CA2768940C - Isoform selective phospholipase d inhibitors - Google Patents
Isoform selective phospholipase d inhibitors Download PDFInfo
- Publication number
- CA2768940C CA2768940C CA2768940A CA2768940A CA2768940C CA 2768940 C CA2768940 C CA 2768940C CA 2768940 A CA2768940 A CA 2768940A CA 2768940 A CA2768940 A CA 2768940A CA 2768940 C CA2768940 C CA 2768940C
- Authority
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- Canada
- Prior art keywords
- optionally substituted
- cycloalkyl
- alkyl
- compound
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000009750 upstream signaling Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22849209P | 2009-07-24 | 2009-07-24 | |
| US61/228,492 | 2009-07-24 | ||
| PCT/US2010/043045 WO2011011680A1 (en) | 2009-07-24 | 2010-07-23 | Isoform selective phospholipase d inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2768940A1 CA2768940A1 (en) | 2011-01-27 |
| CA2768940C true CA2768940C (en) | 2018-03-13 |
Family
ID=43499428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2768940A Expired - Fee Related CA2768940C (en) | 2009-07-24 | 2010-07-23 | Isoform selective phospholipase d inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9127005B2 (OSRAM) |
| EP (1) | EP2456307B1 (OSRAM) |
| JP (1) | JP2013500260A (OSRAM) |
| KR (1) | KR20120090034A (OSRAM) |
| CN (1) | CN102573474A (OSRAM) |
| AU (1) | AU2010275526A1 (OSRAM) |
| BR (1) | BR112012001586A2 (OSRAM) |
| CA (1) | CA2768940C (OSRAM) |
| IL (1) | IL217720A0 (OSRAM) |
| IN (1) | IN2012DN01661A (OSRAM) |
| MX (1) | MX2012001064A (OSRAM) |
| RU (1) | RU2012106657A (OSRAM) |
| SG (1) | SG178102A1 (OSRAM) |
| WO (1) | WO2011011680A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9127005B2 (en) | 2009-07-24 | 2015-09-08 | Vanderbilt University | Isoform selective phospholipase D inhibitors |
| CA2850597A1 (en) * | 2011-09-30 | 2013-04-04 | Vanderbilt University | Antiviral therapies with phospholipase d inhibitors |
| US20140378524A1 (en) * | 2012-12-11 | 2014-12-25 | Vanderbilt University | Methods and compositions comprising akt inhibitors and/or phospholipase d inhibitors |
| WO2014093553A1 (en) * | 2012-12-11 | 2014-06-19 | Vanderbilt University | Methods and compositions of treating hiv infection |
| CN114778844A (zh) * | 2022-03-07 | 2022-07-22 | 天津市肿瘤医院（天津医科大学肿瘤医院） | Pld1作为评估肿瘤患者对于化疗药物敏感性的分子标志物的用途 |
| US20240101572A1 (en) * | 2022-06-16 | 2024-03-28 | Japan Tobacco Inc. | Dihydrooxadiazinone compound and pharmaceutical use thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1281502B1 (it) | 1995-06-13 | 1998-02-18 | Sardinian Antiviral Research C | Impiego di un inibitore non nucleosidico della trascrittasi inversa in associazione con inibitori nucleosidici per il trattamento della |
| US6187559B1 (en) | 1997-08-28 | 2001-02-13 | Novartis Ag | Phospholipase D gene |
| WO2001089449A2 (en) | 2000-05-25 | 2001-11-29 | Ben Williger | Phospholipase d effectors for therapy and screening |
| US6482829B2 (en) * | 2000-06-08 | 2002-11-19 | Hoffmann-La Roche Inc. | Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor |
| KR101144889B1 (ko) | 2002-09-18 | 2012-05-14 | 학교법인 포항공과대학교 | 포스포리파제 ｄ를 포함하는 펩티드 복합체 |
| JP2008525478A (ja) * | 2004-12-27 | 2008-07-17 | アストラゼネカ アクチボラグ | 神経系及び精神医学系障害の治療のための代謝共役型グルタミン酸受容体アゴニストとしてのピラゾロン化合物 |
