CA2776835A1 - Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor - Google Patents
Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor Download PDFInfo
- Publication number
- CA2776835A1 CA2776835A1 CA2776835A CA2776835A CA2776835A1 CA 2776835 A1 CA2776835 A1 CA 2776835A1 CA 2776835 A CA2776835 A CA 2776835A CA 2776835 A CA2776835 A CA 2776835A CA 2776835 A1 CA2776835 A1 CA 2776835A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- esi
- diazabicyclo
- nonan
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25110109P | 2009-10-13 | 2009-10-13 | |
| EP09172872 | 2009-10-13 | ||
| EP09172872.5 | 2009-10-13 | ||
| US61/251,101 | 2009-10-13 | ||
| PCT/EP2010/065160 WO2011045258A1 (en) | 2009-10-13 | 2010-10-11 | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2776835A1 true CA2776835A1 (en) | 2011-04-21 |
Family
ID=42040651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2776835A Abandoned CA2776835A1 (en) | 2009-10-13 | 2010-10-11 | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8841289B2 (enExample) |
| EP (1) | EP2488520B1 (enExample) |
| JP (1) | JP2013507417A (enExample) |
| KR (1) | KR20120100913A (enExample) |
| CN (1) | CN102666540A (enExample) |
| AU (1) | AU2010305825A1 (enExample) |
| BR (1) | BR112012008518A2 (enExample) |
| CA (1) | CA2776835A1 (enExample) |
| IN (1) | IN2012DN02968A (enExample) |
| MX (1) | MX2012004289A (enExample) |
| RU (1) | RU2012119488A (enExample) |
| WO (1) | WO2011045258A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2843383A1 (en) | 2011-07-29 | 2013-02-07 | Taisho Pharmaceutical Co., Ltd. | Amidine compound or salt thereof |
| EP2822656B1 (en) | 2012-03-07 | 2016-10-19 | Institute of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| CA2874193A1 (en) * | 2012-05-22 | 2013-11-28 | Vladimir BAJIC | Combination comprising parthenolide for use in the treatment of alzheimer's disease and other neurodegenerative disorders |
| US9611223B2 (en) | 2013-09-11 | 2017-04-04 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| EP3191459A1 (en) | 2014-09-05 | 2017-07-19 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
| EP3233087B1 (en) | 2014-12-16 | 2019-10-02 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| JP2018504430A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのキナゾリノン及びアザキナゾリノン |
| JP2018504431A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのチエノピリミジノン |
| EP3253759A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| CN106146410B (zh) * | 2015-04-03 | 2018-10-12 | 中南大学 | 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
| CN106279211B (zh) * | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
| JP2018516973A (ja) | 2015-06-10 | 2018-06-28 | フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物 |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
| PL3386591T3 (pl) | 2015-12-09 | 2021-02-22 | Novartis Ag | Heteroaromatyczne modulatory receptorów nmda i ich zastosowania |
| ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
| EP3558318B1 (en) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda receptor modulators and uses thereof |
| CA3105174A1 (en) * | 2018-06-27 | 2020-01-02 | Reborna Biosciences, Inc. | Prophylactic or therapeutic agent for spinal muscular atrophy |
| HU231414B1 (hu) | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
| US20220089609A1 (en) | 2018-07-26 | 2022-03-24 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| RS64359B1 (sr) | 2018-08-03 | 2023-08-31 | Novartis Ag | Heteroaromatični modulatori nmda receptora i njihove upotrebe |
| WO2021198188A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| US12180193B2 (en) | 2020-08-28 | 2024-12-31 | Arvinas Operations, Inc. | Accelerating fibrosarcoma protein degrading compounds and associated methods of use |
| CN112898290B (zh) * | 2021-01-29 | 2022-08-05 | 中南大学 | 异噁唑甲酰胺基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
| EP4584258A1 (en) | 2022-09-07 | 2025-07-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
| TW202539670A (zh) * | 2024-02-23 | 2025-10-16 | 大陸商海思科醫藥集團股份有限公司 | Braf抑制劑的製備方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| JP2005504730A (ja) * | 2001-04-20 | 2005-02-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｇｓｋ−３インヒビターとして有用な組成物 |
