CA2765345C - Peptide therapy for increasing platelet levels - Google Patents

Peptide therapy for increasing platelet levels Download PDF

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Publication number
CA2765345C
CA2765345C CA2765345A CA2765345A CA2765345C CA 2765345 C CA2765345 C CA 2765345C CA 2765345 A CA2765345 A CA 2765345A CA 2765345 A CA2765345 A CA 2765345A CA 2765345 C CA2765345 C CA 2765345C
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Prior art keywords
thrombocytopenia
arg
platelet
peptide
cys
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Active
Application number
CA2765345A
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English (en)
French (fr)
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CA2765345A1 (en
Inventor
Michal Abraham
Amnon Peled
Orly Eizenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biokine Therapeutics Ltd
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Biokine Therapeutics Ltd
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Publication date
Application filed by Biokine Therapeutics Ltd filed Critical Biokine Therapeutics Ltd
Publication of CA2765345A1 publication Critical patent/CA2765345A1/en
Application granted granted Critical
Publication of CA2765345C publication Critical patent/CA2765345C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2765345A 2009-06-14 2010-06-13 Peptide therapy for increasing platelet levels Active CA2765345C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18685709P 2009-06-14 2009-06-14
US61/186,857 2009-06-14
PCT/IL2010/000466 WO2010146578A2 (en) 2009-06-14 2010-06-13 Peptide therapy for increasing platelet levels

Publications (2)

Publication Number Publication Date
CA2765345A1 CA2765345A1 (en) 2010-12-23
CA2765345C true CA2765345C (en) 2016-06-21

Family

ID=43356827

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2765345A Active CA2765345C (en) 2009-06-14 2010-06-13 Peptide therapy for increasing platelet levels

Country Status (11)

Country Link
US (1) US9427456B2 (https=)
EP (1) EP2442822B1 (https=)
JP (1) JP5715622B2 (https=)
KR (1) KR101719339B1 (https=)
CN (1) CN102481332A (https=)
BR (1) BRPI1009663A2 (https=)
CA (1) CA2765345C (https=)
ES (1) ES2462517T3 (https=)
IL (1) IL216912A (https=)
MX (1) MX2011013459A (https=)
WO (1) WO2010146578A2 (https=)

Families Citing this family (19)

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WO2008075371A2 (en) 2006-12-21 2008-06-26 Biokine Therapeutics Ltd. T-140 peptide analogs having cxcr4 super-agonist activity for immunomodulation
BRPI1009663A2 (pt) 2009-06-14 2016-10-11 Biokine Therapeutics Ltd "método para elevação dos níveis plaquetários em um indivíduo com essa necessidade, método de inibição de hemorragia em um indivíduo que a necessite e composição farmacêutica"
US20130303460A1 (en) 2011-01-10 2013-11-14 Biokine Therapeutics Ltd. Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma
EP2841084B1 (en) 2012-04-24 2018-05-30 Biokine Therapeutics Ltd. Cxcr4 antagonist peptide for use in the treatment of large cell lung cancer
JP2015154715A (ja) * 2012-05-22 2015-08-27 国立大学法人旭川医科大学 ヒト単核球由来の新規血管再生細胞群及びその分化誘導法
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
JP6321886B2 (ja) * 2014-05-15 2018-05-09 エンジーケム ライフサイエンシーズ コーポレーションＥｎｚｙｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ 白血球減少症及び血小板減少症に対する治療方法
JP6547274B2 (ja) 2014-10-20 2019-07-24 株式会社デンソー 粒子状物質検出センサ
US10786547B2 (en) 2015-07-16 2020-09-29 Biokine Therapeutics Ltd. Compositions, articles of manufacture and methods for treating cancer
KR102033920B1 (ko) 2016-02-23 2019-10-18 바이오라인알엑스 리미티드 급성 골수성 백혈병을 치료하는 방법
EP3914286B1 (en) * 2019-01-25 2025-05-07 Janssen Pharmaceutica NV Methods of mitigating toxic effects of vesicants and caustic gas
JP2023517616A (ja) * 2020-03-11 2023-04-26 バイオラインアールエックス・リミテッド 急性呼吸窮迫症候群およびウイルス感染の治療用のｃｘｃｒ４阻害剤
JP7710045B2 (ja) 2020-12-30 2025-07-17 バイオラインアールエックス・リミテッド ペプチドの製造プロセス
CA3205658A1 (en) 2020-12-30 2022-07-07 Efrat Halbfinger Composition of bl-8040
CN118027155B (zh) * 2024-04-15 2024-07-16 中国人民解放军军事科学院军事医学研究院 一种tpor结合肽及其应用
WO2025259133A1 (ru) * 2024-06-11 2025-12-18 Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации Пептид ac-his-ala-glu-glu-nh2 и его производные, предназначенные для восстановления дефицита эндогенного компонента крови человека
WO2025259130A1 (ru) * 2024-06-11 2025-12-18 Consumer Cooperative "Vse" ПРИМЕНЕНИЕ ПЕПТИДА Ac-His-Ala-Glu-Glu-NH2 ДЛЯ ВОССТАНОВЛЕНИЯ ДЕФИЦИТА ЭНДОГЕННОГО КОМПОНЕНТА КРОВИ ЖИВОТНЫХ

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Also Published As

Publication number Publication date
KR101719339B1 (ko) 2017-03-23
EP2442822B1 (en) 2014-03-05
KR20120037463A (ko) 2012-04-19
JP2012530130A (ja) 2012-11-29
CA2765345A1 (en) 2010-12-23
BRPI1009663A2 (pt) 2016-10-11
ES2462517T3 (es) 2014-05-23
US9427456B2 (en) 2016-08-30
EP2442822A2 (en) 2012-04-25
CN102481332A (zh) 2012-05-30
US20120094907A1 (en) 2012-04-19
IL216912A0 (en) 2012-02-29
IL216912A (en) 2015-09-24
EP2442822A4 (en) 2013-01-23
WO2010146578A3 (en) 2011-02-10
MX2011013459A (es) 2012-05-08
WO2010146578A2 (en) 2010-12-23
JP5715622B2 (ja) 2015-05-07

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