CA2713871C - Sequences associated with tdp-43 proteinopathies and methods of using the same - Google Patents

Sequences associated with tdp-43 proteinopathies and methods of using the same Download PDF

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Publication number
CA2713871C
CA2713871C CA2713871A CA2713871A CA2713871C CA 2713871 C CA2713871 C CA 2713871C CA 2713871 A CA2713871 A CA 2713871A CA 2713871 A CA2713871 A CA 2713871A CA 2713871 C CA2713871 C CA 2713871C
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Canada
Prior art keywords
seq
tdp
amino acid
array
subject
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CA2713871A
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English (en)
French (fr)
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CA2713871A1 (en
Inventor
Nigel J. Cairns
Robert H. Baloh
Alan Pestronk
Michael A. Gitcho
Alison M. Goate
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Washington University in St Louis WUSTL
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Washington University in St Louis WUSTL
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2713871A 2008-02-01 2009-01-30 Sequences associated with tdp-43 proteinopathies and methods of using the same Active CA2713871C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2537708P 2008-02-01 2008-02-01
US61/025,377 2008-02-01
PCT/US2009/032627 WO2009099941A2 (en) 2008-02-01 2009-01-30 Sequences associated with tdp-43 proteinopathies and methods of using the same

Publications (2)

Publication Number Publication Date
CA2713871A1 CA2713871A1 (en) 2009-08-13
CA2713871C true CA2713871C (en) 2018-05-22

Family

ID=40952637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2713871A Active CA2713871C (en) 2008-02-01 2009-01-30 Sequences associated with tdp-43 proteinopathies and methods of using the same

Country Status (4)

Country Link
US (3) US8889597B2 (https=)
JP (2) JP5798322B2 (https=)
CA (1) CA2713871C (https=)
WO (1) WO2009099941A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5798322B2 (ja) 2008-02-01 2015-10-21 ワシントン ユニバーシティ イン セント ルイス Ｔｄｐ−４３蛋白質症に関連した配列およびその使用法
CA2839777C (en) * 2011-06-22 2021-10-19 Universite Laval Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease
US9587014B2 (en) 2011-10-28 2017-03-07 Biogen International Neuroscience Gmbh TDP-43 specific binding molecules
ITRM20110582A1 (it) 2011-11-05 2013-05-06 Biotechnology Icgeb Modello cellulare per la selezione di molecole che influenzano l aggregazione di tdp-43
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
CN109563130A (zh) * 2016-04-07 2019-04-02 卡斯西部储备大学 用于治疗神经退行性疾病的tdp-43线粒体定位抑制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US7250289B2 (en) * 2002-11-20 2007-07-31 Affymetrix, Inc. Methods of genetic analysis of mouse
EP1815021A2 (en) * 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
JP5798322B2 (ja) 2008-02-01 2015-10-21 ワシントン ユニバーシティ イン セント ルイス Ｔｄｐ−４３蛋白質症に関連した配列およびその使用法

Also Published As

Publication number Publication date
US10683544B2 (en) 2020-06-16
US8889597B2 (en) 2014-11-18
WO2009099941A3 (en) 2009-10-01
JP2011510661A (ja) 2011-04-07
US9523128B2 (en) 2016-12-20
JP6051241B2 (ja) 2016-12-27
WO2009099941A2 (en) 2009-08-13
US20170067112A1 (en) 2017-03-09
CA2713871A1 (en) 2009-08-13
JP5798322B2 (ja) 2015-10-21
US20150065384A1 (en) 2015-03-05
US20110065600A1 (en) 2011-03-17
JP2015119721A (ja) 2015-07-02

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