CA2777066C - Pharmaceutical formulations of nitrite and uses thereof - Google Patents
Pharmaceutical formulations of nitrite and uses thereof Download PDFInfo
- Publication number
- CA2777066C CA2777066C CA2777066A CA2777066A CA2777066C CA 2777066 C CA2777066 C CA 2777066C CA 2777066 A CA2777066 A CA 2777066A CA 2777066 A CA2777066 A CA 2777066A CA 2777066 C CA2777066 C CA 2777066C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- nitrite
- sodium nitrite
- release
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 106
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 title claims abstract description 104
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- 150000003839 salts Chemical class 0.000 claims abstract description 32
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 146
- 235000010288 sodium nitrite Nutrition 0.000 claims description 73
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US25148309P | 2009-10-14 | 2009-10-14 | |
| US61/251,483 | 2009-10-14 | ||
| PCT/US2010/052683 WO2011047161A1 (en) | 2009-10-14 | 2010-10-14 | Pharmaceutical formulations of nitrite and uses thereof |
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| CA2777066A1 CA2777066A1 (en) | 2011-04-21 |
| CA2777066C true CA2777066C (en) | 2020-02-18 |
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| US9649334B2 (en) | 2007-11-15 | 2017-05-16 | The Uab Research Foundation | Use of nitrite salts in chronic ischemia |
| US20120237617A1 (en) | 2009-06-18 | 2012-09-20 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| WO2011047161A1 (en) * | 2009-10-14 | 2011-04-21 | TheraVasc, LLC | Pharmaceutical formulations of nitrite and uses thereof |
| BR112014003414B1 (pt) | 2011-08-17 | 2021-09-21 | Board Of Regents, The University Of Texas System | Composição e sistema de entrega oral para aumento de níveis fisiológicos e terapêuticos de óxido nítrico |
| US8627204B2 (en) * | 2011-10-18 | 2014-01-07 | Microsoft Corporation | Custom optimization of web pages |
| JP2016509030A (ja) | 2013-02-20 | 2016-03-24 | セラバスク インコーポレーテッド | ニトライトの医薬製剤及びそれらの使用 |
| EP2994165A4 (en) * | 2013-05-10 | 2017-01-04 | Nitromega Corp. | Nutritional or dietary supplements containing fatty acids and nitrite |
| GB201309092D0 (en) * | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Transdermal delivery system |
| US20170349438A1 (en) | 2016-06-06 | 2017-12-07 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| JP2020508308A (ja) * | 2017-02-20 | 2020-03-19 | ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュアル アンド メカニカル カレッジ | 心房細動の治療及び予防における硫化水素及び／又は亜硝酸塩 |
| US11850271B1 (en) * | 2023-05-16 | 2023-12-26 | King Faisal University | Topical skin cream |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2914446A (en) * | 1958-06-26 | 1959-11-24 | Upjohn Co | Nitrite stabilized ascorbic acid-cyanocobalamin compositions |
| US4650484A (en) | 1983-02-03 | 1987-03-17 | Alza Corporation | Method for treating ischemic conditions |
| IE64726B1 (en) | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| US5122384A (en) | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| US6709681B2 (en) | 1995-02-17 | 2004-03-23 | Aberdeen University | Acidified nitrite as an antimicrobial agent |
| US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
| US5648101A (en) | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5994444A (en) * | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| US7371415B1 (en) | 1998-04-03 | 2008-05-13 | The Daily Wellness Company | Method and composition for improving sexual fitness |
| US7015876B1 (en) * | 1998-06-03 | 2006-03-21 | Lear Corporation | Heads-up display with improved contrast |
| WO2000003725A1 (en) | 1998-07-14 | 2000-01-27 | Paracelsian, Inc. | Method for identifying and confirming consistent bio-functionality of natural compositions |
| JP2002535353A (ja) | 1999-01-29 | 2002-10-22 | ロザン ファルマ ゲゼルシャフトミットベシュレンクテルハフツンク | 医薬品組成物 |
| GB9905425D0 (en) | 1999-03-09 | 1999-05-05 | Queen Mary & Westfield College | Pharmaceutical composition |
| US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| GB0119011D0 (en) | 2001-08-03 | 2001-09-26 | Univ Aberdeen | Treatment of nail infections |
