DE102008037790A1 - Bicyclische Triazolderivate - Google Patents
Bicyclische Triazolderivate Download PDFInfo
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- DE102008037790A1 DE102008037790A1 DE102008037790A DE102008037790A DE102008037790A1 DE 102008037790 A1 DE102008037790 A1 DE 102008037790A1 DE 102008037790 A DE102008037790 A DE 102008037790A DE 102008037790 A DE102008037790 A DE 102008037790A DE 102008037790 A1 DE102008037790 A1 DE 102008037790A1
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- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008037790A DE102008037790A1 (de) | 2008-08-14 | 2008-08-14 | Bicyclische Triazolderivate |
| BRPI0914555A BRPI0914555A2 (pt) | 2008-08-14 | 2009-07-16 | derivados de triazol bicíclicos para o tratamento de tumores |
| EP09777234.7A EP2310013B1 (de) | 2008-08-14 | 2009-07-16 | Bicyclische triazolderivate zur behandlung von tumoren |
| US13/059,016 US8435986B2 (en) | 2008-08-14 | 2009-07-16 | Bicyclic traizole derivatives for treating of tumors |
| KR1020117005525A KR20110051243A (ko) | 2008-08-14 | 2009-07-16 | 종양 치료용 비시클릭 트리아졸 유도체 |
| CN2009801314380A CN102123710B (zh) | 2008-08-14 | 2009-07-16 | 用于治疗肿瘤的二环三唑衍生物 |
| MX2011001511A MX2011001511A (es) | 2008-08-14 | 2009-07-16 | Derivados de triazol biciclicos para el tratamiento de tumores. |
| AU2009281491A AU2009281491B2 (en) | 2008-08-14 | 2009-07-16 | Bicyclic triazole derivatives for treating tumors |
| HK12100381.3A HK1159989B (en) | 2008-08-14 | 2009-07-16 | Bicyclic triazole derivatives for treating tumors |
| ES09777234.7T ES2648233T3 (es) | 2008-08-14 | 2009-07-16 | Derivados de triazol bicíclico para el tratamiento de tumores |
| CA2733941A CA2733941C (en) | 2008-08-14 | 2009-07-16 | Bicyclic triazole derivatives for the treatment of tumours |
| EA201100334A EA201100334A1 (ru) | 2008-08-14 | 2009-07-16 | Бициклические производные триазола для лечения опухолей |
| PCT/EP2009/005172 WO2010017870A1 (de) | 2008-08-14 | 2009-07-16 | Bicyclische triazolderivate zur behandlung von tumoren |
| JP2011522392A JP5475778B2 (ja) | 2008-08-14 | 2009-07-16 | 腫瘍の治療のための二環式トリアゾール誘導体 |
| ARP090103142A AR073055A1 (es) | 2008-08-14 | 2009-08-14 | Derivados biciclicos de triazol |
| IL211193A IL211193A0 (en) | 2008-08-14 | 2011-02-10 | Bicyclic triazole derivatives for the treatment of tumours |
| ZA2011/01899A ZA201101899B (en) | 2008-08-14 | 2011-03-11 | Bicyclic triazole derivatives for the treatment of tumours |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008037790A DE102008037790A1 (de) | 2008-08-14 | 2008-08-14 | Bicyclische Triazolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102008037790A1 true DE102008037790A1 (de) | 2010-02-18 |
Family
ID=41138729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102008037790A Withdrawn DE102008037790A1 (de) | 2008-08-14 | 2008-08-14 | Bicyclische Triazolderivate |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8435986B2 (https=) |
| EP (1) | EP2310013B1 (https=) |
| JP (1) | JP5475778B2 (https=) |
| KR (1) | KR20110051243A (https=) |
| CN (1) | CN102123710B (https=) |
| AR (1) | AR073055A1 (https=) |
| AU (1) | AU2009281491B2 (https=) |
| BR (1) | BRPI0914555A2 (https=) |
| CA (1) | CA2733941C (https=) |
| DE (1) | DE102008037790A1 (https=) |
| EA (1) | EA201100334A1 (https=) |
| ES (1) | ES2648233T3 (https=) |
| IL (1) | IL211193A0 (https=) |
| MX (1) | MX2011001511A (https=) |
| WO (1) | WO2010017870A1 (https=) |
| ZA (1) | ZA201101899B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2009222122A1 (en) * | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
