JP5798322B2 - Tdp−43蛋白質症に関連した配列およびその使用法 - Google Patents

Tdp−43蛋白質症に関連した配列およびその使用法 Download PDF

Info

Publication number
JP5798322B2
JP5798322B2 JP2010545202A JP2010545202A JP5798322B2 JP 5798322 B2 JP5798322 B2 JP 5798322B2 JP 2010545202 A JP2010545202 A JP 2010545202A JP 2010545202 A JP2010545202 A JP 2010545202A JP 5798322 B2 JP5798322 B2 JP 5798322B2
Authority
JP
Japan
Prior art keywords
tdp
subject
proteinosis
seq
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2010545202A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011510661A (ja
Inventor
ケアンズ、ナイジェル、ジェイ.
バロー、ロバート、エイチ.
ペストロンク、アラン
ギッチョー、マイケル、エー.
ゴート、アリソン、エム.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington University in St Louis WUSTL
Original Assignee
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Washington University in St Louis WUSTL filed Critical Washington University in St Louis WUSTL
Publication of JP2011510661A publication Critical patent/JP2011510661A/ja
Application granted granted Critical
Publication of JP5798322B2 publication Critical patent/JP5798322B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2010545202A 2008-02-01 2009-01-30 Tdp−43蛋白質症に関連した配列およびその使用法 Active JP5798322B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2537708P 2008-02-01 2008-02-01
US61/025,377 2008-02-01
PCT/US2009/032627 WO2009099941A2 (en) 2008-02-01 2009-01-30 Sequences associated with tdp-43 proteinopathies and methods of using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015019179A Division JP6051241B2 (ja) 2008-02-01 2015-02-03 Tdp−43蛋白質症に関連した配列およびその使用法

Publications (2)

Publication Number Publication Date
JP2011510661A JP2011510661A (ja) 2011-04-07
JP5798322B2 true JP5798322B2 (ja) 2015-10-21

Family

ID=40952637

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010545202A Active JP5798322B2 (ja) 2008-02-01 2009-01-30 Tdp−43蛋白質症に関連した配列およびその使用法
JP2015019179A Active JP6051241B2 (ja) 2008-02-01 2015-02-03 Tdp−43蛋白質症に関連した配列およびその使用法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015019179A Active JP6051241B2 (ja) 2008-02-01 2015-02-03 Tdp−43蛋白質症に関連した配列およびその使用法

Country Status (4)

Country Link
US (3) US8889597B2 (https=)
JP (2) JP5798322B2 (https=)
CA (1) CA2713871C (https=)
WO (1) WO2009099941A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5798322B2 (ja) 2008-02-01 2015-10-21 ワシントン ユニバーシティ イン セント ルイス Tdp−43蛋白質症に関連した配列およびその使用法
CA2839777C (en) * 2011-06-22 2021-10-19 Universite Laval Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease
US9587014B2 (en) 2011-10-28 2017-03-07 Biogen International Neuroscience Gmbh TDP-43 specific binding molecules
ITRM20110582A1 (it) 2011-11-05 2013-05-06 Biotechnology Icgeb Modello cellulare per la selezione di molecole che influenzano l aggregazione di tdp-43
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
CN109563130A (zh) * 2016-04-07 2019-04-02 卡斯西部储备大学 用于治疗神经退行性疾病的tdp-43线粒体定位抑制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US7250289B2 (en) * 2002-11-20 2007-07-31 Affymetrix, Inc. Methods of genetic analysis of mouse
EP1815021A2 (en) * 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
JP5798322B2 (ja) 2008-02-01 2015-10-21 ワシントン ユニバーシティ イン セント ルイス Tdp−43蛋白質症に関連した配列およびその使用法

Also Published As

Publication number Publication date
US10683544B2 (en) 2020-06-16
US8889597B2 (en) 2014-11-18
WO2009099941A3 (en) 2009-10-01
JP2011510661A (ja) 2011-04-07
US9523128B2 (en) 2016-12-20
JP6051241B2 (ja) 2016-12-27
WO2009099941A2 (en) 2009-08-13
US20170067112A1 (en) 2017-03-09
CA2713871A1 (en) 2009-08-13
US20150065384A1 (en) 2015-03-05
US20110065600A1 (en) 2011-03-17
JP2015119721A (ja) 2015-07-02
CA2713871C (en) 2018-05-22

Similar Documents

Publication Publication Date Title
JP6051241B2 (ja) Tdp−43蛋白質症に関連した配列およびその使用法
Reed et al. Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history
JP2013178260A5 (https=)
US20020165349A1 (en) Iron regulating protein -2 (IRP-2) as a diagnostic for neurodegenerative disease
Veleri et al. REEP6 mediates trafficking of a subset of Clathrin-coated vesicles and is critical for rod photoreceptor function and survival
JP6378529B2 (ja) 遺伝性疾患の検出方法
US9150923B2 (en) Methods of identifying FHL1 mutations associated with novel X-linked muscular myopathies
KR20190043845A (ko) 감각신경성 난청 진단을 위한 마커 tmem43 및 그의 용도
US20050130171A1 (en) Genes expressed in Alzheimer's disease
KR101289134B1 (ko) 유전성 샤르코-마리-투스 말초신경병증의 cmt4b3 아형에 대한 원인 유전자로서의 sbf1(mtmr5) 돌연변이 유전자 및 이를 이용한 상기 질병의 진단방법 및 진단용 조성물
KR20220061737A (ko) 중추신경계 림프종을 진단하기 위한 마커, 이를 포함하는 중추신경계 림프종 진단 키트 및 중추신경계 림프종을 진단하는 방법
JP4546397B2 (ja) 腎臓疾患または素因を診断する方法
JP4691491B2 (ja) アルツハイマー病の診断および予後のための方法
CN111004844B (zh) 原发性家族性脑钙化致病基因jam2及其应用
Margolis et al. Huntington's disease-like 2: a clinical, pathological, and molecular comparison to Huntington's disease
Porteous et al. Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes
KR101289114B1 (ko) 조기발병하는 상염색체 열성 축삭형 샤르코-마리-투스병의 원인 유전자로서 hadhb 돌연변이 유전자, 이를 이용한 상기 질병의 진단방법 및 진단용 조성물
JP2006327951A (ja) 双極性感情障害、統合失調症等の精神病性障害の予防・治療剤、そのスクリーニング方法、及び該疾患の発症リスクの判定方法
WO2013111064A1 (en) Mutations of the gpr179 gene in congenital stationary night blindness
KR20210141131A (ko) 근육병 진단용 마커 및 그의 용도
CN111228517A (zh) Glb1点突变小鼠模型在gm1神经节苷脂贮积症的治疗药物筛选中的应用
EP4028124A1 (en) Compositions comprising rare genetic sequence variants associated with pulmonary function and methods of use thereof for diagnosis and treatment of asthma in african american patients
Roos et al. CHMP2B Frontotemporal Dementia Synonyms: CHMP2B-FTD, Chromosome 3-Linked Frontotemporal Dementia, FTD-3
Rolando et al. Post-genomic era and gene discovery for psychiatric diseases: There is a new art of the trade?
AU2008202723A1 (en) Iron Regulating Protein-2 (IRP-2) as a Diagnostic For Neurodegenerative Disease

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110629

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131008

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131227

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140407

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140407

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141007

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150203

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150602

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150610

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150804

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150821

R150 Certificate of patent or registration of utility model

Ref document number: 5798322

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250