| WO2006107451A2 (en) | 2005-02-23 | 2006-10-12 | Univ Emory | Honokiol derivatives for the treatment of proliferative disorders |
| ATE481409T1 (de) * | 2006-05-18 | 2010-10-15 | Hoffmann La Roche | Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor |
| US20100009970A1 (en) | 2008-03-19 | 2010-01-14 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| WO2010037081A1 (en) | 2008-09-29 | 2010-04-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific spiro-piperidine compounds |
| CA2756141A1 (en) | 2009-03-31 | 2010-10-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device body |
| EP2435563A4 (en) | 2009-05-29 | 2013-10-02 | Univ Columbia | MODULATION OF PHOSPHOLIPASE D FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| US9127005B2 (en) | 2009-07-24 | 2015-09-08 | Vanderbilt University | Isoform selective phospholipase D inhibitors |
| US9149445B2 (en) | 2009-07-27 | 2015-10-06 | The Trustees Of Princeton University | Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections |
| CA2850597A1 (en) | 2011-09-30 | 2013-04-04 | Vanderbilt University | Antiviral therapies with phospholipase d inhibitors |
| WO2014093553A1 (en) | 2012-12-11 | 2014-06-19 | Vanderbilt University | Methods and compositions of treating hiv infection |
| US20140378524A1 (en) | 2012-12-11 | 2014-12-25 | Vanderbilt University | Methods and compositions comprising akt inhibitors and/or phospholipase d inhibitors |
-
2010
- 2010-07-23 US US13/386,397 patent/US9127005B2/en not_active Expired - Fee Related
- 2010-07-23 MX MX2012001064A patent/MX2012001064A/es not_active Application Discontinuation
- 2010-07-23 SG SG2012005252A patent/SG178102A1/en unknown
- 2010-07-23 IN IN1661DEN2012 patent/IN2012DN01661A/en unknown
- 2010-07-23 KR KR1020127004698A patent/KR20120090034A/ko not_active Withdrawn
- 2010-07-23 BR BRBR112012001586-9A patent/BR112012001586A2/pt not_active IP Right Cessation
- 2010-07-23 EP EP10802947.1A patent/EP2456307B1/en not_active Not-in-force
- 2010-07-23 CA CA2768940A patent/CA2768940C/en not_active Expired - Fee Related
- 2010-07-23 RU RU2012106657/04A patent/RU2012106657A/ru not_active Application Discontinuation
- 2010-07-23 WO PCT/US2010/043045 patent/WO2011011680A1/en not_active Ceased
- 2010-07-23 AU AU2010275526A patent/AU2010275526A1/en not_active Abandoned
- 2010-07-23 JP JP2012521826A patent/JP2013500260A/ja active Pending
- 2010-07-23 CN CN2010800423044A patent/CN102573474A/zh active Pending
-
2012
- 2012-01-24 IL IL217720A patent/IL217720A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013500260A (ja) | 2013-01-07 |
| CA2768940A1 (en) | 2011-01-27 |
| EP2456307B1 (en) | 2016-11-02 |
| RU2012106657A (ru) | 2013-08-27 |
| BR112012001586A2 (pt) | 2015-09-01 |
| US20120214832A1 (en) | 2012-08-23 |
| CN102573474A (zh) | 2012-07-11 |
| IL217720A0 (en) | 2012-03-29 |
| WO2011011680A1 (en) | 2011-01-27 |
| MX2012001064A (es) | 2012-07-17 |
| EP2456307A1 (en) | 2012-05-30 |
| IN2012DN01661A (OSRAM) | 2015-06-05 |
| AU2010275526A1 (en) | 2012-03-15 |
| KR20120090034A (ko) | 2012-08-16 |
| SG178102A1 (en) | 2012-03-29 |
| US9127005B2 (en) | 2015-09-08 |
| EP2456307A4 (en) | 2013-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150722 |
|
| MKLA | Lapsed |
Effective date: 20200831 |