CA2710680C - Anti-c35 antibody combination therapies and methods - Google Patents

Anti-c35 antibody combination therapies and methods Download PDF

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Publication number
CA2710680C
CA2710680C CA2710680A CA2710680A CA2710680C CA 2710680 C CA2710680 C CA 2710680C CA 2710680 A CA2710680 A CA 2710680A CA 2710680 A CA2710680 A CA 2710680A CA 2710680 C CA2710680 C CA 2710680C
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CA
Canada
Prior art keywords
antibody
antigen
use according
seq
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2710680A
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English (en)
French (fr)
Other versions
CA2710680A1 (en
Inventor
Maurice Zauderer
Elizabeth E. Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaccinex Inc
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of CA2710680A1 publication Critical patent/CA2710680A1/en
Application granted granted Critical
Publication of CA2710680C publication Critical patent/CA2710680C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2710680A 2007-12-26 2008-12-23 Anti-c35 antibody combination therapies and methods Expired - Fee Related CA2710680C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1676307P 2007-12-26 2007-12-26
US61/016,763 2007-12-26
PCT/US2008/013998 WO2009082485A1 (en) 2007-12-26 2008-12-23 Anti-c35 antibody combination therapies and methods

Publications (2)

Publication Number Publication Date
CA2710680A1 CA2710680A1 (en) 2009-07-02
CA2710680C true CA2710680C (en) 2018-10-16

Family

ID=40801516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2710680A Expired - Fee Related CA2710680C (en) 2007-12-26 2008-12-23 Anti-c35 antibody combination therapies and methods

Country Status (9)

Country Link
US (1) US8637026B2 (enExample)
EP (1) EP2237792B1 (enExample)
JP (1) JP5690593B2 (enExample)
KR (1) KR101642846B1 (enExample)
CN (1) CN101932333A (enExample)
AU (1) AU2008341050B2 (enExample)
CA (1) CA2710680C (enExample)
NZ (1) NZ586544A (enExample)
WO (1) WO2009082485A1 (enExample)

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EA029023B1 (ru) 2011-10-11 2018-01-31 Вэксинекс, Инк. Применение молекул, связывающих семафорин-4d, для модуляции проницаемости гематоэнцефалического барьера
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
PL3489261T3 (pl) 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
IL282953B2 (en) * 2012-11-13 2026-02-01 Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnutzige Gmbh Agents for the treatment of claudin-expressing cancers
EP2968556A1 (en) 2013-03-13 2016-01-20 University Of Kentucky Research Foundation Methods of administering igg1 antibodies and methods of suppressing angiogenesis
US9243068B2 (en) 2013-06-25 2016-01-26 Vaccinex, Inc. Combination of SEMA-4D inhibitors and immunomodulators to inhibit tumors and metastases
PT3445397T (pt) 2016-04-22 2023-01-13 Vaccinex Inc Exibição de proteína integral de membrana sobre viriões envelopados extracelulares de poxvírus
KR20230047507A (ko) 2016-06-27 2023-04-07 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 암 치료 조합
SG11201900595YA (en) 2016-08-02 2019-02-27 Vaccinex Inc Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
WO2021039592A1 (ja) * 2019-08-29 2021-03-04 コニカミノルタ株式会社 創薬支援方法、創薬支援装置及びプログラム
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Also Published As

Publication number Publication date
CA2710680A1 (en) 2009-07-02
KR101642846B1 (ko) 2016-07-26
US8637026B2 (en) 2014-01-28
EP2237792A4 (en) 2012-07-25
WO2009082485A1 (en) 2009-07-02
US20110008322A1 (en) 2011-01-13
AU2008341050B2 (en) 2013-10-24
NZ586544A (en) 2012-07-27
JP2011509246A (ja) 2011-03-24
EP2237792A1 (en) 2010-10-13
CN101932333A (zh) 2010-12-29
JP5690593B2 (ja) 2015-03-25
KR20100095017A (ko) 2010-08-27
AU2008341050A1 (en) 2009-07-02
EP2237792B1 (en) 2017-05-24

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