JP7409693B2 - マイクロ流体装置 - Google Patents
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- 238000005259 measurement Methods 0.000 claims description 67
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- 239000008280 blood Substances 0.000 claims description 49
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- 239000012530 fluid Substances 0.000 claims description 22
- 238000000926 separation method Methods 0.000 claims description 16
- 238000011049 filling Methods 0.000 claims description 15
- 239000012528 membrane Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 3
- 230000037361 pathway Effects 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 description 5
- 210000000601 blood cell Anatomy 0.000 description 4
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- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
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- 230000036962 time dependent Effects 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
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- 102000008857 Ferritin Human genes 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
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- 238000010241 blood sampling Methods 0.000 description 1
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- 230000003993 interaction Effects 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000409 membrane extraction Methods 0.000 description 1
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- 229940126585 therapeutic drug Drugs 0.000 description 1
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- 238000007704 wet chemistry method Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/126—Paper
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Description
Claims (19)
- 画定された体積の血漿を輸送およびサンプリングし、入口(101)から出口(203)まで流体通路を提供するためのマイクロ流体装置であって、
前記入口(101)を有する第1の領域であって、第1の流動抵抗を有し、全血サンプルを受け取って収集し、かつ血漿を分離するように構成される、第1の領域と、
前記出口(203)を有する第2の領域であって、第2の流動抵抗を有し、前記第1の領域と流体連通し、分離された血漿を計測するように構成される、第2の領域と、
前記第1の領域と前記第2の領域との間の流体コネクタと、
前記出口(203)と流体連通し、前記第1の領域から前記第2の領域の血漿を分離しながら、前記第2の領域の計測される血漿体積を輸送および吸収するのに十分に強い毛細管力を発揮するように構成された毛細管手段(204)と、を備え、
前記第2の領域は、少なくとも1つのベントを備えて配置され、
前記第1の領域の有効な第1の流動抵抗は、血漿を輸送するときに、どの時点においても、前記第2の領域の有効な第2の流動抵抗の値の少なくとも2倍である、マイクロ流体装置。 - 前記第1の領域は、前記入口(101)を含む血漿抽出区画(100)を備え、前記血漿抽出区画は、全血サンプルを受け取って収集し、かつ血漿を分離するように構成され、
前記第2の領域は、前記流体コネクタ(201)により前記出口(203)と前記血漿抽出区画(100)に流体連通される計測チャネル(202)を含む、請求項1に記載の装置。 - 前記計測チャネル(202)は、0.5μl~50μlの体積を有する、請求項2に記載の装置。
- 前記血漿抽出区画(100)は、全血リザーバ(102)と、血漿分離膜(103)と、分離された血漿を収集するための血漿濾過チャンバ(104)のうちの少なくとも1つを備える、請求項2または3に記載の装置。
- 前記流体コネクタは、接続チャネル(201)であり、前記接続チャネル(201)と前記計測チャネル(202)は、異なる諸元を有し、前記諸元は、断面積および/または長さを含む、請求項2~4のいずれか一項に記載の装置。
- 前記接続チャネル(201)は、前記計測チャネル(202)よりも小さい断面積を有する、請求項5に記載の装置。
- 前記接続チャネル(201)は、前記断面積の急激な変化を伴って前記計測チャネル(202)に接続される、請求項5または6に記載の装置。
- 前記接続チャネル(201)は、前記接続チャネル(201)と前記計測チャネル(202)との長手方向の対称軸がそれぞれ90°以下の角度(V)で交差するような方法で、前記計測チャネル(202)と交わる、請求項5~7のいずれか一項に記載の装置。
- 前記計測チャネル(202)は、終端(b)を有する少なくとも1つの分岐を有する、請求項5~8のいずれか一項に記載の装置。
- 前記接続チャネル(201)は、前記計測チャネル(202)を2つの非対称部に分割する点(C)で前記計測チャネル(202)と交わり、第1の部分は第2の部分よりも充填時間が長く、前記出口(203)に接続される、請求項5~9のいずれか一項に記載の装置。
- 前記第1の部分は、前記出口(203)に接続される長い部分(L1)であり、第2の部分は、終端(b)に接続される短い部分(L2)である、請求項10に記載の装置。
- 前記流体コネクタは、前記血漿抽出区画(100)の出口オリフィスと前記計測チャネル(202)の入口との間の接続部であり、好ましくは、該入口から前記出口へ直線状に延在する、請求項2~4のいずれか一項に記載の装置。
- 前記流体コネクタにはベントが設けられている、請求項12に記載の装置。
- 前記全血リザーバは、前記血漿分離膜への血液の流入を制限するように構成され、前記全血リザーバは、前記計測チャネルが1回のみ充填できるように構成される、請求項4に記載の装置。
- 前記出口と前記毛細管手段との間に延在する架橋要素を備える、請求項1~14のいずれか一項に記載の装置。
- 全血リザーバ、計測チャネル、出口領域のうちの少なくとも1つから選択される位置に配置された少なくとも1つのベントを備える、請求項1~14のいずれか一項に記載の装置。
- ベントは血漿分離膜に接続された全血リザーバに配置され、ベントは前記計測チャネルの分岐部に配置され、ベントは前記出口に接続して配置される、請求項16に記載の装置。
- 請求項1~17のいずれか一項に記載の装置により全血のサンプルから計測される体積の血漿を得る方法であって、
(a) 血漿マイクロ流体通路を提供する構造の入口で全血サンプルを受け取るステップと、
(b) 全血から血漿を分離し、血漿抽出チャンバから前記流体通路の計測チャネルへ第1の流動抵抗で血漿を輸送するステップと、