| WO2003062235A1 (en) * | 2002-01-17 | 2003-07-31 | Eli Lilly And Company | Modulators of acetylcholine receptors |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| TW200536830A (en) * | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
| PT1910333E (pt) * | 2005-07-26 | 2013-08-01 | Sanofi Sa | Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase |
| JP5256202B2 (ja) | 2006-09-11 | 2013-08-07 | エム・エス・ディー・オス・ベー・フェー | キナゾリノンおよびイソキノリノンアセトアミド誘導体 |
| KR101545533B1 (ko) * | 2006-12-27 | 2015-08-19 | 사노피 | 치환된 이소퀴놀린 및 Ｒｈｏ-키나아제 억제제로서의 이의 용도 |
| JP2010229035A (ja) | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | ピリドピリミジン−４−オン誘導体 |
| RU2010114662A (ru) * | 2007-11-14 | 2011-12-20 | Ньюросёрч А/С (Dk) | Новые производные 1,4-диазабицикло(3.2.2)нонилпиримидина и их медицинское применение |
| US20100327809A1 (en) | 2008-02-29 | 2010-12-30 | Techno Core International Co., Ltd. | Charging apparatus and quality judging apparatus for packed battery |
-
2010
- 2010-10-11 AU AU2010305825A patent/AU2010305825A1/en not_active Abandoned
- 2010-10-11 CA CA2776835A patent/CA2776835A1/en not_active Abandoned
- 2010-10-11 EP EP10771062.6A patent/EP2488520B1/en active Active
- 2010-10-11 RU RU2012119488/04A patent/RU2012119488A/ru unknown
- 2010-10-11 KR KR1020127009340A patent/KR20120100913A/ko not_active Withdrawn
- 2010-10-11 MX MX2012004289A patent/MX2012004289A/es not_active Application Discontinuation
- 2010-10-11 BR BR112012008518A patent/BR112012008518A2/pt not_active Application Discontinuation
- 2010-10-11 US US13/501,587 patent/US8841289B2/en active Active
- 2010-10-11 IN IN2968DEN2012 patent/IN2012DN02968A/en unknown
- 2010-10-11 CN CN2010800465507A patent/CN102666540A/zh active Pending
- 2010-10-11 JP JP2012533593A patent/JP2013507417A/ja active Pending
- 2010-10-11 WO PCT/EP2010/065160 patent/WO2011045258A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2488520B1 (en) | 2015-09-02 |
| AU2010305825A1 (en) | 2012-04-19 |
| RU2012119488A (ru) | 2013-11-20 |
| BR112012008518A2 (pt) | 2016-04-05 |
| US8841289B2 (en) | 2014-09-23 |
| IN2012DN02968A (enExample) | 2015-07-31 |
| MX2012004289A (es) | 2012-06-12 |
| KR20120100913A (ko) | 2012-09-12 |
| CN102666540A (zh) | 2012-09-12 |
| US20120208796A1 (en) | 2012-08-16 |
| JP2013507417A (ja) | 2013-03-04 |
| WO2011045258A1 (en) | 2011-04-21 |
| EP2488520A1 (en) | 2012-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2488520B1 (en) | Condensed azine-derivatives for the treatment of diseases related to the acetylcholine receptor | |
| US10752624B2 (en) | Kinase inhibitors | |
| JP6673920B2 (ja) | Ｐａｒｇ阻害化合物 | |
| US9637491B2 (en) | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors | |
| KR101862493B1 (ko) | Fgfr4 억제제로서의 고리-융합된 비시클릭 피리딜 유도체 | |
| CN113061132B (zh) | 一类稠环内酰胺类化合物、制备方法和用途 | |
| JP2006505509A (ja) | 受容体型キナーゼモジュレーターおよびその使用方法 | |
| AU2007287319A1 (en) | Pyrimidone compounds as GSK-3 inhibitors | |
| AU2007258435A1 (en) | Heterocyclic aspartyl protease inhibitors | |
| RS59106B1 (sr) | Derivati pirazol aminopirimidina kao lrrk2 modulatori | |
| KR20090038895A (ko) | 융합된 피리미도 화합물 | |
| KR20150016535A (ko) | 파킨슨 병의 치료에 사용하기 위한 lrrk2 조절제로서의 피라졸 아미노피리딘 유도체 | |
| WO2018102325A1 (en) | Tricyclic rho kinase inhibitors | |
| JP7801084B2 (ja) | Ｅｇｆｒ阻害剤としてのインドリン化合物及び誘導体 | |
| WO2012085167A1 (en) | Metabotropic glutamate receptor modulators | |
| KR20150119926A (ko) | 비시클로 2,3-벤조디아제핀 및 스피로시클릭 치환된 2,3-벤조디아제핀 | |
| WO2013153539A1 (en) | Tricyclic compounds as tec kinase inhibitors | |
| CA2674087A1 (en) | 6' substituted compounds having 5-ht6 receptor affinity | |
| RS63661B1 (sr) | Piridopirimidini kao inhibitori histaminskog h4-receptora | |
| WO2009043884A1 (en) | Azabicyclo [3. 1. 0] hexyl derivatives as modulators of dopamine d3 receptors | |
| WO2024261329A1 (en) | Heteroaryl-amine compounds and use thereof as hdac6 inhibitors | |
| WO2026027696A1 (en) | Thiomethyl carbonyl compounds and use thereof as hdac6 inhibitors | |
| AU2022378269A1 (en) | Quinazoline derivative compound and use thereof | |
| CA2716202A1 (en) | Pyrrolo[2,3-d]pyrimidin-2-yl-amine derivatives as pkc-theta inhibitors | |
| WO2025236004A1 (en) | Stat6 inhibitors and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20141014 |