CA2716950C - Barriers for facilitating biological reactions - Google Patents

Barriers for facilitating biological reactions Download PDF

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Publication number
CA2716950C
CA2716950C CA2716950A CA2716950A CA2716950C CA 2716950 C CA2716950 C CA 2716950C CA 2716950 A CA2716950 A CA 2716950A CA 2716950 A CA2716950 A CA 2716950A CA 2716950 C CA2716950 C CA 2716950C
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CA
Canada
Prior art keywords
chamber
sample
reagent
chambers
molecule
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Active
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CA2716950A
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English (en)
French (fr)
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CA2716950A1 (en
Inventor
David M. Kelso
Sur Kunal
Zaheer Parpia
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Northwestern University
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Northwestern University
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Publication of CA2716950A1 publication Critical patent/CA2716950A1/en
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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04Exchange or ejection of cartridges, containers or reservoirs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0677Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CA2716950A 2008-02-29 2009-02-27 Barriers for facilitating biological reactions Active CA2716950C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3265508P 2008-02-29 2008-02-29
US61/032,655 2008-02-29
PCT/US2009/035497 WO2009111316A2 (en) 2008-02-29 2009-02-27 Barriers for facilitating biological reactions

Publications (2)

Publication Number Publication Date
CA2716950A1 CA2716950A1 (en) 2009-09-11
CA2716950C true CA2716950C (en) 2017-07-04

Family

ID=41056566

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2716950A Active CA2716950C (en) 2008-02-29 2009-02-27 Barriers for facilitating biological reactions

Country Status (10)

