CA2731138C - Compositions for treating rosacea - Google Patents

Compositions for treating rosacea Download PDF

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Publication number
CA2731138C
CA2731138C CA2731138A CA2731138A CA2731138C CA 2731138 C CA2731138 C CA 2731138C CA 2731138 A CA2731138 A CA 2731138A CA 2731138 A CA2731138 A CA 2731138A CA 2731138 C CA2731138 C CA 2731138C
Authority
CA
Canada
Prior art keywords
composition according
dicarboxylic acid
composition
present
amounts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2731138A
Other languages
English (en)
French (fr)
Other versions
CA2731138A1 (en
Inventor
Federico Mailland
Emanuela Mura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polichem SA
Original Assignee
Polichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40140031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2731138(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem SA filed Critical Polichem SA
Publication of CA2731138A1 publication Critical patent/CA2731138A1/en
Application granted granted Critical
Publication of CA2731138C publication Critical patent/CA2731138C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2731138A 2008-08-05 2009-07-28 Compositions for treating rosacea Active CA2731138C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08161799.5 2008-08-05
EP08161799A EP2116237A1 (en) 2008-08-05 2008-08-05 Compositions for treating rosacea comprising chitosan and a dicarboxylic acid
PCT/EP2009/059749 WO2009150257A2 (en) 2008-08-05 2009-07-28 Compositions for treating rosacea

Publications (2)

Publication Number Publication Date
CA2731138A1 CA2731138A1 (en) 2009-12-17
CA2731138C true CA2731138C (en) 2016-01-26

Family

ID=40140031

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2731138A Active CA2731138C (en) 2008-08-05 2009-07-28 Compositions for treating rosacea

Country Status (28)

Country Link
US (1) US9034845B2 (enExample)
EP (2) EP2116237A1 (enExample)
JP (1) JP5646477B2 (enExample)
KR (1) KR101623375B1 (enExample)
CN (1) CN102105142B (enExample)
AR (1) AR072917A1 (enExample)
AU (1) AU2009256524B2 (enExample)
BR (1) BRPI0917584B8 (enExample)
CA (1) CA2731138C (enExample)
CL (1) CL2011000174A1 (enExample)
CY (1) CY1118256T1 (enExample)
DK (1) DK2306999T3 (enExample)
EA (1) EA020417B1 (enExample)
ES (1) ES2606233T3 (enExample)
HR (1) HRP20161594T1 (enExample)
HU (1) HUE031171T2 (enExample)
IL (1) IL210695A (enExample)
LT (1) LT2306999T (enExample)
MX (1) MX2011001369A (enExample)
NZ (1) NZ590800A (enExample)
PE (1) PE20110564A1 (enExample)
PL (1) PL2306999T3 (enExample)
PT (1) PT2306999T (enExample)
RS (1) RS55507B1 (enExample)
SI (1) SI2306999T1 (enExample)
SM (1) SMT201600403B (enExample)
WO (1) WO2009150257A2 (enExample)
ZA (1) ZA201100350B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2975004B1 (fr) 2011-05-13 2013-06-28 Expanscience Lab Nouvel actif anti-rougeurs et compositions cosmetiques le comprenant
US9023399B2 (en) 2012-11-16 2015-05-05 NU Technology, LLC Water-soluble anti-inflammatory cream with natural ingredients base
US8613961B1 (en) 2013-01-09 2013-12-24 NU Technology, LLC Dermatological cream with natural ingredients base
EP3233027B1 (en) 2014-12-15 2021-10-13 Unilever IP Holdings B.V. Compositions for providing improved sunscreen protection
GB2600384A (en) 2020-09-30 2022-05-04 Vaderis Therapeutics Ag Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia

Family Cites Families (36)

