CA2720586C - Glucopyranoside derivatives - Google Patents

Glucopyranoside derivatives Download PDF

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Publication number
CA2720586C
CA2720586C CA2720586A CA2720586A CA2720586C CA 2720586 C CA2720586 C CA 2720586C CA 2720586 A CA2720586 A CA 2720586A CA 2720586 A CA2720586 A CA 2720586A CA 2720586 C CA2720586 C CA 2720586C
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Prior art keywords
mixture
denotes
tautomer
stereoisomer
ratio
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Application number
CA2720586A
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English (en)
French (fr)
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CA2720586A1 (en
Inventor
Christos Tsaklakidis
Norbert Beier
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Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of CA2720586A1 publication Critical patent/CA2720586A1/en
Application granted granted Critical
Publication of CA2720586C publication Critical patent/CA2720586C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2720586A 2008-04-07 2009-03-17 Glucopyranoside derivatives Active CA2720586C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008017590A DE102008017590A1 (de) 2008-04-07 2008-04-07 Glucopyranosidderivate
DE102008017590.0 2008-04-07
PCT/EP2009/001946 WO2009124638A1 (de) 2008-04-07 2009-03-17 Glucopyranosidderivate

Publications (2)

Publication Number Publication Date
CA2720586A1 CA2720586A1 (en) 2009-10-15
CA2720586C true CA2720586C (en) 2016-06-21

Family

ID=41051529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2720586A Active CA2720586C (en) 2008-04-07 2009-03-17 Glucopyranoside derivatives

Country Status (9)

Country Link
US (1) US8399509B2 (enExample)
EP (1) EP2260051B1 (enExample)
JP (1) JP5485979B2 (enExample)
AU (1) AU2009235786B2 (enExample)
CA (1) CA2720586C (enExample)
DE (1) DE102008017590A1 (enExample)
ES (1) ES2394240T3 (enExample)
IL (1) IL208065A (enExample)
WO (1) WO2009124638A1 (enExample)

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US9034921B2 (en) * 2011-06-01 2015-05-19 Green Cross Corporation Diphenylmethane derivatives as SGLT2 inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9340521B2 (en) * 2013-03-18 2016-05-17 Green Cross Corporation Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
US11352328B2 (en) 2016-07-12 2022-06-07 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus
US12419865B2 (en) 2018-12-06 2025-09-23 Arisan Therapeutics Inc. Compounds for the treatment of arenavirus infection
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Also Published As

Publication number Publication date
US8399509B2 (en) 2013-03-19
IL208065A (en) 2014-03-31
AU2009235786B2 (en) 2013-09-26
CA2720586A1 (en) 2009-10-15
JP5485979B2 (ja) 2014-05-07
JP2011516511A (ja) 2011-05-26
US20110028414A1 (en) 2011-02-03
ES2394240T3 (es) 2013-01-23
WO2009124638A1 (de) 2009-10-15
DE102008017590A1 (de) 2009-10-08
AU2009235786A1 (en) 2009-10-15
IL208065A0 (en) 2010-12-30
EP2260051B1 (de) 2012-10-17
EP2260051A1 (de) 2010-12-15

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Effective date: 20140314