Country Link
US (6) US8187808B2 (enExample)
EP (1) EP2257802A4 (enExample)
JP (2) JP5390540B2 (enExample)
CN (1) CN102027367B (enExample)
AU (1) AU2009222181B2 (enExample)
BR (1) BRPI0908876A2 (enExample)
CA (1) CA2716950C (enExample)
IL (1) IL207823A0 (enExample)
WO (1) WO2009111316A2 (enExample)
ZA (1) ZA201006088B (enExample)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852148B1 (fr) * 2003-03-07 2014-04-11 Batscap Sa Materiau pour electrode composite, procede pour sa preparation
CA2592204C (en) * 2004-12-23 2013-03-12 I-Stat Corporation Nucleic acid diagnostics system and methods
US8841076B2 (en) 2005-05-09 2014-09-23 Theranos, Inc. Systems and methods for conducting animal studies
US20090047673A1 (en) 2006-08-22 2009-02-19 Cary Robert B Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
EP3756767B1 (en) 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
EP2257802A4 (en) * 2008-02-29 2014-07-02 Univ Northwestern BARRIER FOR BIOLOGICAL REACTIONS
WO2009137059A1 (en) 2008-05-05 2009-11-12 Los Alamos National Security, Llc Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
RU2529467C2 (ru) 2009-06-03 2014-09-27 Конинклейке Филипс Электроникс Н.В. Клапан
US9387484B2 (en) * 2009-10-06 2016-07-12 Koninklijke Philips N.V. Magnetic sample purification
EP2536504A1 (en) * 2010-02-15 2012-12-26 Danmarks Tekniske Universitet Sample processing device and method
US8728410B2 (en) * 2010-02-26 2014-05-20 Wisconsin Alumni Research Foundation Device for and method of extracting a fraction from a biological sample
US8603416B2 (en) * 2010-02-26 2013-12-10 Wisconsin Alumni Research Foundation Device for and method of extracting a fraction from a biological sample
US20130084606A1 (en) * 2010-06-22 2013-04-04 Universal Bio Research Co., Ltd. Composition for Preventing Evaporation of Reaction Solution During Nucleic Acid Amplification Reaction
US9677979B2 (en) 2010-07-16 2017-06-13 Vanderbilt University Low resource processor using surface tension valves for extracting, concentrating and detecting molecular species
CN103229053B (zh) 2010-07-27 2015-06-24 西北大学 过滤血浆的装置和方法
DE102010041621B4 (de) 2010-09-29 2016-11-03 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zum Transport magnetischer Partikel
US8993243B2 (en) 2011-01-10 2015-03-31 Wisconsin Alumni Research Foundation Method for isolating weakly interacting molecules from a fluidic sample
CA3097861A1 (en) 2011-01-21 2012-07-26 Labrador Diagnostics Llc Systems and methods for sample use maximization
US20120220045A1 (en) * 2011-02-25 2012-08-30 Colin Bozarth Double Trench Well for Assay Procedures
WO2012121310A1 (ja) 2011-03-08 2012-09-13 独立行政法人科学技術振興機構 ビーズ封入方法、ターゲット分子を検出する方法、アレイ、キット及びターゲット分子検出装置
US10018627B2 (en) * 2011-03-08 2018-07-10 Japan Science And Technology Agency Method for sealing substances, method for detecting target molecule, array, kit, and target molecule detection device
WO2012133920A1 (ja) * 2011-03-31 2012-10-04 国立大学法人九州大学 固体色素レーザー媒質およびその製造方法
CA2856304C (en) 2011-04-20 2017-05-16 Mesa Tech International, Inc. Oscillating amplification reaction for nucleic acids
US20120288866A1 (en) * 2011-05-11 2012-11-15 Genturadx, Inc. Systems and methods for producing an evaporation barrier in a reaction chamber
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US20130137108A1 (en) * 2011-10-25 2013-05-30 Anubhav Tripathi Magnetic bead separation apparatus and method
US20130158240A1 (en) 2011-12-15 2013-06-20 David Beebe Method Of Extracting A Fraction From A Biological Sample
US20150299766A1 (en) * 2012-02-23 2015-10-22 Dow Agrosciences Llc Automation of barrier-based plant nucleic acid and protein extraction
GB2561425B (en) 2012-03-16 2019-01-16 Cambridge Entpr Ltd Apparatus for obtaining liquid from a solid phase
WO2013169730A1 (en) 2012-05-08 2013-11-14 Quidel Corporation Device for isolating an analyte from a sample, and methods of use
EP2846912A1 (en) 2012-05-08 2015-03-18 North Western University Cartridge for use in an automated system for isolating an analyte from a sample, and methods of use
WO2014031786A1 (en) * 2012-08-23 2014-02-27 Northwestern University Device with controlled fluid dynamics, for isolation of an analyte from a sample
US10564077B2 (en) 2012-09-05 2020-02-18 Wisconsin Alumni Research Foundation Device for and method of isolating and analyzing a fraction in a biological sample
US8728411B2 (en) 2012-09-05 2014-05-20 Wisconsin Alumni Research Foundation Device for and method of isolating a fraction in a biological sample
US9766166B2 (en) 2013-01-09 2017-09-19 Wisconsin Alumni Research Foundation Device and method incorporating a slideable lid for extracting a targeted fraction from a sample
JP6120518B2 (ja) * 2012-10-10 2017-04-26 公益財団法人かずさDna研究所 簡易測定器具