(c)毛細管手段との液体接触を成立させる出口を通して、前記第1の流動抵抗よりも低い第2の流動抵抗で前記計測チャネルを充填するために血漿を受け入れるステップと、
(d) 前記流体通路に残留する血漿を分離しながら、前記毛細管手段の毛細管力によって前記計測チャネルを空にするステップと、
(e) 前記毛細管手段で計測される体積を有する血漿サンプルを得るステップと、を含む方法。 - 前記計測チャネルの少なくとも1つの短い分岐を終端で充填し、続いて、前記計測チャネルのより長い分岐を前記出口と共に充填し、それにより、前記毛細管手段との液体接触を成立させるステップを含む、請求項18に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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SE1830253 | 2018-09-06 | ||
SE1830253-9 | 2018-09-06 | ||
SE1950149-3 | 2019-02-08 | ||
SE1950149 | 2019-02-08 | ||
PCT/SE2019/050837 WO2020050770A1 (en) | 2018-09-06 | 2019-09-05 | A microfluidic device |
Publications (3)
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JP2022504018A JP2022504018A (ja) | 2022-01-13 |
JPWO2020050770A5 JPWO2020050770A5 (ja) | 2022-08-30 |
JP7409693B2 true JP7409693B2 (ja) | 2024-01-09 |
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US (1) | US20210316300A1 (ja) |
EP (1) | EP3847458A4 (ja) |
JP (1) | JP7409693B2 (ja) |
CN (1) | CN113167785A (ja) |
WO (1) | WO2020050770A1 (ja) |
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EP4363110A1 (en) | 2021-06-29 | 2024-05-08 | Capitainer AB | Microfluidic devices |
WO2023277773A1 (en) | 2021-06-29 | 2023-01-05 | Capitainer Ab | Microfluidic devices |
Citations (6)
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JP2000074907A (ja) | 1998-09-01 | 2000-03-14 | Fuji Photo Film Co Ltd | 血液成分分離器 |
JP2003194806A (ja) | 2001-12-27 | 2003-07-09 | Minolta Co Ltd | 血球分離用チップ |
JP2008501938A (ja) | 2004-06-04 | 2008-01-24 | ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血液を収集して血液成分を分離するデバイス、血液成分を分離する方法及びデバイスの用途 |
WO2015044454A2 (en) | 2013-09-30 | 2015-04-02 | Göran Stemme | A microfluidic device, use and methods |
US20170065973A1 (en) | 2015-09-04 | 2017-03-09 | North Carolina State University | Passive pumps for microfluidic devices |
JP2018524612A (ja) | 2015-06-20 | 2018-08-30 | キャピテイナー アーベー | 血漿分離マイクロ流体デバイス |
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BRPI0907148B1 (pt) | 2008-02-27 | 2021-01-12 | Boehringer Ingelheim Microparts Gmbh | dispositivo para a separação do plasma |
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US10532325B2 (en) * | 2014-06-13 | 2020-01-14 | GattaCo, Inc | Capillary pressure re-set mechanism and applications |
WO2017015243A1 (en) * | 2015-07-21 | 2017-01-26 | Mcneely Michael Ryan | Automatic plasma separation and metering |
-
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- 2019-09-05 WO PCT/SE2019/050837 patent/WO2020050770A1/en unknown
- 2019-09-05 EP EP19857238.0A patent/EP3847458A4/en active Pending
- 2019-09-05 CN CN201980063512.3A patent/CN113167785A/zh active Pending
- 2019-09-05 JP JP2021512540A patent/JP7409693B2/ja active Active
- 2019-09-05 US US17/273,890 patent/US20210316300A1/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000074907A (ja) | 1998-09-01 | 2000-03-14 | Fuji Photo Film Co Ltd | 血液成分分離器 |
JP2003194806A (ja) | 2001-12-27 | 2003-07-09 | Minolta Co Ltd | 血球分離用チップ |
JP2008501938A (ja) | 2004-06-04 | 2008-01-24 | ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血液を収集して血液成分を分離するデバイス、血液成分を分離する方法及びデバイスの用途 |
WO2015044454A2 (en) | 2013-09-30 | 2015-04-02 | Göran Stemme | A microfluidic device, use and methods |
JP2018524612A (ja) | 2015-06-20 | 2018-08-30 | キャピテイナー アーベー | 血漿分離マイクロ流体デバイス |
US20170065973A1 (en) | 2015-09-04 | 2017-03-09 | North Carolina State University | Passive pumps for microfluidic devices |
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Publication number | Publication date |
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US20210316300A1 (en) | 2021-10-14 |
EP3847458A4 (en) | 2022-06-15 |
EP3847458A1 (en) | 2021-07-14 |
WO2020050770A1 (en) | 2020-03-12 |
JP2022504018A (ja) | 2022-01-13 |
CN113167785A (zh) | 2021-07-23 |
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