IL212919A - Highly concentrated concentrates with low viscosity - Google Patents
Highly concentrated concentrates with low viscosityInfo
- Publication number
- IL212919A IL212919A IL212919A IL21291911A IL212919A IL 212919 A IL212919 A IL 212919A IL 212919 A IL212919 A IL 212919A IL 21291911 A IL21291911 A IL 21291911A IL 212919 A IL212919 A IL 212919A
- Authority
- IL
- Israel
- Prior art keywords
- low viscosity
- highly concentrated
- concentrated suspensions
- viscosity highly
- suspensions
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11508008P | 2008-11-16 | 2008-11-16 | |
| PCT/US2009/063852 WO2010056657A2 (en) | 2008-11-16 | 2009-11-10 | Low viscosity highly concentrated suspensions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL212919A0 IL212919A0 (en) | 2011-07-31 |
| IL212919A true IL212919A (en) | 2017-07-31 |
Family
ID=42170660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL212919A IL212919A (en) | 2008-11-16 | 2011-05-16 | Highly concentrated concentrates with low viscosity |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8779094B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2376522A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5711138B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110103961A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2743789C (cg-RX-API-DMAC7.html) |
| IL (1) | IL212919A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010056657A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5658031B2 (ja) | 2007-06-22 | 2015-01-21 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 薄膜凍結による安定したサブミクロンのペプチド又はタンパク質粒子の形成 |
| CN103096934A (zh) * | 2010-03-09 | 2013-05-08 | 詹森生物科技公司 | 非水性高浓度低粘度混悬剂 |
| US9072668B2 (en) | 2010-03-09 | 2015-07-07 | Janssen Biotech, Inc. | Non-aqueous high concentration reduced viscosity suspension formulations of antibodies |
| US20110223208A1 (en) * | 2010-03-09 | 2011-09-15 | Beth Hill | Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations |
| US9445990B2 (en) * | 2010-10-06 | 2016-09-20 | Medtronic, Inc. | TNF inhibitor formulation for use in implantable infusion devices |
| AU2012225277A1 (en) * | 2011-03-10 | 2013-09-26 | Board Of Regents, The University Of Texas System | Protein nanoparticle dispersions |
| CN108771655A (zh) * | 2011-10-28 | 2018-11-09 | 诚信生物公司 | 含有氨基酸的蛋白质制剂 |
| EP2776091B1 (en) | 2011-11-07 | 2021-03-03 | Battelle Memorial Institute | Processes for delivery of viscous drug therapies |
| SG10201709555SA (en) * | 2012-05-18 | 2017-12-28 | Genentech Inc | High-concentration monoclonal antibody formulations |
| US20140342006A1 (en) * | 2013-03-15 | 2014-11-20 | Ansun Biopharma, Inc. | Methods for Preparing Injectable Protein Microparticle Suspensions |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| CN103976947B (zh) * | 2014-06-05 | 2016-08-17 | 段明星 | 一种含酶油悬浮剂及其制备方法与应用 |
| KR102497368B1 (ko) * | 2014-10-01 | 2023-02-10 | 이글 바이올로직스 인코포레이티드 | 점도-저하제를 함유하는 폴리삭카라이드 및 핵산 제형 |
| CN107743396B (zh) | 2014-12-12 | 2021-01-15 | Motejo股份有限公司 | 皮下注射用剂 |
| JP5774190B1 (ja) * | 2014-12-12 | 2015-09-09 | ジーンメディカル株式会社 | 皮下注射用剤及び皮下注射用剤を含有する注射器の製造方法 |
| US11459401B2 (en) * | 2016-10-06 | 2022-10-04 | Amgen Inc. | Reduced viscosity protein pharmaceutical formulations |
| EP3544724A4 (en) | 2016-11-22 | 2020-10-14 | Elektrofi, Inc | PARTICLES INCLUDING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND THEIR METHODS OF USE |
| WO2019023392A1 (en) | 2017-07-25 | 2019-01-31 | Elektrofi, Inc. | FORMATION OF PARTICLES COMPRISING AGENTS |
| US12115262B2 (en) | 2018-05-24 | 2024-10-15 | Elektrofi, Inc. | Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof |
| KR102051808B1 (ko) | 2018-07-23 | 2019-12-04 | 주식회사 종근당 | 테스토스테론 운데카노에이트를 포함하는 안정한 약제학적 조성물 |
| AU2020214626B2 (en) | 2019-01-31 | 2025-10-16 | Elektrofi, Inc. | Particle formation and morphology |
| KR20210125032A (ko) | 2019-02-05 | 2021-10-15 | 린디 바이오사이언시스, 아이엔씨. | 세포 배양 성분 및 액체 세포 배양 배지로부터 이를 단리하는 방법 |
| US20200376128A1 (en) * | 2019-06-01 | 2020-12-03 | Lupin Holdings B.V. | Monodisperse resorbable polyester polymer compositions, systems, and methods |
| AU2020344675A1 (en) * | 2019-09-13 | 2022-03-31 | Elektrofi, Inc. | Compositions and methods for the delivery of therapeutic biologics for treatment of disease |
| JP2023522627A (ja) | 2020-04-17 | 2023-05-31 | エレクトロフィ,インコーポレイテッド | 連続的な液滴形成及び脱水によって粒子を形成する方法 |
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| BE795516A (fr) | 1972-02-17 | 1973-08-16 | Ciba Geigy | Preparations de peptides huileuses et injectables et procede pour leur preparation |
| US4310516A (en) | 1980-02-01 | 1982-01-12 | Block Drug Company Inc. | Cosmetic and pharmaceutical vehicle thickened with solid emulsifier |
| EP0079143A3 (en) | 1981-10-20 | 1984-11-21 | Adnovum Ag | Pseudoplastic gel transfer |