US9347056B2 (en) 2012-10-26 2016-05-24 Seiko Epson Corporation Nucleic acid extraction device, and nucleic acid extraction method, nucleic acid extraction kit, and nucleic acid extraction apparatus, each using the same
JP2014093988A (ja) * 2012-11-12 2014-05-22 Seiko Epson Corp 固相担体の操作方法及び固相担体の操作装置
WO2014138563A1 (en) 2013-03-07 2014-09-12 Quidel Corporation Dual chamber liquid packaging system
US9869675B2 (en) 2013-03-13 2018-01-16 Vanderbilt University Low resource processor using surface tension valves for extracting, concentrating, and detecting whole cells
US11029310B2 (en) 2013-03-14 2021-06-08 Wisconsin Alumni Research Foundation Device and method for extracting a targeted fraction from a sample
TWI639705B (zh) * 2016-03-01 2018-11-01 奎克生技光電股份有限公司 多工試片裝置及其操作方法
US11135592B2 (en) * 2013-06-27 2021-10-05 Quark Biosciences Taiwan, Inc. Multiplex slide plate device having storage tank
US10415084B2 (en) 2013-06-27 2019-09-17 Quark Biosciences Taiwan, Inc. Multiplex slide plate device and operation method thereof
TWI499779B (zh) * 2013-07-04 2015-09-11 Ind Tech Res Inst 檢測晶片及其使用方法
US9463461B2 (en) 2013-10-25 2016-10-11 The Johns Hopkins University Self-contained cartridge and methods for integrated biochemical assay at the point-of-care
CN103808923A (zh) * 2013-11-25 2014-05-21 珠海迪尔生物工程有限公司 一种可移动式磁分离荧光免疫检测分析方法及装置
JP2015104363A (ja) * 2013-11-29 2015-06-08 セイコーエプソン株式会社 核酸増幅反応用カートリッジ、及び核酸増幅反応用カートリッジキット
JP2015104364A (ja) * 2013-11-29 2015-06-08 セイコーエプソン株式会社 核酸増幅反応用容器、核酸増幅反応用カートリッジ、及び核酸増幅反応用カートリッジキット
WO2015086652A1 (en) 2013-12-12 2015-06-18 Altra Tech Limited A sample preparation method and apparatus
EP3080294B1 (en) 2013-12-12 2018-06-13 Altratech Limited A capacitive sensor and method of use
US10040062B2 (en) 2014-01-14 2018-08-07 Wisconsin Alumni Research Foundation Device and method for transferring a target between locations
US10195609B2 (en) * 2016-10-25 2019-02-05 Fannin Partners, LLC Assay wells with hydrogel as a well-contents separator and a pigment-based temperature indicator
CA2937975A1 (en) 2014-01-27 2015-07-30 Brevitest Technologies, Llc Discontinuous fluidic systems for point-of-care analyte measurement
US10828636B2 (en) 2016-10-25 2020-11-10 Fannin Partners Llc Automated remotely instructed driving of an assay
FR3017793B1 (fr) * 2014-02-21 2019-08-23 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment une substance biologique
FR3017792B1 (fr) * 2014-02-21 2019-08-23 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment une substance biologique
EP3161485B1 (en) 2014-06-25 2018-10-31 Koninklijke Philips N.V. Biosensor for the detection of target components in a sample
WO2016001963A1 (ja) * 2014-06-30 2016-01-07 株式会社日立製作所 核酸解析用アレイデバイス、核酸解析装置及び核酸解析方法
AU2015286488B2 (en) 2014-07-08 2020-07-16 Japan Science And Technology Agency Substance sealing method and target molecule detecting method
JP2016067275A (ja) * 2014-09-30 2016-05-09 セイコーエプソン株式会社 核酸精製デバイス
JP2016093157A (ja) * 2014-11-17 2016-05-26 セイコーエプソン株式会社 容器収納体
JP2016093158A (ja) * 2014-11-17 2016-05-26 セイコーエプソン株式会社 容器収納体
JP2016093156A (ja) * 2014-11-17 2016-05-26 セイコーエプソン株式会社 容器収納体
US10616219B2 (en) * 2014-12-11 2020-04-07 FlowJo, LLC Single cell data management and analysis systems and methods
CN104714026B (zh) * 2014-12-31 2018-08-21 北京热景生物技术股份有限公司 一种甲胎蛋白异质体的分离检测组合物、系统及其应用
JP6830443B2 (ja) 2015-04-24 2021-02-17 メサ バイオテック,インク. 流体検査用カセット
WO2016184924A1 (en) * 2015-05-19 2016-11-24 Bio-Rad Innovations Use of a low-density immiscible compound in a device for detecting an analyte in a sample
JP6651794B2 (ja) * 2015-11-05 2020-02-19 富士レビオ株式会社 心筋トロポニンi測定試薬及び方法
JP2017127224A (ja) * 2016-01-19 2017-07-27 株式会社島津製作所 核酸前処理キット、および塩基配列解析方法
DE102016209904A1 (de) * 2016-06-06 2017-12-07 Robert Bosch Gmbh Verfahren und mikrofluidische Vorrichtung zum Verarbeiten einer Probe biologischen Materials
US11249075B2 (en) * 2016-06-20 2022-02-15 Beckman Coulter, Inc. Dry-down processes for dye-conjugated reagents
US10590409B2 (en) * 2016-12-06 2020-03-17 Wisconsin Alumni Research Foundation Method and device for disaggregation via heterogeneous particles
ES2928184T3 (es) * 2016-12-12 2022-11-16 Cepheid Inmuno-PCR integrado y análisis de ácidos nucleicos en un cartucho de reacción automatizado
US12300357B2 (en) 2016-12-14 2025-05-13 FlowJo, LLC Applied computer technology for management, synthesis, visualization, and exploration of parameters in large multi-parameter data sets
US11573182B2 (en) 2017-05-25 2023-02-07 FlowJo, LLC Visualization, comparative analysis, and automated difference detection for large multi-parameter data sets
WO2018226891A1 (en) 2017-06-06 2018-12-13 Northwestern University Trans-interfacial magnetic separation
WO2018234115A1 (en) 2017-06-19 2018-12-27 Lab-On-A-Bead Ab Combinatory separation
EP3460077B1 (en) * 2017-09-20 2020-06-17 Altratech Limited Diagnostic device and system
WO2019057515A1 (en) 2017-09-20 2019-03-28 Altratech Limited DIAGNOSTIC SYSTEM AND DEVICE
