CA2740192C - Methods and compositions for detection of complement fixing antibodies - Google Patents

Methods and compositions for detection of complement fixing antibodies Download PDF

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Publication number
CA2740192C
CA2740192C CA2740192A CA2740192A CA2740192C CA 2740192 C CA2740192 C CA 2740192C CA 2740192 A CA2740192 A CA 2740192A CA 2740192 A CA2740192 A CA 2740192A CA 2740192 C CA2740192 C CA 2740192C
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Prior art keywords
complement
clq
biological sample
microparticle
hlas
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CA2740192A
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English (en)
French (fr)
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CA2740192A1 (en
Inventor
Dolly B. Tyan
Ge Chen
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2740192A 2008-12-01 2009-11-25 Methods and compositions for detection of complement fixing antibodies Active CA2740192C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11894908P 2008-12-01 2008-12-01
US61/118,949 2008-12-01
PCT/US2009/065984 WO2010065425A1 (en) 2008-12-01 2009-11-25 Methods and compositions for detection of complement fixing antibodies

Publications (2)

Publication Number Publication Date
CA2740192A1 CA2740192A1 (en) 2010-06-10
CA2740192C true CA2740192C (en) 2019-12-31

Family

ID=42233567

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2740192A Active CA2740192C (en) 2008-12-01 2009-11-25 Methods and compositions for detection of complement fixing antibodies

Country Status (8)

Country Link
US (1) US10338080B2 (enExample)
EP (2) EP2353005B1 (enExample)
JP (2) JP5792626B2 (enExample)
CN (2) CN105866426B (enExample)
AU (1) AU2009322607B2 (enExample)
BR (1) BRPI0923199B8 (enExample)
CA (1) CA2740192C (enExample)
WO (1) WO2010065425A1 (enExample)

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AU2014236882B2 (en) * 2013-03-14 2019-01-31 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting donor-specific antibodies and systems for practicing the same
US20160041185A1 (en) * 2013-03-14 2016-02-11 The Board Of Trustees Of The Leland Stanford Junior University Methods of Detecting Complement Fixing and Non-Complement Fixing Antibodies and Systems for Practicing the Same
SG11201510316UA (en) 2013-07-09 2016-01-28 Annexon Inc Anti-complement factor c1q antibodies and uses thereof
PL3215527T3 (pl) * 2014-11-05 2025-04-28 Annexon, Inc. Humanizowane przeciwciała przeciwko czynnikowi dopełniacza C1Q i ich zastosowanie
EP4212175A1 (en) 2015-04-06 2023-07-19 Bioverativ USA Inc. Humanized anti-c1s antibodies and methods of use thereof
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
FI3380518T3 (fi) 2015-11-24 2026-05-29 Annexon Inc Antikomplementtitekijä-C1Q:n Fab-fragmentteja ja niiden käyttöjä
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WO2017187656A1 (ja) * 2016-04-27 2017-11-02 株式会社Jimro 抗医薬品抗体の測定方法
EP3239711B1 (en) * 2016-04-27 2019-12-25 JIMRO Co., Ltd. Method for measuring anti-drug antibody
IL326479A (en) 2016-10-12 2026-04-01 Bioverativ Usa Inc Anti-c1s antibodies and methods of use thereof
US20190383805A1 (en) * 2017-01-25 2019-12-19 Northeastern University Electrochemical Antibody-Based Biosensor
CN114910635B (zh) * 2017-10-26 2025-05-02 科美诊断技术股份有限公司 一种无基质效应的均相免疫检测试剂盒及其应用
CN111398580B (zh) * 2017-11-03 2023-06-13 科美诊断技术股份有限公司 一种检测样本中目标IgM抗体的方法
CN109991405B (zh) * 2017-12-29 2023-01-24 上海索昕生物科技有限公司 一种免疫检测试剂盒及其应用
JP7153493B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
JP7153494B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
DE202020006093U1 (de) * 2019-05-06 2025-04-09 The Regents Of The University Of California Nicht-HLA-Marker der Transplantatabstoßung
CN111812336A (zh) * 2020-08-10 2020-10-23 苏州康和顺医疗技术有限公司 用于检测冠状病毒抗体的检测试剂盒及其制备方法
WO2022076865A1 (en) * 2020-10-09 2022-04-14 Takeda Vaccines, Inc. Methods for determining complement-fixing antibodies
WO2022212704A1 (en) * 2021-03-31 2022-10-06 Takeda Vaccines, Inc. Methods for characterizing the immune response of a subject to a dengue virus composition
EP4089413A1 (en) * 2021-05-12 2022-11-16 Cisbio Bioassays Method for determining the binding of an antibody to the complement component 1q (c1q)
US12486322B2 (en) 2021-12-13 2025-12-02 Annexon, Inc. Anti-complement factor C1q antibodies with single binding arms and uses thereof
MA71249A (fr) 2022-06-24 2025-04-30 Bioverativ Usa Inc. Méthodes de traitement de maladies médiées par complément
CN118604345A (zh) * 2024-05-31 2024-09-06 上海览屹医药科技有限公司 酶联免疫方法测定单克隆抗体浓度
CN120142127A (zh) * 2025-05-16 2025-06-13 上海荻硕贝肯基因科技有限公司 一种供者特异性抗体的检测方法

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Also Published As

Publication number Publication date
EP2353005B1 (en) 2018-10-03
CN102203610A (zh) 2011-09-28
CN105866426A (zh) 2016-08-17
US20110281757A1 (en) 2011-11-17
EP3460480B1 (en) 2022-11-02
EP2353005A4 (en) 2012-10-17
JP2012510618A (ja) 2012-05-10
EP3460480A1 (en) 2019-03-27
US10338080B2 (en) 2019-07-02
WO2010065425A1 (en) 2010-06-10
BRPI0923199A2 (pt) 2016-02-16
AU2009322607A1 (en) 2010-06-10
CN105866426B (zh) 2018-11-23
EP2353005A1 (en) 2011-08-10
BRPI0923199B1 (pt) 2020-10-20
AU2009322607B2 (en) 2015-05-14
BRPI0923199B8 (pt) 2021-07-27
JP5792626B2 (ja) 2015-10-14
CA2740192A1 (en) 2010-06-10
JP2015007651A (ja) 2015-01-15

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