CA2708822A1 - Kinesin inhibitors as cancer therapeutics - Google Patents

Kinesin inhibitors as cancer therapeutics Download PDF

Info

Publication number
CA2708822A1
CA2708822A1 CA2708822A CA2708822A CA2708822A1 CA 2708822 A1 CA2708822 A1 CA 2708822A1 CA 2708822 A CA2708822 A CA 2708822A CA 2708822 A CA2708822 A CA 2708822A CA 2708822 A1 CA2708822 A1 CA 2708822A1
Authority
CA
Canada
Prior art keywords
substituted
carcinoma
compound
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2708822A
Other languages
English (en)
French (fr)
Inventor
Tinya Abrams
Paul Barsanti
David Duhl
Michel Faure
Paul A. Renhowe
Annette Olga Walter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2708822(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2708822A1 publication Critical patent/CA2708822A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2708822A 2007-12-14 2008-12-12 Kinesin inhibitors as cancer therapeutics Abandoned CA2708822A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1396607P 2007-12-14 2007-12-14
US61/013,966 2007-12-14
PCT/EP2008/067412 WO2009077448A1 (en) 2007-12-14 2008-12-12 Kinesin inhibitors as cancer therapeutics

Publications (1)

Publication Number Publication Date
CA2708822A1 true CA2708822A1 (en) 2009-06-25

Family

ID=40328566

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2708822A Abandoned CA2708822A1 (en) 2007-12-14 2008-12-12 Kinesin inhibitors as cancer therapeutics

Country Status (30)

Country Link
US (2) US8252832B2 (Direct)
EP (1) EP2229170B1 (Direct)
JP (1) JP5501976B2 (Direct)
KR (1) KR20100098394A (Direct)
CN (1) CN101939005B (Direct)
AR (1) AR069676A1 (Direct)
AU (1) AU2008337570B2 (Direct)
BR (1) BRPI0821248A2 (Direct)
CA (1) CA2708822A1 (Direct)
CL (1) CL2008003707A1 (Direct)
CO (1) CO6290651A2 (Direct)
CR (1) CR11412A (Direct)
DO (1) DOP2010000175A (Direct)
EA (1) EA018014B1 (Direct)
EC (1) ECSP10010248A (Direct)
ES (1) ES2459442T3 (Direct)
GE (1) GEP20125647B (Direct)
GT (1) GT201000172A (Direct)
IL (1) IL205831A0 (Direct)
MA (1) MA31872B1 (Direct)
MY (1) MY150214A (Direct)
NI (1) NI201000091A (Direct)
NZ (1) NZ585142A (Direct)
PA (1) PA8807801A1 (Direct)
PE (1) PE20091451A1 (Direct)
SM (1) SMP201000095B (Direct)
TN (1) TN2010000204A1 (Direct)
TW (1) TW200930704A (Direct)
UY (1) UY31532A1 (Direct)
WO (1) WO2009077448A1 (Direct)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
WO2011128388A2 (en) * 2010-04-15 2011-10-20 Novartis Ag Oxazole and thiazole compounds as ksp inhibitors
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
JP2016516035A (ja) * 2013-03-15 2016-06-02 ノバルティス アーゲー 細胞増殖阻害剤およびそれらのコンジュゲート
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
EP4406606A3 (de) 2015-06-22 2024-10-09 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren g
CN105418527A (zh) * 2015-12-28 2016-03-23 青岛友诚高新技术有限公司 一种具有抗乳腺导管癌活性的化合物及其制备方法、用途
CN105646361B (zh) * 2016-02-17 2017-12-01 吉首大学 一种2,4,5‑三芳基咪唑型化合物及其制法和用途
JP7066714B2 (ja) 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート（ａｄｃ）
CN106668863B (zh) * 2017-02-21 2019-04-23 南方医科大学 靶向ktn1治疗皮肤鳞状细胞癌的药物
GB201706162D0 (en) * 2017-04-19 2017-05-31 Nat Univ Singapore Compounds
CN111954532A (zh) * 2018-04-13 2020-11-17 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物的抗肿瘤多药耐药性、治疗癌症的用途和蛋白质-药物分子复合物
CN109646679A (zh) * 2019-01-28 2019-04-19 中国科学院长春应用化学研究所 铁离子螯合剂及其可药用盐的用途
CN111529526B (zh) * 2020-04-14 2021-04-23 广州领晟医疗科技有限公司 一种化合物在制备治疗急性胰腺炎的药物中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006002236A1 (en) * 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. N- (1- (1-benzyl -4-phenyl-1h-imidazol-2-yl) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer
US7271271B2 (en) 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
MY147188A (en) 2005-08-09 2012-11-14 Novartis Ag Substituted imidazole compounds as ksp inhibitors
JP2010515687A (ja) 2007-01-05 2010-05-13 ノバルティス アーゲー キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体

Also Published As

Publication number Publication date
TN2010000204A1 (en) 2011-11-11
AR069676A1 (es) 2010-02-10
JP2011506402A (ja) 2011-03-03
TW200930704A (en) 2009-07-16
KR20100098394A (ko) 2010-09-06
ES2459442T3 (es) 2014-05-09
SMP201000095B (it) 2011-09-09
EP2229170B1 (en) 2014-01-22
AU2008337570A1 (en) 2009-06-25
PA8807801A1 (es) 2009-07-23
NZ585142A (en) 2012-03-30
EP2229170A1 (en) 2010-09-22
US20130012560A1 (en) 2013-01-10
PE20091451A1 (es) 2009-10-19
GT201000172A (es) 2012-04-30
CO6290651A2 (es) 2011-06-20
CN101939005B (zh) 2015-12-16
ECSP10010248A (es) 2010-07-30
EA018014B1 (ru) 2013-04-30
US8252832B2 (en) 2012-08-28
CL2008003707A1 (es) 2009-06-05
GEP20125647B (en) 2012-09-25
US8664256B2 (en) 2014-03-04
US20090239922A1 (en) 2009-09-24
WO2009077448A1 (en) 2009-06-25
BRPI0821248A2 (pt) 2015-06-16
CN101939005A (zh) 2011-01-05
EA201000900A1 (ru) 2011-02-28
SMAP201000095A (it) 2010-09-10
MA31872B1 (fr) 2010-11-01
MY150214A (en) 2013-12-13
NI201000091A (es) 2011-03-15
JP5501976B2 (ja) 2014-05-28
IL205831A0 (en) 2010-11-30
UY31532A1 (es) 2009-08-03
CR11412A (es) 2010-06-30
AU2008337570B2 (en) 2012-04-05
DOP2010000175A (es) 2010-06-30

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20141212