CA2743789C - Low viscosity highly concentrated suspensions - Google Patents

Low viscosity highly concentrated suspensions Download PDF

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Publication number
CA2743789C
CA2743789C CA2743789A CA2743789A CA2743789C CA 2743789 C CA2743789 C CA 2743789C CA 2743789 A CA2743789 A CA 2743789A CA 2743789 A CA2743789 A CA 2743789A CA 2743789 C CA2743789 C CA 2743789C
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CA
Canada
Prior art keywords
suspension
antibody
salt
micron
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2743789A
Other languages
English (en)
French (fr)
Other versions
CA2743789A1 (en
Inventor
Keith P. Johnston
Maria Andrea Mazuski
Joshua Engstrom
Miguel Angelo Rodrigues
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of CA2743789A1 publication Critical patent/CA2743789A1/en
Application granted granted Critical
Publication of CA2743789C publication Critical patent/CA2743789C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2743789A 2008-11-16 2009-11-10 Low viscosity highly concentrated suspensions Active CA2743789C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11508008P 2008-11-16 2008-11-16
US61/115,080 2008-11-16
PCT/US2009/063852 WO2010056657A2 (en) 2008-11-16 2009-11-10 Low viscosity highly concentrated suspensions

Publications (2)

Publication Number Publication Date
CA2743789A1 CA2743789A1 (en) 2010-05-20
CA2743789C true CA2743789C (en) 2017-10-31

Family

ID=42170660

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2743789A Active CA2743789C (en) 2008-11-16 2009-11-10 Low viscosity highly concentrated suspensions

Country Status (7)

Country Link
US (2) US8779094B2 (cg-RX-API-DMAC7.html)
EP (1) EP2376522A4 (cg-RX-API-DMAC7.html)
JP (2) JP5711138B2 (cg-RX-API-DMAC7.html)
KR (1) KR20110103961A (cg-RX-API-DMAC7.html)
CA (1) CA2743789C (cg-RX-API-DMAC7.html)
IL (1) IL212919A (cg-RX-API-DMAC7.html)
WO (1) WO2010056657A2 (cg-RX-API-DMAC7.html)

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US20110223208A1 (en) * 2010-03-09 2011-09-15 Beth Hill Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations
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AU2012225277A1 (en) * 2011-03-10 2013-09-26 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
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US9737662B2 (en) 2011-11-07 2017-08-22 Battelle Memorial Institute Processes for delivery of viscous drug therapies
CN104427974B (zh) * 2012-05-18 2018-03-23 基因泰克公司 高浓度单克隆抗体配制剂
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CN103976947B (zh) * 2014-06-05 2016-08-17 段明星 一种含酶油悬浮剂及其制备方法与应用
EP3200804A4 (en) 2014-10-01 2018-04-18 Eagle Biologics, Inc. Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
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US12115262B2 (en) 2018-05-24 2024-10-15 Elektrofi, Inc. Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof
KR102051808B1 (ko) 2018-07-23 2019-12-04 주식회사 종근당 테스토스테론 운데카노에이트를 포함하는 안정한 약제학적 조성물
CN113365609A (zh) 2019-01-31 2021-09-07 伊勒卓菲公司 颗粒形成和形态
JP2022519690A (ja) 2019-02-05 2022-03-24 リンディー バイオサイエンシーズ，インク． 単離された細胞培養成分、及びそれを液状の細胞培養培地から単離する方法
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CN115484934A (zh) 2020-04-17 2022-12-16 伊勒卓菲公司 通过连续液滴形成和脱水形成颗粒的方法

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Also Published As

Publication number Publication date
WO2010056657A2 (en) 2010-05-20
JP2015083582A (ja) 2015-04-30
JP5711138B2 (ja) 2015-04-30
EP2376522A4 (en) 2013-12-25
CA2743789A1 (en) 2010-05-20
KR20110103961A (ko) 2011-09-21
IL212919A (en) 2017-07-31
IL212919A0 (en) 2011-07-31
US20110280864A1 (en) 2011-11-17
WO2010056657A3 (en) 2010-10-14
US20140378370A1 (en) 2014-12-25
US8779094B2 (en) 2014-07-15
JP2012508744A (ja) 2012-04-12
WO2010056657A8 (en) 2010-08-26
EP2376522A2 (en) 2011-10-19

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Effective date: 20141106