| EP1492509A1 (en) | 2001-12-18 | 2005-01-05 | ALZA Corporation | Dosage form providing time-varying patterns of drug delivery |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| CN100430399C (zh) * | 2002-03-20 | 2008-11-05 | 昆士兰大学 | 包含一氧化氮供体和阿片样物质止痛剂的组合物和方法 |
| CA2379211A1 (fr) | 2002-03-28 | 2003-09-28 | Institut De Cardiologie De Montreal | Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase) |
| JP5564157B2 (ja) * | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 心臓血管状態の処置のための亜硝酸塩の使用方法 |
| WO2005018561A2 (en) | 2003-08-20 | 2005-03-03 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
| US20050113409A1 (en) | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| US7362274B1 (en) | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20060083824A1 (en) | 2004-10-20 | 2006-04-20 | Pbm Products Llc | Nutritional supplements for glucose intolerant individuals |
| JP5175107B2 (ja) * | 2005-02-11 | 2013-04-03 | ノーラブズ エービー | 酸化窒素による神経障害の治療デバイス、方法および使用 |
| JP2008542300A (ja) | 2005-05-24 | 2008-11-27 | ウェルルゲン インコーポレーテッド | 炎症と関連した状態を予防及び治療するための組成物及び方法 |
| BRPI0621321A2 (pt) * | 2006-02-10 | 2011-12-06 | Mannatech Inc | formulações de suplemento dietético de multivitamìnico e multimineral natural para melhor absorção e utilização biológica |
| GB0607402D0 (en) | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| US8333997B2 (en) | 2006-06-21 | 2012-12-18 | Albert Einstein College Of Medicine Of Yeshiva University | Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof |
| AU2008219834C1 (en) | 2007-02-26 | 2015-11-12 | Heartbeet Ltd. | New use of nitrites and nitrates and compositions containing these |
| ES2618655T3 (es) | 2007-02-26 | 2017-06-21 | Heartbeet Ltd. | Composición que mejora el rendimiento y uso de la misma |
| WO2008153762A2 (en) | 2007-05-25 | 2008-12-18 | N30 Pharmaceuticals, Llc | S-nitrosothiol formulations and storage systems |
| JP5592790B2 (ja) * | 2007-08-06 | 2014-09-17 | トリニティ ラボラトリーズ インコーポレイテッド | 慢性疼痛およびニューロパシーに関連する疼痛を治療する医薬組成物 |
| US9649334B2 (en) | 2007-11-15 | 2017-05-16 | The Uab Research Foundation | Use of nitrite salts in chronic ischemia |
| US20090196930A1 (en) | 2007-12-27 | 2009-08-06 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide -donating compounds and uses thereof |
| WO2010036236A1 (en) | 2008-09-23 | 2010-04-01 | Baker Hughes Incorporated | Anchor assembly |
| US8568793B2 (en) * | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| US20120237617A1 (en) | 2009-06-18 | 2012-09-20 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| WO2011047161A1 (en) | 2009-10-14 | 2011-04-21 | TheraVasc, LLC | Pharmaceutical formulations of nitrite and uses thereof |
| US20130209584A1 (en) | 2009-10-14 | 2013-08-15 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| WO2012135623A1 (en) | 2011-03-31 | 2012-10-04 | Theravasc Inc. | Use of nitrites for the treatment of cerebral amyloid angiopathy, age associated dementia, and cognitive decline |
| WO2012142413A2 (en) | 2011-04-14 | 2012-10-18 | Theravasc Inc. | Nitrite compositions and uses thereof |
| US9294956B2 (en) | 2011-12-29 | 2016-03-22 | Qualcomm Incorporated | Application-server-assisted preemptive multicast bearer establishment for real-time low-latency applications |
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2010
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2012
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2015
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2020
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| US20200085861A1 (en) | 2020-03-19 |
| JP6125567B2 (ja) | 2017-05-10 |
| US20200297756A1 (en) | 2020-09-24 |
| US20160067279A1 (en) | 2016-03-10 |
| EP2488035A1 (en) | 2012-08-22 |
| ES2633618T3 (es) | 2017-09-22 |
| IN2012DN03428A (enExample) | 2015-10-23 |
| JP2013508289A (ja) | 2013-03-07 |
| JP2017141275A (ja) | 2017-08-17 |
| EP2488035B1 (en) | 2017-04-26 |
| US20110086069A1 (en) | 2011-04-14 |
| CN102686111A (zh) | 2012-09-19 |
| AU2010306755B2 (en) | 2015-12-24 |
| WO2011047161A1 (en) | 2011-04-21 |
| IL219155A0 (en) | 2012-06-28 |
| US10307441B2 (en) | 2019-06-04 |
| CA2777066A1 (en) | 2011-04-21 |
| CN107260756A (zh) | 2017-10-20 |
| JP2015180674A (ja) | 2015-10-15 |
| JP5758904B2 (ja) | 2015-08-05 |
| US10463689B2 (en) | 2019-11-05 |
| AU2010306755A1 (en) | 2012-05-03 |
| EP2488035A4 (en) | 2013-07-31 |
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