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| US5288479A (en) | 1989-01-17 | 1994-02-22 | Sterling Drug, Inc. | Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof |
| SE465950B (sv) | 1989-10-23 | 1991-11-25 | Medinvent Sa | Kombination av ett aggregat partikelformat, kristallint eller frystorkat laekemedel med en pseudoplastisk gel foer beredning av ett injicerbart preparat samt foerfarande foer dess framstaellning |
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| US5512293A (en) | 1992-07-23 | 1996-04-30 | Alza Corporation | Oral sustained release drug delivery device |
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| DE69431533T2 (de) | 1994-06-13 | 2003-10-02 | Alza Corp., Palo Alto | Dosierungsform zur verabreichung von flüssige arzneimittel formulierung |
| US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
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| AU737664B2 (en) | 1996-07-03 | 2001-08-30 | Alza Corporation | Non-aqueous protic peptide formulations |
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| IN184589B (cg-RX-API-DMAC7.html) | 1996-10-16 | 2000-09-09 | Alza Corp | |
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| ATE322889T1 (de) | 1999-02-08 | 2006-04-15 | Alza Corp | Stabile nicht wässerige einphasige visköse vehikeln und formulierungen die diese vehikeln verwenden |
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| FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
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| MXPA06012992A (es) | 2004-05-12 | 2007-02-12 | Baxter Int | Microesferas que comprenden proteina y que muestran inyectabilidad en altas concentraciones de este agente. |
| US20060141040A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
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| US20070015689A1 (en) | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
| AU2006330627A1 (en) | 2005-12-16 | 2007-07-05 | University Of Kansas | Nanoclusters for delivery of therapeutics |
| US20090304599A1 (en) | 2005-12-20 | 2009-12-10 | Fujifilm Corporation | Protein Nanoparticles and the Use of the Same |
| US20080102128A1 (en) * | 2006-07-28 | 2008-05-01 | Flamel Technologies, Inc. | Modified-release microparticles based on amphiphilic copolymer and on active principles(s) and pharmaceutical formulations comprising them |
| JP5658031B2 (ja) * | 2007-06-22 | 2015-01-21 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 薄膜凍結による安定したサブミクロンのペプチド又はタンパク質粒子の形成 |
| CN101081882A (zh) * | 2007-07-06 | 2007-12-05 | 天津大学 | 大分子印迹交联聚乙烯基吡咯烷酮微球及低温悬浮聚合制备方法 |
| JP2009173610A (ja) | 2008-01-28 | 2009-08-06 | Fujifilm Corp | タンパク質ナノ粒子 |
| BRPI0909780B1 (pt) | 2008-03-05 | 2022-05-03 | Baxter International Inc | Suspensão contendo uma partícula com superfície modificada, composição farmacêutica compreendendo a referida suspensão, método para aprimorar a absorção celular de um agente ativo, uso de partículas com superfície modificada, e método de preparação de uma partícula com superfície modificada |
| RU2010146684A (ru) | 2008-05-09 | 2012-06-20 | Саут Дакота Стейт Юниверсити (US) | Способ получения неиммуногенных гидрофобных белковых наночастиц и их применения |
| US20100009007A1 (en) | 2008-07-10 | 2010-01-14 | Baxter International Inc. | Non-covalent modification of microparticles and process of preparing same |
| US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| WO2010100200A2 (en) | 2009-03-05 | 2010-09-10 | Novartis Ag | Lyophilised antibody formulation |
-
2009
- 2009-11-10 EP EP09826617.4A patent/EP2376522A4/en not_active Withdrawn
- 2009-11-10 KR KR1020117013867A patent/KR20110103961A/ko not_active Withdrawn
- 2009-11-10 JP JP2011536414A patent/JP5711138B2/ja not_active Expired - Fee Related
- 2009-11-10 US US13/129,283 patent/US8779094B2/en active Active
- 2009-11-10 WO PCT/US2009/063852 patent/WO2010056657A2/en not_active Ceased
- 2009-11-10 CA CA2743789A patent/CA2743789C/en active Active
-
2011
- 2011-05-16 IL IL212919A patent/IL212919A/en active IP Right Grant
-
2014
- 2014-06-05 US US14/297,403 patent/US20140378370A1/en not_active Abandoned
- 2014-12-08 JP JP2014247793A patent/JP2015083582A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2743789C (en) | 2017-10-31 |
| WO2010056657A3 (en) | 2010-10-14 |
| US20110280864A1 (en) | 2011-11-17 |
| IL212919A0 (en) | 2011-07-31 |
| JP2012508744A (ja) | 2012-04-12 |
| KR20110103961A (ko) | 2011-09-21 |
| US20140378370A1 (en) | 2014-12-25 |
| CA2743789A1 (en) | 2010-05-20 |
| EP2376522A4 (en) | 2013-12-25 |
| WO2010056657A8 (en) | 2010-08-26 |
| EP2376522A2 (en) | 2011-10-19 |
| US8779094B2 (en) | 2014-07-15 |
| JP2015083582A (ja) | 2015-04-30 |
| JP5711138B2 (ja) | 2015-04-30 |
| WO2010056657A2 (en) | 2010-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |