CA2716411C - Apparatus for the separation of plasma - Google Patents
Apparatus for the separation of plasma Download PDFInfo
- Publication number
- CA2716411C CA2716411C CA2716411A CA2716411A CA2716411C CA 2716411 C CA2716411 C CA 2716411C CA 2716411 A CA2716411 A CA 2716411A CA 2716411 A CA2716411 A CA 2716411A CA 2716411 C CA2716411 C CA 2716411C
- Authority
- CA
- Canada
- Prior art keywords
- channel
- sample liquid
- membrane
- blood
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000926 separation method Methods 0.000 title description 8
- 239000007788 liquid Substances 0.000 claims abstract description 94
- 239000012528 membrane Substances 0.000 claims abstract description 68
- 210000004369 blood Anatomy 0.000 claims abstract description 33
- 239000008280 blood Substances 0.000 claims abstract description 33
- 239000012503 blood component Substances 0.000 claims abstract description 9
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 abstract description 35
- 239000000126 substance Substances 0.000 description 23
- 239000000463 material Substances 0.000 description 15
- 238000011835 investigation Methods 0.000 description 12
- 238000010276 construction Methods 0.000 description 10
- 239000012530 fluid Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000003466 welding Methods 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 238000007493 shaping process Methods 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 238000009736 wetting Methods 0.000 description 4
- 238000004026 adhesive bonding Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 230000004941 influx Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/014—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements with curved filtering elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/05—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements supported
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/087—Single membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2201/00—Details relating to filtering apparatus
- B01D2201/04—Supports for the filtering elements
- B01D2201/0415—Details of supporting structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2201/00—Details relating to filtering apparatus
- B01D2201/44—Special measures allowing the even or uniform distribution of fluid along the length of a conduit
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008011339 | 2008-02-27 | ||
| DE102008011339.5 | 2008-02-27 | ||
| PCT/EP2009/001383 WO2009106331A2 (de) | 2008-02-27 | 2009-02-26 | Vorrichtung zur plasmaseparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2716411A1 CA2716411A1 (en) | 2009-09-03 |
| CA2716411C true CA2716411C (en) | 2015-11-24 |
Family
ID=40640360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2716411A Active CA2716411C (en) | 2008-02-27 | 2009-02-26 | Apparatus for the separation of plasma |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9539572B2 (enExample) |
| EP (1) | EP2268405B1 (enExample) |
| JP (1) | JP5475692B2 (enExample) |
| CN (1) | CN101959602A (enExample) |
| AU (1) | AU2009218752B2 (enExample) |
| BR (1) | BRPI0907148B1 (enExample) |
| CA (1) | CA2716411C (enExample) |
| MX (1) | MX346456B (enExample) |
| RU (1) | RU2523681C2 (enExample) |
| WO (1) | WO2009106331A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2950544B1 (fr) * | 2009-09-29 | 2011-12-09 | Ecole Polytech | Circuit microfluidique |
| US8496889B2 (en) * | 2010-03-23 | 2013-07-30 | California Institute Of Technology | Microfluidic device for separating and sorting particles in a fluid medium |
| EP2413138B1 (de) * | 2010-07-27 | 2020-04-29 | BOEHRINGER INGELHEIM microParts GmbH | Vorrichtung und verfahren zur abtrennung von bestandteilen einer probenflüssigkeit |
| JP5850373B2 (ja) | 2010-07-27 | 2016-02-03 | ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミットベシュレンクテル ハフツングＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ ｍｉｃｒｏＰａｒｔｓ ＧｍｂＨ | サンプル液体の成分を分離する器具及び方法 |
| US9116089B2 (en) | 2010-11-10 | 2015-08-25 | Boehringer Ingelheim Microparts Gmbh | Device for filtering blood |
| EP2688672A2 (de) | 2011-03-24 | 2014-01-29 | Boehringer Ingelheim Microparts GmbH | Vorrichtung und verfahren zur filtration von blut |
| US20130084647A1 (en) * | 2011-09-30 | 2013-04-04 | Michael W. LaCourt | Disposable foil punch for immunohematology test elements |
| US9386948B2 (en) | 2012-12-05 | 2016-07-12 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample transport |
| US10248765B1 (en) | 2012-12-05 | 2019-04-02 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection, transport, and handling |
| JP2014173937A (ja) * | 2013-03-07 | 2014-09-22 | Toshiba Corp | 半導体マイクロ分析チップ及び検体流動方法 |
| EP2972184A4 (en) | 2013-03-15 | 2016-11-30 | Theranos Inc | Methods and devices for sample collection and sample separation |
| US20140323911A1 (en) * | 2013-03-15 | 2014-10-30 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| ES2539843B2 (es) * | 2013-11-15 | 2015-11-16 | Universitat Politècnica De Catalunya | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
| JP6566319B2 (ja) * | 2013-12-03 | 2019-08-28 | 国立大学法人 東京大学 | 分離ユニット、分離方法、流体デバイス、複合型流体デバイス及びキット |
| WO2015095491A1 (en) * | 2013-12-19 | 2015-06-25 | The Trustees Of The University Of Pennsylvania | Plasma separator apparatus and associated methods |
| CA2953755C (en) * | 2014-07-03 | 2022-05-03 | Abionic Sa | Capsule for rapid molecular quantification of a fluid sample such as whole blood |
| US10071373B2 (en) | 2014-08-08 | 2018-09-11 | Ortho-Clinical Diagnostics, Inc. | Lateral-flow assay device having flow constrictions |
| US11033896B2 (en) | 2014-08-08 | 2021-06-15 | Ortho-Clinical Diagnostics, Inc. | Lateral-flow assay device with filtration flow control |
| US10073091B2 (en) * | 2014-08-08 | 2018-09-11 | Ortho-Clinical Diagnostics, Inc. | Lateral flow assay device |
| CN107108199B (zh) * | 2014-11-11 | 2020-01-10 | 微研生物科技有限公司 | 用于研究基于细胞的相互作用的微流体平台 |
| US10690653B2 (en) | 2014-12-12 | 2020-06-23 | The Trustees Of The University Of Pennsylvania | Fluid separator for point of care molecular diagnostics |
| US10829804B2 (en) | 2015-03-23 | 2020-11-10 | The University Of North Carolina At Chapel Hill | Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or DNA methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions |
| EP3274091B1 (en) * | 2015-03-23 | 2020-12-02 | The University of North Carolina at Chapel Hill | Universal molecular processor for precision medicine |
| CA2989764C (en) | 2015-06-20 | 2021-11-30 | Goran Stemme | A plasma separating microfluidic device |
| WO2016208362A1 (ja) * | 2015-06-22 | 2016-12-29 | 株式会社村田製作所 | 濾過フィルター |
| US10371606B2 (en) | 2015-07-21 | 2019-08-06 | Theraos IP Company, LLC | Bodily fluid sample collection and transport |
| WO2017044888A1 (en) | 2015-09-09 | 2017-03-16 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| US10730044B2 (en) | 2015-10-01 | 2020-08-04 | The Regents Of The University Of Michigan | Assay plate and uses thereof |
| US10369567B2 (en) * | 2015-11-04 | 2019-08-06 | International Business Machines Corporation | Continuous, capacitance-based monitoring of liquid flows in a microfluidic device |
| WO2017210199A1 (en) | 2016-05-31 | 2017-12-07 | Oregon State University | Fluidic devices for chromatographic separation and methods of making and using the same |
| CN116747613B (zh) * | 2016-06-07 | 2024-07-19 | 苏州苏瑞膜纳米科技有限公司 | 流体处理装置及其制备方法 |
| JP6729026B2 (ja) * | 2016-06-15 | 2020-07-22 | ウシオ電機株式会社 | マイクロ流路チップおよび検体濃度測定装置 |
| KR101891401B1 (ko) * | 2016-08-12 | 2018-08-23 | 고려대학교 산학협력단 | 미세유체 소자 및 이의 제조방법 |
| RU175245U1 (ru) * | 2017-01-13 | 2017-11-28 | Сергей Викторович Минаев | Сепарационное устройство для определения биохимических показателей и маркеров заболеваний в плазме крови |
| US11857966B1 (en) | 2017-03-15 | 2024-01-02 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
