CA2770241C - Method and probes to detect nucleic acid differences - Google Patents

Method and probes to detect nucleic acid differences Download PDF

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Publication number
CA2770241C
CA2770241C CA2770241A CA2770241A CA2770241C CA 2770241 C CA2770241 C CA 2770241C CA 2770241 A CA2770241 A CA 2770241A CA 2770241 A CA2770241 A CA 2770241A CA 2770241 C CA2770241 C CA 2770241C
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domain
nucleic acid
reporter
anchor
probe
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CA2770241A
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English (en)
French (fr)
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CA2770241A1 (en
Inventor
Stephen Gordon Will
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CA2770241A1 publication Critical patent/CA2770241A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2770241A 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences Active CA2770241C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23418909P 2009-08-14 2009-08-14
US61/234,189 2009-08-14
PCT/EP2010/004963 WO2011018232A1 (en) 2009-08-14 2010-08-13 Format of probes to detect nucleic acid differences

Publications (2)

Publication Number Publication Date
CA2770241A1 CA2770241A1 (en) 2011-02-17
CA2770241C true CA2770241C (en) 2016-03-29

Family

ID=43027741

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2770241A Active CA2770241C (en) 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences

Country Status (7)

Country Link
US (2) US8409802B2 (show.php)
EP (1) EP2464745B1 (show.php)
JP (1) JP5632476B2 (show.php)
CN (2) CN102471805A (show.php)
CA (1) CA2770241C (show.php)
ES (1) ES2608455T3 (show.php)
WO (1) WO2011018232A1 (show.php)

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US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences
EP3246416B1 (en) 2011-04-15 2024-06-05 The Johns Hopkins University Safe sequencing system
EP3382039B1 (en) 2011-05-04 2023-09-13 Biocept, Inc. Methods for detecting nucleic acid sequence variants
ES2736977T3 (es) * 2011-09-14 2020-01-09 Ngk Insulators Ltd Método para detectar ácido nucleico diana
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
EP2780481A4 (en) * 2011-11-16 2015-10-14 Canon Us Life Sciences Inc DETECTION OF MUTATIONS IN HIGHLY HOMOLOGOUS GENOME REGIONS
EP2912468B1 (en) 2012-10-29 2018-09-12 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US9637791B2 (en) * 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
CN107109398B (zh) * 2014-12-19 2020-08-18 荣研化学株式会社 单核苷酸多态性检测用寡核苷酸探针及单核苷酸多态性检测方法
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
CN108431234A (zh) * 2015-09-03 2018-08-21 纳米线科技公司 具有单核苷酸分辨率的多价探针
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
CA3072195A1 (en) 2017-08-07 2019-04-04 The Johns Hopkins University Methods and materials for assessing and treating cancer
MX2022010038A (es) 2020-02-14 2022-09-05 Univ Johns Hopkins Metodos y materiales para la evaluacion de acidos nucleicos.
CN117778575A (zh) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 一种用于检测SNV位点的TaqMan探针及其应用

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US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
DE3529478A1 (de) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
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US6734291B2 (en) 1999-03-24 2004-05-11 Exiqon A/S Synthesis of [2.2.1]bicyclo nucleosides
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EP1825000A4 (en) * 2004-11-23 2009-05-13 Xiao Bing Wang DETECTION OF NUCLEIC ACID VARIATIONS BY CLEANING REINFORCEMENT PROCEDURES
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US20080076131A1 (en) * 2005-12-02 2008-03-27 Chagovetz Alexander M Methods and devices for nucleic acid amplification on a surface
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CN100564542C (zh) * 2006-11-03 2009-12-02 罗光华 检测脱氧核糖核酸的单核苷酸多态性的方法
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Also Published As

Publication number Publication date
EP2464745A1 (en) 2012-06-20
US8409802B2 (en) 2013-04-02
CA2770241A1 (en) 2011-02-17
JP5632476B2 (ja) 2014-11-26
US9068225B2 (en) 2015-06-30
ES2608455T3 (es) 2017-04-11
CN107254540A (zh) 2017-10-17
US20110039264A1 (en) 2011-02-17
EP2464745B1 (en) 2016-11-09
JP2013501508A (ja) 2013-01-17
US20130266938A1 (en) 2013-10-10
CN107254540B (zh) 2021-11-16
CN102471805A (zh) 2012-05-23
WO2011018232A1 (en) 2011-02-17

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