BRPI0914555A2 - derivados de triazol bicíclicos para o tratamento de tumores - Google Patents

derivados de triazol bicíclicos para o tratamento de tumores

Info

Publication number
BRPI0914555A2
BRPI0914555A2 BRPI0914555A BRPI0914555A BRPI0914555A2 BR PI0914555 A2 BRPI0914555 A2 BR PI0914555A2 BR PI0914555 A BRPI0914555 A BR PI0914555A BR PI0914555 A BRPI0914555 A BR PI0914555A BR PI0914555 A2 BRPI0914555 A2 BR PI0914555A2
Authority
BR
Brazil
Prior art keywords
tumors
treatment
triazole derivatives
bicyclic triazole
bicyclic
Prior art date
Application number
BRPI0914555A
Other languages
English (en)
Portuguese (pt)
Inventor
Andree Blaukat
Frank Stieber
Oliver Schadt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0914555A2 publication Critical patent/BRPI0914555A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0914555A 2008-08-14 2009-07-16 derivados de triazol bicíclicos para o tratamento de tumores BRPI0914555A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008037790A DE102008037790A1 (de) 2008-08-14 2008-08-14 Bicyclische Triazolderivate
PCT/EP2009/005172 WO2010017870A1 (de) 2008-08-14 2009-07-16 Bicyclische triazolderivate zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
BRPI0914555A2 true BRPI0914555A2 (pt) 2015-12-15

Family

ID=41138729

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914555A BRPI0914555A2 (pt) 2008-08-14 2009-07-16 derivados de triazol bicíclicos para o tratamento de tumores

Country Status (16)

Country Link
US (1) US8435986B2 (https=)
EP (1) EP2310013B1 (https=)
JP (1) JP5475778B2 (https=)
KR (1) KR20110051243A (https=)
CN (1) CN102123710B (https=)
AR (1) AR073055A1 (https=)
AU (1) AU2009281491B2 (https=)
BR (1) BRPI0914555A2 (https=)
CA (1) CA2733941C (https=)
DE (1) DE102008037790A1 (https=)
EA (1) EA201100334A1 (https=)
ES (1) ES2648233T3 (https=)
IL (1) IL211193A0 (https=)
MX (1) MX2011001511A (https=)
WO (1) WO2010017870A1 (https=)
ZA (1) ZA201101899B (https=)

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CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
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TW202334164A (zh) 2022-01-12 2023-09-01 美商戴納立製藥公司 （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型

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Also Published As

Publication number Publication date
AU2009281491A1 (en) 2010-02-18
US8435986B2 (en) 2013-05-07
CA2733941A1 (en) 2010-02-18
DE102008037790A1 (de) 2010-02-18
US20110135600A1 (en) 2011-06-09
EP2310013A1 (de) 2011-04-20
CA2733941C (en) 2016-10-04
AR073055A1 (es) 2010-10-13
JP5475778B2 (ja) 2014-04-16
EP2310013B1 (de) 2017-08-23
ES2648233T3 (es) 2017-12-29
IL211193A0 (en) 2011-04-28
AU2009281491B2 (en) 2014-02-20
CN102123710B (zh) 2012-11-07
WO2010017870A1 (de) 2010-02-18
JP2011530545A (ja) 2011-12-22
MX2011001511A (es) 2011-03-15
KR20110051243A (ko) 2011-05-17
HK1159989A1 (en) 2012-08-10
CN102123710A (zh) 2011-07-13
ZA201101899B (en) 2011-11-30
EA201100334A1 (ru) 2011-08-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2383 DE 06-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.