CA2720264C - A membrane for supporting the growth of retinal pigmented epithelial cells - Google Patents

A membrane for supporting the growth of retinal pigmented epithelial cells Download PDF

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Publication number
CA2720264C
CA2720264C CA2720264A CA2720264A CA2720264C CA 2720264 C CA2720264 C CA 2720264C CA 2720264 A CA2720264 A CA 2720264A CA 2720264 A CA2720264 A CA 2720264A CA 2720264 C CA2720264 C CA 2720264C
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Prior art keywords
membrane
cells
membrane according
pores
pigmented epithelial
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CA2720264A
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English (en)
French (fr)
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CA2720264A1 (en
Inventor
Peter Coffey
Lyndon Da Cruz
Karen Cheetham
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UCL Business Ltd
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UCL Business Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813Epithelial cells, e.g. keratinocytes, urothelial cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2720264A 2008-04-14 2009-04-08 A membrane for supporting the growth of retinal pigmented epithelial cells Active CA2720264C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0806746.4 2008-04-14
GBGB0806746.4A GB0806746D0 (en) 2008-04-14 2008-04-14 Membrane
PCT/GB2009/000917 WO2009127809A1 (en) 2008-04-14 2009-04-08 Membrane

Publications (2)

Publication Number Publication Date
CA2720264A1 CA2720264A1 (en) 2009-10-22
CA2720264C true CA2720264C (en) 2016-09-27

Family

ID=39433610

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2720264A Active CA2720264C (en) 2008-04-14 2009-04-08 A membrane for supporting the growth of retinal pigmented epithelial cells

Country Status (19)