* Cited by examiner, † Cited by third party
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DE3541305A1 (de) 1985-11-22 1987-05-27 Wella Ag Kosmetische mittel auf der basis von n-hydroxypropylchitosanen, neue n-hydroxypropyl-chitosane sowie verfahren zu ihrer herstellung
DE3723811A1 (de) * 1987-07-18 1989-01-26 Wella Ag Nagellack auf der basis von o-benzyl-n-hydroxyalkylchitosanen sowie neue o-benzyl-n-hydroxyalkylderivate des chitosans
JPH05339152A (ja) * 1992-06-09 1993-12-21 Nippon Soda Co Ltd 皮膚病変局所投与薬剤含有キトサン誘導体フィルム剤
DE69424100T2 (de) * 1993-08-10 2000-10-12 Kao Corp Organopolysiloxane und ein Verfahren zum Haarfestigen unter Verwendung derselben
JP2001512471A (ja) * 1997-02-21 2001-08-21 バイヤースドルフ・アクチエンゲゼルシヤフト しゅさの処置のための調製物
JP4185173B2 (ja) 1997-08-07 2008-11-26 株式会社ノエビア 両親媒性キトサン誘導体及びこれを含有する皮膚外用剤
US6391334B1 (en) * 1999-10-25 2002-05-21 Amway Corporation Barrier-forming composition
US6734210B2 (en) * 2000-02-24 2004-05-11 Rolland F. Hebert Therapeutically improved salts of azelaic acid
US6451773B1 (en) * 2000-03-31 2002-09-17 Cognis Corporation Chitosan formulation with azelaic acid and other actives for the treatment of acne
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KR20020048534A (ko) 2000-12-18 2002-06-24 안병로 파라핀 왁스를 유효성분으로 하는 피부 맛사지 팩제
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GB0126923D0 (en) 2001-11-09 2002-01-02 Procter & Gamble Chitosan compositions
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CN1816287A (zh) * 2003-01-31 2006-08-09 宝洁公司 改善哺乳动物角质组织外观的方法
US20040156873A1 (en) * 2003-02-10 2004-08-12 Gupta Shyam K. Topically Bioavailable Acne and Rosacea Treatment Compositions
US20040220264A1 (en) * 2003-03-17 2004-11-04 Yu Ruey J Bioavailability and improved delivery of acidic pharmaceutical drugs
EP1491202A1 (en) 2003-06-23 2004-12-29 Polichem S.A. Nail restructuring compositions for topical application
US20080069779A1 (en) * 2003-08-04 2008-03-20 Foamix Ltd. Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof
US7416525B2 (en) * 2003-09-18 2008-08-26 Myrakelle, Llc Rotary blood pump
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JP2005306746A (ja) 2004-04-19 2005-11-04 Jiyugaoka Clinic 顔面用シワ治療剤
US20060024339A1 (en) * 2004-07-29 2006-02-02 Howard Murad Methods of managing the redness associated with a dermatological condition
ITMI20041567A1 (it) * 2004-07-30 2004-10-30 Maycos Italiana Di Comini Miro "derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici"
CN1813664A (zh) * 2005-11-24 2006-08-09 曾能 一种水凝胶美容护肤贴和精华护肤液的制造工艺及产品
TWI367109B (en) * 2006-01-19 2012-07-01 Mary Kay Inc Compositions comprising kakadu plum extract or acai berry extract
JP4866173B2 (ja) * 2006-01-25 2012-02-01 大日精化工業株式会社 ヒドロキシアルキル化キトサン溶液
WO2007149868A2 (en) * 2006-06-20 2007-12-27 The Regents Of The University Of California Controlled release encapsulated anti-bacterial and anti-inflammatory nanoparticles
WO2008038147A2 (en) * 2006-07-05 2008-04-03 Foamix Ltd. Foamable vehicle comprising dicarboxylic acid or dicarboxylic acid ester and pharmaceutical compositions thereof
EP1958613A1 (en) * 2007-02-15 2008-08-20 Polichem S.A. Dermal film-forming liquid formulations for drug release to skin

Also Published As

Publication number Publication date
DK2306999T3 (en) 2016-12-05
MX2011001369A (es) 2011-03-04
CL2011000174A1 (es) 2011-06-17
AU2009256524B2 (en) 2014-05-01
US9034845B2 (en) 2015-05-19
HUE031171T2 (hu) 2017-06-28
EP2306999A2 (en) 2011-04-13
ZA201100350B (en) 2012-05-01
CN102105142A (zh) 2011-06-22
EA201100243A1 (ru) 2011-08-30
HK1150774A1 (zh) 2012-01-13
CY1118256T1 (el) 2017-06-28
PE20110564A1 (es) 2011-08-05
EP2116237A1 (en) 2009-11-11
US20110207696A1 (en) 2011-08-25
EP2306999B1 (en) 2016-09-07
LT2306999T (lt) 2016-12-12
CA2731138A1 (en) 2009-12-17
WO2009150257A3 (en) 2010-02-04
EA020417B1 (ru) 2014-11-28
KR20110050450A (ko) 2011-05-13
SI2306999T1 (sl) 2016-12-30
SMT201600403B (it) 2017-01-10
IL210695A0 (en) 2011-03-31
JP5646477B2 (ja) 2014-12-24
PL2306999T3 (pl) 2017-05-31
RS55507B1 (sr) 2017-05-31
CN102105142B (zh) 2013-06-26
NZ590800A (en) 2012-09-28
JP2011529936A (ja) 2011-12-15
AU2009256524A1 (en) 2009-12-17
HRP20161594T1 (hr) 2017-01-13
ES2606233T3 (es) 2017-03-23
BRPI0917584A2 (pt) 2015-11-17
BRPI0917584B1 (pt) 2019-11-05
AU2009256524A2 (en) 2011-02-17
KR101623375B1 (ko) 2016-05-23
IL210695A (en) 2016-05-31
BRPI0917584B8 (pt) 2021-05-25
PT2306999T (pt) 2016-12-07
AR072917A1 (es) 2010-09-29
WO2009150257A2 (en) 2009-12-17

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