| CN108722504A (zh) * | 2017-04-19 | 2018-11-02 | 光宝电子(广州)有限公司 | 检测装置及其注入口结构 |
| JP6877745B2 (ja) * | 2017-06-08 | 2021-05-26 | セルスペクト株式会社 | 血漿分離装置及び血漿分離方法 |
| TWI651074B (zh) * | 2017-10-25 | 2019-02-21 | 台達電子工業股份有限公司 | 粒子凝集混合方法及混合設備 |
| US11207455B2 (en) * | 2018-05-14 | 2021-12-28 | Oregon State University | Membrane device for blood separation and methods of making and using the same |
| JP2019209238A (ja) * | 2018-05-31 | 2019-12-12 | 日東電工株式会社 | 血液濾過膜 |
| CA3103453A1 (en) * | 2018-06-12 | 2019-12-19 | Nowdiagnostics, Inc. | Device and method for collecting plasma |
| US12326445B2 (en) | 2018-08-31 | 2025-06-10 | National Institute Of Advanced Industrial Science And Technology | Assay device |
| JP7409693B2 (ja) | 2018-09-06 | 2024-01-09 | キャピテイナー アーベー | マイクロ流体装置 |
| US10422729B1 (en) | 2019-03-08 | 2019-09-24 | Biodesix, Inc. | Blood sample separation devices and methods |
| US20220212474A1 (en) * | 2019-04-25 | 2022-07-07 | Kyocera Corporation | Flow path device, cartridge, and measurement system |
| CN120361622A (zh) * | 2019-10-02 | 2025-07-25 | 奥斯龙-明士克公司 | 血液成分收集和分离介质、血液成分收集和分离装置以及血液成分分离和提取方法 |
| CN113828028A (zh) * | 2021-10-31 | 2021-12-24 | 康硕(江西)智能制造有限公司 | 一种可更换滤网3d打印用陶瓷浆料过滤器 |
| US20250325986A1 (en) * | 2022-06-23 | 2025-10-23 | Solventum Intellectual Properties Company | Methods and devices for removing particles from fluids |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323536A (en) | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
| JPH06103300B2 (ja) | 1986-03-25 | 1994-12-14 | ピービー ダイアグノスティック システムズ，インコーポレーテッド | 生物学的診断装置 |
| US6767510B1 (en) | 1992-05-21 | 2004-07-27 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US6156270A (en) * | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US5458852A (en) | 1992-05-21 | 1995-10-17 | Biosite Diagnostics, Inc. | Diagnostic devices for the controlled movement of reagents without membranes |
| GB9324310D0 (en) * | 1993-11-26 | 1994-01-12 | Univ Birmingham | Liquid transfer device |
| US5756129A (en) * | 1994-07-01 | 1998-05-26 | Kabushiki Kaisha Kobe Seiko Sho | Filter member and screen changer for use in resin extruder |
| US5733449A (en) * | 1995-12-08 | 1998-03-31 | Orbital Biosciences, Llc | Microconcentrator device |
| US5922604A (en) * | 1997-06-05 | 1999-07-13 | Gene Tec Corporation | Thin reaction chambers for containing and handling liquid microvolumes |
| DE19753849A1 (de) | 1997-12-04 | 1999-06-10 | Roche Diagnostics Gmbh | Analytisches Testelement mit sich verjüngendem Kapillarkanal |
| WO2001024931A1 (en) | 1999-10-05 | 2001-04-12 | Roche Diagnostic Gmbh | Capillary device for separating undesired components from a liquid sample and related method |
| AU2001274558A1 (en) * | 2000-06-20 | 2002-01-02 | Kawamura Institute Of Chemical Research | Microdevice having multilayer structure and method for fabricating the same |
| DK1201304T3 (da) | 2000-10-25 | 2006-11-13 | Boehringer Ingelheim Micropart | Mikrostruktureret platform til undersögelse af en væske |
| US6776294B2 (en) * | 2000-12-18 | 2004-08-17 | Millipore Corporation | Device for microbiological examination of a sample of liquid under pressure and method for draining this device |
| AU2002352746A1 (en) * | 2001-11-15 | 2003-06-10 | Arryx, Inc. | Sample chip |
| SE0201738D0 (sv) | 2002-06-07 | 2002-06-07 | Aamic Ab | Micro-fluid structures |
| DE10326607A1 (de) * | 2003-06-13 | 2005-01-05 | Steag Microparts Gmbh | Vorrichtung zum Handhaben von Flüssigkeiten |
| US20040265171A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
| US6938526B2 (en) * | 2003-07-30 | 2005-09-06 | Black & Decker Inc. | Impact wrench having an improved anvil to square driver transition |
| KR20060079791A (ko) * | 2003-08-08 | 2006-07-06 | 마이크롤리스 코포레이션 | 단순형 필터 장치 |
| DE10352535A1 (de) * | 2003-11-07 | 2005-06-16 | Steag Microparts Gmbh | Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit |
| DE10360220A1 (de) * | 2003-12-20 | 2005-07-21 | Steag Microparts Gmbh | Mikrostrukturierte Anordnung zur blasenfreien Befüllung zumindest eines Systems zur Ableitung von Flüssigkeiten, Vorrichtung mit einer solchen Anordnung und Befüllungsverfahren |
| DE102004027422A1 (de) * | 2004-06-04 | 2005-12-29 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen |
| EP1685900B1 (de) * | 2005-01-27 | 2011-03-30 | Boehringer Ingelheim microParts GmbH | Verwendung einer Vorrichtung zur Untersuchung von Probenflüssigkeit |
| DE102005017653A1 (de) * | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit |
| US7344465B2 (en) * | 2005-07-28 | 2008-03-18 | Caterpillar Inc. | Drive system for a machine |
-
2009
- 2009-02-26 BR BRPI0907148-2A patent/BRPI0907148B1/pt active IP Right Grant
- 2009-02-26 EP EP09714713.6A patent/EP2268405B1/de active Active
- 2009-02-26 WO PCT/EP2009/001383 patent/WO2009106331A2/de not_active Ceased
- 2009-02-26 AU AU2009218752A patent/AU2009218752B2/en active Active
- 2009-02-26 RU RU2010139578/14A patent/RU2523681C2/ru active
- 2009-02-26 US US12/867,335 patent/US9539572B2/en active Active
- 2009-02-26 CN CN200980106816XA patent/CN101959602A/zh active Pending
- 2009-02-26 JP JP2010548023A patent/JP5475692B2/ja active Active
- 2009-02-26 MX MX2010009331A patent/MX346456B/es active IP Right Grant
- 2009-02-26 CA CA2716411A patent/CA2716411C/en active Active
-
2016
- 2016-11-22 US US15/358,185 patent/US10363559B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0907148B1 (pt) | 2021-01-12 |
| CA2716411A1 (en) | 2009-09-03 |
| EP2268405A2 (de) | 2011-01-05 |
| CN101959602A (zh) | 2011-01-26 |
| US20110011781A1 (en) | 2011-01-20 |
| RU2010139578A (ru) | 2012-04-10 |
| WO2009106331A3 (de) | 2010-02-25 |
| US10363559B2 (en) | 2019-07-30 |
| JP5475692B2 (ja) | 2014-04-16 |
| AU2009218752B2 (en) | 2014-07-10 |
| US9539572B2 (en) | 2017-01-10 |
| BRPI0907148A2 (pt) | 2020-08-25 |
| EP2268405B1 (de) | 2017-01-04 |
| WO2009106331A2 (de) | 2009-09-03 |
| MX346456B (es) | 2017-03-21 |
| JP2011513718A (ja) | 2011-04-28 |
| RU2523681C2 (ru) | 2014-07-20 |
| WO2009106331A4 (de) | 2010-04-22 |
| AU2009218752A1 (en) | 2009-09-03 |
| US20170165666A1 (en) | 2017-06-15 |
| MX2010009331A (es) | 2010-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2716411C (en) | Apparatus for the separation of plasma | |
| JP4977601B2 (ja) | 血液を収集して血液成分を分離するデバイス、血液成分を分離する方法及びデバイスの用途 | |
| JP3234369U (ja) | 試料流体分析用の使い捨てカートリッジ | |
| EP2560756B1 (de) | Vorrichtung zur plasmaseparation mittels einer zentralen kanalstruktur | |
| US8956530B2 (en) | System for separating bodily fluid constituents and method for producing such a system | |
| TWI356164B (en) | Injector pump and device comprising the same | |
| US9333707B2 (en) | Joining method and joint for microfluidic components | |
| EP2191279B1 (en) | Microfluidic chip for analysis of fluid sample | |
| JP4102796B2 (ja) | キャピラリチャンネルを形成する網目状構造物（ｎｅｔｗｏｒｋ）を含んでなる分析用テストエレメント | |
| EP3049186B1 (de) | Analyseeinheit zum durchführen einer polymerasekettenreaktion, verfahren zum betreiben einer solchen analyseeinheit und verfahren zum herstellen einer solchen analyseeinheit | |
| US8470259B2 (en) | Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis | |
| WO2019219844A1 (de) | Fluidisches system zur aufnahme, abgabe und bewegung von flüssigkeiten, verfahren zur verarbeitung von fluiden in einem fluidischen system | |
| CN207102625U (zh) | 一种微流体分析盒 | |
| EP2353721A2 (en) | Microfluidic device | |
| CN113167785B (zh) | 微流体装置 | |
| EP3544790B1 (en) | Ultrasonic welding of a microfluidic device | |
| US11090650B2 (en) | Method for manufacturing a test element for detecting an analyte in a body fluid | |
| GB2616016A (en) | Integrated microfluidic test strip | |
| WO2020165501A1 (en) | Sample handling device | |
| HK1022214A1 (en) | Process for the production of analytical devices | |
| HK1022214B (en) | Process for the production of analytical devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140214 |