indwelling device |
| US4373519A (en) | 1981-06-26 | 1983-02-15 | Minnesota Mining And Manufacturing Company | Composite wound dressing |
| US4392858A (en) | 1981-07-16 | 1983-07-12 | Sherwood Medical Company | Wound drainage device |
| US4419097A (en) | 1981-07-31 | 1983-12-06 | Rexar Industries, Inc. | Attachment for catheter tube |
| SE429197B (sv) | 1981-10-14 | 1983-08-22 | Frese Nielsen | Anordning for behandling av sar |
| DE3146266A1 (de) | 1981-11-21 | 1983-06-01 | B. Braun Melsungen Ag, 3508 Melsungen | Kombinierte vorrichtung fuer eine medizinische saugdrainage |
| US4551139A (en) | 1982-02-08 | 1985-11-05 | Marion Laboratories, Inc. | Method and apparatus for burn wound treatment |
| US4475909A (en) | 1982-05-06 | 1984-10-09 | Eisenberg Melvin I | Male urinary device and method for applying the device |
| DE3361779D1 (en) | 1982-07-06 | 1986-02-20 | Dow Corning | Medical-surgical dressing and a process for the production thereof |
| NZ206837A (en) | 1983-01-27 | 1986-08-08 | Johnson & Johnson Prod Inc | Thin film adhesive dressing:backing material in three sections |
| US4548202A (en) | 1983-06-20 | 1985-10-22 | Ethicon, Inc. | Mesh tissue fasteners |
| US4540412A (en) | 1983-07-14 | 1985-09-10 | The Kendall Company | Device for moist heat therapy |
| US4543100A (en) | 1983-11-01 | 1985-09-24 | Brodsky Stuart A | Catheter and drain tube retainer |
| US4525374A (en) | 1984-02-27 | 1985-06-25 | Manresa, Inc. | Treating hydrophobic filters to render them hydrophilic |
| CA1286177C (en) | 1984-05-03 | 1991-07-16 | Smith And Nephew Associated Companies Plc | Adhesive wound dressing |
| US4897081A (en) | 1984-05-25 | 1990-01-30 | Thermedics Inc. | Percutaneous access device |
| US5215522A (en) | 1984-07-23 | 1993-06-01 | Ballard Medical Products | Single use medical aspirating device and method |
| GB8419745D0 (en) | 1984-08-02 | 1984-09-05 | Smith & Nephew Ass | Wound dressing |
| US4872450A (en) | 1984-08-17 | 1989-10-10 | Austad Eric D | Wound dressing and method of forming same |
| US4655754A (en) | 1984-11-09 | 1987-04-07 | Stryker Corporation | Vacuum wound drainage system and lipids baffle therefor |
| US4826494A (en) | 1984-11-09 | 1989-05-02 | Stryker Corporation | Vacuum wound drainage system |
| US4605399A (en) | 1984-12-04 | 1986-08-12 | Complex, Inc. | Transdermal infusion device |
| GB2171030B (en) * | 1985-01-10 | 1988-09-28 | Kansai Paint Co Ltd | Coating method |
| US5037397A (en) | 1985-05-03 | 1991-08-06 | Medical Distributors, Inc. | Universal clamp |
| US4640688A (en) | 1985-08-23 | 1987-02-03 | Mentor Corporation | Urine collection catheter |
| US4710165A (en) | 1985-09-16 | 1987-12-01 | Mcneil Charles B | Wearable, variable rate suction/collection device |
| US4758220A (en) | 1985-09-26 | 1988-07-19 | Alcon Laboratories, Inc. | Surgical cassette proximity sensing and latching apparatus |
| US4733659A (en) | 1986-01-17 | 1988-03-29 | Seton Company | Foam bandage |
| US4838883A (en) | 1986-03-07 | 1989-06-13 | Nissho Corporation | Urine-collecting device |
| JPS62281965A (ja) | 1986-05-29 | 1987-12-07 | テルモ株式会社 | カテ−テルおよびカテ−テル用固定部材 |
| GB8621884D0 (en) | 1986-09-11 | 1986-10-15 | Bard Ltd | Catheter applicator |
| GB2195255B (en) | 1986-09-30 | 1991-05-01 | Vacutec Uk Limited | Apparatus for vacuum treatment of an epidermal surface |
| US4743232A (en) | 1986-10-06 | 1988-05-10 | The Clinipad Corporation | Package assembly for plastic film bandage |
| DE3634569A1 (de) | 1986-10-10 | 1988-04-21 | Sachse Hans E | Kondomkatheter, ein harnroehrenkatheter zur verhinderung von aufsteigenden infektionen |
| JPS63135179A (ja) | 1986-11-26 | 1988-06-07 | 立花 俊郎 | 薬物の経皮投与具 |
| GB8628564D0 (en) | 1986-11-28 | 1987-01-07 | Smiths Industries Plc | Anti-foaming agent suction apparatus |
| GB8706116D0 (en) | 1987-03-14 | 1987-04-15 | Smith & Nephew Ass | Adhesive dressings |
| US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| US4863449A (en) | 1987-07-06 | 1989-09-05 | Hollister Incorporated | Adhesive-lined elastic condom cathether |
| GB8726777D0 (en) * | 1987-11-16 | 1987-12-23 | Smith & Nephew Ass | Adhesive dressings |
| US5176663A (en) | 1987-12-02 | 1993-01-05 | Pal Svedman | Dressing having pad with compressibility limiting elements |
| US4906240A (en) | 1988-02-01 | 1990-03-06 | Matrix Medica, Inc. | Adhesive-faced porous absorbent sheet and method of making same |
| US4985019A (en) | 1988-03-11 | 1991-01-15 | Michelson Gary K | X-ray marker |
| GB8812803D0 (en) | 1988-05-28 | 1988-06-29 | Smiths Industries Plc | Medico-surgical containers |
| US4919654A (en) | 1988-08-03 | 1990-04-24 | Kalt Medical Corporation | IV clamp with membrane |
| US5000741A (en) | 1988-08-22 | 1991-03-19 | Kalt Medical Corporation | Transparent tracheostomy tube dressing |
| US5059596A (en) | 1989-01-16 | 1991-10-22 | Roussel Uclaf | Azabicyclo compounds |
| US5261893A (en) | 1989-04-03 | 1993-11-16 | Zamierowski David S | Fastening system and method |
| US5527293A (en) | 1989-04-03 | 1996-06-18 | Kinetic Concepts, Inc. | Fastening system and method |
| US4969880A (en) | 1989-04-03 | 1990-11-13 | Zamierowski David S | Wound dressing and treatment method |
| US5100396A (en) | 1989-04-03 | 1992-03-31 | Zamierowski David S | Fluidic connection system and method |
| JP2719671B2 (ja) | 1989-07-11 | 1998-02-25 | 日本ゼオン株式会社 | 創傷被覆材 |
| US5358494A (en) | 1989-07-11 | 1994-10-25 | Svedman Paul | Irrigation dressing |
| US5232453A (en) | 1989-07-14 | 1993-08-03 | E. R. Squibb & Sons, Inc. | Catheter holder |
| GB2235877A (en) | 1989-09-18 | 1991-03-20 | Antonio Talluri | Closed wound suction apparatus |
| US5134994A (en) | 1990-02-12 | 1992-08-04 | Say Sam L | Field aspirator in a soft pack with externally mounted container |
| US5092858A (en) | 1990-03-20 | 1992-03-03 | Becton, Dickinson And Company | Liquid gelling agent distributor device |
| US5149331A (en) | 1991-05-03 | 1992-09-22 | Ariel Ferdman | Method and device for wound closure |
| US5591709A (en) * | 1991-08-30 | 1997-01-07 | Life Medical Sciences, Inc. | Compositions and methods for treating wounds |
| US5278100A (en) | 1991-11-08 | 1994-01-11 | Micron Technology, Inc. | Chemical vapor deposition technique for depositing titanium silicide on semiconductor wafers |
| US5645081A (en) | 1991-11-14 | 1997-07-08 | Wake Forest University | Method of treating tissue damage and apparatus for same |
| US5636643A (en) | 1991-11-14 | 1997-06-10 | Wake Forest University | Wound treatment employing reduced pressure |
| US5279550A (en) | 1991-12-19 | 1994-01-18 | Gish Biomedical, Inc. | Orthopedic autotransfusion system |
| US5167613A (en) | 1992-03-23 | 1992-12-01 | The Kendall Company | Composite vented wound dressing |
| FR2690617B1 (fr) | 1992-04-29 | 1994-06-24 | Cbh Textile | Pansement adhesif transparent. |
| DE4306478A1 (de) | 1993-03-02 | 1994-09-08 | Wolfgang Dr Wagner | Drainagevorrichtung, insbesondere Pleuradrainagevorrichtung, und Drainageverfahren |
| US6241747B1 (en) | 1993-05-03 | 2001-06-05 | Quill Medical, Inc. | Barbed Bodily tissue connector |
| US5342376A (en) | 1993-05-03 | 1994-08-30 | Dermagraphics, Inc. | Inserting device for a barbed tissue connector |
| US5344415A (en) | 1993-06-15 | 1994-09-06 | Deroyal Industries, Inc. | Sterile system for dressing vascular access site |
| US5437651A (en) | 1993-09-01 | 1995-08-01 | Research Medical, Inc. | Medical suction apparatus |
| US5549584A (en) | 1994-02-14 | 1996-08-27 | The Kendall Company | Apparatus for removing fluid from a wound |
| US5607388A (en) | 1994-06-16 | 1997-03-04 | Hercules Incorporated | Multi-purpose wound dressing |
| US5556375A (en) | 1994-06-16 | 1996-09-17 | Hercules Incorporated | Wound dressing having a fenestrated base layer |
| US5664270A (en) | 1994-07-19 | 1997-09-09 | Kinetic Concepts, Inc. | Patient interface system |
| DE29504378U1 (de) | 1995-03-15 | 1995-09-14 | MTG Medizinisch, technische Gerätebau GmbH, 66299 Friedrichsthal | Elektronisch geregelte Niedervakuumpumpe für die Thorax- und Wunddrainage |
| US5709868A (en) * | 1995-09-20 | 1998-01-20 | Perricone; Nicholas V. | Lipoic acid in topical compositions |
| GB2320431B (en) | 1996-12-20 | 2000-08-30 | Johnson & Johnson Medical | Compositions for the treatment of chronic wounds |
| US6135116A (en) | 1997-07-28 | 2000-10-24 | Kci Licensing, Inc. | Therapeutic method for treating ulcers |
| GB9719520D0 (en) | 1997-09-12 | 1997-11-19 | Kci Medical Ltd | Surgical drape and suction heads for wound treatment |
| AU755496B2 (en) | 1997-09-12 | 2002-12-12 | Kci Licensing, Inc. | Surgical drape and suction head for wound treatment |
| US6071267A (en) | 1998-02-06 | 2000-06-06 | Kinetic Concepts, Inc. | Medical patient fluid management interface system and method |
| US6488643B1 (en) | 1998-10-08 | 2002-12-03 | Kci Licensing, Inc. | Wound healing foot wrap |
| US6287316B1 (en) | 1999-03-26 | 2001-09-11 | Ethicon, Inc. | Knitted surgical mesh |
| AR042572A1 (es) | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
| US6856821B2 (en) | 2000-05-26 | 2005-02-15 | Kci Licensing, Inc. | System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure |
| US7799004B2 (en) | 2001-03-05 | 2010-09-21 | Kci Licensing, Inc. | Negative pressure wound treatment apparatus and infection identification system and method |
| US6991643B2 (en) | 2000-12-20 | 2006-01-31 | Usgi Medical Inc. | Multi-barbed device for retaining tissue in apposition and methods of use |
| US6500443B1 (en) | 1999-06-30 | 2002-12-31 | Kimberly-Clark Worldwide, Inc. | Delivery of a sacrificial substrate to inhibit protease permeation into skin |
| JP4129536B2 (ja) | 2000-02-24 | 2008-08-06 | ヴェネテック インターナショナル，インコーポレイテッド | 高適合性カテーテルアンカリングシステム |
| US6539968B1 (en) * | 2000-09-20 | 2003-04-01 | Fugasity Corporation | Fluid flow controller and method of operation |
| US7700819B2 (en) * | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US6540705B2 (en) | 2001-02-22 | 2003-04-01 | Core Products International, Inc. | Ankle brace providing upper and lower ankle adjustment |
| US20020168400A1 (en) * | 2001-05-11 | 2002-11-14 | Biocore Medical Technologies, Inc. | Collagen/synthetic resin foam wound dressing |
| US7494482B2 (en) | 2001-05-15 | 2009-02-24 | The Brigham And Women's Hospital, Inc. | Methods and apparatus for application of micro-mechanical forces to tissues |
| US20040170703A1 (en) | 2001-11-29 | 2004-09-02 | Greystone Medical Group, Inc. | Reduction of reactive oxygen species in chronic wound management |
| JP4475959B2 (ja) | 2002-04-24 | 2010-06-09 | インセンス・リミテッド | 水和ヒドロゲル類および酵素類を含む傷被覆材 |
| US20070237812A1 (en) | 2006-04-11 | 2007-10-11 | Tyco Healthcare Group | Multi-layer wound dressings |
| US20050281858A1 (en) | 2004-06-18 | 2005-12-22 | Kloke Tim M | Devices, articles, coatings, and methods for controlled active agent release |
| GB2415382A (en) | 2004-06-21 | 2005-12-28 | Johnson & Johnson Medical Ltd | Wound dressings for vacuum therapy |
| EP1771138A4 (en) * | 2004-07-26 | 2009-08-19 | Kci Licensing Inc | METHOD FOR COVERING ANTIMICROBIAL AGENT SUBSTRATE AND PRODUCT THUS FORMED |
| US7485112B2 (en) | 2004-11-08 | 2009-02-03 | Boehringer Technologies, L.P. | Tube attachment device for wound treatment |
