CN102892406B - 缓释核酸基质组合物 - Google Patents

缓释核酸基质组合物 Download PDF

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Publication number
CN102892406B
CN102892406B CN201180006572.5A CN201180006572A CN102892406B CN 102892406 B CN102892406 B CN 102892406B CN 201180006572 A CN201180006572 A CN 201180006572A CN 102892406 B CN102892406 B CN 102892406B
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another embodiment
matrix composition
nucleic acid
matrix
lipid
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Chinese (zh)
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CN102892406A (zh
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诺姆·埃马努埃尔
优素福·波森菲尔德
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Polypid Ltd
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Polypid Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
CN201180006572.5A 2010-01-19 2011-01-18 缓释核酸基质组合物 Active CN102892406B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29604010P 2010-01-19 2010-01-19
US61/296,040 2010-01-19
PCT/IL2011/000054 WO2011089595A2 (en) 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions

Publications (2)

Publication Number Publication Date
CN102892406A CN102892406A (zh) 2013-01-23
CN102892406B true CN102892406B (zh) 2015-04-08

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Family Applications (1)

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CN201180006572.5A Active CN102892406B (zh) 2010-01-19 2011-01-18 缓释核酸基质组合物

Country Status (7)

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US (2) US8795726B2 (enExample)
EP (1) EP2525778B1 (enExample)
JP (1) JP5860409B2 (enExample)
CN (1) CN102892406B (enExample)
AU (1) AU2011208374B2 (enExample)
CA (1) CA2783001C (enExample)
WO (1) WO2011089595A2 (enExample)

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PL2299953T3 (pl) 2008-07-14 2017-10-31 Polypid Ltd Kompozycja nośnika leku o przedłużonym uwalnianiu
IN2012DN00570A (enExample) 2009-07-14 2015-06-12 Polypid Ltd
CN103500847B (zh) * 2013-10-02 2016-08-17 中国地质大学（武汉） 锂硫电池添加剂、含有该添加剂的正极材料及其制备方法
WO2015069870A1 (en) * 2013-11-07 2015-05-14 The University Of North Carolina At Chapel Hill Particles containing phospholipids or bioactive fatty acid
US20160340659A1 (en) 2014-01-30 2016-11-24 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same
JP2016023148A (ja) * 2014-07-17 2016-02-08 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
HUE056523T2 (hu) * 2014-10-02 2022-02-28 Polypid Ltd Készítmények és eljárások mûtéti sebfertõzések kezelésére és megelõzésére
BR112020006136A2 (pt) * 2017-09-26 2020-10-06 Nanomi B.V. método para a preparação de micropartículas pela técnica de dupla emulsão
CN107823725B (zh) * 2017-10-11 2020-10-09 上海君联医疗设备有限公司 一种可延期回收的血栓滤器及其制作方法
JP6388700B2 (ja) * 2017-10-20 2018-09-12 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
US11464860B2 (en) 2017-10-27 2022-10-11 Massachusetts Institute Of Technology Poly (beta-amino esters) and uses thereof
KR20210093232A (ko) 2018-10-09 2021-07-27 더 유니버시티 오브 브리티시 콜롬비아 유기용매와 세제가 없는 형질감염 적격 소포를 포함하는 조성물과 시스템 및 관련 방법
CA3117781A1 (en) * 2018-10-26 2020-04-30 Massachusetts Institute Of Technology Polymer-lipids and compositions
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids

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Also Published As

Publication number Publication date
US20140335165A1 (en) 2014-11-13
CA2783001A1 (en) 2011-07-28
US8795726B2 (en) 2014-08-05
CN102892406A (zh) 2013-01-23
AU2011208374A1 (en) 2012-06-21
AU2011208374B2 (en) 2016-09-08
EP2525778A2 (en) 2012-11-28
CA2783001C (en) 2017-12-12
JP5860409B2 (ja) 2016-02-16
EP2525778B1 (en) 2018-08-01
US20120294944A1 (en) 2012-11-22
EP2525778A4 (en) 2013-07-03
JP2013517265A (ja) 2013-05-16
WO2011089595A2 (en) 2011-07-28
WO2011089595A3 (en) 2011-10-20
US9616032B2 (en) 2017-04-11

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