CA2741563A1 - Process for the preparation of substituted phenylalanines - Google Patents

Process for the preparation of substituted phenylalanines Download PDF

Info

Publication number
CA2741563A1
CA2741563A1 CA2741563A CA2741563A CA2741563A1 CA 2741563 A1 CA2741563 A1 CA 2741563A1 CA 2741563 A CA2741563 A CA 2741563A CA 2741563 A CA2741563 A CA 2741563A CA 2741563 A1 CA2741563 A1 CA 2741563A1
Authority
CA
Canada
Prior art keywords
alkyl
formula
compound
aryl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2741563A
Other languages
English (en)
French (fr)
Inventor
Hugh Alfred Burgoon
Ramanaiah C. Kanamarlapudi
Iain Fraser Pickersgill
Zhi-Cai Shi
Wenxue Wu
Haiming Zhang
Matthew Mangzhu Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lexicon Pharmaceuticals Inc
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of CA2741563A1 publication Critical patent/CA2741563A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
CA2741563A 2008-10-24 2008-10-24 Process for the preparation of substituted phenylalanines Abandoned CA2741563A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/081054 WO2010047712A1 (en) 2008-10-24 2008-10-24 Process for the preparation of substituted phenylalanines

Publications (1)

Publication Number Publication Date
CA2741563A1 true CA2741563A1 (en) 2010-04-29

Family

ID=40785295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2741563A Abandoned CA2741563A1 (en) 2008-10-24 2008-10-24 Process for the preparation of substituted phenylalanines

Country Status (11)

Country Link
EP (1) EP2358685A1 (ja)
JP (1) JP2012506427A (ja)
KR (1) KR20110074875A (ja)
CN (1) CN102203069A (ja)
AU (1) AU2008363274A1 (ja)
BR (1) BRPI0823136A2 (ja)
CA (1) CA2741563A1 (ja)
IL (1) IL211996A0 (ja)
MX (1) MX2011004168A (ja)
RU (1) RU2011120822A (ja)
WO (1) WO2010047712A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015089137A1 (en) * 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
IL277071B1 (en) 2018-03-08 2024-03-01 Incyte Corp Aminopyrizine diol compounds as PI3K–y inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0620756B1 (pt) * 2005-12-29 2021-06-01 Tersera Therapeutics Llc Derivados de aminoácido multicíclicos, formulação farmacêutica compreendendo os mesmos e seus usos para inibir a atividade de triptofano hidroxilase 1 (tph1)
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

Also Published As

Publication number Publication date
IL211996A0 (en) 2011-06-30
AU2008363274A1 (en) 2010-04-29
RU2011120822A (ru) 2012-11-27
CN102203069A (zh) 2011-09-28
EP2358685A1 (en) 2011-08-24
BRPI0823136A2 (pt) 2015-06-16
JP2012506427A (ja) 2012-03-15
MX2011004168A (es) 2011-05-23
WO2010047712A1 (en) 2010-04-29
KR20110074875A (ko) 2011-07-04

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20131024