| JP3819016B2 (ja) | 2004-12-24 | 2006-09-06 | 株式会社キネシオ | 身体貼着用テープ |
| CN101257938A (zh) | 2005-09-07 | 2008-09-03 | 泰科保健集团有限合伙公司 | 具有真空储存器的伤口敷料 |
| EP1922044B1 (en) | 2005-09-07 | 2015-03-04 | Smith & Nephew, Inc. | Self contained wound dressing apparatus |
| US8029498B2 (en) * | 2006-03-14 | 2011-10-04 | Kci Licensing Inc. | System for percutaneously administering reduced pressure treatment using balloon dissection |
| US20070299410A1 (en) * | 2006-06-26 | 2007-12-27 | Eknoian Michael W | Skin treatment article |
| DE202006020459U1 (de) * | 2006-08-16 | 2008-08-07 | Lohmann & Rauscher Gmbh & Co. Kg | Zubereitung mit marinem Kollagen zur Proteinasehemmung |
| US20080114277A1 (en) * | 2006-11-09 | 2008-05-15 | Archel Ambrosio | Porous bioresorbable dressing conformable to a wound and methods of making same |
| RU2542471C2 (ru) * | 2006-11-15 | 2015-02-20 | Коуда Терапьютикс, Инк. | Улучшенные способы и композиции для заживления ран |
| ITMI20070644A1 (it) * | 2007-03-29 | 2008-09-30 | Difass Sa | Composizioni topiche comprendenti magaldrato |
| ITMI20070798A1 (it) | 2007-04-18 | 2008-10-19 | Biofarmitalia Spa | Dispositivo per distendere le rughe della pelle umana |
| JP2010525873A (ja) | 2007-05-01 | 2010-07-29 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | 創傷治癒デバイス |
| US20090177133A1 (en) * | 2008-01-04 | 2009-07-09 | Kristine Kieswetter | Reduced pressure dressing coated with biomolecules |
| US9782300B2 (en) * | 2008-02-01 | 2017-10-10 | Kci Licensing, Inc. | Fiber-microsphere bioresorbable composite scaffold for wound healing |
| CN101959539B (zh) * | 2008-02-25 | 2014-06-04 | 帝国制药株式会社 | 水凝胶创伤被覆材料 |
| SE533167C2 (sv) * | 2008-04-09 | 2010-07-13 | Moelnlycke Health Care Ab | Anordning för att behandla sår och sätt för att tillverka sårdynor |
| WO2009137074A1 (en) * | 2008-05-06 | 2009-11-12 | Indigene Pharmaceuticals, Inc. | Compositions and methods for treating diabetic ulcers |
| CA2840415C (en) * | 2008-06-25 | 2018-01-02 | Kci Licensing, Inc. | Absorbable, reduced-pressure manifolds and systems |
| WO2010017282A1 (en) * | 2008-08-05 | 2010-02-11 | Biomimedica, Inc. | Polyurethane-grafted hydrogels |
-
2010
- 2010-04-09 US US12/757,562 patent/US8632512B2/en active Active
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2011
- 2011-04-06 AU AU2011237638A patent/AU2011237638B2/en not_active Ceased
- 2011-04-06 WO PCT/US2011/031441 patent/WO2011127188A2/en not_active Ceased
- 2011-04-06 JP JP2013503918A patent/JP5988309B2/ja active Active
- 2011-04-06 CA CA2790559A patent/CA2790559A1/en not_active Abandoned
- 2011-04-06 CN CN201510354734.4A patent/CN105126156A/zh active Pending
- 2011-04-06 CN CN201180015381.5A patent/CN103402556B/zh active Active
- 2011-04-06 EP EP11715141.5A patent/EP2555805B1/en active Active
- 2011-04-08 TW TW100112283A patent/TW201141548A/zh unknown
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2016
- 2016-04-22 JP JP2016085736A patent/JP6189473B2/ja not_active Expired - Fee Related
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|---|---|
| US20110251566A1 (en) | 2011-10-13 |
| EP2555805A2 (en) | 2013-02-13 |
| JP6189473B2 (ja) | 2017-08-30 |
| AU2011237638A1 (en) | 2012-08-23 |
| TW201141548A (en) | 2011-12-01 |
| EP2555805B1 (en) | 2020-08-19 |
| CN105126156A (zh) | 2015-12-09 |
| JP2013536156A (ja) | 2013-09-19 |
| US8632512B2 (en) | 2014-01-21 |
| CN103402556A (zh) | 2013-11-20 |
| JP5988309B2 (ja) | 2016-09-07 |
| AU2011237638B2 (en) | 2016-05-05 |
| WO2011127188A2 (en) | 2011-10-13 |
| WO2011127188A3 (en) | 2015-09-17 |
| JP2016175921A (ja) | 2016-10-06 |
| CN103402556B (zh) | 2015-07-22 |
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| FZDE | Discontinued |
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