CA2733941C - Bicyclic triazole derivatives for the treatment of tumours - Google Patents

Bicyclic triazole derivatives for the treatment of tumours Download PDF

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Publication number
CA2733941C
CA2733941C CA2733941A CA2733941A CA2733941C CA 2733941 C CA2733941 C CA 2733941C CA 2733941 A CA2733941 A CA 2733941A CA 2733941 A CA2733941 A CA 2733941A CA 2733941 C CA2733941 C CA 2733941C
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hal
het
tautomer
stereoisomer
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CA2733941A
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English (en)
French (fr)
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CA2733941A1 (en
Inventor
Frank Stieber
Oliver Schadt
Dieter Dorsch
Andree Blaukat
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of CA2733941A1 publication Critical patent/CA2733941A1/en
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Publication of CA2733941C publication Critical patent/CA2733941C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2733941A 2008-08-14 2009-07-16 Bicyclic triazole derivatives for the treatment of tumours Active CA2733941C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008037790.2 2008-08-14
DE102008037790A DE102008037790A1 (de) 2008-08-14 2008-08-14 Bicyclische Triazolderivate
PCT/EP2009/005172 WO2010017870A1 (de) 2008-08-14 2009-07-16 Bicyclische triazolderivate zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
CA2733941A1 CA2733941A1 (en) 2010-02-18
CA2733941C true CA2733941C (en) 2016-10-04

Family

ID=41138729

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2733941A Active CA2733941C (en) 2008-08-14 2009-07-16 Bicyclic triazole derivatives for the treatment of tumours

Country Status (16)

Country Link
US (1) US8435986B2 (https=)
EP (1) EP2310013B1 (https=)
JP (1) JP5475778B2 (https=)
KR (1) KR20110051243A (https=)
CN (1) CN102123710B (https=)
AR (1) AR073055A1 (https=)
AU (1) AU2009281491B2 (https=)
BR (1) BRPI0914555A2 (https=)
CA (1) CA2733941C (https=)
DE (1) DE102008037790A1 (https=)
EA (1) EA201100334A1 (https=)
ES (1) ES2648233T3 (https=)
IL (1) IL211193A0 (https=)
MX (1) MX2011001511A (https=)
WO (1) WO2010017870A1 (https=)
ZA (1) ZA201101899B (https=)

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EP3052107B1 (en) 2013-10-04 2018-05-02 Novartis AG Organic compounds to treat hepatitis b virus
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TWI707849B (zh) 2018-02-13 2020-10-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
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Also Published As

Publication number Publication date
AU2009281491A1 (en) 2010-02-18
KR20110051243A (ko) 2011-05-17
DE102008037790A1 (de) 2010-02-18
ES2648233T3 (es) 2017-12-29
MX2011001511A (es) 2011-03-15
JP2011530545A (ja) 2011-12-22
HK1159989A1 (en) 2012-08-10
US20110135600A1 (en) 2011-06-09
EP2310013B1 (de) 2017-08-23
AR073055A1 (es) 2010-10-13
ZA201101899B (en) 2011-11-30
IL211193A0 (en) 2011-04-28
AU2009281491B2 (en) 2014-02-20
BRPI0914555A2 (pt) 2015-12-15
CN102123710B (zh) 2012-11-07
CN102123710A (zh) 2011-07-13
EP2310013A1 (de) 2011-04-20
WO2010017870A1 (de) 2010-02-18
US8435986B2 (en) 2013-05-07
JP5475778B2 (ja) 2014-04-16
EA201100334A1 (ru) 2011-08-30
CA2733941A1 (en) 2010-02-18

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