CA2711878A1 - Therapeutic inhibitors of pai-1 function and methods of their use - Google Patents
Therapeutic inhibitors of pai-1 function and methods of their use Download PDFInfo
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- CA2711878A1 CA2711878A1 CA2711878A CA2711878A CA2711878A1 CA 2711878 A1 CA2711878 A1 CA 2711878A1 CA 2711878 A CA2711878 A CA 2711878A CA 2711878 A CA2711878 A CA 2711878A CA 2711878 A1 CA2711878 A1 CA 2711878A1
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- C—CHEMISTRY; METALLURGY
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2451—Glucanases acting on alpha-1,6-glucosidic bonds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01099—Arabinan endo-1,5-alpha-L-arabinosidase (3.2.1.99)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US2013708P | 2008-01-09 | 2008-01-09 | |
| US61/020,137 | 2008-01-09 | ||
| US8064008P | 2008-07-14 | 2008-07-14 | |
| US61/080,640 | 2008-07-14 | ||
| PCT/US2009/000155 WO2009089059A2 (en) | 2008-01-09 | 2009-01-09 | Therapeutic inhibitors of pai-1 function methods of their use |
Publications (1)
| Publication Number | Publication Date |
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| CA2711878A1 true CA2711878A1 (en) | 2009-07-16 |
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| CA2711878A Abandoned CA2711878A1 (en) | 2008-01-09 | 2009-01-09 | Therapeutic inhibitors of pai-1 function and methods of their use |
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| EP (1) | EP2242501A4 (ko) |
| JP (2) | JP2011509093A (ko) |
| KR (1) | KR101712208B1 (ko) |
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| CA (1) | CA2711878A1 (ko) |
| IL (1) | IL206891A0 (ko) |
| MX (1) | MX2010007586A (ko) |
| RU (1) | RU2010133847A (ko) |
| WO (1) | WO2009089059A2 (ko) |
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| CN102123721A (zh) | 2008-01-09 | 2011-07-13 | 英特瑞克斯顿股份有限公司 | Pai-1功能的治疗性抑制剂及其使用方法 |
| JP5986627B2 (ja) | 2012-05-01 | 2016-09-06 | 富士フイルム株式会社 | 多能性幹細胞の培養方法及びこれに用いるポリペプチド |
| CN103421781B (zh) * | 2012-07-04 | 2014-12-31 | 华中农业大学 | 猪肌肉组织特异性表达基因myf6启动子及应用 |
| CN105793285A (zh) * | 2013-12-10 | 2016-07-20 | 豪夫迈·罗氏有限公司 | 多亚基结构的亚基的结合结构域用于将药物活性实体靶向递送至多亚基结构的用途 |
| JP7168990B2 (ja) | 2016-12-15 | 2022-11-10 | タレンゲン インターナショナル リミテッド | 肥満症を予防および治療するための方法および薬物 |
| US11547746B2 (en) | 2016-12-15 | 2023-01-10 | Talengen International Limited | Method for treating coronary atherosclerosis and complications thereof |
| US11389515B2 (en) | 2016-12-15 | 2022-07-19 | Talengen International Limited | Method for mitigating heart disease |
| JOP20210146A1 (ar) | 2018-12-28 | 2023-01-30 | Vertex Pharma | بولي ببتيدات منشط بلازمينوجين من نوع يوروكيناز معدلة وطرق استخدامها |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
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| US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
| AU1191001A (en) * | 1999-10-07 | 2001-05-10 | Human Genome Sciences, Inc. | Plasminogen-like polynucleotides, polypeptides, and antibodies |
| DE10053251A1 (de) * | 2000-10-26 | 2002-05-08 | Boehringer Ingelheim Pharma | Epitope von PAI-1 |
| US20030211095A1 (en) * | 2002-05-08 | 2003-11-13 | Abd. Al-Roof Higazi | Peptide for regulation of urokinase plasminogen activator and method of optimizing therapeutic efficacy |
| US20030199463A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | DNA enzyme to inhibit plasminogen activator inhibitor-1 |
| EP1509236A4 (en) | 2002-05-13 | 2008-07-30 | Children S Hospital Los Angele | TREATMENT AND PREVENTION OF ABNORMAL SCALING IN KELOIDS AND OTHER SKIN OR INTERNAL WOUNDS OR LESIONS |
