CA2777066C - Pharmaceutical formulations of nitrite and uses thereof - Google Patents
Pharmaceutical formulations of nitrite and uses thereof Download PDFInfo
- Publication number
- CA2777066C CA2777066C CA2777066A CA2777066A CA2777066C CA 2777066 C CA2777066 C CA 2777066C CA 2777066 A CA2777066 A CA 2777066A CA 2777066 A CA2777066 A CA 2777066A CA 2777066 C CA2777066 C CA 2777066C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- nitrite
- sodium nitrite
- release
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 106
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 title claims abstract description 104
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- 150000003839 salts Chemical class 0.000 claims abstract description 32
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 146
- 235000010288 sodium nitrite Nutrition 0.000 claims description 73
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Inorganic Chemistry (AREA)
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- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US25148309P | 2009-10-14 | 2009-10-14 | |
| US61/251,483 | 2009-10-14 | ||
| PCT/US2010/052683 WO2011047161A1 (en) | 2009-10-14 | 2010-10-14 | Pharmaceutical formulations of nitrite and uses thereof |
Publications (2)
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| CA2777066A1 CA2777066A1 (en) | 2011-04-21 |
| CA2777066C true CA2777066C (en) | 2020-02-18 |
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| IN (1) | IN2012DN03428A (enExample) |
| WO (1) | WO2011047161A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2008322437B2 (en) | 2007-11-15 | 2013-11-07 | Louisiana State University | Use of nitrite salts in chronic ischemia |
| WO2010147742A2 (en) | 2009-06-18 | 2010-12-23 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| JP5758904B2 (ja) | 2009-10-14 | 2015-08-05 | セラバスク インコーポレーテッド | ニトライトの医薬製剤及びそれらの使用 |
| MX388990B (es) | 2011-08-17 | 2025-03-20 | Univ Texas | Método de producción de niveles fisiológicos y terapéuticos de óxido nítrico por medio de un sistema de suministro oral. |
| US8627204B2 (en) * | 2011-10-18 | 2014-01-07 | Microsoft Corporation | Custom optimization of web pages |
| CA2899602C (en) * | 2013-02-20 | 2024-01-30 | Theravasc Inc. | Pharmaceutical uses of inorganic nitrites |
| WO2014183108A1 (en) * | 2013-05-10 | 2014-11-13 | Nitromega Corp. | Nutritional or dietary supplements containing fatty acids and nitrite |
| GB201309092D0 (en) | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Transdermal delivery system |
| WO2017214157A1 (en) | 2016-06-06 | 2017-12-14 | Theravasc Inc. | Pharmaceutical formulations of nitrite uses thereof |
| EP3582791A4 (en) * | 2017-02-20 | 2021-03-31 | The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | HYDROGEN SULPHIDE AND / OR NITRITE IN THE TREATMENT AND PREVENTION OF ATRIAL FIBRILLATION |
| US11850271B1 (en) * | 2023-05-16 | 2023-12-26 | King Faisal University | Topical skin cream |
| WO2026006722A1 (en) | 2024-06-28 | 2026-01-02 | The Regents Of The University Of Michigan | Nitric oxide generating medical devices and methods |
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| US2914446A (en) * | 1958-06-26 | 1959-11-24 | Upjohn Co | Nitrite stabilized ascorbic acid-cyanocobalamin compositions |
| US4650484A (en) * | 1983-02-03 | 1987-03-17 | Alza Corporation | Method for treating ischemic conditions |
| IE64726B1 (en) * | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| US5122384A (en) * | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
| US5278192A (en) | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| US6709681B2 (en) * | 1995-02-17 | 2004-03-23 | Aberdeen University | Acidified nitrite as an antimicrobial agent |
| US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
| US5648101A (en) * | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| US5770645A (en) * | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5994444A (en) * | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| US7371415B1 (en) | 1998-04-03 | 2008-05-13 | The Daily Wellness Company | Method and composition for improving sexual fitness |
| US7015876B1 (en) * | 1998-06-03 | 2006-03-21 | Lear Corporation | Heads-up display with improved contrast |
| AU4995699A (en) | 1998-07-14 | 2000-02-07 | Paracelsian, Inc. | Method for identifying and confirming consistent bio-functionality of natural compositions |
| MXPA01007463A (es) | 1999-01-29 | 2002-06-04 | Losan Pharma Gmbh | Composiciones farmaceuticas. |
| GB9905425D0 (en) | 1999-03-09 | 1999-05-05 | Queen Mary & Westfield College | Pharmaceutical composition |
| US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| GB0119011D0 (en) | 2001-08-03 | 2001-09-26 | Univ Aberdeen | Treatment of nail infections |
| US20030125714A1 (en) | 2001-12-18 | 2003-07-03 | Edgren David Emil | Dosage form for time-varying patterns of drug delivery |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| AU2003209850B2 (en) * | 2002-03-20 | 2009-09-03 | The University Of Queensland | Methods and compositions comprising nitric oxide donors and opioid analgesics |