| EA030141B1 (ru) | 2009-12-31 | 2018-06-29 | Хатчисон Медифарма Лимитед | Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения |
| NZ604306A (en) * | 2010-05-17 | 2015-02-27 | Incozen Therapeutics Pvt Ltd | Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases |
| CA2812449A1 (en) * | 2010-09-23 | 2012-03-29 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| EP3053923B1 (en) * | 2013-09-30 | 2018-04-11 | Korea Research Institute of Chemical Technology | Triazolopyrazine derivatives as tyrosin kinase inhibitors |
| HK1221912A1 (zh) | 2013-10-04 | 2017-06-16 | Novartis Ag | 用於治疗乙肝病毒的有机化合物 |
| EP3052464B1 (en) * | 2013-10-04 | 2020-04-15 | Novartis AG | 3'end caps for rna-interferring agents for use in rna interference |
| GB201321740D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| BR112016015235A2 (pt) * | 2013-12-30 | 2017-08-08 | Genentech Inc | Composto, composição farmacêutica, método de inibição da atividade da proteína quinase erk e método de tratamento |
| IL287136B2 (en) | 2016-02-05 | 2023-09-01 | Denali Therapeutics Inc | Receptor inhibitors - interacting with protein kinase 1 |
| JP7208137B2 (ja) | 2016-12-09 | 2023-01-18 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物および方法 |
| KR20180092096A (ko) | 2017-02-08 | 2018-08-17 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
| CN108570053A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元并六元杂环化合物、制备方法、中间体、组合和应用 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| TW202334164A (zh) | 2022-01-12 | 2023-09-01 | 美商戴納立製藥公司 | （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型 |
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2008
- 2008-08-14 DE DE102008037790A patent/DE102008037790A1/de not_active Withdrawn
-
2009
- 2009-07-16 US US13/059,016 patent/US8435986B2/en not_active Expired - Fee Related
- 2009-07-16 EA EA201100334A patent/EA201100334A1/ru unknown
- 2009-07-16 MX MX2011001511A patent/MX2011001511A/es not_active Application Discontinuation
- 2009-07-16 CA CA2733941A patent/CA2733941C/en active Active
- 2009-07-16 ES ES09777234.7T patent/ES2648233T3/es active Active
- 2009-07-16 EP EP09777234.7A patent/EP2310013B1/de active Active
- 2009-07-16 WO PCT/EP2009/005172 patent/WO2010017870A1/de not_active Ceased
- 2009-07-16 JP JP2011522392A patent/JP5475778B2/ja not_active Expired - Fee Related
- 2009-07-16 CN CN2009801314380A patent/CN102123710B/zh not_active Expired - Fee Related
- 2009-07-16 AU AU2009281491A patent/AU2009281491B2/en not_active Ceased
- 2009-07-16 KR KR1020117005525A patent/KR20110051243A/ko not_active Withdrawn
- 2009-07-16 BR BRPI0914555A patent/BRPI0914555A2/pt not_active IP Right Cessation
- 2009-08-14 AR ARP090103142A patent/AR073055A1/es unknown
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2011
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| AU2009281491A1 (en) | 2010-02-18 |
| US8435986B2 (en) | 2013-05-07 |
| CA2733941A1 (en) | 2010-02-18 |
| US20110135600A1 (en) | 2011-06-09 |
| EP2310013A1 (de) | 2011-04-20 |
| CA2733941C (en) | 2016-10-04 |
| AR073055A1 (es) | 2010-10-13 |
| JP5475778B2 (ja) | 2014-04-16 |
| EP2310013B1 (de) | 2017-08-23 |
| BRPI0914555A2 (pt) | 2015-12-15 |
| ES2648233T3 (es) | 2017-12-29 |
| IL211193A0 (en) | 2011-04-28 |
| AU2009281491B2 (en) | 2014-02-20 |
| CN102123710B (zh) | 2012-11-07 |
| WO2010017870A1 (de) | 2010-02-18 |
| JP2011530545A (ja) | 2011-12-22 |
| MX2011001511A (es) | 2011-03-15 |
| KR20110051243A (ko) | 2011-05-17 |
| HK1159989A1 (en) | 2012-08-10 |
| CN102123710A (zh) | 2011-07-13 |
| ZA201101899B (en) | 2011-11-30 |
| EA201100334A1 (ru) | 2011-08-30 |
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