| US7241613B1 (en) * | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| US7785871B2 (en) | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
| US20080050808A1 (en) | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
| US7071295B2 (en) | 2002-12-02 | 2006-07-04 | Intrexon Corporation | Signal for targeting molecules to the sarco(endo)plasmic reticulum |
| ATE430731T1 (de) | 2002-12-10 | 2009-05-15 | Wyeth Corp | Substituierte indoloxoacetylaminoessigsäurederivate als inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| WO2005116231A1 (en) | 2004-05-18 | 2005-12-08 | Intrexon Corporation | Methods for dynamic vector assembly of dna cloning vector plasmids |
| WO2007048103A2 (en) | 2006-10-18 | 2007-04-26 | Intrexon Corporation | Pkd ligands and polynucleotides encoding pkd ligands |
| US8153598B2 (en) | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
| US7943732B2 (en) | 2006-06-05 | 2011-05-17 | Intrexon Corporation | AKT ligands and polynucleotides encoding AKT ligands |
| US8993263B2 (en) | 2006-08-07 | 2015-03-31 | Intrexon Corporation | PKA ligands and polynucleotides encoding PKA ligands |
| US8999666B2 (en) | 2006-08-09 | 2015-04-07 | Intrexon Corporation | PKC ligands and polynucleotides encoding PKC ligands |
| US8283445B2 (en) | 2006-11-13 | 2012-10-09 | Intrexon Corporation | Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide |
| US8729225B2 (en) | 2006-11-13 | 2014-05-20 | Intrexon Corporation | Glycogen synthase kinase heteropolyligand polypeptide |
| US7705122B2 (en) | 2006-12-04 | 2010-04-27 | Intrexon Corporation | mTOR ligands and polynucleotides encoding mTOR ligands |
| DK2126064T3 (da) | 2007-03-27 | 2012-09-10 | Intrexon Corp | MEK-ligander og polynukleotider til kodning af MEK-ligander |
| WO2009014564A2 (en) * | 2007-04-27 | 2009-01-29 | The University Of Toledo | Modified plasminogen activator inhibitor type-1 molecule and methods based thereon |
| CN102123721A (zh) | 2008-01-09 | 2011-07-13 | 英特瑞克斯顿股份有限公司 | Pai-1功能的治疗性抑制剂及其使用方法 |
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- 2009-01-09 KR KR1020107017701A patent/KR101712208B1/ko active IP Right Grant
- 2009-01-09 JP JP2010542283A patent/JP2011509093A/ja not_active Withdrawn
- 2009-01-09 MX MX2010007586A patent/MX2010007586A/es active IP Right Grant
- 2009-01-09 BR BRPI0906867A patent/BRPI0906867A2/pt not_active IP Right Cessation
- 2009-01-09 EP EP09700772A patent/EP2242501A4/en not_active Withdrawn
- 2009-01-09 AU AU2009204464A patent/AU2009204464B2/en not_active Ceased
- 2009-01-09 RU RU2010133847/10A patent/RU2010133847A/ru not_active Application Discontinuation
- 2009-01-09 US US12/812,127 patent/US8431363B2/en not_active Expired - Fee Related
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- 2009-01-09 WO PCT/US2009/000155 patent/WO2009089059A2/en active Application Filing
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2011509093A (ja) | 2011-03-24 |
| EP2242501A4 (en) | 2011-10-19 |
| KR20100129271A (ko) | 2010-12-08 |
| US20130267022A1 (en) | 2013-10-10 |
| AU2009204464A1 (en) | 2009-07-16 |
| US8828686B2 (en) | 2014-09-09 |
| WO2009089059A2 (en) | 2009-07-16 |
| MX2010007586A (es) | 2011-02-22 |
| US8431363B2 (en) | 2013-04-30 |
| US20110055940A1 (en) | 2011-03-03 |
| BRPI0906867A2 (pt) | 2019-09-24 |
| AU2009204464B2 (en) | 2014-12-04 |
| IL206891A0 (en) | 2010-12-30 |
| CN102123721A (zh) | 2011-07-13 |
| KR101712208B1 (ko) | 2017-03-03 |
| JP2012135307A (ja) | 2012-07-19 |
| EP2242501A2 (en) | 2010-10-27 |
| RU2010133847A (ru) | 2012-05-20 |
| WO2009089059A3 (en) | 2009-09-24 |
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