CA2760768A1 - Modele de tissu pulmonaire - Google Patents

Modele de tissu pulmonaire Download PDF

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Publication number
CA2760768A1
CA2760768A1 CA2760768A CA2760768A CA2760768A1 CA 2760768 A1 CA2760768 A1 CA 2760768A1 CA 2760768 A CA2760768 A CA 2760768A CA 2760768 A CA2760768 A CA 2760768A CA 2760768 A1 CA2760768 A1 CA 2760768A1
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CA
Canada
Prior art keywords
cells
pulmonary
model
tissue
tissue culture
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Granted
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CA2760768A
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English (en)
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CA2760768C (fr
Inventor
Judit Erzsebet Pongracz
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PECS, University of
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PECS, University of
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Publication of CA2760768A1 publication Critical patent/CA2760768A1/fr
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne une culture tissulaire d'un modèle pulmonaire tridimensionnel dépourvu de structure tissulaire mise au point par génie tissulaire, qui est exempte de toute structure artificielle; des modèles tridimensionnels de tissu pulmonaire sain ainsi que des tissus pathologiques. Le produit de l'invention peut être commercialisé, p. ex. sous la forme de cultures tissulaires, de plaques ou de réseaux comprenant ces cultures ou de trousses. L'invention peut être appliquée dans la recherche médicale et scientifique pour tester l'effet de composés sur un tissu pulmonaire, à des fins de criblage, d'essai et/ou d'évaluation de médicaments, et dans certains cas pour diagnostiquer des maladies pulmonaires.
CA2760768A 2009-05-05 2010-05-05 Modele de tissu pulmonaire Active CA2760768C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0900819A HUP0900819A2 (en) 2009-05-05 2009-05-05 Lung tissue culture
HUP0900819 2009-05-05
PCT/IB2010/051978 WO2010128464A1 (fr) 2009-05-05 2010-05-05 Modèle de tissu pulmonaire

Publications (2)

Publication Number Publication Date
CA2760768A1 true CA2760768A1 (fr) 2010-11-11
CA2760768C CA2760768C (fr) 2019-10-29

Family

ID=89989476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2760768A Active CA2760768C (fr) 2009-05-05 2010-05-05 Modele de tissu pulmonaire

Country Status (7)

Country Link
JP (1) JP2013504303A (fr)
CN (1) CN102369277B (fr)
AU (1) AU2010244121B2 (fr)
CA (1) CA2760768C (fr)
HU (1) HUP0900819A2 (fr)
SG (1) SG175425A1 (fr)
WO (1) WO2010128464A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029316T2 (en) 2010-11-04 2017-03-28 Univ Of Pecs Tüdõszövetmodell
JP5778412B2 (ja) * 2010-11-29 2015-09-16 花王株式会社 Ｃｇｒｐ応答調節剤の評価又は選択方法
TWI438145B (zh) * 2011-12-08 2014-05-21 中原大學 連續式產氫裝置及其方法
US20140099709A1 (en) * 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
JP6463275B2 (ja) * 2013-01-08 2019-01-30 イエール ユニバーシティ ヒトおよび大型哺乳動物の肺のバイオリアクター
WO2015061372A1 (fr) 2013-10-21 2015-04-30 Hemoshear, Llc Modèle in vitro pour micro-environnement tumoral
CN104316661B (zh) * 2014-10-08 2016-03-23 清华大学 用于生物毒性检测的肺组织模型及生物毒性检测方法
CA2972226A1 (fr) * 2014-12-24 2016-06-30 Ube Industries, Ltd. Fluide de surnageant de culture de cellules derive de tissu pulmonaire
MX2018012143A (es) * 2016-04-04 2019-10-09 Humeltis Métodos de diagnóstico para la toma de decisiones terapéuticas específicas del paciente en el cuidado del cáncer.
CN106754669B (zh) * 2016-11-23 2020-04-17 河海大学常州校区 基于反应-扩散模型的多细胞结构的制备方法及制备系统
CN107267439A (zh) * 2017-05-16 2017-10-20 苏州大学 三维肺微组织模型的构建方法及应用
CN108660076A (zh) * 2018-05-21 2018-10-16 中国科学院苏州生物医学工程技术研究所 一种仿真肺芯片模型
CN109161531A (zh) * 2018-10-16 2019-01-08 首都医科大学附属北京胸科医院 一种基于类器官技术个体化肺癌原代细胞培养的方法
GB202005154D0 (en) * 2020-04-07 2020-05-20 Univ Of Hertfordshire Higher Education Corporation Method and model

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828111B2 (en) * 2000-01-13 2004-12-07 Wayne State University Three-dimensional in vitro model of human preneoplastic breast disease
CA2454807C (fr) * 2001-07-26 2012-09-18 Kazunori Kataoka Construction cellulaire cultivee contenant des spheroides de cellules animales cultivees et utilisation correspondante
WO2007083504A1 (fr) * 2003-08-01 2007-07-26 Norimasa Nakamura Tissu synthétique en 3d auto-organisé sans échafaudage
US7709256B2 (en) * 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US8628964B2 (en) * 2006-10-11 2014-01-14 Drexel University Fetal pulmonary cells and uses thereof
US20100034791A1 (en) * 2007-02-14 2010-02-11 Drexel University Engineered Lung Tissue Construction for High Throughput Toxicity Screening and Drug Discovery

Also Published As

Publication number Publication date
AU2010244121A1 (en) 2011-12-15
HUP0900819A2 (en) 2011-01-28
CN102369277A (zh) 2012-03-07
CA2760768C (fr) 2019-10-29
SG175425A1 (en) 2011-12-29
CN102369277B (zh) 2014-12-17
AU2010244121B2 (en) 2015-07-16
WO2010128464A1 (fr) 2010-11-11
JP2013504303A (ja) 2013-02-07
HU0900819D0 (en) 2010-07-28

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