CN107748160B (zh) * 2017-09-21 2020-06-02 中山大学 一种poct即用型微流控芯片及应用方法
CN107561262A (zh) * 2017-09-30 2018-01-09 郑州安图生物工程股份有限公司 一体化生物及化学反应装置
US20200292565A1 (en) * 2017-10-11 2020-09-17 Shanghai Rendu Biotechnology Co., Ltd. Automated nucleic acid sample preparation, detection, and analysis system
CN108796038B (zh) * 2018-06-26 2019-10-18 杭州优思达生物技术有限公司 一种核酸一体化检测方法及检测试剂管
CN114258321B (zh) * 2019-03-12 2023-09-15 诺维卢克斯有限责任公司 即时浓度分析仪
EP4031647A4 (en) * 2019-09-20 2023-03-01 Siemens Healthcare Diagnostics, Inc. IMPROVED ROTOR MIXER FOR STIRRING FLUIDS DURING SAMPLE PREPARATION
EP4118204B1 (en) * 2020-03-13 2024-11-13 Siemens Healthcare Diagnostics, Inc. A sample lysis and nucleic acid extraction apparatus
US20230201833A1 (en) * 2020-05-28 2023-06-29 The Johns Hopkins University Magnetofluidic cartridges, devices and related methods of sample analysis
US12269031B2 (en) 2020-06-05 2025-04-08 Wisconsin Alumni Research Foundation Device and method for accelerated material extraction and detection
BR112023015291A2 (pt) 2021-01-29 2023-11-07 Abbott Diagnostics Scarborough Inc Transferência de ar por partículas magnéticas
EP4334469A4 (en) * 2021-05-06 2025-01-29 Abbott Molecular Inc. COMPOSITIONS AND METHODS OF COLLECTION OF SINGLE SAMPLES
GB2618578A (en) * 2022-05-11 2023-11-15 Stratec Se Method and consumable for nucleic acid extraction
DE102022111890B3 (de) 2022-05-12 2023-03-16 Dermagnostix GmbH Verfahren zur Deparaffinierung von Formalin-fixiertem Paraffin-eingebettetem Gewebe
JP7784545B2 (ja) * 2022-06-14 2025-12-11 株式会社日立ハイテク 核酸溶離液及び当該核酸溶離液を用いた核酸の溶離方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921612A (en) * 1985-10-22 1990-05-01 The Trustees Of Stevens Institute Of Technology Asymmetrically-wettable porous membrane process
ATE91023T1 (de) * 1987-12-01 1993-07-15 Biotope Inc Verfahren und vorrichtungen zur durchfuehrung von untersuchungen.
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5279936A (en) * 1989-12-22 1994-01-18 Syntex (U.S.A.) Inc. Method of separation employing magnetic particles and second medium
AU675054B2 (en) * 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
KR100463475B1 (ko) * 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5912129A (en) * 1998-03-05 1999-06-15 Vinayagamoorthy; Thuraiayah Multi-zone polymerase/ligase chain reaction
US6328782B1 (en) * 2000-02-04 2001-12-11 Commodore Separation Technologies, Inc. Combined supported liquid membrane/strip dispersion process for the removal and recovery of radionuclides and metals
TW517154B (en) * 1999-08-11 2003-01-11 Asahi Chemical Ind Analyzing cartridge and liquid feed control device
US20020151040A1 (en) * 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
FI120863B (fi) * 2002-10-18 2010-04-15 Biocontrol Systems Inc Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
EP1603674B1 (en) * 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
FR2858688A1 (fr) * 2003-08-04 2005-02-11 Gilbert Skorski Methode et dispositif pour mesurer plusieurs parametres biochimiques dans un echantillon
WO2005069015A1 (ja) 2004-01-15 2005-07-28 Japan Science And Technology Agency 化学分析装置及び化学分析方法
US7445939B2 (en) * 2004-02-27 2008-11-04 Varian, Inc. Stable liquid membranes for liquid phase microextraction
US7867443B2 (en) * 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
CA2592204C (en) * 2004-12-23 2013-03-12 I-Stat Corporation Nucleic acid diagnostics system and methods
EP1890157A4 (en) * 2005-06-07 2011-11-02 Arkray Inc LIQUID REPLACEMENT METHOD, COMPONENT EXTRACTING METHOD, COMPOSITE CONTAINER, AND AUTOMATIC ANALYZER
WO2007022026A2 (en) * 2005-08-11 2007-02-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
AU2006299414A1 (en) * 2005-09-30 2007-04-12 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
WO2007094739A1 (en) * 2006-02-13 2007-08-23 Agency For Science, Technology And Research Method of processing a biological and/or chemical sample
JP4987885B2 (ja) * 2006-03-09 2012-07-25 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ 小滴中で反応を行うための装置及びその使用方法
ATE490971T1 (de) * 2006-04-18 2010-12-15 Advanced Liquid Logic Inc Biochemie auf tröpfchenbasis
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US7745129B1 (en) * 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
US7820454B2 (en) * 2006-12-29 2010-10-26 Intel Corporation Programmable electromagnetic array for molecule transport
US8298763B2 (en) * 2007-03-02 2012-10-30 Lawrence Livermore National Security, Llc Automated high-throughput flow-through real-time diagnostic system
EP2072133A1 (en) * 2007-12-20 2009-06-24 Koninklijke Philips Electronics N.V. Multi-compartment device with magnetic particles
EP2257802A4 (en) * 2008-02-29 2014-07-02 Univ Northwestern BARRIER FOR BIOLOGICAL REACTIONS

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