Country Link
US (2) US8642072B2 (enExample)
EP (1) EP2265711B1 (enExample)
JP (1) JP5552478B2 (enExample)
KR (2) KR101317094B1 (enExample)
CN (1) CN102016009B (enExample)
AU (1) AU2009237462B2 (enExample)
BR (1) BRPI0910936A2 (enExample)
CA (1) CA2720264C (enExample)
CO (1) CO6311115A2 (enExample)
DK (1) DK2265711T3 (enExample)
ES (1) ES2665284T3 (enExample)
GB (1) GB0806746D0 (enExample)
IL (1) IL208745A (enExample)
MX (1) MX2010011232A (enExample)
MY (1) MY159049A (enExample)
NZ (1) NZ587753A (enExample)
RU (1) RU2530169C2 (enExample)
WO (1) WO2009127809A1 (enExample)
ZA (1) ZA201006326B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110112101A1 (en) * 2009-03-05 2011-05-12 Sanofi-Aventis Treatment for ocular-related disorders
JP5867926B2 (ja) * 2010-05-10 2016-02-24 公立大学法人名古屋市立大学 細胞シート作製方法
EP4245370A3 (en) 2010-07-12 2023-11-29 University of Southern California Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
CN103459593A (zh) * 2011-02-25 2013-12-18 独立行政法人理化学研究所 视网膜色素上皮细胞片层的生产方法
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
US10478206B2 (en) 2011-04-29 2019-11-19 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
WO2012177968A1 (en) * 2011-06-22 2012-12-27 The Schepens Eye Research Institute, Inc. A scaffold for subretinal cell transplantation and drug delivery
US9763777B2 (en) 2011-07-11 2017-09-19 Ear Science Institute Australia Device for ear drum repair
CN103007355B (zh) * 2011-09-20 2014-08-13 同济大学 一种水凝胶-纳米纤维膜及其制备方法和用途
CA2792081C (en) * 2011-10-11 2020-10-27 Bond University Ltd Layered compositions comprising 3d nanofibre webbing for tissue repair
CA2855941A1 (en) 2011-11-14 2013-05-23 Advanced Cell Technology, Inc. Pharmaceutical preparations of human rpe cells and uses thereof
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
US20130330825A1 (en) * 2012-06-07 2013-12-12 City Of Hope Attachment substrates for directed differentiation of human embryonic stem cells in culture
US11033586B2 (en) 2012-08-24 2021-06-15 Riken Method for producing retinal pigment epithelial cell sheet
RU2518972C1 (ru) * 2012-12-24 2014-06-10 Общество с ограниченной ответственностью "НАНО КАСКАД" Трековая мембрана для фильтрации крови
EP3080248A1 (en) 2013-12-11 2016-10-19 Pfizer Limited Method for producing retinal pigment epithelial cells
CN105013010B (zh) * 2015-07-07 2018-01-12 中山大学中山眼科中心 一种辅助iPS‑RPE移植的层粘连蛋白膜
CN105597145A (zh) * 2016-02-22 2016-05-25 中山大学中山眼科中心 一种视网膜细胞支架生物手术粘合剂及其制备方法
CN109790508A (zh) * 2016-06-28 2019-05-21 国立研究开发法人农业·食品产业技术综合研究机构 细胞封入用设备及其用途
WO2020047380A1 (en) 2018-08-31 2020-03-05 Wisconsin Alumni Research Foundation Generating arterial endothelial cell-seeded vascular grafts
TWI820330B (zh) * 2019-04-26 2023-11-01 國立研究開發法人理化學研究所 包含神經視網膜與視網膜色素上皮細胞與水凝膠之複合體及其製造方法
RU2704094C1 (ru) * 2019-05-16 2019-10-23 федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ трансплантации ретинального пигментного эпителия в форме многоклеточных 3D сфероидов в эксперименте
JP2021141877A (ja) * 2020-03-13 2021-09-24 大日本印刷株式会社 細胞培養基材、細胞付細胞培養基材、細胞培養容器、細胞付細胞培養容器、上皮細胞シート及びその製造方法、被験物質の評価方法並びに評価キット
JP7676135B2 (ja) * 2020-12-14 2025-05-14 日本バイリーン株式会社 細胞培養担体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0118984D0 (en) * 2001-08-03 2001-09-26 Intercytex Ltd Fusion of cells
CN1739813A (zh) * 2005-09-15 2006-03-01 上海赐人合元企业发展有限公司 组织工程表皮替代物及其制备方法
KR100901343B1 (ko) 2007-07-23 2009-06-05 (주)실리콘화일 결정질 반도체 박막 제조 방법
RU2368359C1 (ru) * 2008-07-22 2009-09-27 Государственное учреждение "УФИМСКИЙ НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ ГЛАЗНЫХ БОЛЕЗНЕЙ" Академии наук Республики Башкортостан (УфНИИ ГБ АН РБ) Способ лечения возрастной макулярной дегенерации

Also Published As

Publication number Publication date
GB0806746D0 (en) 2008-05-14
EP2265711A1 (en) 2010-12-29
IL208745A0 (en) 2010-12-30
DK2265711T3 (en) 2018-04-30
WO2009127809A1 (en) 2009-10-22
MX2010011232A (es) 2011-02-23
KR101317094B1 (ko) 2013-10-16
KR20100128329A (ko) 2010-12-07
ZA201006326B (en) 2011-09-28
BRPI0910936A2 (pt) 2015-10-06
US8889179B2 (en) 2014-11-18
CN102016009A (zh) 2011-04-13
ES2665284T3 (es) 2018-04-25
IL208745A (en) 2015-04-30
MY159049A (en) 2016-12-15
CN102016009B (zh) 2015-05-20
JP5552478B2 (ja) 2014-07-16
CO6311115A2 (es) 2011-08-22
US8642072B2 (en) 2014-02-04
JP2011517696A (ja) 2011-06-16
US20140127282A1 (en) 2014-05-08
RU2010144399A (ru) 2012-05-20
EP2265711B1 (en) 2018-03-07
AU2009237462A1 (en) 2009-10-22
KR20130065737A (ko) 2013-06-19
RU2530169C2 (ru) 2014-10-10
CA2720264A1 (en) 2009-10-22
AU2009237462B2 (en) 2012-12-20
NZ587753A (en) 2012-07-27
US20110236464A1 (en) 2011-09-29

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