| CA2379211A1 (fr) * | 2002-03-28 | 2003-09-28 | Institut De Cardiologie De Montreal | Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase) |
| JP5564158B2 (ja) * | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| JP2007502831A (ja) * | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
| WO2005023189A2 (en) | 2003-09-03 | 2005-03-17 | Pharmacia Corporation | Method of cox-2 selective inhibitor and nitric oxide-donating agent |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20060083824A1 (en) | 2004-10-20 | 2006-04-20 | Pbm Products Llc | Nutritional supplements for glucose intolerant individuals |
| JP5175107B2 (ja) | 2005-02-11 | 2013-04-03 | ノーラブズ エービー | 酸化窒素による神経障害の治療デバイス、方法および使用 |
| JP2008542300A (ja) | 2005-05-24 | 2008-11-27 | ウェルルゲン インコーポレーテッド | 炎症と関連した状態を予防及び治療するための組成物及び方法 |
| BRPI0621321A2 (pt) * | 2006-02-10 | 2011-12-06 | Mannatech Inc | formulações de suplemento dietético de multivitamìnico e multimineral natural para melhor absorção e utilização biológica |
| GB0607402D0 (en) | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| WO2007149520A2 (en) | 2006-06-21 | 2007-12-27 | Albert Einstein College Of Medicine Of Yeshiva University | Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof |
| JP2010519336A (ja) | 2007-02-26 | 2010-06-03 | ルンドベルク，ヨン | 亜硝酸塩及び硝酸塩及びこれらを含む組成物の新規使用 |
| WO2008105730A1 (en) | 2007-02-26 | 2008-09-04 | Jon Lundberg | Performance enhancing composition and use thereof |
| WO2008153762A2 (en) | 2007-05-25 | 2008-12-18 | N30 Pharmaceuticals, Llc | S-nitrosothiol formulations and storage systems |
| US10300031B2 (en) * | 2007-08-06 | 2019-05-28 | Trinity Laboratories Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| AU2008322437B2 (en) * | 2007-11-15 | 2013-11-07 | Louisiana State University | Use of nitrite salts in chronic ischemia |
| JP2011507968A (ja) * | 2007-12-27 | 2011-03-10 | エイヤーズ ファーマシューティカルズ、インク． | エアロゾル化ニトライトおよび一酸化窒素供与性化合物ならびにそれらの使用 |
| WO2010036236A1 (en) | 2008-09-23 | 2010-04-01 | Baker Hughes Incorporated | Anchor assembly |
| US8568793B2 (en) * | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| WO2010147742A2 (en) | 2009-06-18 | 2010-12-23 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| US20130209584A1 (en) | 2009-10-14 | 2013-08-15 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| JP5758904B2 (ja) * | 2009-10-14 | 2015-08-05 | セラバスク インコーポレーテッド | ニトライトの医薬製剤及びそれらの使用 |
| US20140127329A1 (en) | 2011-03-31 | 2014-05-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Use of nitrites for the treatment of cerebral amyloid angiopathy, age associated dementia, and cognitive decline |
| US20140112983A1 (en) | 2011-04-14 | 2014-04-24 | Theravasc Inc. | Nitrite compositions and uses thereof |
| US9294956B2 (en) | 2011-12-29 | 2016-03-22 | Qualcomm Incorporated | Application-server-assisted preemptive multicast bearer establishment for real-time low-latency applications |
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2010
- 2010-10-14 JP JP2012534359A patent/JP5758904B2/ja active Active
- 2010-10-14 AU AU2010306755A patent/AU2010306755B2/en not_active Ceased
- 2010-10-14 CA CA2777066A patent/CA2777066C/en active Active
- 2010-10-14 CN CN2010800568984A patent/CN102686111A/zh active Pending
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- 2010-10-14 IN IN3428DEN2012 patent/IN2012DN03428A/en unknown
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2012
- 2012-04-15 IL IL219155A patent/IL219155A0/en unknown
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2015
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- 2015-09-08 US US14/847,966 patent/US10307441B2/en active Active
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2017
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2019
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2020
- 2020-06-11 US US16/898,460 patent/US20200297756A1/en not_active Abandoned
Also Published As
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| WO2011047161A1 (en) | 2011-04-21 |
| CN107260756A (zh) | 2017-10-20 |
| US10463689B2 (en) | 2019-11-05 |
| IL219155A0 (en) | 2012-06-28 |
| CA2777066A1 (en) | 2011-04-21 |
| ES2633618T3 (es) | 2017-09-22 |
| AU2010306755B2 (en) | 2015-12-24 |
| CN102686111A (zh) | 2012-09-19 |
| EP2488035A4 (en) | 2013-07-31 |
| EP2488035B1 (en) | 2017-04-26 |
| US20160067279A1 (en) | 2016-03-10 |
| US20200297756A1 (en) | 2020-09-24 |
| IN2012DN03428A (enExample) | 2015-10-23 |
| JP5758904B2 (ja) | 2015-08-05 |
| JP2017141275A (ja) | 2017-08-17 |
| JP2015180674A (ja) | 2015-10-15 |
| AU2010306755A1 (en) | 2012-05-03 |
| JP2013508289A (ja) | 2013-03-07 |
| US10307441B2 (en) | 2019-06-04 |
| US20110086069A1 (en) | 2011-04-14 |
| JP6125567B2 (ja) | 2017-05-10 |
| US20200085861A1 (en) | 2020-03-19 |
| EP2488035A1 (en) | 2012-08-22 |
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