CA2783001C - Sustained-release nucleic acid matrix compositions - Google Patents
Sustained-release nucleic acid matrix compositions Download PDFInfo
- Publication number
- CA2783001C CA2783001C CA2783001A CA2783001A CA2783001C CA 2783001 C CA2783001 C CA 2783001C CA 2783001 A CA2783001 A CA 2783001A CA 2783001 A CA2783001 A CA 2783001A CA 2783001 C CA2783001 C CA 2783001C
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- Prior art keywords
- another embodiment
- matrix composition
- matrix
- lipid
- nucleic acid
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- 239000011159 matrix material Substances 0.000 title claims abstract description 215
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 152
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- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 140
- 238000013268 sustained release Methods 0.000 title claims description 18
- 239000012730 sustained-release form Substances 0.000 title claims description 12
- 238000000034 method Methods 0.000 claims abstract description 80
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
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| EP2525778B1 (en) | 2018-08-01 |
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| EP2525778A4 (en) | 2013-07-03 |
| JP2013517265A (ja) | 2013-05-16 |
| WO2011089595A2 (en) | 2011-07-28 |
| CN102892406B (zh) | 2015-04-08 |
| WO2011089595A3 (en) | 2011-10-20 |
| US9616032B2 (en) | 2017-04-11 |
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