CA2771232A1 - Purification of vwf for increased removal of non-lipid enveloped viruses - Google Patents

Purification of vwf for increased removal of non-lipid enveloped viruses Download PDF

Info

Publication number
CA2771232A1
CA2771232A1 CA2771232A CA2771232A CA2771232A1 CA 2771232 A1 CA2771232 A1 CA 2771232A1 CA 2771232 A CA2771232 A CA 2771232A CA 2771232 A CA2771232 A CA 2771232A CA 2771232 A1 CA2771232 A1 CA 2771232A1
Authority
CA
Canada
Prior art keywords
cation exchange
exchange resin
protein
vwf
wash buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2771232A
Other languages
English (en)
French (fr)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christa Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43063204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2771232(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of CA2771232A1 publication Critical patent/CA2771232A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2771232A 2009-08-20 2010-08-20 Purification of vwf for increased removal of non-lipid enveloped viruses Pending CA2771232A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23557009P 2009-08-20 2009-08-20
US61/235,570 2009-08-20
PCT/US2010/046180 WO2011022657A1 (en) 2009-08-20 2010-08-20 Purification of vwf for increased removal of non-lipid enveloped viruses

Publications (1)

Publication Number Publication Date
CA2771232A1 true CA2771232A1 (en) 2011-02-24

Family

ID=43063204

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2771232A Pending CA2771232A1 (en) 2009-08-20 2010-08-20 Purification of vwf for increased removal of non-lipid enveloped viruses

Country Status (18)

Country Link
US (1) US9315560B2 (enExample)
EP (1) EP2467399B2 (enExample)
JP (1) JP5838159B2 (enExample)
KR (1) KR101894600B1 (enExample)
CN (2) CN106008697B (enExample)
AU (1) AU2010284116B9 (enExample)
BR (1) BR112012003802B1 (enExample)
CA (1) CA2771232A1 (enExample)
DK (1) DK2467399T3 (enExample)
ES (1) ES2562256T5 (enExample)
HU (1) HUE026907T2 (enExample)
IN (1) IN2012DN01849A (enExample)
MX (1) MX2012002129A (enExample)
NZ (1) NZ598249A (enExample)
PL (1) PL2467399T3 (enExample)
PT (1) PT2467399E (enExample)
SG (2) SG178478A1 (enExample)
WO (1) WO2011022657A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
EP2349314B1 (en) 2008-10-21 2013-02-27 Baxter International Inc. Lyophilized recombinant vwf formulations
WO2013192009A1 (en) * 2012-06-21 2013-12-27 Baxter International Inc. Virus filtration of cell culture media
JP6320429B2 (ja) * 2013-02-22 2018-05-09 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 負帯電粒子を用いるウイルス調製物のクロマトグラフィー精製
BR112016026842A2 (pt) * 2014-06-06 2017-12-12 Octapharma Ag preparação compreendendo fator viii e peptídeos de fator de von willebrand
EP3158055B1 (en) 2014-06-13 2019-09-11 CSL Limited Improved production of recombinant von willebrand factor in a bioreactor
EP3672644A1 (en) 2017-08-23 2020-07-01 CSL Behring GmbH Method for virus filtration of von willebrand factor
CA3094644A1 (en) 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods
EP4490042A4 (en) 2022-03-08 2026-03-04 Equashield Medical Ltd FLUID TRANSFER STATION IN A ROBOTIC PHARMACEUTICAL PREPARATION SYSTEM

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
WO1986006096A1 (en) 1985-04-11 1986-10-23 The Children's Medical Center Corporation Von willebrand factor
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
AT406373B (de) * 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
AT405403B (de) * 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT405485B (de) 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
US6531577B1 (en) 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
ATE370961T1 (de) * 1998-05-06 2007-09-15 Genentech Inc Reinigung von antikörpern durch ionenaustauschchromatographie
AU2005322067B8 (en) 2004-12-27 2012-07-26 Takeda Pharmaceutical Company Limited Polymer-von Willebrand factor-conjugates

Also Published As

Publication number Publication date
JP5838159B2 (ja) 2015-12-24
BR112012003802B1 (pt) 2022-10-25
MX2012002129A (es) 2012-06-08
PT2467399E (pt) 2016-03-18
EP2467399B1 (en) 2015-11-11
ES2562256T5 (es) 2023-07-20
CN106008697A (zh) 2016-10-12
JP2013502434A (ja) 2013-01-24
US20110092681A1 (en) 2011-04-21
BR112012003802A2 (pt) 2016-11-22
KR101894600B1 (ko) 2018-09-03
EP2467399B2 (en) 2023-02-01
AU2010284116B9 (en) 2015-03-26
KR20120065342A (ko) 2012-06-20
AU2010284116B2 (en) 2015-02-12
HUE026907T2 (en) 2016-07-28
PL2467399T3 (pl) 2016-05-31
US9315560B2 (en) 2016-04-19
DK2467399T3 (en) 2017-01-23
WO2011022657A1 (en) 2011-02-24
NZ598249A (en) 2014-04-30
CN106008697B (zh) 2020-08-04
ES2562256T3 (es) 2016-03-03
CN102482341A (zh) 2012-05-30
AU2010284116A1 (en) 2012-03-08
IN2012DN01849A (enExample) 2015-08-21
SG178478A1 (en) 2012-04-27
SG10201408106WA (en) 2015-01-29
EP2467399A1 (en) 2012-06-27

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