CN102369277B - 肺组织模型 - Google Patents

肺组织模型 Download PDF

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Publication number
CN102369277B
CN102369277B CN201080020612.7A CN201080020612A CN102369277B CN 102369277 B CN102369277 B CN 102369277B CN 201080020612 A CN201080020612 A CN 201080020612A CN 102369277 B CN102369277 B CN 102369277B
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China
Prior art keywords
cell
model
culture
tissue culture
dimensional
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Expired - Fee Related
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CN201080020612.7A
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English (en)
Chinese (zh)
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CN102369277A (zh
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尤迪特·E·蓬格拉茨
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PECS, University of
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PECS, University of
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0688Cells from the lungs or the respiratory tract
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323Adult fibroblasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/28Vascular endothelial cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00Use of cells in diagnostics
    • C12N2503/04Screening or testing on artificial tissues

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201080020612.7A 2009-05-05 2010-05-05 肺组织模型 Expired - Fee Related CN102369277B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP0900819 2009-05-05
HU0900819A HUP0900819A2 (en) 2009-05-05 2009-05-05 Lung tissue culture
PCT/IB2010/051978 WO2010128464A1 (fr) 2009-05-05 2010-05-05 Modèle de tissu pulmonaire

Publications (2)

Publication Number Publication Date
CN102369277A CN102369277A (zh) 2012-03-07
CN102369277B true CN102369277B (zh) 2014-12-17

Family

ID=89989476

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080020612.7A Expired - Fee Related CN102369277B (zh) 2009-05-05 2010-05-05 肺组织模型

Country Status (7)

Country Link
JP (1) JP2013504303A (fr)
CN (1) CN102369277B (fr)
AU (1) AU2010244121B2 (fr)
CA (1) CA2760768C (fr)
HU (1) HUP0900819A2 (fr)
SG (1) SG175425A1 (fr)
WO (1) WO2010128464A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029316T2 (en) 2010-11-04 2017-03-28 Univ Of Pecs Tüdõszövetmodell
JP5778412B2 (ja) * 2010-11-29 2015-09-16 花王株式会社 Cgrp応答調節剤の評価又は選択方法
TWI438145B (zh) * 2011-12-08 2014-05-21 中原大學 連續式產氫裝置及其方法
US20140099709A1 (en) * 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
JP6463275B2 (ja) * 2013-01-08 2019-01-30 イエール ユニバーシティ ヒトおよび大型哺乳動物の肺のバイオリアクター
WO2015061372A1 (fr) 2013-10-21 2015-04-30 Hemoshear, Llc Modèle in vitro pour micro-environnement tumoral
CN104316661B (zh) * 2014-10-08 2016-03-23 清华大学 用于生物毒性检测的肺组织模型及生物毒性检测方法
CA2972226A1 (fr) * 2014-12-24 2016-06-30 Ube Industries, Ltd. Fluide de surnageant de culture de cellules derive de tissu pulmonaire
US20190128870A1 (en) * 2016-04-04 2019-05-02 Humeltis Diagnostic Methods For Patient Specific Therapeutic Decision Making In Cancer Care
CN106754669B (zh) * 2016-11-23 2020-04-17 河海大学常州校区 基于反应-扩散模型的多细胞结构的制备方法及制备系统
CN107267439A (zh) * 2017-05-16 2017-10-20 苏州大学 三维肺微组织模型的构建方法及应用
CN108660076A (zh) * 2018-05-21 2018-10-16 中国科学院苏州生物医学工程技术研究所 一种仿真肺芯片模型
CN109161531A (zh) * 2018-10-16 2019-01-08 首都医科大学附属北京胸科医院 一种基于类器官技术个体化肺癌原代细胞培养的方法
GB202005154D0 (en) * 2020-04-07 2020-05-20 Univ Of Hertfordshire Higher Education Corporation Method and model

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080112890A1 (en) * 2006-10-11 2008-05-15 Lelkes Peter I Fetal pulmonary cells and uses thereof
WO2007146267A3 (fr) * 2006-06-15 2008-06-05 Vaxdesign Corp Incorporation d'un modèle de maladie dans un système immunitaire artificiel (sia)
WO2008100555A2 (fr) * 2007-02-14 2008-08-21 Drexel University Construction de tissu pulmonaire de synthèse pour le dépistage de toxicité et la découverte de médicament à efficacité élevée

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828111B2 (en) * 2000-01-13 2004-12-07 Wayne State University Three-dimensional in vitro model of human preneoplastic breast disease
WO2003010302A1 (fr) * 2001-07-26 2003-02-06 Kazunori Kataoka Construction cellulaire cultivee contenant des spheroides de cellules animales cultivees et utilisation correspondante
WO2007083504A1 (fr) * 2003-08-01 2007-07-26 Norimasa Nakamura Tissu synthétique en 3d auto-organisé sans échafaudage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007146267A3 (fr) * 2006-06-15 2008-06-05 Vaxdesign Corp Incorporation d'un modèle de maladie dans un système immunitaire artificiel (sia)
US20080112890A1 (en) * 2006-10-11 2008-05-15 Lelkes Peter I Fetal pulmonary cells and uses thereof
WO2008100555A2 (fr) * 2007-02-14 2008-08-21 Drexel University Construction de tissu pulmonaire de synthèse pour le dépistage de toxicité et la découverte de médicament à efficacité élevée

Also Published As

Publication number Publication date
WO2010128464A1 (fr) 2010-11-11
SG175425A1 (en) 2011-12-29
CN102369277A (zh) 2012-03-07
AU2010244121B2 (en) 2015-07-16
HUP0900819A2 (en) 2011-01-28
JP2013504303A (ja) 2013-02-07
CA2760768C (fr) 2019-10-29
CA2760768A1 (fr) 2010-11-11
AU2010244121A1 (en) 2011-12-15
HU0900819D0 (en) 2010-07-28

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