CA2736833A1 - Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof - Google Patents

Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof Download PDF

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Publication number
CA2736833A1
CA2736833A1 CA2736833A CA2736833A CA2736833A1 CA 2736833 A1 CA2736833 A1 CA 2736833A1 CA 2736833 A CA2736833 A CA 2736833A CA 2736833 A CA2736833 A CA 2736833A CA 2736833 A1 CA2736833 A1 CA 2736833A1
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CA
Canada
Prior art keywords
polymer
cryogel
vinyl alcohol
weight
monomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2736833A
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English (en)
French (fr)
Inventor
Albert Mihranyan
Maria Stroemme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
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Publication of CA2736833A1 publication Critical patent/CA2736833A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F216/04—Acyclic compounds
    • C08F216/06—Polyvinyl alcohol ; Vinyl alcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/02—Esters of monocarboxylic acids
    • C08F218/04—Vinyl esters
    • C08F218/08—Vinyl acetate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerisation Methods In General (AREA)
CA2736833A 2008-09-15 2009-09-14 Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof Abandoned CA2736833A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9697608P 2008-09-15 2008-09-15
US61/096,976 2008-09-15
PCT/IB2009/054012 WO2010029517A1 (en) 2008-09-15 2009-09-14 Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof

Publications (1)

Publication Number Publication Date
CA2736833A1 true CA2736833A1 (en) 2010-03-18

Family

ID=41226623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736833A Abandoned CA2736833A1 (en) 2008-09-15 2009-09-14 Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof

Country Status (13)

Country Link
US (1) US8975309B2 (https=)
EP (1) EP2331587A1 (https=)
JP (1) JP5694167B2 (https=)
KR (1) KR20110069093A (https=)
CN (1) CN102149735A (https=)
AU (1) AU2009290442A1 (https=)
BR (1) BRPI0918673A2 (https=)
CA (1) CA2736833A1 (https=)
EA (1) EA018466B1 (https=)
IL (1) IL211383A0 (https=)
MX (1) MX2011002746A (https=)
NZ (1) NZ591708A (https=)
WO (1) WO2010029517A1 (https=)

Families Citing this family (16)

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US20120160254A1 (en) * 2009-03-16 2012-06-28 Protista Biotechnology Ab Cryotropic hydrogels and their use as filters
EP2440321B1 (en) 2009-06-11 2017-11-22 Case Western Reserve University Low density hydrophobic material and method of making the same
US8608991B2 (en) 2009-06-11 2013-12-17 Case Western Reserve University Porous material having controlled voids and method of making the same
EP2701745B1 (en) * 2011-04-28 2018-07-11 President and Fellows of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
JP5705056B2 (ja) * 2011-07-28 2015-04-22 日本合成化学工業株式会社 ポリビニルアルコール系重合体粒子の製造方法
WO2014022749A1 (en) * 2012-08-02 2014-02-06 President And Fellows Of Harvard College Porous electrolytic polymer cryogels for enhanced electrical collapsibility
RU2543895C2 (ru) * 2013-05-17 2015-03-10 Общество С Ограниченной Ответственностью "Научно-Производственный Центр "Амфион" Гидрогелевый материал на основе сшиваемого поливинилового спирта
US10939677B2 (en) * 2013-06-12 2021-03-09 Nanyang Technological University Antibacterial cryogel and porous hydrogel, their preparation method, and their use for disinfecting water
CN105859945B (zh) * 2016-03-24 2018-06-15 合众（佛山）化工有限公司 一种改性聚乙烯醇共聚物交联型陶瓷坯体增强剂的制备方法
RU2729025C1 (ru) * 2019-07-19 2020-08-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Н.Н. Приорова" Минздрава России) Способ хирургического лечения гнойно-воспалительных процессов костных и мягкотканых структур опорно-двигательной системы пациента с использованием мягких спейсеров, импрегнированных антибактериальными средствами
CN112825981B (zh) * 2020-12-31 2023-05-09 内江师范学院 芦荟皮饲料用功能添加剂、制备方法及应用
CN114014969B (zh) * 2021-11-15 2023-08-11 上海华峰新材料研发科技有限公司 一种水溶性聚合物及其制备方法和应用
CN114426681B (zh) * 2021-12-24 2023-11-10 东华大学 一种稠杂环类还原物-聚丙烯酰胺粘附水凝胶的制备方法
WO2025154722A1 (en) * 2024-01-16 2025-07-24 Kuraray Co., Ltd. Polyvinyl alcohol copolymer and particulate water-soluble diverting agent formed therefrom
CN119979127A (zh) * 2025-02-26 2025-05-13 上海第二工业大学 一种冷链运输用高焓值相变凝胶材料及其制备方法
CN121554813A (zh) * 2026-01-22 2026-02-24 浙江省肿瘤医院 一种用于术后腹腔组织积液引流的高强可变形多孔水凝胶

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GB835651A (en) 1957-03-15 1960-05-25 Shawinigan Chem Ltd Stable vinyl acetate-acrylamide copolymer emulsions and water-resistant films therefrom
JPS5227455A (en) * 1975-07-24 1977-03-01 Sumitomo Chem Co Ltd Process for preparing a high polymer material having water absorption properties
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JPS57130543A (en) * 1981-02-05 1982-08-13 Nippon Oil Co Ltd Preparation of gel
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US5981826A (en) * 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
JP4132467B2 (ja) 1999-09-14 2008-08-13 株式会社クラレ ビニルアルコール系重合体の製法
US20030153708A1 (en) 2002-01-11 2003-08-14 Caneba Gerald Tablada Free radical retrograde precipitation copolymers and process for making same
CN100415821C (zh) * 2003-04-15 2008-09-03 英诺格尔股份公司 聚乙烯醇凝胶
RU2252945C1 (ru) 2003-10-30 2005-05-27 Институт элементоорганических соединений им. А.Н. Несмеянова РАН (ИНЭОС РАН) Полимерная композиция для получения криогеля поливинилового спирта
CN1320931C (zh) * 2004-05-14 2007-06-13 中国科学院长春应用化学研究所 含药物、壳聚糖的聚乙烯醇水凝胶敷料及其制备方法
KR101429774B1 (ko) * 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
CA2641582A1 (en) 2006-02-09 2007-08-16 Gerard T. Caneba Multifunctional multipolymeric surfactants for oil and bitumen recovery and other applications

Also Published As

Publication number Publication date
CN102149735A (zh) 2011-08-10
EA018466B1 (ru) 2013-08-30
KR20110069093A (ko) 2011-06-22
EA201100494A1 (ru) 2011-10-31
IL211383A0 (en) 2011-04-28
MX2011002746A (es) 2011-05-30
NZ591708A (en) 2013-07-26
WO2010029517A1 (en) 2010-03-18
US20110230567A1 (en) 2011-09-22
AU2009290442A1 (en) 2010-03-18
US8975309B2 (en) 2015-03-10
BRPI0918673A2 (pt) 2015-12-01
EP2331587A1 (en) 2011-06-15
JP5694167B2 (ja) 2015-04-01
JP2012503036A (ja) 2012-02-02

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